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Headache disorders in multiple sclerosis: Is there an association? A systematic review and meta-analysis.

OBJECTIVE: To look for any potential association of headache disorders with multiple sclerosis (MS). BACKGROUND: The prevalence of headache disorders has been found to be increased in people with MS (pwMS), however, an association has not been established. Existing studies have provided conflicting results mostly because of methodological differences. METHODS: PubMed, Embase and Scopus were searched to identify eligible studies. Studies were included if they were cross-sectional, case-control or cohort. Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias of the included studies.…

Improving criteria for dissemination in space in multiple sclerosis by including additional regions.

OBJECTIVE: We investigated the effects of adding regions to current dissemination in space (DIS) criteria for multiple sclerosis (MS). METHODS: Participants underwent brain, optic nerve, and spinal cord MRI. Baseline DIS was assessed by 2017 McDonald criteria and versions including optic nerve, temporal lobe, or corpus callosum as a fifth region (requiring 2/5), a version with all regions (requiring 3/7) and optic nerve variations requiring 3/5 and 4/5 regions. Performance was evaluated against MS diagnosis (2017 McDonald criteria) during follow-up. RESULTS: Eighty-four participants were rec…

A Prospective Observational Study of Posterior Tibial Nerve Stimulation in Multiple Sclerosis.

INTRODUCTION AND HYPOTHESIS: The objective was to examine the outcomes of posterior tibial nerve stimulation (PTNS) on bladder, bowel, and sexual health-related quality of life among a cohort of patients with multiple sclerosis (MS) with refractory lower urinary tract symptoms (LUTS). METHODS: Patients with MS and refractory LUTS were recruited for a prospective, observational study using PTNS to treat their symptoms. Patients underwent 12 weekly 30-min PTNS sessions and bladder, bowel, and sexual symptoms were evaluated at baseline, 3, 12, and 24 months with voiding diaries, visual analog sc…

Heterophoria in multiple sclerosis patients: a proof of principle cross-sectional study.

OBJECTIVES: The pathophysiology of multiple sclerosis (MS) involves inflammatory neurodegeneration in the brainstem, cerebellum, and retina. The clinical relevance of oculomotor involvement in MS, however, remains uncertain. METHODS: In this cross-sectional study, we evaluated heterophoria as a (sub)clinical tool in 54 MS patients and 55 age-matched healthy controls (HCs). We quantified heterophoria in prism diopters for distance and near range with orthoptic examination. Our primary outcome was high degrees of horizontal heterophoria (HDHH) defined as measurements beyond ±2 standard deviatio…

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis.

IMPORTANCE: Multiple sclerosis (MS) misdiagnosis remains an important issue in clinical practice. OBJECTIVE: To quantify the performance of cortical lesions (CLs) and central vein sign (CVS) in distinguishing MS from other conditions showing brain lesions on magnetic resonance imaging (MRI). DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective, cross-sectional multicenter study, with clinical and MRI data acquired between January 2010 and May 2020. Centralized MRI analysis was conducted between July 2020 and December 2022 by 2 raters blinded to participants' diagnosis. Participants we…

Varicella Zoster Associated Vasculopathy and Retinitis with Natalizumab Use in Multiple Sclerosis.

Natalizumab (Tysabri®, NTZ) is a monoclonal autoantibody approved for treatment of relapsing-remitting multiple sclerosis. NTZ inhibits leukocyte migration across the blood-brain barrier, preventing autoreactive cells from inciting an inflammatory immune response. This immunosuppression is highly efficacious in attenuating the risk of relapse of disease, but has been associated with opportunistic central nervous system (CNS) infections, most notably progressive multifocal leukoencephalopathy. Varicella-zoster and herpes simplex viruses have also been associated with NTZ, inciting a spectrum of…

Intracerebral haemorrhage in multiple sclerosis: assessing the impact of disease-modifying medications.

Multiple Sclerosis (MS) is a complex autoimmune disorder that significantly impacts the central nervous system, leading to a range of complications. While intracranial haemorrhage (ICH) is a rare but highly morbid complication, more common CNS complications include progressive multifocal leukoencephalopathy (PML) and other CNS infections. This severe form of stroke, known for its high morbidity and mortality rates, presents a critical challenge in the management of MS. The use of disease-modifying drugs (DMDs) in treating MS introduces a nuanced aspect to patient care, with certain medications…

The role of alemtuzumab in the development of secondary autoimmunity in multiple Sclerosis: a systematic review.

BackgroundSecondary autoimmune disease (SAID) in the context of alemtuzumab treatment is one of the main safety concerns that may arise following administration in people with multiple sclerosis (pwMS). Contributing factors underlying this adverse event are not well understood. The purpose of this systematic review was to appraise the literature investigating the role of alemtuzumab in the development of SAID in pwMS following treatment and identify potential biomarkers/ risk factors that may be predictive of onset of this manifestation.MethodsRelevant publications were retrieved from PubMed, …

Осуществление диализабельной экстракта лейкоцита для лечения множественного склероза: клинический случай.

Множественный склероз (MS) — аутоиммунное демиелинирующее заболевание, которое влияет на центральную нервную систему (CNS) с ее хроническим подстрекательским компонентом. При лечении MS кортикостероиды обычно применяются для снижения уровня воспаления болезни. В данном случае мы представляем пациента с MS, который первоначально получал кортикостероиды, что повысило его уязвимость к инфекциям, особенно респираторным. В связи с этим лечение было изменено на диализируемый экстракт лейкоцита (DLE) "Уральный перевод". До сих пор уровень воспаления снизился, замедляя эволюцию MS, уменьшая клинически

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS) with its chronic inflammatory component. In the treatment of MS, corticosteroids are usually implemented to reduce the disease's inflammation rate. In this case study, we present a patient with MS that initially received corticosteroids, which heighte…

A Clinical Care Algorithm for Detecting Progression in Multiple Sclerosis: RetratEMos Project.

OBJECTIVE: The diagnosis of secondary progressive multiple sclerosis (SPMS) is often established retrospectively leading to a delay in detection. This work presents a clinical care algorithm that aims to facilitate the recognition of the secondary progressive phase of the disease, analyzing its usefulness and the feasibility of its implementation in routine clinical practice. METHODS: The algorithm was developed in four phases: 1) choice of validated diagnostic tools for the detection of progression; 2) assessment of these tools based on experience of use, applicability, time consumed, percei…

Reliability and validity of the community balance and mobility scale in individuals with multiple sclerosis.

AIMS: This study aims to evaluate the reliability and validity of the Community Balance and Mobility Scale (CB&M) in people with multiple sclerosis (PwMS). METHODS: A total of 65 PwMS (Expanded Disability Status Scale (EDSS) ≤ 5.5) were included in the study. Test-retest, internal consistency (item-total score correlation, Cronbach's alpha coefficient) intra-rater, and inter-rater reliability were investigated for the reliability of the CB&M. For intra-rater and inter-rater reliability, CB&M measurements of 34 PwMS were videotaped. The validity of the CB&M was assessed through criterion (pred…

Association of Menopause With Functional Outcomes and Disease Biomarkers in Women With Multiple Sclerosis.

BACKGROUND AND OBJECTIVE: The impact of menopause on the brain is not well understood. Hormonal changes, including puberty and pregnancy, influence the onset and course of multiple sclerosis (MS). After menopause, a worsening of MS disease trajectory measured on the clinician-rated Expanded Disability Status Scale (EDSS) was reported in some, but not all, studies. Evaluating the association between menopause and more objective measures of CNS injury is warranted. This study sought to assess the trajectory of objective functional outcomes and disease biomarkers in women with MS before and after…

Роль митохондриальных вариантов ДНК и дисфункции в патогенезе и прогрессирование множественных склерозов.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, затрагивающее центральную нервную систему (КНС). Этиология MS по-прежнему остается неуловимой, при этом сложное взаимодействие генетических и экологических факторов способствует ее патогенезу. Недавние исследования показали, что митохондриальная ДНК (mtDNA) является потенциальным игроком в разработке и развитии MS. Эти исследования охватывали варианты mtDNA, варианты числа копий и Haplogroups. Целью этого описательного обзора является обобщение нынешнего понимания роли MtDNA в НР. Результаты этого обзора свидетельствуют о том,

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). The etiology of MS remains elusive, with a complex interplay of genetic and environmental factors contributing to its pathogenesis. Recent studies showed mitochondrial DNA (mtDNA) as a potential player in the development and progression of MS. These studies…

Наблюдение за сезонными колебаниями усталости в множестве склероза зависит от измерительного прибора.

Обсуждается вопрос о том, способствуют ли сезонные колебания внешней температуры утомлению MS, что является одним из наиболее распространенных симптомов болезни. Мы проанализировали влияние сезона на базовые уровни усталости в наших случайных, контролируемых плацебо, перекрестных испытаниях с двойным слепым слоем, лечении усталости от метилфенидата, Modafinil и амантадина в MS (TRIUMPANT-MS), проведенных на двух участках с очень различным климатом. Усталость измерялась с использованием двух проверенных инструментов (изменение степени усталости (MFIS) и оценка усталости Neuro-QoL). Оценки УМФС

Совпадение в аннотации оригинала
It is debated whether seasonal variation in outside temperature contributes to MS fatigue, one of the disease's most common symptoms. We ana … ed with season and study site, while Neuro-QoL fatigue scores did not. The impact of temperature on multiple sclerosis fatigue depends on the specific patient-reported outcome measure employed.

Методологии изучения мозговых органоидов для изучения механизмов заболевания в прогрессивном множественном склерозе.

Множественный склероз (MS) — изнуряющее аутоиммунное расстройство, направленное против центральной нервной системы (CNS), отмечен непрерывным обезвоживанием и воспалением. В клинической форме она представляет в трех различных формах: повторные выбросы MS (RRMS), первичные прогрессивные MS (PPMS) и вторичные прогрессивные MS (SPMS). Несмотря на то, что лечение с целью изменения болезней (ДМР) оказывает определенное содействие людям, страдающим СВЗ, варианты лечения прогрессивных СЗМ (ПМС) по-прежнему являются крайне неадекватными. Этот пробел свидетельствует о настоятельной необходимости примен

Совпадение в аннотации оригинала
Multiple sclerosis (MS), a debilitating autoimmune disorder targeting the central nervous system (CNS), is marked by relentless demyelination and inflammation. Clinically, it presents in three distinct forms: relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS). While disease-modifying therapies (DMTs) offer some …

Оценка дисфагии и ее связей у пациентов с вторичным прогрессивным множественным склерозом.

В этом перекрестном исследовании у пациентов с вторичным прогрессивным множественным склерозом, получающих антиCD20 моноколональные антитела, мы провели оценку жалобы на дисфагию и оценили их связь с полом, возрастом, продолжительностью болезни, степенью инвалидности и лечением с целью изменения заболеваний. Была использована проверенная персидская версия вопросника Dysphagia в мультиклерозе (DYMUS). В общей сложности было охвачено 66 пациентов. Средний балл DYMUS составил 1,0 [внутренний диапазон: 0,0-2,3] и 40 (60,6%) был положительным. Только DMT продемонстрировал значительную связь с оценк

Совпадение в аннотации оригинала
In this cross-sectional study in patients with secondary progressive multiple sclerosis receiving anti-CD20 monoclonal antibodies, we assessed complaint of dysphagia and evaluated their association with sex, age, disease duration, disability severity, and disease-modifying therapies (DMTs). The validated Persian version of Dysphagia in Multiple Sclerosis (DY…

The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis-A Pilot Study.

(1) Background: Multiple sclerosis (MS), a chronic progressive neurological disorder which affects the central nervous system (CNS), can result in disorders of all the functions controlled by the CNS: motor, sensory, cognitive and emotional. Physical therapy (PT), conducted through proprioceptive neuromuscular facilitation (PNF) techniques, can be customized to the individual patient's needs and has the potential to improve the patient's evolution. This study aims to establish if PT based on PNF techniques has a beneficial role in MS treatment. (2) Methods: We performed a prospective study on …

Co-occurrence of glioma and multiple sclerosis: Prevailing theories and emerging therapies.

Though the concurrence of primary brain tumors and multiple sclerosis (MS) is exceedingly rare, instances have been noted in the literature as early as 1949. Given these observations, researchers have proposed various ideas as to how these malignancies may be linked to MS. Due to insufficient data, none have gained traction or been widely accepted amongst neurologists or neuro-oncologists. What is abundantly clear, however, is the mounting uncertainty faced by clinicians when caring for these individuals. Concerns persist about the potential for disease modifying therapies (DMTs) to initiate o…

Ankle dorsiflexion asymmetry and the relationship with walking performance in people with multiple sclerosis.

BACKGROUND: Multiple sclerosis (MS) is a neurological disease characterized by demyelination disrupting the central nervous system. Persons with MS may exhibit symptomatic strength asymmetry (SA) that impacts motor gait and ankle mobility. The purpose of the present study was to investigate ankle dorsiflexion SA in people with MS and its relationship to functional performance. RESEARCH QUESTION: Is their a difference in dorsiflexion SA in MS participants compared to healthy individuals and does it impact functional performance? METHODS: 13 MS participants (EDSS 3.5 + 1.8) and 13 age matched …

Clinical significance and prognostic value of serum autoantibody tests in multiple sclerosis.

INTRODUCTION: It is known that multiple sclerosis (MS) often coexists with other autoimmune diseases. Hence, autoantibody (auto-Ab) tests may prove useful in the differential diagnosis of MS. The objectives of this study were to: (a) investigate the prevalence of auto-Ab positivity at the beginning of the MS diagnostic process; (b) assess whether Auto-Ab+ and Auto-Ab- patients differ in baseline clinical, laboratory, and radiological parameters; and (c) investigate the prognostic value during a two-year follow-up period. MATERIAL AND METHODS: This retrospective study consisted of 450 patients…