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Psychosocial distress in young adults surviving hematological malignancies: a pilot study.

PurposeSurvivors of cancer during young adulthood face multiple psychosocial challenges following treatment. This study explores psychosocial distress and unmet needs among young adult survivors treated of hematological malignancies.MethodsA total of 85 young adults aged between 18 and 39 years at time of diagnosis, were invited to join the survey after the completion of treatment with curative intent. Sociodemographic data and the need for advice were gathered with a self-report questionnaire. A set of standardized questionnaires for quality of life (EORTC QLQ-C30), psychosocial stressors (PH

Best of JACC: Case Reports From ACC.23.

This dedicated issue of JACC: Case Reports highlights the top ranked Complex Clinical Cases from the ACC 2023 Scientific Sessions. These cases were reviewed and selected by a committee of peers in the months leading up to the annual meeting. These reviewers were ACC members with no affiliation to the JACC: Case Reports Editorial Board. While the cases were presented at the meeting and included in the formal Abstract Book from ACC, they have not been published elsewhere. These cases illustrate how the ACC can be a place for cardiovascular professionals to come together to learn, grow, and share

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… Ingestion of Taxus baccata (English Yew) may lead to cardiotoxicity and death. Intoxication is known to be resistant to standard treatments with no effective antidotes. … Endomyocardial biopsy showed cytoplasmic vacuolation of cardio-myocytes, interstitial fibrosis and vascular endothelial swelling, suggestive of cardiotoxicity (E). Cardiotropic viruses were absent in myocytes. Based on the suspicion of cardiac toxicity, tacrolimus was switched to everolimus. …

The role of tumor types in immune-related adverse events.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitors of T cell activation and function. With the widespread use of ICIs in cancer therapy, immune-related adverse events (irAEs) have gradually emerged as urgent clinical issues. Tumors not only exhibit high heterogeneity, and their response to ICIs varies, with "hot" tumors showing better anti-tumor effects but also a higher susceptibility to irAEs. The manifestation of irAEs displays a tumor-heterogeneous pattern, correlating with the tumor type in terms of the affected organs, incidence, median onset time, and se

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… Immune checkpoint inhibitor-associated cardiotoxicity: current understanding on its mechanism, diagnosis and management. Front Pharmacol. 2019;10:1350. 31849640 10.3389/fphar.2019.01350 PMC6897286 74. … Challenges and solutions in management of cardiotoxicity induced by checkpoint inhibitors. Klinicka Onkologie Casopis Ceske a Slovenske Onkologicke Spolecnosti. 2020;33(5):350–5. 33108879 10.14735/amko2020350 106. …

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity-A Pharmaco-Toxicological Screening.

Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to the infectious diseases problem. However, the excessive use of antibiotics worldwide has generated a critical public health issue and the bacterial resistance correlated with antibiotics inefficiency is still unsolved. Finding novel therapeutic approaches to overcome bacterial resistance is imperative, and natural compounds with antibacterial effects could be considered a promising option. The role played by antibiotics in tumorigenesis and their interrelation with the microbiota are sti

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… Cardiac Adverse Effects A cardiotoxic side effect of antibiotics is the prolongation of the QT interval that can lead to ventricular arrhythmias (e.g., torsades de pointes). … The mechanism underlying macrolides and fluoroquinolones’ cardiotoxicity involve the blockage of the rapid component (IKr) on the delayed rectifier potassium current on cell membrane of the cardiac myocytes [ 83 , 84 ]. The cardiotoxicity of aminoglycosides was also evaluated. …

Metal-on-Metal Total Hip Resurfacing Arthroplasty: An Evidence-Based Analysis.

OBJECTIVE: The objective of this review was to assess the safety and effectiveness of metal on metal (MOM) hip resurfacing arthroplasty for … cantly higher risk of leukemia. All patients who had leukemia were aged over than 60 years. COBALT CARDIOTOXICITY: EPIDEMIOLOGICAL STUDIES OF MYOCARDIOPATHY OF BEER DRINKERS: An unusual type of myocardiopathy, characterized by pericardial effusion, elevated hemoglobin concentrations, and congestive heart failure, occurred as an epidemic affecting 48 habitual be …

Molecular targeted therapy for anticancer treatment.

Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served as a fundamental backbone in precision medicine for cancer treatment. These approaches are now used clinically as first-line therapy for various types of human cancers. Compared to conventional chemotherapy, targeted therapeutic agents have efficient anticancer effects with fewer side effects. However, the emergence of drug resistanc

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… + metastatic breast cancer progressing with prior therapy (in combination with capecitabine, 2007) | Triple-positive metastatic breast cancer (in combination with letrozole, 2010) | Crosstalk with ER HER2 mutation PIK3CA mutation AXL elevation HER2 L755S mutation | Diarrhea, skin rash, asymptomatic cardiotoxicity … The side effects of targeted therapy include asthenia, anorexia, dyspnea, diarrhea, nausea, vomiting, mucositis, skin rash, fever, hand-foot syndrome, fatigue, cardiotoxicity, hypertension, and bleeding 49 , 50 . …

Редактор специального выпуска: последние методы и прикладные методы диагностики

Технологии добиваются гигантских успехов и все больше совершенствуют диагностику как частых, так и редких острых и хронических заболеваний [...]

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… In addition, recent technological developments, with strain techniques and the aid of advanced post-processing software have opened a huge chapter of study concerning the cardiotoxicity of oncological therapies, allowing the myriad of adverse cardiovascular effects associated with antineoplastic therapy …

Extensive Intracardiac Cement Embolism in a Patient Undergoing Workup for Bone Marrow Transplant.

Cement emboli are a well-established complication of kyphoplasties and vertebroplasties and can easily be mistaken for wires. While kyphoplasties are commonly performed for vertebral fractures caused by metastases from malignancies such as multiple myeloma, the implication of cement emboli in bone marrow transplant (BMT) patients is not well documented. Our patient presented with an incidental intracardiac cement embolism found while undergoing workup for BMT. He was managed conservatively, but transplant workup was put on hold until the embolism could be removed due to the risks associated wi

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… BMT patients are already at high risk of infection, cardiotoxicity, and bleeding. Furthermore, some cancer therapies such as lenalidomide further increase thrombotic risk [ 15 ]. …

An Analysis Regarding the Association Between Proteasome (PSM) and Hepatocellular Carcinoma (HCC).

BackgroundThe Proteasome (PSM) is a large multi-catalytic protease complex consisting of a 20S core particle and a 19S regulatory particle whose main function is to accept and degrade ubiquitinated substrates, are now considered as one of the potential regulators of tumor proliferation, and stemness maintenance. However, to date, studies on the relationship between PSM and hepatocellular carcinoma (HCC) are limited.MethodsThis study used a bioinformatics approach combining validation experiments to investigate the biological mechanisms that may be related with PSM. A series of experiments in v

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… treat other forms of cancer including lymphocytoma, colorectal cancer, and thyroid cancer, further strengthening the evidence that targeted PSM is an effective strategy in the fight against cancer. 24 , 25 However, frustratingly, apart from toxicities that severely affect patients’ quality of life (eg cardiotoxicity … Proteasome Inhibitor-Related Cardiotoxicity: mechanisms, Diagnosis, and Management. Curr Oncol Rep . 2020;22(7):66. doi: 10.1007/s11912-020-00931-w 27. Yamamoto S, Egashira N. Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy. …

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers.

Recently, targeted nanoparticles (NPs) have attracted much attention in cancer treatment due to their high potential as carriers for drug delivery. In this article, we present a novel bioconjugate (DOX-AuNPs-Tmab) consisting of gold nanoparticles (AuNPs, 30 nm) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), which exhibited specific binding to HER2 receptors. The size and shape of synthesized AuNPs, as well as their surface modification, were analyzed by the TEM (transmission electron microscopy) and DLS (dynamic light scattering) methods. Bi

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… Unfortunately, DOX, although an effective anti-tumor drug, displays serious side effects including rapid excretion, short retention time, and particularly cardiotoxicity as well as life-threatening cardiomyopathy and congestive heart failure [ 6 ]. … As the cardiotoxic effects of DOX remained a key limiting factor, targeted therapy with the use of this anthracycline and guiding vector Tmab might limit the damage to healthy tissues, well as improve the clinical outcomes of patients suffering from HER2+ cancers. …

Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients.

BackgroundBoth human and veterinary cancer chemotherapy are undergoing a paradigm shift from a "one size fits all" approach to more personalized, patient-oriented treatment strategies. Personalized chemotherapy is dependent on the identification and validation of biomarkers that can predict treatment outcome and/or risk of toxicity. Many cytotoxic chemotherapy agents, including doxorubicin, base their mechanism of action by interaction with DNA and disruption of normal cellular processes. We developed a high-resolution/accurate-mass liquid chromatography-mass spectrometry DNA screening approac

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… Treatment with DOX is not universally effective and may lead to adverse events, including dose-dependent cardiotoxicity. The intensity of these adverse events varies from patient to patient [ 21 , 22 ]. … Transcriptional analysis of doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2006;290(3):H1098–H1102. doi: 10.1152/ajpheart.00832.2005. 46. Nozaki N, Shishido T, Takeishi Y, Kubota I. Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice. …

Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis.

Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) is still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity against tumor cells. Here, we exploit the potential benefit of ATO/AA combination in generating cytotoxicity to CRC cells, which may lay the groundwork for the potential combinational chemotherapy of CRCs. According to the results, we found that ATO and AA effectively inhibited the viability of human CRC cells in a synergistic manner.

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… Moreover, the required doses of ATO increased the risk of side effects such as its cardiotoxicity, including long QT syndrome or torsade de pointes leading to sudden cardiac death ( Chu et al., 2012 ). … Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity. Basic Clin. Pharmacol. Toxicol. 102 (5), 419–425. 10.1111/j.1742-7843.2007.00150.x Zhou B., Zhang J. Y., Liu X. S., Chen H. Z., Ai Y. L., Cheng K., et al. (2018). …

Physical Activity and Cancer Care-A Review.

In 2020, 19.3 million new cancer cases were diagnosed, and almost 10 million deaths from cancer were recorded. Cancer patients may experience fatigue, depression, anxiety, reduced quality of life and sleep problems. Cancer treatments cause numerous side effects and have a negative impact on all body systems. Physical activity is important for cancer patients. The aim of this review is to analyse recent studies on the role of physical activity in cancer patients and emphasize its importance. The review included 36 papers published in English between 2017 and 2021. The findings from these studie

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… However, there is no evidence that physical activity mitigates the cardiotoxicity induced by cytostatic drugs [ 21 ]. 3.2. … Aerobic exercise in anthracycline-induced cardiotoxicity: A systematic review of current evidence and future directions. Am. J. Physiol. Heart Circ. Physiol. 2017;312:H213–H222. doi: 10.1152/ajpheart.00646.2016. 22. Dun L., Xian-Yi W., Xiao-Ying J. …

Predicting Survival for Patients with Malignant Pleural Effusion: Development of the CONCH Prognostic Model.

BackgroundMalignant pleural effusion (MPE) is a frequent complication of advanced malignancies that leads to a poor quality of life and limits treatment options.ObjectiveThe objective of this study was to identify biomarkers of survival in patients with MPE, which will greatly facilitate the clinical management of this complication.MethodsThis retrospective study recruited patients who had been pathologically diagnosed with MPE, regardless of the type of primary cancer, at Beijing Chao-Yang Hospital over 158 months. Demographic, clinical, hematological, and pleural fluid data were collected an

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… Pavo et al indicated that NT-pro-BNP levels could be elevated in cancer patients ahead of any cardiotoxic therapy and increased with advancing tumor stage, and this elevation is closely related to all-cause mortality. 51 This was especially the case in our study since MPE occurs in the late stages of … Cardiotoxicity of anticancer treatments: epidemiology, detection, and management . CA Cancer J Clin . 2016 ; 66 ( 4 ). 10.3322/caac.21341 26919165 51. Pavo N , Raderer M , Hulsmann M , et al. Cardiovascular biomarkers in patients with cancer and their association with all-cause mortality . …

Epithelial-Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications.

Radiation therapy is a fundamental component of cancer treatment, benefiting 50%-70% of patients by selectively targeting malignant tissues. However, radioresistance remains a significant challenge, often driven by epithelial-mesenchymal transition (EMT). EMT increases cancer invasiveness and metastasis by upregulating mesenchymal markers, including vimentin and N-cadherin, and downregulating epithelial markers, such as E-cadherin. EMT under radiation involves principal signaling pathways, including TGF-β, Wnt/β-catenin, Notch, and ERK, which regulate EMT through transcription factors such as

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… Cancer types | Drug | Target mechanism | Toxicity | EMT | Ref Liver cancer | Sorafenib | VEGFR, RAF kinases | Hepatotoxicity, hand–foot syndrome | Inhibits EMT by blocking TGF‐β signaling, but resistance can induce EMT in residual cells | [ 92 ] Doxorubicin | DNA intercalation, Topoisomerase II | Cardiotoxicity … Inhibits EMT by targeting HER2, but resistance may activate EMT pathways | [ 95 ] Paclitaxel | Microtubule stabilization | Peripheral neuropathy, myelosuppression | Promotes EMT by increasing TGF‐β signaling, leading to enhanced metastasis | [ 96 ] Doxorubicin | DNA intercalation, Topoisomerase II | Cardiotoxicity …

Лечебно-стойкий провокационный демиелинирующий псевдоопухоль с марбургскими особенностями: подход, основанный на описательном обзоре лечения.

Воспламенительное демиелинирование псевдотумора (ИДП) имитирует внутричерепные новообразования как с точки зрения клинического представления, так и с точки зрения изображений. МВУ с марбургскими особенностями представляют собой серьезную форму подстрекательского демиелинационного энцефаломиэлита, отмеченного драматическим наступлением, агрессивным курсом, отсутствием ремиссии и наличием повреждений центральной нервной системы, подобных опухоли. Ключевые характеристики ВПЛ в магнитно-резонансной съемке мозга включают в себя открытое или неполное расширение кольца, низкое значение обода Т2, огра

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… However, in one study, mitoxantrone was discontinued due to cardiotoxicity,[ 14 ] and another study reported a failure to respond to mitoxantrone.[ 15 ] In contrast, two studies demonstrated the effectiveness of mitoxantrone in improving patient outcomes.[ 16 17 ] Monoclonal antibodies Other agents …

Targeting Cancer Through Thymoquinone: From Molecular Mechanisms to Clinical Prospects.

Thymoquinone (TQ), the active compound in Nigella sativa (black seed), has shown promising effects against cancer in many laboratory studies. In this review, we explore how TQ works on different aspects of cancer, from stopping cancer cell growth and spread, to triggering cancer cell death, reducing inflammation, and helping the immune system fight back. We also highlight how TQ may overcome one of the biggest problems in cancer treatment-chemoresistance. When used together with common treatments like chemotherapy, radiation, or immunotherapy, TQ has been shown to improve their effects and red

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… With anthracyclines (doxorubicin), TQ often augments mitochondrial apoptosis and may reduce cardiotoxicity when delivered in nano formulations [ 88 ]. … Thymoquinone and its Nanoformulation Attenuate Colorectal and Breast Cancers and Alleviate Doxorubicin-Induced Cardiotoxicity. Nanomedicine. 2021;16:1457–1469. doi: 10.2217/nnm-2021-0103. 92. Khalife R., Stephany E.H., Tarras O., Hodroj M.H., Rizk S. …

Resveratrol Nanoformulations for Cancer Management: A Comprehensive Review of Disease-Specific Strategies and Clinical Translational Barriers.

Cancer remains a leading cause of mortality worldwide, highlighting the need for therapeutic strategies that reduce systemic toxicity and drug resistance. Resveratrol (RES), a natural polyphenolic stilbenoid, possesses antioxidant, anti-inflammatory, pro-apoptotic, anti-metastatic, and chemosensitizing activities. However, its clinical translation is limited by poor aqueous solubility, chemical instability, rapid metabolic clearance, and consequently low systemic bioavailability. Nanotechnology-based drug delivery systems provide a promising strategy to address these limitations. This review s

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… cytotoxicity relative to free doxorubicin at equivalent concentrations (IC 5 0 of free doxorubicin ≈ 5 μM in H9c2), while in L5178 lymphoma cells the same formulation enhanced doxorubicin’s antitumor activity—together demonstrating the dual benefit of resveratrol co-delivery in mitigating off-target cardiotoxicity …

Стратегии лечения множественной миеломы, основанные на наномедицине.

Множественная миелома (ММ) принадлежит к гематологическим маньякам, и общее число случаев заболевания MM растет во всем мире. В течение последних нескольких десятилетий повышенное внимание уделялось развитию и патогенезу MM. Существенные изменения произошли также в парадигме лечения MM, включая протеаозные ингибиторы, иммуномодуляторы и анти CD38 моноклонные антитела, которые значительно улучшили выживание пациентов. Уделение все большего внимания наномедицине обусловлено ее способностью улучшить лечение MM за счет уменьшения системных побочных эффектов и создания возможностей для более точног

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… However, due to the side effects of DOX in practical applications, such as cardiotoxicity, hepatotoxicity, bone marrow suppression, etc, the clinical application of DOX is limited to some extent. … The PEGylated liposomal formulation of DOX has been demonstrated to reduce cardiotoxicity. The loading of carfilzomib (CFZ) into liposomes in conjunction with DOX was undertaken to enhance the anticancer effects of the combination at its optimal synergistic ratio. …

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study.

PurposeCancer-related cognitive impairment (CRCI) following chemotherapy is commonly reported in breast cancer survivors, even years after treatment. Data from preclinical studies suggest that exercise during chemotherapy may prevent or diminish cognitive problems; however, clinical data are scarce.MethodsThis is a pragmatic follow-up study of two original randomized trials, which compares breast cancer patients randomized to exercise during chemotherapy to non-exercise controls 8.5 years post-treatment. Cognitive outcomes include an online neuropsychological test battery and self-reported cog

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… Also, delayed adverse effects, which take years or even decades to become clinically apparent, can be detected by post-trial FU [ 56 ], as exemplified by former studies documenting the cardiotoxic properties of high-dose thoracic radiotherapy [ 57 – 59 ]. … Aleman BMP Late cardiotoxicity after treatment for Hodgkin lymphoma Blood 2007 109 5 1878 1886 10.1182/BLOOD-2006-07-034405 17119114 60. …