Результаты поиска

Сердечно-сосудистые заболевания

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Cancer-associated thrombosis: clinical presentation and survival.

BackgroundThromboembolic events are important causes of morbidity and mortality in cancer patients. Clinical presentation in a community-based setting has not been fully clarified. The purpose of this study was to evaluate the incidence, risk factors, role of thrombophilia, and subsequent survival following thrombosis in cancer patients.MethodsA retrospective review was undertaken of clinical data for all consecutive patients with histologically confirmed cancer seen by the author at a regional cancer center, with emphasis on cancer-related thrombosis.ResultsBetween 2005 and 2012, of 1874 canc

Совпадение в полном тексте источника
… . 32 Activation of coagulation confers a selective survival advantage for tumor cells, and the interplay between tumor and hemostasis persists for many years, even after successful therapy and cure. 32 Such a thrombophilic state in cancer presents as a systemic disorder linked to chronic, low-grade disseminated … intravascular coagulation, with thrombotic episodes occurring alone or in the presence of disseminated intravascular coagulation, at different levels of expression in the majority of patients with malignancies. 32 , 33 This was partly supported in a recent study on 1178 cancer patients. …

Epidemiology, Pathophysiology, and Management of Cancer-Associated Ischemic Stroke.

Cancer and stroke are leading causes of global disability and mortality. With improvements in cancer-associated mortality and advancements in treatment of active malignancy, it is more common to encounter patients with ischemic stroke and active malignancy. Evidence suggests that cancer-associated ischemic stroke is a unique subtype of stroke; however, there is limited guidance when considering diagnostic workup, secondary prevention, rehabilitation, and future directions within this population. In this narrative review, we aim to describe the epidemiology, pathophysiological mechanisms, manag

Совпадение в полном тексте источника
… Fibrin monomer levels have been found to be a better indicator than plasma D-dimer in distinguishing patients with overtly disseminated intravascular coagulation [ 20 ], though utilization in patients with CAIS is unclear. … Evaluation of the Diagnostic Performance of Fibrin Monomer in Comparison to d-Dimer in Patients With Overt and Nonovert Disseminated Intravascular Coagulation. Clin. Appl. Thromb. Hemost. 2017;23:460–465. doi: 10.1177/1076029615615959. 21. …

Plesiomonas shigelloides Bacteremia: A Scoping Review of Epidemiology, Clinical Characteristics, Outcomes, and Implications of Antimicrobial Stewardship.

Plesiomonas shigelloides, an aquatic Gram-negative bacillus often associated with self-limiting gastroenteritis, has been reported worldwide. However, to date, no reviews have specifically investigated P. shigelloides bacteremia, which is rare and potentially fatal. This scoping review aimed to examine the existing literature to identify the epidemiology, clinical characteristics, antimicrobial susceptibility, and outcomes of P. shigelloides bacteremia. A PRISMA-ScR-guided search of PubMed, Scopus, Web of Science, and Embase identified 22 published cases, all reported as single-patient case re

Совпадение в полном тексте источника
… Disseminated intravascular coagulation (DIC) was reported in a minority of cases [ 19 , 20 , 24 ]; however, other patients showed no hematological involvement. Less common organ-specific manifestations were also documented. … Markers of severe illness further distinguished these groups, with higher rates of septic shock (66.7% vs. 25%), multiorgan failure (50% vs. 12.5%), and disseminated intravascular coagulation (33.3% vs. 6.3%) observed among fatal cases. …

The Debut Signal of Bone Metastasis and Stealthy Gastric Cancer Unmasked in a Young Male: A Case Report.

Gastric cancer is the fifth leading cause of cancer-related deaths in the world. The occurrence of bone metastases (BM) in gastric cancer without prior gastrointestinal (GI) symptoms is a rare phenomenon that has been sporadically documented in the existing literature. We report a case of a 27-year-old male presenting with chief complaints of severe backache for one month. After an upper gastrointestinal endoscopy and biopsy, the primary source of cancer was identified as a solitary gastric adenocarcinoma, supporting the diagnosis of bony metastases on the magnetic resonance imaging (MRI) of t

Совпадение в полном тексте источника
… Acute disseminated intravascular coagulation syndrome in cancer patients. Pasquini E, Gianni L, Aitini E, et al. Oncology. 1995;52:505–508. doi: 10.1159/000227520. 13. Lymph and blood capillaries of the human gastric mucosa. A morphologic basis for metastasis in early gastric carcinoma. … Gastric cancer associated with acute disseminated intravascular coagulation: successful initial treatment with weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin. Yeh KH, Cheng AL. Br J Haematol. 1998;100:769–772. doi: 10.1046/j.1365-2141.1998.00613.x. 18. …

The diagnostic role of complete MICM-P in metastatic carcinoma of bone marrow (MCBM) presented with atypical symptoms: A 7-year retrospective study of 45 cases in a single center.

Metastatic carcinoma of bone marrow (MCBM) tends to present with atypical symptoms and can be easily misdiagnosed or miss diagnosed. This study was conducted to investigate the clinical-pathological and hematological characteristics of MCBM patients in order to develop strategies for early detection, staging, treatment selection and prognosis predicting. We retrospectively analyzed 45 patients with MCBM diagnosed by bone marrow biopsy in our hospital during the past 7 years. The clinical symptoms, hemogram and myelogram features, Hematoxylin and eosin staining and immunohistochemistry staining

Совпадение в полном тексте источника
… intravascular coagulation occurrence in 1117 patients with solid tumors. [ 16 ] In our study, the main symptoms of MCBM are anemia (82.2%), bone pain (73.3%), hemorrhage (33.3%) and fever (8.9%). … Disseminated intravascular coagulation in solid tumors: clinical and pathologic study . Thromb Haemost . 2001 ; 86 : 828 – 33 . 11583315 [17] Dicksheet SJP Surgery R Kanhere MH . Role of bone marrow examination in staging of carcinoma of the breast . …

Cancer-Associated Thrombosis: Epidemiology, Pathophysiological Mechanisms, Treatment, and Risk Assessment.

Cancer patients represent a growing population with drastically difficult care and a lowered quality of life, especially due to the heightened risk of vast complications. Thus, it is well established so far that one of the most prominent complications in individuals with cancer is venous thromboembolism. Since there are various improved methods for screening and diagnosing cancer and its complications, the incidence of cancer-associated thrombosis has been on the rise in recent years. Therefore, the high mortality and morbidity rates among these patients are not a surprise. Consequently, there

Совпадение в полном тексте источника
… intravascular coagulation that manifests in individuals diagnosed with cancer. … All of these overlapping pathways may also result in the development of disseminated intravascular coagulation, which is a significant contributor to thromboembolic complications. Tumor necrosis factor-alpha and IL-1β are widely recognized as prominent pro-inflammatory cytokines. …

Intramedullary Nailing with and without the Use of Bone Cement for Impending and Pathologic Fractures of the Humerus in Multiple Myeloma and Metastatic Disease.

Although intramedullary nailing (IMN) is considered the standard of care for the surgical management of most femur metastatic diseases, the optimal treatment of metastatic humeral impending and/or pathologic fractures is still debatable. Moreover, the use of cemented humeral nails has not been thoroughly studied, and only a few small series have compared their results with uncemented nails. The purpose of this study was to compare the (1) survivorship, (2) functional outcomes, and (3) perioperative complications in patients receiving cemented versus uncemented humerus IMN for impending or comp

Совпадение в полном тексте источника
… Other recorded complications included gastrointestinal bleeding, Clostridium difficile infection, coagulopathies such as disseminated intravascular coagulation, deep vein thrombosis, and thrombocytopenia, sepsis, urinary tract infection, as well as transaminitis with hyperbilirubinemia. … sepsis and variceal bleeding with disseminated intravascular coagulation at 4 weeks Medical/ Miscellaneous † | F | 60 | Multiple myeloma | Diaphysis | Impending | Postoperative | Quadriparesis from cervical metastasis/hypotension/respiratory distress postop day #2 | Urgent neurosurgical decompression …

Cancer and stroke: commonly encountered by clinicians, but little evidence to guide clinical approach.

The association between stroke and cancer is well-established. Because of an aging population and longer survival rates, the frequency of synchronous stroke and cancer will become even more common. Different pathophysiologic mechanisms have been proposed how cancer or cancer treatment directly or via coagulation disturbances can mediate stroke. Increased serum levels of D-dimer, fibrin degradation products, and CRP are more often seen in stroke with concomitant cancer, and the clot retrieved during thrombectomy has a more fibrin- and platelet-rich constitution compared with that of atheroscler

Совпадение в полном тексте источника
… intravascular coagulation that can lead to both ischemic and hemorrhagic cerebrovascular events. 42 Disseminated intravascular coagulation is usually characterized by increased levels of D-dimer, prolonged prothrombin time, and low levels of fibrinogen and platelets. 42 Cancer-mediated hypercoagulability … Disseminated intravascular coagulation characterized by increased levels of D-dimer, prolonged prothrombin time, and low levels of fibrinogen and platelets can lead to both ischemic and hemorrhagic cerebrovascular events. …

Differences in Perspectives and Policies Regarding End-of-Life Care Between Hematologists and Gastroenterologists.

BackgroundPatients with hematologic malignancies often receive aggressive treatment until the terminal phase and transition to end-of-life (EOL) care less frequently than those with solid tumors. A 2015 survey compared hematologists' and solid tumor-oncologists' attitudes toward EOL care, revealing differences. A decade later, no similar reports have appeared despite therapeutic advances. Therefore, we repeated the survey with additional questions to examine whether perspectives on EOL care have changed.MethodsA 50-item questionnaire was administered to hematologists and gastroenterologists. R

Совпадение в полном тексте источника
… BS, broad‐spectrum; DIC, disseminated intravascular coagulation; PCWs, palliative care wards; PCHs, palliative care hospitals. … BS, broad‐spectrum; CPR, cardiopulmonary resuscitation; DIC, disseminated intravascular coagulation; ICU, intensive care unit; PCW/PCH, palliative care ward/palliative care hospital. …

Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases.

Purpose(153)Sm-ethylenediaminetetramethylenephosphonic acid (EDTMP; Quadramet) is indicated for the treatment of painful bone metastases, whereas zoledronic acid (Zometa) is indicated for the prevention of skeletal complications. Because of the different therapeutic effects, combining the treatments may be beneficial. Both, however, accumulate in areas with increased osteoblastic activity. Possible drug interactions were investigated.MethodsPatients with hormone-refractory prostate cancer were treated with 18.5 MBq/kg (153)Sm-EDTMP in weeks 1 and 3 and with 37 MBq/kg in week 15. Treatment with

Совпадение в полном тексте источника
… Two patients were withdrawn because of adverse events (increase in creatinine level, disseminated intravascular coagulation), four patients were recommended to start with radiotherapy or chemotherapy because of progressive disease, and one patient was withdrawn due to decreasing PSA level after the start … A third patient had disseminated intravascular coagulation, causing him to develop grade 3 hematoma and grade 4 thrombopenia. These patients went off-study. No further unexpected toxicity occurred (Table 3 ). …

Association between Thrombin Generation and Clinical Characteristics in COVID-19 Patients.

IntroductionCoronavirus disease 2019 (COVID-19) disease is associated with coagulopathy and an increased risk of thrombosis. An association between thrombin generation (TG) capacity, disease severity, and outcomes has not been well described.MethodsWe assessed the correlation of TG with sequential organ failure assessment (SOFA) and sepsis-induced coagulopathy (SIC) scores and clinical outcomes by analysis of plasma samples obtained from hospitalized COVID-19 patients.Results32 patients (68.8% male), whose median age was 69 years, were assessed, of whom only 3 patients did not receive anticoag

Совпадение в полном тексте источника
… Diagnosis and management of sepsis induced coagulopathy and disseminated intravascular coagulation. J Thromb Haemost. 2019;17((11)):1989–1994. doi: 10.1111/jth.14578. 26. …

Short- and Long-Term Prognosis in Hemodynamically Stable Pulmonary Embolism With Unresectable or Metastatic Malignancies: The Role of Performance Status.

BackgroundThe simplified Pulmonary Embolism Severity Index (sPESI) has limitations when evaluating acute pulmonary embolism (PE) in patients with concurrent malignancy. Despite its utility in predicting outcomes among cancer patients, the role of the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in acute PE remains underexplored. This study aims to assess the prognostic significance of ECOG PS ≥ 3 on short- and long-term mortality in acute PE with malignancy, correlating it with the sPESI.Methods and resultsWe retrospectively analyzed 44 hemodynamically stable acute PE patien

Совпадение в полном тексте источника
… The direct causes of death included type 1 respiratory failure (one case), brainstem infarction due to disseminated intravascular coagulation (DIC) (one case), and severe dehydration and malnutrition due to cachexia (one case) (Table 2 ). … Abbreviation: BSC, best supportive care; DIC, disseminated intravascular coagulation; PS, Performance Status; sPESI, simplified Pulmonary Embolism Severity Index. …

Thrombotic microangiopathy in oncology - a review.

Thrombotic microangiopathy is a syndrome triggered by a wide spectrum of situations, some of which are specific to the Oncology setting. It is characterized by a Coombs-negative microangiopathic haemolytic anemia, thrombocytopenia and organ injury, with characteristic pathological features, resulting from platelet microvascular occlusion. TMA is rare and its cancer-related subset even more so. TMA triggered by drugs is the most common within this group, including classic chemotherapy and the latest targeted therapies. The neoplastic disease itself and hematopoietic stem-cell transplantation co

Совпадение в полном тексте источника
… Disseminated intravascular coagulation Disseminated intravascular coagulation (DIC), a condition closely related to cancer, must be considered in the differential diagnosis of MAHA and thrombocytopenia in these patients. … Disseminated intravascular coagulation. N. Engl. J. Med. 1999;341(8):586–592. doi: 10.1056/NEJM199908193410807. 146. Wada H., Matsumoto T., Suzuki K., Imai H., Katayama N., Iba T. Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy. …

Emergency Care

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Indications for fresh whole blood transfusion include disorders of hemostasis and coagulopathies including disseminated intravascular coagulation (DIC), von Willebrand disease, and hemophilia. … Table 1-3 Indications for Administration of Blood Products DIC, Disseminated intravascular coagulation; NSAIDS, nonsteroidal antiinflammatory drugs. * Must be purchased because logistically one cannot obtain enough blood simultaneously to provide a significant amount of platelets; platelets infused have …

Serious adverse events and coping strategies of CAR-T cells in the treatment of malignant tumors.

Chimeric antigen receptor T (CAR-T) cells technology has been successfully used in the treatment of B cell-derived hematological tumors and multiple myeloma. CAR-T cells are also being studied in a variety of solid tumors. Current clinical reports on CAR-T cells in the treatment of malignant tumors are abundant. The tumor-killing activity of CAR-T cells and the unique adverse effects of CAR-T cells have been confirmed by many studies. There is evidence that serious adverse events can be life-threatening. CAR-T cells therapy is increasingly used in clinical settings, so it is important to pay a

Совпадение в полном тексте источника
… DIC, disseminated intravascular coagulation. Table 3 The incidence of clinical serious adverse events of CAR-T in solid tumors. All clinicaltrials can be downloaded from www.clinicaltrials.gov (accessed October 02, 2022). … The incidence of SAEs from high to low is febrile neutropenia (187 cases), neutropenia (12 cases), anaemia (9 cases), pancytopenia (8 cases), thrombocytopenia (5 cases), and disseminated intravascular coagulation (DIC) (5 cases), etc ( Table 2 ). …

Mortality in patients with alpha-mannosidosis: a review of patients' data and the literature.

BACKGROUND: Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder (LSD) caused by reduced activity of alpha-mannosidase. Clinical manifestations include skeletal dysmorphism, mental impairment, hearing loss and recurrent infections. The severe type of the disease leads to early childhood death, while patients with milder forms can live into adulthood. There are no mortality studies to date. This study aimed to investigate the age at death and the causes of death of patients with alpha-mannosidosis who had not received disease-modifying treatment. METHODS: Clinicians and

Совпадение в полном тексте источника
… intravascular coagulation | | F | 3.5 | [ 25 , 26 ] | Other | 1 (14.3) | | | 7 | Ketoacidosis and dehydration, suspected intracranial pressure | | M | 4.3 | [ 27 – 29 ] Studies were published in six countries: France (Reunion Island) (n = 1), Italy (n = 1), South Africa (n = 1), Sweden (n = 1 … Studies reported two patients with respiratory failure as a cause of death, with one patient described as deceased due to respiratory failure and disseminated intravascular coagulation. One study recorded pneumonia following aspiration as the cause of death. …

Predicting the complicated neutropenic fever in the emergency department.

ObjectivesThe purpose of this study was to identify independent factors that can be used to predict whether febrile neutropenic patients who appear healthy at presentation will develop subsequent complications, using variables that are readily available in the emergency department (ED).MethodThe medical records of 192 episodes in which the patients presented to the ED with neutropenic fever resulting from chemotherapy, with an alert mental state and haemodynamic stability were retrospectively reviewed. Endpoints examined were fever response to administered antibiotics, death or severe medical

Совпадение в полном тексте источника
… Complications | N (%) Hypotension* | 13 (34.2%) Respiratory failure† | 9 (23.7%) Disseminated intravascular coagulation | 7 (18.4%) Renal failure‡ | 2 (5.3%) Severe bleeding to require tranfusion | 2 (5.3%) Altered mental state | 1 (2.6%) Arrhythmia requiring treatment | 1 (2.6%) Others | 3 (7.9%) These …

Surgical management with radiation therapy for metastatic spinal tumors located on cervicothoracic junction : a single center study.

ObjectiveThe cervicothoracic junction (CTJ) is a biomechanically and anatomically complex region that has traditionally posed problems for surgical access. In this retrospective study, we describe our clinical experiences of the treatment of metastatic spinal tumors at the CTJ and the results.MethodsFrom June 2006 to December 2011, 23 patients who underwent surgery for spinal tumors involving the CTJ were enrolled in our study. All of the patients were operated on through the posterior approach, and extent of resection was classified as radical, debulking, and simple neural decompression. Adju

Совпадение в полном тексте источника
… Table 1 Epidemiologic and clinical information of 23 patients enrolled in the study LN : lymph node, RT : radiation therapy, MRC : Medical Research Council, d : decompression, e : en bloc resection, f : fusion, n : no fusion, DIC : disseminated intravascular coagulation, ARF : acute renal failure, CSF … Table 2 Postoperative complications reoperation and perioperative death after surgery DIC : disseminated intravascular coagulation, ARF : acute renal failure, CSF : cerebrospinal fluid Fig. 1 Annual prevalence of perioperative mortality and morbidity during enrolled period. …

Acute respiratory distress syndrome in patients with hematological malignancies: a one-year retrospective nationwide cohort study.

BACKGROUND: Acute respiratory distress syndrome (ARDS) occurring in patients with hematological malignancies (HM) is a life-threatening condition with specific features. Mortality rate remains high but improvement has been described over the past several years. We aimed to describe characteristics and outcomes of ARDS in HM patients admitted in French ICUs (Intensive Care Units) during a one year-period. Data for this nationwide cohort study were collected from the French national hospital database (Programme de Médicalisation des Systèmes d'Information (PMSI)). All patients (18 years or older

Совпадение в полном тексте источника
… disseminated intravascular coagulation (DIC), Graft-versus-host (GVH) disease, bronchial compression, adverse events of oncological treatments. leukostasis. Detailed codes for oncological characteristics are listed in appendix 2 . … intravascular coagulation | 91 (9.19%) | 122 (4.45%) | 557 (6.11%) | 0.0002 | 0.1160 | < 0.0001 | 0.1891 Graft-versus-host disease | 41 (4.14%) | 1 (0.04%) | 0 | < 0.0001 | 0.2940 | < 0.0001 | 0.2900 Bronchial compression | 5 (0.51%) | 15 (0.55%) | 15 (0.16%) | 0.0399 | 0.0590 | 0.8778 | 0.0058 Adverse …