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Rare Loxoscelism-Associated IgG Coombs-Positive Hemolytic Anemia Treated Successfully With Systemic Corticosteroids.

Loxoscelism-associated hemolytic anemia is a rare but critical complication of brown recluse spider bites. It may lead to various systemic manifestations, including jaundice, dark urine, and anemia-related symptoms, in addition to general loxoscelism symptoms such as skin lesions, fever, myalgia, nausea, and vomiting. Prompt diagnosis is crucial and requires recognizing typical laboratory findings such as low hemoglobin, elevated lactate dehydrogenase, reduced haptoglobin levels, and possibly a positive direct antiglobulin test. There is no definitive guideline for the treatment of loxoscelism

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… Further workup revealed a low haptoglobin level, elevated lactate dehydrogenase (LDH), and a negative disseminated intravascular coagulation (DIC) panel (Table 2 ). A peripheral blood smear obtained and reviewed by a pathologist showed severe anemia with spherocytosis (Figure 2 ). …

Toxicities of CAR T-cell therapy: a review of current literature.

The chimeric antigen receptor (CAR) design, first invented by Zelig Eshhar, paved the way for the use of genetically modified T-cells in targeted therapy against cancer cells. Since then, it has gone through many generations, especially with the integration of co-stimulation in the second and third-generation CARs. However, it also mounts a hyperactive immune response named as cytokine release syndrome with the release of several cytokines eventually resulting in multiple end-organ toxicities. The severity of cytokine release syndrome depends upon certain factors such as the tumor burden, choi

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… In some cases 8 , disseminated intravascular coagulation may be the consequence of the hematological toxicity. …

Оценка здоровья и функциональности микроциркуляции с использованием термоизображения.

Микроциркуляция, состоящая из судов диаметром менее 100 мкм, поддерживает перфузию тканей и метаболический обмен. Его дисфункция все чаще связана с хроническими, подстрекательскими и тромботическими расстройствами, такими, как диабет, сепсис, сердечно - сосудистые заболевания и Длинный COVID. Таким образом, точная, неинвазивная оценка микроваскулярного здоровья имеет клиническое значение. Инфракрасная тепловая съемка обеспечивает быстрые, неконтактные и физиологически последовательные средства визуализации распределения температуры, которые отражают основной поток крови. Поскольку термические

Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms.

Malignant hematological diseases, such as lymphoma, leukemia, and multiple myeloma, are frequently accompanied by clinical challenges including local progressive lesions, relapsed/refractory conditions, and poor tolerance to standard treatments in special populations. Systemic therapies represented by chemotherapy and targeted therapy have inherent limitations in addressing local tumor burden, relieving organ compression, and being suitable for frail patients. As a minimally invasive local treatment technology, ablation has been widely used in solid tumor therapy due to its advantages of preci

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… In severe cases, it can lead to disseminated intravascular coagulation, multiple organ failure, and even death, while thermal ablation usually does not induce SIRS [ 63 ]. …

Clinical Outcomes of Endoscopic Submucosal Dissection for Early Gastric Cancer Patients With Concurrent Advanced Malignancies With Expected Poor Prognosis.

AimsDespite improved outcomes for malignant tumors, evidence regarding the management of patients with multiple malignancies remains limited. We aimed to evaluate the clinical outcomes and prognosis of patients undergoing endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) complicated by advanced malignancies in other organs with a poor prognosis.Methods and resultsWe retrospectively reviewed 3703 gastric cancer patients who underwent ESD at our hospital (2005-2022), focusing on those with advanced extra-gastric malignancies with a 5-year survival rate of ConclusionsRecently,

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… The patient with perforation had surgery but died from disseminated intravascular coagulation (DIC) and uncontrolled bleeding. All three developed DIC and died within 30 days of ESD. Eleven patients died of primary advanced cancer within 4 years. … Abbreviations: DIC, disseminated intravascular coagulation; ESD, endoscopic submucosal dissection. …

Mechanistic Insights in Hemophagocytic Lymphohistiocytosis: Subsequent Acute Hepatic Failure in a Multiple Myeloma Patient Following Therapy with Ixazomib-Lenalidomide-Dexamethasone.

Hemophagocytic lymphohistiocytosis (HLH) is a rare, elusive, and life-threatening condition that is characterized by the pathologic and uncontrolled secondary activation of the cytotoxic T-cells, natural killer cells (NK-cells), and macrophages of the innate immune system. This condition can develop in sporadic or familial contexts associated with hematological malignancies, as a paraneoplastic syndrome, or linked to an infection related to immune system deficiency. This leads to the systemic inflammation responsible for the overall clinical manifestations. Diagnosis should be thorough, and tr

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… intravascular coagulation, skin manifestations (rash, purpura, petechiae), lymphadenopathy (due to the sequestration of lymphocytes), or a sepsis-like syndrome that may progress to multiple organ failure [ 4 , 28 ]. … Coagulopathy with disseminated intravascular coagulation can quickly follow [ 42 ]. Liver biopsy can reveal chronic hepatitis with periportal lymphocytic infiltration [ 43 ]. Pleocytosis, elevated protein levels and hemophagocytosis can be found in the cerebrospinal fluid in 50% of patients [ 12 ]. …

Search for novel biomarkers of febrile neutropenia in hematological patients: an overview.

A single-center prospective study was conducted at a tertiary care hospital in Kuopio Finland over the past two decades, searching for novel biomarker candidates to predict complicated course of febrile neutropenia (FN) in hematological patients. In Dec 2006‒Dec 2015, 85 patients with acute myeloid leukemia and 179 autologous hematopoietic stem cell transplant recipients were included. More than 20 biomarkers were evaluated in subsequent patient cohorts and compared to C-reactive protein (CRP) and procalcitonin (PCT). The samples were taken on d0-d2 from the beginning of FN. Here, we provide a

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… Yamakawa K Okamoto K Seki Y Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis Int J Hematol 2025 121 5 592 604 10.1007/s12185-024-03896-9 39676120 Yamakawa K, Okamoto K, Seki Y, et al. … Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis. Int J Hematol. 2025;121(5):592–604. 10.1007/s12185-024-03896-9. 39676120 10.1007/s12185-024-03896-9 21. …

babesiosis при ультранизком паразите, представляющем в качестве вторичного гемофагоцитического лимфохистиоцитоза у пациента на клеточной терапии B.

Бэбэзия микроти, паразит, передающийся клещами иксодов, может вызывать инфекции, начиная от асимптоматических и заканчивая болезненными, угрожающими жизни болезнями. Ocrelizumab, anti-CD20 Б-лимфоциты моноклональные антитела, используемые для лечения множественных склерозов, повышают риск серьезных или повторных инфекций патогенами, передаваемыми тиками. В редких случаях младециоз может вызвать гемофагоцитический лимфохистицитоз (HLH). КАСЕ КРАТКОЕ ИЗЛОЖЕНИЕ: Мы сообщаем о случае, когда педициоз проявляется в субакуте с вторичным HLH. 51-year-old Женщина с клеточной терапией B. Она представила

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… Severe manifestations of the disease include acute respiratory distress syndrome, renal failure, and disseminated intravascular coagulation ( 4 , 5 ). …

Why do patients with cancer die?

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier depl

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… In some cases, disseminated intravascular coagulation [G] can lead to thrombotic obstruction of small and midsize vessels leading to organ failure ( 12 ). … How I treat disseminated intravascular coagulation. [cited 2024 Jan 21];Blood. 2018 Feb 22;131(8):845–54. doi: 10.1182/blood-2017-10-804096. [Internet] 13. Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, et al. Advanced cancer is also a heart failure syndrome: a hypothesis. …

Biomarkers in individualized management of chimeric antigen receptor T cell therapy.

The development of chimeric antigen receptor (CAR) T cell immunotherapy has achieved promising results, both in clinical studies and in commercial products for patients with hematologic malignancies. Despite high remission rates of CAR-T cell therapy in previously untreatable, refractory and/or relapsed patients, several challenges in CAR-T therapy remain to be overcome, especially in integrating such therapies into personalized disease management approaches. Given the unique characteristics of CAR-T therapy, it is particularly urgent to identify biomarkers to maximize their clinical benefits.

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… Endothelial cell dysfunction is consistent with clinical evidence of coagulatory abnormalities and disseminated intravascular coagulation (DIC) in patients with severe encephalic toxicity. … intravascular coagulation Severe CRES Diffuse large B-cell lymphomas Severe CRS Event-free survival Transforming growth factor Food and Drug Administration Tumor lysis syndrome Fred Hutchinson Cancer Research Center Tumor microenvironment Fms-like tyrosine kinase Tumor necrosis factor Fludarabine …

The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges.

The frequency of chronic cutaneous wounds are sharply increasing in aging populations. Patients with age-related diseases, such as diabetes, tumors, renal failure and stroke are prone to soft tissue and skin injury, compounded by slowed healing in aging. Imbalance of wound inflammation, loss of growth factor secretion, and impairment of tissue repair abilities are all possible reasons for failed healing. Therefore, it is vital to explore novel approaches to accelerate wound healing. Platelet-rich plasma (PRP) as a cell therapy has been widely applied for tissue repair and regeneration. PRP pro

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… In 2015, Tae-ho et al. (2015) used al-PRP to treat beagle dogs with acute pancreatitis complicated by disseminated intravascular coagulation causing large-area skin defects. After 2 days of treatment, granulation tissue began to grow. After 21 days, the wounds were completely healed. … Topical allogeneic platelet-rich plasma treatment for a massive cutaneous lesion induced by disseminated intravascular coagulation in a toy breed dog. Ir. Vet. J. 68, 4. 10.1186/s13620-015-0032-7 Tamagawa-Mineoka R. (2015). Important roles of platelets as immune cells in the skin. J. Dermatol. …

Epidemiology of infections in cancer patients.

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications.

Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from chemotherapy and radiation. This review evaluates immune-based therapies and their complications for emergency clinicians. Therapy complications include immune-related adverse events (irAE), cytokine release syndrome (CRS), autoimmune toxicity, and chimeric antigen receptor (CAR) T-cell-related encephalopathy syndrome (CRES). Immune-related adverse

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… intravascular coagulation Neurologic | Headache, confusion, altered mental status, delirium, aphasia, hallucination, tremor, seizure, dysmetria, ataxia As Table 3 demonstrates, signs and symptoms of CRS overlap with sepsis, macrophage activation syndrome (hemophagocytic lymphohistiocytosis), neutropenic … Severe cases can include hypotension and shock, disseminated intravascular coagulation, and multiorgan failure. 104 – 106 , 116 – 120 Respiratory symptoms such as cough and tachypnea can progress to acute respiratory distress syndrome. …

Acute ischaemia of the lower limb due to non-bacterial thrombotic endocarditis with recent venous thrombo-embolic disease as the initial manifestation of lung adenocarcinoma: a case report.

BackgroundNon-bacterial thrombotic endocarditis is a rare condition. Optimal management is based on early diagnosis which remains difficult.Case summaryA 75-year-old male patient was admitted to the hospital with acute ischaemia of the left lower limb due to popliteal artery occlusion despite anticoagulation with rivaroxaban for pulmonary embolism diagnosed 2 weeks earlier. Transoesophageal echocardiography (TOE) showed a mobile vegetation with mild mitral valve regurgitation. Positron emission tomography (PET) scan did not show hyperfixation at the mitral valve but rather lymphadenopathy hype

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… These various thrombotic events may occur as venous thromboembolism, superficial migratory thrombophlebitis, arterial thrombosis, disseminated intravascular coagulation, thrombotic microangiopathy, and less often, as a non-bacterial thrombotic endocarditis (NBTE). …

The Deadly Duo of COVID-19 and Cancer!

As of September 19, 2020, about 30 million people have been infected with the novel corona virus disease 2019 (COVID-19) globally, and the numbers are increasing at an alarming rate. The disease has a tremendous impact on every aspect of life, but one of the biggest, related to human health and medical sciences, is its effect on cancer. Nearly 2% of the total COVID-19 patients prior to May 2020 had cancer, and the statistics are quite frightening as the patient can be referred to as "doubly unfortunate" to suffer from cancer with the added misery of infection with COVID-19. Data regarding the

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… Events such as thrombotic microangiopathy and disseminated intravascular coagulation are observed in cancer patients. Tumoral factors such as tissue factor (TF), podoplanin, plasminogen activator factor (PAI-1), cytokines, NET, and mucins trigger the risk for thrombosis ( Thålin et al., 2019 ). …

Determining Risk Factors Associated with Cardiovascular Complications in Patients with Acute Leukemia: A Systematic Review.

BackgroundPatients with acute leukemia (AL) are at heightened risk of cardiovascular complications due to both disease-related and treatment-related factors. These complications include heart failure, arrhythmias, myocardial infarction, and thromboembolic events which may significantly impact morbidity and mortality.ObjectiveTo identify the risk factors contributing to cardiovascular complications in patients with acute leukemia.MethodsThis systematic review was conducted according to the PRISMA reporting guideline. Multiple databases including PubMed, Scopus, IEEE Xplore, the Cochrane Library

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… time-dependent relationship between the occurrence of venous thromboembolic (VTE) and arterial thromboembolic (ATE) events and the diagnosis of hematological malignancies, as well as the initiation of onco-hematological treatment | ALL, AML | Type of leukemia Comorbidities Age Chemotherapy initiation Disseminated … intravascular coagulation in AML Thromboembolism (VTE or ATE) | VTE, ATE | During Treatment to Late-onset | AML and ALL raised VTE risk during treatment, with chemotherapy and disseminated intravascular coagulation contributing to AML, and higher VTE rates were seen in ALL. …

Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences.

Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-HSCT). Severe CRS can be life-threatening in some cases and requires prompt management of those toxicities and is still a great challenge for physicians. The pathophysiology of CRS is still not fully understood, which also applies to the identifications of predictive biomarkers that can forecast the

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… Trans-signaling is believed to contribute to the development of many CRS symptoms and signs, i.e., disseminated intravascular coagulation, vascular leakage and myocardial dysfunction [ 57 , 58 , 59 ]. …

Cancer-Associated Thrombosis: A New Light on an Old Story.

Cancer-associated thrombosis (CAT) is a rising and significant phenomenon, becoming the second leading cause of death in cancer patients. Pathophysiology of CAT differs from thrombosis in the non-cancer population. There are additional risk factors for thrombosis specific to cancer including cancer type, histology, and treatment, such as chemotherapy. Recently developed scoring systems use these risk factors to stratify the degree of risk and encourage thromboprophylaxis in intermediate- to high-risk patients. Anticoagulation is safely used for prophylaxis and treatment of CAT. Both of these h

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… Thrombotic events encompass venous thromboembolisms (VTEs), including deep vein thrombosis (DVT) and pulmonary embolism (PE), arterial thrombotic events (ATEs) and disseminated intravascular coagulation (DIC) [ 4 ]. …

Pulmonary origin and risk assessment of cancer-associated thrombosis.

Cancer-associated thrombosis (CAT) is a serious complication frequently observed in patients with cancer; however, its exact mechanism is not yet fully understood. Recent research in 2025 suggests that the lungs play a significant role in providing prothrombotic factors. Both primary and metastatic lung tumors have the potential to induce a state of hypercoagulability through various pathways, such as the secretion of procoagulant molecules, such as tissue factor (TF), triggering local inflammatory responses, platelet activation, and alterations in the function of vascular endothelial cells. F

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… Disseminated intravascular coagulation disease (DIC) is diagnosed in approximately 7–20% of patients with solid tumors, and autopsies have revealed that occult DIC is present in nearly all cancer patients [ 3 ]. … Abbreviations Cancer-associated thrombosis Disseminated intravascular coagulation Tissue factor Venous thromboembolism ROS proto-Oncogene 1, receptor tyrosine kinase Small extracellular vesicles Small extracellular vesicles containing integrin β2 C-X-C motif chemokine 13 Tumor necrosis factor-alpha …

From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance.

Monoclonal gammopathy and peripheral neuropathy are common diseases of elderly patients, and almost 10% of patients with neuropathy of unknown cause have paraprotein. However, growing evidence suggests that several hematological malignancies synthesize and release monoclonal proteins that damage the peripheral nervous system through different mechanisms. The spectrum of the disease varies from mild to rapidly progressive symptoms, sometimes affecting not only sensory nerve fibers, but also motor and autonomic fibers. Therefore, a multidisciplinary approach, mainly between hematologists and neu