Результаты поиска

Частота и коррелация перинатальной депрессии.

ЦЕЛЬ: Этот систематический обзор систематических обзоров призван дать первую глобальную картину распространенности и корреляции перинатальной депрессии и изучить общие черты и расхождения в литературе. МЕТОДЫ: Seven :: Поиск баз данных с момента их создания и до апреля 2022. Полнотекстовая проверка и извлечение данных проводились независимо two Для оценки методологического качества использовались исследователи и инструмент AMSTAR. Результаты: 128 В анализ были включены систематические обзоры. Средняя распространенность перинатальной депрессии, дородовой депрессии и послеродовой депрессии 26.3%

Роль неизлечимой терапии восстановления с помощью кладрибинных таблеток в борьбе с повторным множественным склерозом у пожилых пациентов.

Патофизиология и представление повторных множественных склерозов (RMS) существенно различаются между молодыми и пожилыми пациентами. Пожилые пациенты, как правило, страдают меньшим числом рецидивов MS, но имеют хронически воспалительный фенотип (инфламагирование), связанный с ускоренными возрастными изменениями адаптивной и врожденной иммунной системы (иммунонесценность). Как представляется, эффективность большинства методов коррекции заболеваний (ДМТ) снижается с увеличением возраста, что, вероятно, объясняется отходом от воспаления мозга в качестве основной движущей силы развития НР. В резул

Implementation of a hospital-at-home (HAH) unit for hematological patients during the COVID-19 pandemic: safety and feasibility.

Background"Hospital-at-home" (HAH) programs have been shown to optimize resource utilization, shorten hospitalization and prevent nosocomial infection.MethodsWe retrospectively analysed data regarding implementation of an HAH unit for caring patients with hematological malignancies in our center, during the COVID-19 pandemic.ResultsBetween January and November 2020, 105 patients were treated in the HAH unit for a total of 204 episodes. Nine patients with multiple myeloma (MM) received autologous HSCT (auto-HSCT). Three patients with acute myeloid leukemia (AML) received consolidation therapy,

Recent Advances in Therapeutics for the Treatment of Alzheimer's Disease.

The most prevalent chronic neurodegenerative illness in the world is Alzheimer's disease (AD). It results in mental symptoms including behavioral abnormalities and cognitive impairment, which have a substantial financial and psychological impact on the relatives of the patients. The review discusses various pathophysiological mechanisms contributing to AD, including amyloid beta, tau protein, inflammation, and other factors, while emphasizing the need for effective disease-modifying therapeutics that alter disease progression rather than merely alleviating symptoms. This review mainly covers m

Neoplasm related mortality risk in Systemic Sclerosis: a nationwide study.

BackgroundThe higher mortality rates in patients with Systemic sclerosis (SSc) are related to SSc activity, cardiovascular disease, and neoplasms, among other factors. Our objective was to assess the impact of solid organ neoplasms (SON) and hematological neoplasms (HN) on mortality among SSc patients.MethodsA retrospective, observational comparison of SON and HN-related deaths in SSc patients with those in the general Spanish population was conducted using data from the Spanish Hospital Discharge Database. Binary logistic regression was used to analyze the impact of SSc on mortality risk from

Advances in Leukemia detection and classification: A Systematic review of AI and image processing techniques.

BACKGROUND: Leukemia, a heterogeneous group of blood cancers, poses significant challenges to global health due to its complexity, diverse risk factors, and variable outcomes. Accurate and early diagnosis is critical but remains a significant hurdle, particularly in low-resource settings. Recent advancements in artificial intelligence (AI) and image processing offer transformative solutions to improve leukemia detection and classification, addressing limitations in traditional diagnostic methods. METHODS: This study systematically reviewed over 25,000 scientific articles sourced from Scopus,

Peripheral Neuropathy Instruments for Individuals with Cancer: A COSMIN-Based Systematic Review of Measurement Properties.

Although the literature on patient-reported outcomes (PROMs) continues to expand, challenges persist in selecting reliable and valid instruments for assessing peripheral neuropathy (PN) in patients with cancer. This systematic review aimed to identify all validated self-report PN scales and critically appraise their measurement properties. This review was conducted using the COSMIN methodology for PROMs and the PRISMA statement. Five databases were searched from inception to August 2024, identifying 46 eligible studies and 16 PROMs. Evidence quality ranged from "very low" to "moderate", with n

The role of compounded mouthwash with or without acyclovir in managing chemotherapy-induced oral mucositis in cancer patients: a randomized controlled trial.

BackgroundChemotherapy-induced oral mucositis (CIOM) is a prevalent and debilitating condition observed in cancer patients, especially in those suffering from hematologic malignancies. The present study assessed the efficacy of a compounded mouthwash, both with and without the addition of acyclovir, in the management of CIOM. Although various treatment options exist for this condition, their effectiveness remains limited, underscoring the necessity for innovative approaches to the formulation of compounded mouthwashes for improved management of CIOM.MethodsA prospective, double-blind, randomiz

miRNAs in the Regulation of Cancer Immune Response: Effect of miRNAs on Cancer Immunotherapy.

In the last few decades, carcinogenesis has been extensively explored and substantial research has identified immunogenic involvement in various types of cancers. As a result, immune checkpoint blockers and other immune-based therapies were developed as novel immunotherapeutic strategies. However, despite being a promising therapeutic option, immunotherapy has significant constraints such as a high cost of treatment, unpredictable toxicity, and clinical outcomes. miRNAs are non-coding, small RNAs actively involved in modulating the immune system's multiple signalling pathways by binding to the

Using Genomic Data in Personalized Oncology Medicine: An Exploratory Expert-Elicitation Study with Narrative Regulatory Mapping of Regulations, Implementations, and Challenges in Saudi Arabia.

BACKGROUND/OBJECTIVES: Personalized medicine represents a transformative approach to healthcare in Saudi Arabia. However, a significant research gap exists regarding the specific regulatory, implementation, and practical challenges of integrating genomic data into personalized oncology care in the Saudi context. We aimed to conduct an exploratory assessment of the current regulatory landscape, practices, and challenges related to genomic data use in personalized oncology in Saudi Arabia and to identify regulatory and practical gaps, propose actionable solutions, and outline future directions f

Совпадение в полном тексте источника
… Cancer in the Arab World. Springer; Singapore: 2022. pp. 215–233. 3. International Agency for Research on Cancer . GLOBOCAN 2022: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2022. World Health Organization; Lyon, France: 2024. [(accessed on 21 February 2026)]. …

Palestinian Patients with Cancer at King Hussein Cancer Center.

BackgroundThe Palestinian Ministry of Health (MoH) routinely refers Palestinian patients with cancer to King Hussein Cancer Center (KHCC), the largest cancer center in the Middle East.AimsWe aimed to describe the characteristics of Palestinian patients with cancer.MethodsWe performed a retrospective chart review of all Palestinian patients with cancer who were treated at KHCC during 2018 and 2019, of which demographic and clinical characteristics were presented.ResultsWe initially started with 521 cases, out of which 41 (7.9%) cases were excluded due to misdiagnosis as malignant on pathology r

Совпадение в полном тексте источника
… Prostate cancer in the Arab world: A view from the inside. Clin Genitourin Cancer (2015) 13:505–11. doi: 10.1016/j.clgc.2015.05.010 10. Kanavos P. The rising burden of cancer in the developing world. Ann Oncol (2006) 17 Suppl 8:viii15–23. doi: 10.1093/annonc/mdl983 11. …

Качество жизни и ее детерминанты среди иорданских пациентов с множественным склерозом: перекрестное аналитическое исследование.

Множественный склероз (MS) является нетравматической инвалидностью, которая влияет на центральную нервную систему и снижает качество жизни (QoL). Ни одно исследование, проведенное Иорданией, конкретно не оценивало КОЛ у пациентов с синдромом MS. ЦЕЛИ: Оценка QoL среди иорданских пациентов с НР и изучение ее связи с социально-демографическими и медицинскими характеристиками. МЕТОДЫ: Это межсекторальное аналитическое исследование охватывало взрослых иорданских пациентов-носителей (возраст) ≥18 ), посещавших отделение МЗ в правительственном учебном госпитале < < Альбашир > > в Аммане

Оценка лечения множественных склерозов и его воздействия на здоровье мозга: опыт Объединенного центра Арабских Эмиратов.

Множественный склероз является хроническим, сложным неврологическим заболеванием, которое часто вызывает как видимые, так и невидимые симптомы, которые существенно влияют на повседневное функционирование. Комплексный подход к многоплановому склерозовому уходу имеет важное значение для благополучия пациентов, особенно в уникальном социокультурном контексте Объединенных Арабских Эмиратов, где такие факторы, как страхование и наличие специалистов, могут создавать дополнительные проблемы. МЕТОДОЛОГИЯ: В одном из специализированных центров Объединенных Арабских Эмиратов было проведено ретроспективн

Brave new world: expanding home care in stem cell transplantation and advanced therapies with new technologies.

Hematopoietic stem cell transplantation and cell therapies like CAR-T are costly, complex therapeutic procedures. Outpatient models, including at-home transplantation, have been developed, resulting in similar survival results, reduced costs, and increased patient satisfaction. The complexity and safety of the process can be addressed with various emerging technologies (artificial intelligence, wearable sensors, point-of-care analytical devices, drones, virtual assistants) that allow continuous patient monitoring and improved decision-making processes. Patients, caregivers, and staff can also

Clinical Practice Guidelines for management of Sexual Disorders in Elderly.

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Social relationship challenges perceived by cancer patients and survivors: a qualitative meta-synthesis.

BackgroundA cancer diagnosis can significantly disrupt patients' social lives, leading to strained relationships and increased social isolation. Many encounter uneasy interactions or feel judged by others, amplifying loneliness and a sense of exclusion. While existing research has predominantly focused on clinical outcomes, the social relationship challenges faced by cancer patients have not been fully explored. Consequently, this study aims to synthesize qualitative studies that examine the social relationship experiences of cancer patients and survivors, offering a deeper insight into this i

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments.

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target tumor-associated antigens. CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. Bi-specific chimeric antigen receptors may contribute to mitigating tumor anti

Integrating digital and narrative medicine in modern healthcare: a systematic review.

The increasing integration of digital technologies in healthcare, such as electronic health records, telemedicine, and diagnostic algorithms, improved efficiency but raised concerns about the depersonalization of care. Narrative medicine has emerged as a pedagogical and clinical response to this shift, emphasizing the value of patient stories, socio-cultural contexts, and reflective practice. Understanding how digital tools support, rather than undermine, narrative competencies is critical for developing a more human-centered healthcare education. This review systematically examined empirical

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

Healthcare Disparities and Outcomes of Cancer Patients in a Community Setting from a COVID-19 Epicenter.

There have been numerous studies demonstrating how cancer patients are at an increased risk of mortality. Within New York City, our community hospital emerged as an epicenter of the first wave of the pandemic in the spring of 2020 and serves a unique population that is predominately uninsured, of a lower income, and racially/ethnically diverse. In this single institution retrospective study, the authors seek to investigate COVID-19 diagnosis, severity and mortality in patients with an active cancer diagnosis. Demographic, clinical characteristics, treatment, SARS-CoV-2 laboratory results, and