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[Investigation of pathogenic agents causing acute respiratory tract infections in pediatric patients in a children's hospital assigned for case screening in Beijing during the outbreak of COVID-19].

Objective: To investigate the spectrum of pathogenic agents in pediatric patients with acute respiratory infections (ARI) during the outbrea … 0.005) . In 2018, the positive rate of pathogens was 61.0% (50/82), with the highest rate for human bocavirus (HBoV) (13.4%, 11/82) and followed by ADV (11.0%, 9/82), and significant difference was shown in the positive rate of HBoV with that in 2020 (χ(2)=6.776, P=0.009). Conclusions: The infection rate of 2019-nCoV is low among children in Beijing with no …

Inside the lungs of COVID-19 disease.

In the setting of the coronavirus disease 2019 (COVID-19) pandemic, only few data regarding lung pathology induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is available, especially without medical intervention interfering with the natural evolution of the disease. We present here the first case of forensic autopsy of a COVID-19 fatality occurring in a young woman, in the community. Diagnosis was made at necropsy and lung histology showed diffuse alveolar damage, edema, and interstitial pneumonia with a geographically heterogeneous pattern, mostly affecting the central pa

Comparison of acute pneumonia caused by SARS-COV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak.

BACKGROUND: Until January 18, 2021, coronavirus disease-2019 (COVID-19) has infected more than 93 million individuals and has caused a certain degree of panic. Viral pneumonia caused by common viruses such as respiratory syncytial virus, rhinovirus, human metapneumovirus, human bocavirus, and parainfluenza viruses have been more common in children. However, the incidence of COVID-19 in children was significantly lower than that in adults. The purpose of this study was to describe the clinical manifestations, treatment and outcomes of COVID-19 in children compared with those of other sources of…

Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study.

BACKGROUND: Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveil … a (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of pathogen-confirmed SARI patients had a bimodal distribution, with the first peak in the summer and the second peak in the winter. Statistically significant differences were observed with respect to the rates …

Sustained circulation of genotype I and the first whole-genome sequencing of feline calicivirus in Turkish cats.

This study was conducted to expand the limited knowledge regarding the detection, molecular characterization, and epidemiology of feline calicivirus (FCV) in Türkiye by examining viral pathogens associated with ulcerative stomatitis in cats. Analysis of forty clinical samples revealed twelve FCV-positive cases. Additional viral agents identified included feline chaphamaparvovirus (FChPV; n = 6), feline alphaherpesvirus 1 (FHV-1; n = 4), and feline panleukopenia virus (FPLV; n = 9), while no feline bocavirus (FBoV) or feline bufavirus (FBuV) infections were detected. Five coinfection events wer…

Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing.

BACKGROUND: To explore the effect of non-pharmacological interventions (NPIs) on respiratory pathogen profiles among hospitalized infants ag … y syncytial virus, parainfluenza virus (PIV), adenovirus (ADV), human metapneumovirus (HMPV), human bocavirus, human rhinovirus (HRV), coronavirus, Chlamydia trachomatis, Chlamydia pneumoniae (C.pn), Mycoplasma pneumoniae, Bordetella pertussis, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RESULTS: A total of 1,184 infants, including 64 …

[Evaluation of the Epidemiological, Clinical and Radiological Features of Pneumonia Cases Caused by Mycoplasma pneumoniae in Childhood].

The current study aimed to investigate the clinical, laboratory and radiological findings of the pneumonia cases in children that were confi … by viruses at the rate of 40.3%. The most common accompanying viruses were rhinovirus, adenovirus, bocavirus and metapneumovirus. The 55.8% of the patients had lobar-segmental consolidation, 46.8% had parahilar-peribronchial thickening, 18.2% had atelectasis, 11.7% had pleural effusion, 9.1% had increase in reticulonodular density, 6.5% had lymphadenopathy …

[Investigation of viral respiratory tract infection agents by multiplex PCR method in autopsy cases: A five-year study].

Viral respiratory infections are one of the leading causes of morbidity and mortality, especially in children, elderly and immunocompromised … za viruses (PIV) (1, 2, 3, 4), influenza virus type A and B (INF-A, INF-B), enterovirus (EV), human bocavirus (HBoV), adenovirus (AdV), human coronavirus (HCoV 229,63,HKU,43), human metapneumovirus A ve B (HMPV-A/B), parechovirus, respiratory syncytial virus (RSV A/B) and Mycoplasma pneumoniae. In our study, at least one respiratory virus was detected by Rt …

[Simultaneous detection of respiratory viruses and influenza A virus subtypes using multiplex PCR].

This study was conducted to investigate the respiratory viruses and subtyping of influenza A virus when positive by multiplex PCR in patient … H5 (aH5)] and 11 other respiratory viruses [Adenovirus, parainfluenza virus (PIV) types 1-4, human bocavirus (HBoV), human metapneumovirus (HMPV), rhinovirus types A and B, human coronaviruses (HCoV) OC43, 229E/NL63] were investigated with those tests. In the study, 53.6% (375/700) of the patients were found to be infected with at least one virus and multi …

[Etiology of acute respiratory tract infection in hospitalized children in Suzhou from 2005 to 2011].

OBJECTIVE: To elucidate the etiology of acute respiratory tract infection (ARI) in hospitalized children in Suzhou from 2005 to 2011. METHO … type 1-3 (PIV-1-PIV-3) and adenovirus (ADV) were detected by direct immunofluorescence assay. Human bocavirus (HBoV), mycoplasma pneumoniae (MP) and chlamydia pneumoniae (CP) were detected by fluorescent quantitative PCR while human metapneumovirus (hMPV) was detected by reverse transcription PCR (RT-PCR). Sputum culture was applied to detect bacterial infe …

Epidemiological and etiological characteristics of 1266 patients with severe acute respiratory infection in central China, 2018-2020: a retrospective survey.

BACKGROUND: Severe acute respiratory infection (SARI), a significant global health concern, imposes a substantial disease burden. In China, … identify human influenza virus, respiratory syncytial virus, parainfluenza virus, adenovirus, human bocavirus, human coronavirus, human metapneumovirus, and rhinovirus. Bacterial cultures of respiratory specimens were performed with a particular focus on pathogenic microorganisms, including S. pneumoniae, S. aureus, K. pneumoniae, P. aeruginosa, Strep A, H. …

Acute Pneumonia

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… CHILDREN | ADULTS Common | Common Respiratory syncytial virus Parainfluenza virus types 1, 2, 3 Influenza A virus Influenza B virus Rhinovirus Bocavirus Human metapneumovirus | Influenza A virus Influenza B virus Respiratory syncytial virus Human metapneumovirus Adenovirus types 4 and 7 (in military … Available assays can detect influenza A, influenza B, parainfluenza viruses, respiratory syncytial virus (RSV), human metapneumovirus, coronaviruses, rhinoviruses, and bocavirus in respiratory secretions with high sensitivity and specificity for the presence of viral nucleic acid. …

Идентификация и каталог регуляторов вирусной транскрипции заболеваний человека.

Вирусные геномы кодируют регуляторы вирусной транскрипции (vTRs), которые манипулируют экспрессией гена хоста, чтобы облегчить воспроизведение и избежать иммунной обнаружения. Тем не менее их роль в нераковых болезнях по-прежнему в значительной степени недооценивается. Здесь мы представили 268 новых кандидатов в VTR из 14 из 20 вирусных семей, которые мы расследовали. Мы картировали связующие профили генома VTR и определили их потенциальные цели человека, которые были обогащены иммунно-посредованными путями, нейродегенеративными расстройствами и раком. На основе анализа предпочтений VTR, имеющ

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… These 600 vTRs correspond to 191 different viruses (species), including vTRs identified in 97 new viruses (species) such as Bocavirus, Akhmeta virus, and Alston virus ( Table S1 ). … We next performed comprehensive analyses to catalog vTRs across virus families, including regulators from understudied viruses such as Akhmeta, Alston, and Bocavirus. …

Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation.

Patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT) are highly susceptible to infections. The consequent use of masks on wards for allo-HSCT has been controversial in the past decades and was not common before the COVID-19 pandemic. We retrospectively compared incidence and outcomes of viral respiratory infections during allo-HSCT on our specialized ward between 01/2018 and 09/2020 to the era of FFP2 masking between 10/2020 and 10/2022 covering similar seasons of the year. Each group consisted of 150 matched patients. The usage of FFP2 masks reduced the incidence

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… Proven pathogens in the era before obligatory masking were 19 cases of rhinovirus, 6 of parainfluenza, 4 of coronavirus (not covid-19), 2 of metapneumovirus and 1 bocavirus with one patient having 2 RVIs during his stay. After masking was implemented, just 3 cases of rhinovirus were diagnosed. …

Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea.

Hematopoietic stem cell transplantation (HSCT) is a treatment for hematologic malignancies, immune deficiencies, or genetic diseases, ect. Recently, the number of HSCTs performed in Korea has increased and the outcomes have improved. However, infectious complications account for most of the morbidity and mortality after HSCT. Post-HSCT infectious complications are usually classified according to the time after HSCT: pre-engraftment, immediate post-engraftment, and late post-engraftment period. In addition, the types and risk factors of infectious complications differ according to the stem cell

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… In addition, human metapneumovirus, adenovirus, coronavirus, and bocavirus can cause URTIs and LRTIs in HSCT patients [ 129 , 137 ]. … No antiviral is available to treat CRV, rhinovirus, human metapneumovirus, and bocavirus LRTIs, so supportive care is the mainstay. HSCT patients with CRV infection are often susceptible to other pathogens, and so work-up for co-existent pathogens is required [ 129 , 137 , 140 ]. …

Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients.

Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV infection, making HCoV the fourt

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… Pinana JL Madrid S Perez A Hernandez-Boluda JC Gimenez E Terol MJ Epidemiologic and clinical characteristics of coronavirus and bocavirus respiratory infections after allogeneic stem cell transplantation: a prospective single-center study Biol Blood Marrow Transplant 2018 24 563 70 10.1016/j.bbmt.2017.11.001 …

Incidence, Risk Factors, and Outcomes of Idiopathic Pneumonia Syndrome after Allogeneic Hematopoietic Cell Transplantation.

Our current knowledge of idiopathic pneumonia syndrome (IPS) predates improved specificity in the diagnosis of IPS and advances in hematopoietic cell transplantation (HCT) and critical care practices. In this study, we describe and update the incidence, risk factors, and outcomes of IPS. We performed a retrospective cohort study of all adults who underwent allogeneic HCT at the Fred Hutchinson Cancer Research Center between 2006 and 2013 (n = 1829). IPS was defined using the National Heart, Lung, and Blood Institute consensus definition: multilobar airspace opacities on chest imaging, absence

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… In addition, a multiplex quantitative reverse-transcriptase PCR panel was used to detect 12 respiratory viruses, including influenza A, influenza B, RSV, parainfluenza virus types 1 to 4, adenovirus, human metapneumovirus, coronavirus, rhinovirus, and bocavirus [14] . …

Respiratory syncytial virus in hematopoietic cell transplant recipients and patients with hematologic malignancies.

In the USA and other western nations, respiratory syncytial virus is one of the most commonly encountered respiratory viruses among patients who have been diagnosed with a hematologic malignancy or who have undergone a stem cell transplant. Multiple studies have been performed to evaluate the complications associated with respiratory syncytial virus infections. Other studies have evaluated therapeutic agents and strategies in which these agents can be used. There have also been numerous reports of outbreaks in bone marrow transplant units and oncology wards, where infection control measures ha

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… viruses that may lead to the death of HCT recipients and HM patients is respiratory syncytial virus (RSV), 4 – 10 whose incidence is second only to that of influenza according to prior reports; 4 , 5 , 8 , 11 , 12 other viruses include parainfluenza virus, metapneumovirus, adenovirus, rhinovirus, and bocavirus …

Epidemiology of infections in cancer patients.

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and

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… Saccharomyces cerevisiae and S. boulardii Phaeohyphomycosis Cryptococcus gattii Viruses Respiratory viruses Influenza, including emerging and pandemic strains Parainfluenza Respiratory syncytial virus Human metapneumovirus Coronaviruses including SARS CoV and MERS CoV Adenovirus Rhinovirus Bocavirus … Clinicians caring for cancer patients must familiarize themselves with respiratory viruses such as influenza, including emerging and pandemic strains; parainfluenza; respiratory syncytial virus; human metapneumovirus; coronaviruses, including SARS CoV and MERS CoV; adenovirus; rhinovirus; bocavirus; …

What the Intensivist Needs to Know About Hematopoietic Stem Cell Transplantation?

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… HHV-8) Pneumonitis Encephalitis Rash Fever Marrow suppression JC virus Multifocal leukoencephalopathy Common respiratory viruses Respiratory syncytial virus (RSV) Human metapneumovirus Parainfluenza viruses (most commonly parainfluenza virus 3) Influenza virus Rhinovirus and enterovirus Coronavirus Bocavirus …