Результаты поиска

Health and economic impact of caregiving on informal caregivers of people with chronic diseases in sub-Saharan Africa: A systematic review.

With a disproportionate burden of chronic diseases and severe shortage of health workers in sub-Saharan Africa, the region implicitly relies on informal caregivers (ICGs) to support the patients both within and outside the health facilities. The aim of this review is to systematically summarise evidence on the health and economic impact of caregiving on informal caregivers of patients with chronic diseases in sub-Saharan Africa. Medline (Ovid), CINAHL (EBSCOhost), PsycINFO (Ovid), Embase (Ovid), Global Health, and Web of Science databases were systematically searched to identify original artic

B-cells in pulmonary arterial hypertension: friend, foe or bystander?

There is an unmet need for new therapeutic strategies that target alternative pathways to improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity has been involved in the development and progression of vascular lesions in PAH, we review the potential contribution of B-cells in its pathogenesis and evaluate the relevance of B-cell-targeted therapies. Circulating B-cell homeostasis is altered in PAH patients, with total B-cell lymphopenia, abnormal subset distribution (expansion of naïve and antibody-secreting cells, reduction of memory B-cells) and chronic acti

Совпадение в полном тексте источника
… González-Tajuelo R, de la Fuente-Fernández M, Morales-Cano D, et al. Spontaneous pulmonary hypertension associated with systemic sclerosis in P-selectin glycoprotein ligand 1-deficient mice. Arthritis Rheumatol 2020; 72: 477–487. doi: 10.1002/art.41100 115. …

Targeting Sphingosine 1-Phosphate Metabolism as a Therapeutic Avenue for Prostate Cancer.

Prostate cancer (PC) is the second most common cancer in men worldwide. More than 65% of men diagnosed with PC are above 65. Patients with localized PC show high long-term survival, however with the disease progression into a metastatic form, it becomes incurable, even after strong radio- and/or chemotherapy. Sphingosine 1-phosphate (S1P) is a bioactive lipid that participates in all the steps of oncogenesis including tumor cell proliferation, survival, migration, invasion, and metastatic spread. The S1P-producing enzymes sphingosine kinases 1 and 2 (SK1 and SK2), and the S1P degrading enzyme

Совпадение в полном тексте источника
… Morales P.R., Dillehay D.L., Moody S.J., Pallas D.C., Pruett S., Allgood J.C., Symolon H., Merrill A.H. Safingol toxicology after oral administration to TRAMP mice: Demonstration of safingol uptake and metabolism by N-acylation and N-methylation. Drug Chem. …

Triple-Negative Breast Cancer: Basic Biology and Immuno-Oncolytic Viruses.

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer. TNBC diagnoses account for approximately one-fifth of all breast cancer cases globally. The lack of receptors for estrogen, progesterone, and human epidermal growth factor 2 (HER-2, CD340) results in a lack of available molecular-based therapeutics. This increases the difficulty of treatment and leaves more traditional as well as toxic therapies as the only available standards of care in many cases. Recurrence is an additional serious problem, contributing substantially to its higher mortality rate as compared to

Совпадение в полном тексте источника
… Garza-Morales R. Gonzalez-Ramos R. Chiba A. De Oca-Luna R.M. McNally L.R. McMasters K.M. Gomez-Gutierrez J.G. Temozolomide enhances triple-negative breast cancer virotherapy in vitro Cancers 2018 10 144 10.3390/cancers10050144 29772755 PMC5977117 120. Ang L. Guo L. Wang J. Huang J. Lou X. Zhao M. …

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps.

Leishmaniasis is a neglected tropical disease endemic primarily to low- and middle-income countries, for which there has been inadequate development of affordable, safe, and efficacious therapies. Clinical manifestations of leishmaniasis range from self-healing skin lesions to lethal visceral infection with chances of relapse. Although treatments are available, secondary effects limit their use outside the clinic and negatively impact the quality of life of patients in endemic areas. Other non-medicinal treatments, such as thermotherapies, are limited to use in patients with cutaneous leishman

Совпадение в полном тексте источника
… Peris MP, Esteban-Gil A, Ares-Gómez S, Morales M, Castillo JA, Moreno B. Characterization of lesions in the temporal muscle and the male reproductive system (epididymis and testicle) of dogs experimentally infected with Leishmania infantum with different clinical stages. …

Nerve Growth Factor and Autoimmune Diseases.

NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and neurotransmitters controlling the immune system activation in inflamed tissues. Evidence suggests that NGF is involved in the pathogenesis of numerous immune diseases including autoimmune thyroiditis, chronic arthritis, multiple sclerosis, systemic lupus erythematosus, mastocytosis, and chronic granulomatous disease. Furthermore, as NGF levels have been link

Совпадение в полном тексте источника
… Morales-Ruiz T. Gómez-Fernández A. Flores-Rojas K. Gil-Campos M. Martin-Borreguero P. Ariza R.R. Roldán-Arjona T. Perez-Navero J.L. Analysis of Global and Local DNA Methylation Patterns in Blood Samples of Patients With Autism Spectrum Disorder Front. …

Targeting Protein Degradation Pathways in Tumors: Focusing on their Role in Hematological Malignancies.

Cells must maintain their proteome homeostasis by balancing protein synthesis and degradation. This is facilitated by evolutionarily-conserved processes, including the unfolded protein response and the proteasome-based system of protein clearance, autophagy, and chaperone-mediated autophagy. In some hematological malignancies, including acute myeloid leukemia, misfolding or aggregation of the wild-type p53 tumor-suppressor renders cells unable to undergo apoptosis, even with an intact p53 DNA sequence. Moreover, blocking the proteasome pathway triggers lymphoma cell apoptosis. Extensive studie

Совпадение в полном тексте источника
… Morales-Martínez M., Vega M.I. Roles and Regulation of BCL-xL in Hematological Malignancies. Int. J. Mol. Sci. 2022;23:2193. doi: 10.3390/ijms23042193. 84. Schoenwaelder S.M., Jarman K.E., Gardiner E.E., Hua M., Qiao J., White M.J., Josefsson E.C., Alwis I., Ono A., Willcox A., et al. …

Cannabidiol (CBD) in Cancer Management.

The plant Cannabis sativa has been in use medicinally for several thousand years. It has over 540 metabolites thought to be responsible for its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating effects. Preclinical and clinical research indicates that CBD has a wide range of therapeutic effects, and many of them are relevant to the management of cancer. In this article, we explore some of the potential mechanisms of action of CBD in cancer, and evidence of its efficacy in the integr

Совпадение в полном тексте источника
… Villa-Morales M. Moreno E. Hamann S. Martín-Villar E. Flores J.M. Role of cannabinoid receptor CB2 in HRE2 pro-oncogenic signalling in breast cancer J. Natl. Cancer Inst. 2015 107 dvj077 10.1093/jnci/djv077 25855725 89. Jung C.K. Kang W.K. Park J.M. Ahn H.J. Kim S.W. Oh S.T. Choi K.Y. …

Molecular Mechanism of Autophagy and Its Regulation by Cannabinoids in Cancer.

Autophagy is a "self-degradation" process whereby malfunctioned cytoplasmic constituents and protein aggregates are engulfed by a vesicle called the autophagosome, and subsequently degraded by the lysosome. Autophagy plays a crucial role in sustaining protein homeostasis and can be an alternative source of energy under detrimental circumstances. Studies have demonstrated a paradoxical function for autophagy in cancer, displaying both tumour suppressive and tumour promotive roles. In early phases of tumour development autophagy promotes cancer cell death. In later phases, autophagy enables canc

Совпадение в полном тексте источника
… Morales P., Jagerovic N. Antitumor Cannabinoid Chemotypes: Structural Insights. Front. Pharmacol. 2019;10:621. doi: 10.3389/fphar.2019.00621. 126. Pertwee R.G., Howlett A.C., Abood M.E., Alexander S.P., di Marzo V., Elphick M.R., Greasley P.J., Hansen H.S., Kunos G., Mackie K., et al. …

Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage-Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities.

Philadelphia chromosome (Ph) results from a translocation between the breakpoint cluster region (BCR) gene on chromosome 9 and ABL proto-oncogene 1 (ABL1) gene on chromosome 22. The fusion gene, BCR-ABL1, is a constitutively active tyrosine kinase which promotes development of leukemia. Depending on the breakpoint site within the BCR gene, different isoforms of BCR-ABL1 exist, with p210 and p190 being the most prevalent. P210 isoform is the hallmark of chronic myeloid leukemia (CML), while p190 isoform is expressed in majority of Ph-positive B cell acute lymphoblastic leukemia (Ph+ B-ALL) case

Совпадение в полном тексте источника
… Cramer-Morales K. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells J. Clin. Investig. 2017 127 2392 2406 10.1172/JCI90825 28481221 PMC5451241 25. Houshmand M. Simonetti G. Circosta P. Gaidano V. Cignetti A. Martinelli G. Saglio G. …

Intravenous Vitamin C for Cancer Therapy - Identifying the Current Gaps in Our Knowledge.

The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense controversy. Despite this, high dose IVC has been administered for decades by complementary health care practitioners and physicians, with little evidence base resulting in inconsistent clinical practice. In this review we pose a series of questions of relevance to both researchers and clinicians, and also patients themselves, in order to identify current gaps in our knowledge. These questions include: Do oncology patients have compromised vitamin C status? Is intravenous the optimal route of vitamin C a

Совпадение в полном тексте источника
… Cramer-Morales K. L. Furqan M. ( 2017 ). O2- and H2O2-Mediated Disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM Cancer cells to pharmacological ascorbate. Cancer Cell. 31 487.e8 – 500.e8 . 10.1016/j.ccell.2017.02.018 28366679 PMC5497844 Seely D. Stempak D. …

Историческое развитие иммуноэндокринных концепций психических расстройств и их терапии.

Отношения между центральной нервной, иммунной и эндокринной системами являются предметом психиатрических исследований, особенно в области депрессии и шизофрения. У поля длинные предтечи. Наблюдаемые явления, связанные с этими отношениями, восходят к неолитической эпохе. Теории иммуноэндокринной системы в самом широком смысле записаны в древности. В 19th Крепелин и Вагнер-Джаурег сообщили о первых клинических наблюдениях у пациентов психиатрических учреждений. Von Bestow, Эддисон и Кушинг описали психические симптомы у пациентов, страдающих эндокринными заболеваниями. :: 20th откровение века с

Anti-Cancer Research Progress of Triptolide: Mechanisms of Action, Structural Modifications, Nanodelivery Systems and Clinical Challenges.

Triptolide is a bioactive diterpenoid lactone from traditional Chinese medicine with notable anti-tumor, immunosuppressive, and anti-inflammatory properties. However, its clinical utility is hampered by poor solubility, a narrow therapeutic index, and multi-organ toxicity. In response, extensive efforts have been made to improve its efficacy and safety profile. This review critically examines recent progress in Triptolide research, covering its mechanisms of action, derivative design, drug delivery systems, and cancer-specific applications. It also evaluates its clinical potential against panc

Совпадение в полном тексте источника
… Uriostegui-Arcos M, Aguayo-Ortiz R, Valencia-Morales MDP, et al. Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer. Open Biol. 2020;10:200050. doi:10.1098/rsob.200050 29. Meng C, Zhu H, Song H, et al. …

Иммунотерапевтический ландшафт амиотропического бокового склероза: библиометрический анализ тенденций в области исследований, приоритетов в области перевода и сетей сотрудничества (см.2006-2025).

Амиотрофный боковой склероз (ALS) по-прежнему является серьезной терапевтической проблемой, при этом иммунная диагностика все чаще признается в качестве одного из важнейших факторов развития заболеваний. Несмотря на обширные механистические исследования, никакой иммунотерапевтический подход не привел к последовательному изменению болезней, в связи с чем возникают вопросы о том, отражает ли этот переводный пробел биологическую сложность или структурную несогласованность в исследовательской экосистеме. Чтобы охарактеризовать интеллектуальную эволюцию исследований иммунотерапевтии ALS, определить

Совпадение в полном тексте источника
… Camu W, Mickunas M, Veyrune J-L, Payan C, Garlanda C, Locati M, Juntas-Morales R, Pageot N, Malaspina A, Andreasson U, et al. Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): a phase 2a randomised, double-blind, placebo-controlled trial. …

Next-Generation HDAC Inhibitors: Advancing Zinc-Binding Group Design for Enhanced Cancer Therapy.

Histone deacetylases (HDACs) are pivotal epigenetic regulators that control gene expression, cell proliferation, and differentiation, and their dysregulation is closely associated with the onset and progression of multiple cancers. The therapeutic importance of these enzymes is reflected by FDA approval of HDAC inhibitors for oncology indications. Despite this clinical success, most FDA-approved agents employ conventional zinc-binding groups (ZBGs) such as hydroxamic acid and 2-aminoanilide, which are frequently linked to metabolic instability, genotoxicity, and poor pharmacokinetic behavior.

Совпадение в полном тексте источника
… Morales-Herrejón G., García-Vázquez J.B., Fernández-Pomares C., Bakalara N., Correa-Basurto J., Mendoza-Figueroa H.L. …

Cardiac Amyloidosis: Tribulations and New Frontiers.

This review article aims to provide an overview of the pathophysiology, diagnosis, and contemporary management of cardiac amyloidosis (CA) as well as identify the knowledge gaps and areas of potential research. CA can be divided into two main groups: transthyretin cardiac amyloidosis (ATTR-CA) and light chain cardiac amyloidosis (AL-CA). The former further separates into wild-type transthyretin (ATTRwt) and hereditary transthyretin (ATTRv). African Americans, males, and people older than 75 are the most common demographics affected by this disease. Thanks to an increased understanding of this

Корреляция когнитивных дисфункций и мер по диффузионному измерению МРТ в предметах, имеющих ОРД.

КОЛИЧЕСТВО: Когнитивная дисфункция - это обычное нарушение, наблюдаемое у лиц с множественным склерозом (MS), затрагивающее такие ключевые области, как внимание, скорость обработки информации, память и исполнительные функции. Этот дефицит, как правило, выявляется на основе всеобъемлющих нейропсихологических оценок, которые представляют собой золотой стандарт для когнитивной оценки. В последние годы были активизированы усилия по интеграции нейропсихологических результатов с передовыми методами нейроимации, с тем чтобы лучше понять нейронные субстраты когнитивной дисфункции. Среди них Difsusion

Совпадение в полном тексте источника
… Morales S. Naranjo V. Sempere Á. P. ( 2021 ). Contribution of gray matter atrophy and white matter damage to cognitive impairment in mildly disabled relapsing-remitting multiple sclerosis patients . …

Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review).

As a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain‑containing protein 4) is a chromatin‑associated protein that interacts with acetylated histones and actively recruits regulatory proteins, leading to the modulation of gene expression and chromatin remodeling. The cellular and epigenetic functions of BRD4 implicate normal development, fibrosis and inflammation. BRD4 has been suggested as a potential therapeutic target as it is often overexpressed and plays a critical role in regulating gene expression programs that drive tumor cell proliferation, survival, mi

Совпадение в полном тексте источника
… Joshi S, Singh AR, Liu KX, Pham TV, Zulcic M, Skola D, Chun HB, Glass CK, Morales GA, Garlich JR, et al. SF2523: Dual PI3K/BRD4 inhibitor blocks tumor immunosuppression and promotes adaptive immune responses in cancer. Mol Cancer Ther. 2019;18:1036–1044. doi: 10.1158/1535-7163.MCT-18-1206. 141. …

Targeting the DNA Damage Response for Cancer Therapy.

Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability. Defects in the DNA damage response pathways can give rise to various diseases, including cancer. The DNA damage response (DDR) system is instrumental in safeguarding genomic stability. The accumulation of DNA damage and the weakening of DDR function both promote the initiation and progression of tumors. Simultaneously, they offer opportunities and targets for cancer therapeutics. This article primarily elucid

Совпадение в полном тексте источника
… Fabián-Morales E. Santibáñez M. González-Barrios R. Díaz-Chávez J. Andonegui M.A. Association between ERCC1 and XPA expression and polymorphisms and the response to cisplatin in testicular germ cell tumours Br. J. Cancer 2013 109 68 75 10.1038/bjc.2013.303 23807173 PMC3708571 167. Gajjar K.K. …

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest develo

Совпадение в полном тексте источника
… Saitawee D, Teerakapong A, Morales NP, Jitprasertwong P, Hormdee D. Photodynamic therapy of Curcuma longa extract stimulated with blue light against Aggregatibacter actinomycetemcomitans. Photodiagnosis Photodyn Ther (2018) 22:101–5. doi: 10.1016/j.pdpdt.2018.03.001 43. …