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Therapeutic Efficacy of Traditional Chinese Medicine Syndrome-Based Formulae to Neuropathic Pain Caused by Chemotherapy.

ObjectiveChemotherapy-induced neuropathic pain (CINP) is a troublesome complication of anti-cancer treatment. The aim of this retrospective study was to investigate the effectiveness of classic Chinese herbal formulae (CHF) Huang Qi Gui Zhi Wu Wu Tang (HQGZWWT) and Dang Gui Si Ni Tang (DGSNT) in the treatment of CINP.Materials and methodsDouleur Neuropathique 4 (DN4) and Functional Assessment of Cancer Therapy-General (FACT-G) questionnaires were rated at baseline and after 3-monthly CHF treatment.ResultsBy searching through our medical records of all the CIPN patients from 2018 to 2019, we id

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… Angelica Sinensis, Rx. Paeoniae Alba, Ram. Cinnamomi, Hb. cum Rx. Asari, Rx. Glycyrrhizae Preparata, Fr. Jujube, Caul. … Angelicae Sinensis, Rx. Paeoniae Alba, Rx. Chuanxiong, Poria, Rx. …

Regulating effect of Qifu Yin on intestinal microbiota in mice with memory impairment induced by scopolamine hydrobromide.

ETHNOPHARMACOLOGICAL RELEVANCE: Qifu Yin (QFY) originates from "Jingyue Quanshu · Volume 51 · New Fang Bazhen · Buzhen" a work by Zhang Jingyue, a distinguished Chinese medical practitioner from the Ming Dynasty. QFY is composed of Ginseng Radix et Rhizoma, Rehmanniae Radix Praeparata, Angelicae Sinensis Radix, Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, Ziziphi Spinosae Semen, and Polygalae Radix. QFY is frequently employed to address memory loss and cognitive impairment stemming from vascular dementia, Alzheimer's disease (AD), and related conditio…

Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty.

Frailty and sarcopenia have recently gained considerable attention in terms of preventive care in Japan, which has an ever-increasing aging population. Sarcopenia is defined as atrophy of skeletal muscles caused by the age-related decrease in growth hormone/insulin-like growth factor and sex hormones. The Japanese Ministry of Health, Labor and Welfare reports that frailty can lead to impairment of both mental and physical functioning. Chronic diseases such as diabetes and dementia may underlie frailty. It is important to prevent progression of frailty and extend the healthy lifespan. In herbal

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… Effects of Ninjin'yoeito and Mechanism of Action Ninjin'yoeito is composed of 12 crude drugs: peony root, Japanese angelica root, C. unshiu peel, Astragalus root, cinnamon bark, ginseng, Atractylodes rhizome, Glycyrrhiza, Rehmannia root, Schisandra fruit, Poria sclerotium, and Polygala root. … Uto T Tung NH Taniyama R Miyanowaki T Morinaga O Shoyama Y: Anti-inflammatory activity of constituents isolated from aerial part of angelica acutiloba kitagawa Phytother Res . ( 2015 ) 29 : 1956 – 63 . 10.1002/ptr.5490 26463105 42. …

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom.

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic

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… also be used as an adjuvant antitumor drug National Drug Standards of the National State Food and Drug Administration, WS 3 -B-3345-98-2013 Tianchan capsule (天蟾胶囊) Corydalis Decumbentis Rhizoma, Aconiti Radix Cocta, Bufonis Venenum, Cirald Daphne Bark, Chelidonii Herba, Gentianae Macrophyllae Radix, Angelicae … Drug Standards of Ministry of Health, Prescription preparation of Chinese medicine, Volume 20, WS 3 -B-3844-98 Xianchan tablet (仙蟾片) Strychni Semen Pulveratum, Processed Pinelliae Rhizoma, Ginseng Radix Et Rhizoma, Astragali Radix, Agrimoniae Herba, Psoraleae Fructus, Curcumae Radix, Bufonis Venenum, Angelicae …

Shengma Biejia Decoction Inhibits Cell Growth in Multiple Myeloma by Inducing Autophagy-Mediated Apoptosis Through the ERK/mTOR Pathway.

Shengma Biejia decoction (SMBJD), a traditional Chinese formula recorded in the Golden Chamber, has been widely used for the treatment of malignant tumors. However, its underlying molecular targets and mechanisms are still unclear. This study showed that SMBJD inhibited tumor growth and stimulated hemogram recovery significantly in a multiple myeloma xenograft model. Western blot and immunohistochemistry assays of tumor tissues showed that SMBJD reduced the ratio of autophagy-related proteins LC3-II/LC3-I, while P62 and apoptosis-related proteins cleaved caspase-3/caspase-3 and Bax/Bcl-2 were

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… Moon (Tongguanteng); Carapax Trionycis (Biejia); Angelica sinensis (Oliv.) Diels (Danggui); Strobilanthes cusia (Nees) Kuntze (Qinghdai); and Glycyrrhiza uralensis Fisch. ex DC (Gancao) combined in a ratio of 35:40:10:5:5:5 ( Table 1 ). … toxicity, promoting yang qi | 35 Marsdenia tenacissima (Roxb.) moon (Tongguanteng) | Yunnan | Stem | Clearing heat, removing toxicity, relieivng cough and asthma, expectorant, promoting lactation | 40 Carapax trionycis ( B iejia) | Henan | Carapace | Nourishing yin, anti-febrile, softening hardness | 10 Angelica …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… Hsiao Angelica sinensis (Oliv.) Diels | Male ICR mice with lung fibroblasts model | 0.1 mL/10 g (the dosage of Huangqi and Danggui is 50 g:10 g, 30 g:30 g, 10 g:50 g, 25 g: 5 g, 15 g:15 g, 5 g:25 g) | ↓: Hyp | Lung | NA | Li et al. (2015) Breviscapine | Erigeron breviscapus (Vaniot) Hand. … Huangqi ( Astragalus ) and Danggui ( Angelica ) were revealed the ability to induce relaxation in airway smooth muscle, scavenge free radicals, inhibit platelet aggregation, and suppress the release of inflammatory mediators such as thromboxane ( Li et al., 2015 ). …

The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy.

Cancer is a major disease with ever-increasing morbidity and mortality. The metabolites derived from traditional Chinese medicine (TCM) have played a significant role in combating cancers with curative efficacy and unique advantages. Ferroptosis, an iron-dependent programmed death characterized by the accumulation of lipid peroxide, stands out from the conventional forms of cell death, such as apoptosis, pyroptosis, necrosis, and autophagy. Recent evidence has demonstrated the potential of TCM metabolites targeting ferroptosis for cancer therapy. We collected and screened related articles publ

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… Alloimperatorin (AM) is a metabolite derived from Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. [ Apiaceae ; Angelica dahurica root ]. … Nannf. [ Campanulaceae ; C. pilosula root] , Astragalus mongholicus Bunge [ Fabaceae ; A. mongholicus root], and Angelica sinensis (Oliv.) Diels [ Apiaceae ; A. sinensis root]. It is most commonly prescribed for HCC treatment in Beijing Ditan Hospital ( Yang et al., 2021 ). …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… viral replication | [ 110 ] β-Sitosterol ( Isatis indigotica ) | Image 54 | SARS CoV | Against 3CL Pro | [ 107 ] Flavaglines Silvestrol ( Algaria sp. ) | Image 55 | MERS-CoV | Targets RNA helicase | [ 111 ] Glucosides Sinigrin | Image 56 | SARS CoV | Against 3CL Pro | [ 107 ] Chalcones Xanthoangelol ( Angelica … Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV J. Enzym. Inhib. Med. Chem. 31 1 2016 23 30 10.3109/14756366.2014.1003215 25683083 113 Park J.Y. Jeong H.J. Kim J.H. Kim Y.M. Park S.J. Kim D. Park K.H. Lee W.S. Ryu Y.B. …

Exosomes-loaded with traditional Chinese medicine constituents: a novel therapeutic avenue for aplastic anemia.

Aplastic anemia (AA) is a life-threatening blood disorder characterized by bone marrow failure and pancytopenia. Treatments such as immunosuppressive therapy (IST) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) have limitations, including poor long-term remission and donor shortages. Exosomes, nanosized extracellular vesicles, are promising drug delivery systems (DDS) due to their biocompatibility, targeted delivery, and capacity to penetrate biological barriers. Traditional Chinese medicine (TCM) regulates hematopoiesis and immunity but faces challenges with delivery. This

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… Multi-component synergy and clinical integration TCM's holistic approach leverages herb pairs (e.g., “ Angelicae Sinensis Radix ” in “Xin-Sheng-Hua Granule”) to synergistically improve erythropoiesis in hemolytic AA models [ 137 ]. … Comparatively evaluating the role of herb pairs containing angelicae sinensis radix in Xin-Sheng-Hua granule by withdrawal analysis. Evid Based Complement Alternat Med. 2020;2020:9456350. 138. Yu N, Huang H, Wu F. …

Case Report: Acute Kidney Injury Due to Chronic Milk-Alkali Syndrome in a Patient With Colon Cancer.

BACKGROUND: Common causes of hypercalcemia include primary hyperparathyroidism and paraneoplastic syndrome of malignancy. Because of this, physicians can easily miss extrinsic causes of hypercalcemia such as milk-alkali syndrome in patients with cancer. We successfully treated a case of acute kidney injury due to severe hypercalcemia caused by milk-alkali syndrome due to long-term milk drinking in a patient with colon cancer. CASE DESCRIPTION: A 62-year-old man was referred to nephrology for hypercalcemia and azotemia that was found during preoperative evaluation for colon cancer surgery. The

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… He took mixed extract from Angelica, Chaenomeles, Ledebouriella, Dipsacus for arthralgia. He had even consumed milk continuously during admission. We advised withdrawal of milk and the herbal pills. …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Shurentang Brand Sanqi Xiyangshen Ma Deer Antler Wine | Cervi Cornu Pantotrichum, Notoginseng Radix Et Rhizoma, Panacis Quinquefolii Radix, Ganoderma, Polygonati Rhizoma, Lycii Frustus, Hippophae Fructus, Fructus Mori | G20110717 Zhangzisong Brand Antler Maidenhair Wine | Cervi Cornu Pantotrichum, Angelicae … Dahurica Capsules | Perillae Fructus, Cassiae Semen, Angelicae Dahuricae Radix, Laminariae Thallus, Coicis Semen | G20100547 Lurong | Zhangzisong Brand Antler and Ginseng Oral Liquid | Ginkgo Folium, Hawthorn, Alismatis Rhizoma, Ginseng Radix Et Rhizoma, Cervi Cornu Pantotrichum | G20140455 Maintaining …

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening.

Natural products have been used for centuries to treat various human ailments. In recent decades, multi-drug combinations that utilize natural products to synergistically enhance the therapeutic effects of cancer drugs have been identified and have shown success in improving treatment outcomes. While drug synergy research is a burgeoning field, there are disagreements on the definitions and mathematical parameters that prevent the standardization and proper usage of the terms synergy, antagonism, and additivity. This contributes to the relatively small amount of data on the antagonistic effect

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… anticancer activity of bortezomib by direct chemical interaction with its boronic acid moiety | U266- 6.70/3.08/4.22 RPMI/8226-11.39/3.34/8.54 MC/CAR-27.24/6.94/4.97 (TA/GA/CA) | [ 36 ] Si-Wu-Tang | | Combination: Radix Paeoniae Alba (bai shao yao), Rhizoma Ligusticum Chuanxiong (chuan xiong), Radix Angelica … Si-Wu-Tang (SWT) Si-Wu-Tang (SWT) is a form of traditional Chinese medicine comprised of the combined extracts from four herbs: Radix Paeoniae Alba (bai shao yao), Rhizoma Ligusticum Chuanxiong (chuan xiong), Radix Angelica Sinensis (dang gui), and Radix Rehmanniae Preparata (shu di huang). …

Traditional chinese medicine in cancer care: a review of case series published in the chinese literature.

Traditional Chinese medicine (TCM) has been widely used in cancer in China. Case series report a series of cases exposed to a certain intervention. To understand the current situation of case series of TCM for cancer, we performed this review. We included case series of cancer patients treated with TCM therapy. Electronic searches were conducted in four main Chinese databases until February 2011. A total of 1,217 reports of case series (92,945 patients) were included. The top five types of cancer were lung cancer, liver cancer, stomach cancer, leukemia, and esophageal cancer. Leukopenia and hi

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… The administration of injection was applied for either injection extracted from herbs (including angelica injection, astragalus injection, and Shenmai injection) or injection of western medicine (including dexamethasone, lidocaine, vitamin B1, vitamin B6, vitamin B12, vitamin K1, vitamin K3, and anticholinergic …

Impact of Ninjin'Yoeito on Fatigue in Patients Receiving Nab-Paclitaxel Plus Gemcitabine Therapy: A Prospective, Single-Arm, Phase II Open Label, Nonrandomized, Historically-Controlled Study.

BackgroundNinjin'yoeito, a traditional Japanese herbal medicine, is used to prevent fatigue, loss of appetite, and coldness of limbs. Fatigue is an especially common issue during chemotherapy and can affect quality of life and the ability to complete scheduled treatment.ObjectivesThis prospective exploratory trial evaluates the efficacy of ninjin'yoeito for fatigue in patients undergoing nab-paclitaxel plus gemcitabine therapy for unresectable pancreatic cancer. The primary end point was evaluation of fatigue according to Functional Assessment of Chronic Illness Therapy-Fatigue score during 2

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… Japanese herbal medicine and is used to prevent fatigue, loss of appetite, and coldness of limbs, among other uses. 9 , 10 NYT extract granules ( Ninjin'yoeito TJ-108; Tsumura & Co, Tokyo, Japan) are manufactured as dried extract of the following mixed crude drugs: 12.9% rehmannia root, 12.9% Japanese angelica …

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

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… effect on PLT aggregation (by ADP and epi) ( 138 ) to reduced PLT aggregation with epinephrine only ( 139 ) to reduced PLT aggregation and inhibition of TXB 2 production* ( 140 ) Green tea ¶ | Reduced platelet aggregation ( 13 , 141 ) Cinnamomum cassia | Reduced platelet aggregation ( 142 ) ‡ Dong Quai (Angelica …

Active Pharmacovigilance Study: A Follow-Up Model of Oral Anti-Cancer Drugs under Additional Monitoring.

Adverse drug reactions (ADRs) are responsible for almost 5% of hospital admissions, making it necessary to implement different pharmacovigilance strategies. The additional monitoring (AM) concept has been highlighted and intended to increase the number of suspected ADRs reported, namely in medicines with limited safety data. A prospective, descriptive study of active pharmacovigilance (AP) was conducted between 2019 and 2021 in the Local Health Unit of Matosinhos (LHUM) (Porto, Portugal). A model of AP for medicines under AM, namely oral antineoplastic agents, was designed. Follow-up consultat

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… Angelica R. Crisafulli S. Ingrasciotta Y. Salvo F. Spina E. Trifirò G. The economic burden of preventable adverse drug reactions: A systematic review of observational studies Expert Opin. Drug Saf. 2018 17 681 695 10.1080/14740338.2018.1491547 29952667 6. Singh S. Dhasmana D.C. Bisht M. Singh P.K. …

Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials.

Background and objective: Cancer is a life-threatening disease worldwide and current standard therapy cannot fulfill all clinical needs. Chinese herbal injections have been widely used for cancer in Chinese and Western hospitals in China. This study aimed to apply evidence mapping in order to provide an overview of the clinical application of Chinese herbal injections in cancer care based on randomized controlled trials, systematic reviews, and meta-analyses. Methods and results: Seven databases were systematically searched for eligible randomized controlled trials, systematic reviews, and met

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… Therapeutic Effect of Angelica and its Compound Formulas for Hypertension and the Complications: Evidence Mapping. Phytomedicine 59, 152767. 10.1016/j.phymed.2018.11.027 Xu Y., Mao J. J., Sun L., Yang L., Li J., Hao Y., et al. (2017). …

Long-term follow-up of vertebral compression fractures in inpatients treated with integrative Korean medicine: An observational study.

Conservative management is the recommended first-line treatment for thoracolumbar vertebral compression fractures (VCFs), with integrative Korean medicine (IKM) being widely used for treatment in Korea. However, evidence regarding long-term treatment outcomes is lacking. We aimed to investigate the effectiveness of IKM treatment for thoracolumbar VCFs. Data from inpatients with thoracolumbar VCFs who received IKM treatment, comprising acupuncture, pharmacopuncture, electroacupuncture, Chuna manual therapy, and herbal medicine, at 4 KM hospitals from April 1, 2016 to June 30, 2022 were analyzed

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… The hot packs are steamed herbal medicine sachets containing 23 ingredients ( A bidentata Blume, Saposhnikoviae Radix , Angelicae dahuricae Radix, etc) with anti-inflammatory and analgesic effects. Hot pack therapy was applied to the lumbar region for 15 to 20 minutes once daily. …

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.

The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms

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… In a clinical trial on 105 patients, a mixture of citronella isolated from Tianzhukui (Geranium) and extracts from Lingzhi (Ganoderma lucidum), Dangshen (Codonopsis pilosula) and Danggui (Angelicae sinensis) could apparently reduce the leukocyte depletion for cancer patients undergoing chemotherapy or …

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination.

The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mammary gland development may offer insights into the mechanisms of breast cancer (BC) biology. In fact, the unregulated mammary fibroblast signaling pathways, associated with alterations in extracellular matrix (ECM) remodeling and branching morphogenesis, drive breast cancer microenvironment (BCM) rem

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… (Angelica Avagliano); writing—review and editing A.A. (Alessandro Arcucci), A.A. (Angelica Avagliano), G.F., M.R.R., N.M., E.V., L.I., D.R., A.A. (Antonello Accurso), S.M. (Stefania Masone), S.M. (Stefania Montagnani). All authors have read and agreed to the published version of the manuscript. …