Результаты поиска

BCL-2 and BCL-xL in Cancer: Regulation, Function, and Therapeutic Targeting.

The BCL-2 family of proteins plays a central role in the regulation of apoptosis, with BCL-2 and BCL-xL representing two of its most prominent antiapoptotic members. This review explores the molecular regulation of BCL-2 and BCL-xL genes, emphasizing the structural domains that define the functions of the broader BCL-2 family. Beyond their canonical roles in preventing mitochondrial outer membrane permeabilization, both proteins contribute significantly to cancer development. Their overexpression enhances invasiveness and tumor progression, supports angiogenesis, and critically modulates cellu

Совпадение в полном тексте источника
… CDK1 in association with cyclin B1 also phosphorylates BCL-2 at Thr69, Ser70, Thr74, and Ser87, leading to increased affinity to BAK and BIM [ 92 ]. … Cell fate of mitotic arrested cells is defined by the duration of the arrest, cyclin B1 degradation, and apoptotic signaling. …

Benzyl isothiocyanate suppresses development of thyroid carcinoma by regulating both autophagy and apoptosis pathway.

Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer, characterized by rapid growth and invasion and poor prognosis. Due to its rarity and aggressive nature, ATC is a difficult condition to treat, thus knowledge of the mechanisms underlying its progression represents important research challenges. Benzyl isothiocyanate (BITC) is a natural compound that has shown promising anticancer properties. The aim of this study was to evaluate the antitumor effect of BITC in ATC, highlighting signaling pathways involved in BITC mechanism of action. This work included in vitro a

Совпадение в полном тексте источника
… B1 proteins. 46 Our findings revealed the ability of BITC to induce cell-cycle arrest through the downregulation of CDK2 and cyclin A, confirming the role in blocking the transition from G1 phase to S phase, but also G2 phase. … Benzyl Isothiocyanate Induces Apoptosis and Inhibits Tumor Growth in Canine Mammary Carcinoma via Downregulation of the Cyclin B1/Cdk1 Pathway. Front. Vet. Sci. 2020;7 doi: 10.3389/fvets.2020.580530. 64. Ohnishi K., Ota I., Yane K., Takahashi A., Yuki K., Emoto M., Hosoi H., Ohnishi T. …

The role of Rhizoma Paridis saponins on anti-cancer: The potential mechanism and molecular targets.

Cancer is a disease characterized by uncontrolled cell proliferation, leading to excessive growth and invasion that can spread to other parts of the body. Traditional Chinese medicine has made new advancements in the treatment of cancer, providing new perspectives and directions for cancer treatment. Rhizoma Paridis is a widely used Chinese herbal medicine with documented anti-cancer effects dating back to ancient times. Modern research has shown that Rhizoma Paridis saponins (RPS) have various pharmacological activities. RPS can inhibit cancer in multiple ways, such as suppressing tumor growt

Совпадение в полном тексте источника
… When liver cancer cells were treated with polyphyllin D, the levels of Cyclin/CDK markers (including Cyclin D3, Cyclin E1, Cyclin A2, Cyclin B1, CDK2, and CDK4) decreased, confirming the significant impact of polyphyllin D on cell cycle arrest. … Polyphyllin II significantly downregulated the protein levels of Cyclin B1, Cyclin A2, and CDC2 in colorectal cancer cells. Additionally, polyphyllin II upregulated the protein level of p21 in colorectal cancer cells, leading to cell cycle arrest at the G2/M phase [ 58 ]. …

An overview of the potential anticancer properties of cardamonin.

Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effects and high toxicities, leaving room for significant advancements to be made in the field. In recent years, several phytochemicals from plants and natural bioresources have been extracted and tested against various human malignancies using both in vitro and in vivo preclinical model systems. Cardamonin, a chalcone extracted from the Alpinia species, is an example of a natural therapeutic agent that

Совпадение в полном тексте источника
… B1, ↑p21 | [ 49 ] BCG-823 and BCG-823/5-FU | Enhanced chemosensitivity of 5-FU; induced apoptosis, and cell cycle arrest | ↓p-glycoprotein, ↓β-catenin, ↓TCF-4, ↓Wnt/β-catenin | [ 50 ] Glioblastoma | CD133 + GSCs | Inhibited proliferation; induced apoptosis | ↓STAT3, ↓Bcl-2, ↓Bcl-L, ↓Mcl-1, ↓Survivin … Furthermore, cardamonin was reported to increase of p21, and decrease CDK1, cyclin B1, and CDC25c to block the AGS cells in the G0/G1 phase of the cell cycle [ 49 ]. …

Stochasticity of anticancer mechanisms underlying clinical effectiveness of vorinostat.

The Food and Drug Administration (FDA) has approved vorinostat, also called Zolinza®, for its effectiveness in fighting cancer. This drug is a suberoyl-anilide hydroxamic acid belonging to the class of histone deacetylase inhibitors (HDACis). Its HDAC inhibitory potential allows it to accumulate acetylated histones. This, in turn, can restore normal gene expression in cancer cells and activate multiple signaling pathways. Experiments have proven that vorinostat induces histone acetylation and cytotoxicity in many cancer cell lines, increases the level of p21 cell cycle proteins, and enhances p

Совпадение в полном тексте источника
… Cyclin B1: a protein called “Cyclin B1,” which is a regulatory protein involved in the cell cycle. CRC: colorectal cancer. BIM: a protein called “BIM,” which is a pro-apoptotic member of the Bcl-2 protein family. TP: thymidine phosphorylase. TS: thymidylate synthase. … In addition, vorinostat was observed to induce histone H3 acetylation while simultaneously suppressing the expression of growth-associated genes such as cyclin B1, cyclin D1, and c-myc ( Fig. 2 ). …

Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway.

Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for MM, the disease remains incurable for most patients owing to emergence of drug-resistant cancerous cells. Guggulsterone (GS), a phytosteroid, extracted from the gum resin of guggul plant, has displayed various anticancer activities in vitro and in vivo; however, the molecular mechanisms of its anticancer activity have not been evaluated in MM cells. Therefore, in this study,

Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers.

Cancer is a serious disease with an increasing number of reported cases and high mortality worldwide. Gastrointestinal cancer defines a group of cancers in the digestive system, e.g., liver cancer, colorectal cancer, and gastric cancer. Coptidis Rhizoma (C. Rhizoma; Huanglian, in Chinese) is a classical Chinese medicinal botanical drug for the treatment of gastrointestinal disorders and has been shown to have a wide variety of pharmacological activity, including antifungal, antivirus, anticancer, antidiabetic, hypoglycemic, and cardioprotective effects. Recent studies on C. Rhizoma present sig

Совпадение в полном тексте источника
… Rhizoma extract regulates the cell cycle in squamous cell carcinoma (KB, SCC-25) cells mediated by CDK4, CDK6, cyclin B1, cyclin E, cyclin D1, and p27 ( Wang et al., 2011 ). … Moreover, berberine induces G 2 /M arrest in leukemia (HL-60, WEHI-3) cells by inhibiting cyclin B1 and promoting Wee1 expression ( Lin et al., 2006 ). …

Keyword Index for Volume 100

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1.

MicroRNAs (miRNAs) with tumor-suppressor potential might have therapeutic applications in multiple myeloma (MM) through the modulation of still undiscovered molecular pathways. Here, we investigated the effects of enforced expression of miR-29b on the apoptotic occurrence in MM and highlighted its role in the context of a new transcriptional loop that is finely tuned by the proteasome inhibitor bortezomib. In details, in vitro growth inhibition and apoptosis of MM cells was induced by either transient expression of synthetic miR-29b or its stable lentivirus-enforced expression. We identified S

Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy.

Despite the advances in biomedical research and clinical applications, cancer remains a leading cause of death worldwide. Given the limitations of conventional chemotherapeutics, including serious toxicities and reduced quality of life for patients, the development of safe and efficacious alternatives with known mechanism of action is much needed. Prevention of cancer through dietary intervention may hold promise and has been investigated extensively in the recent years. AMP-activated protein kinase (AMPK) is an energy sensor that plays a key role in the regulation of protein and lipid metabol

Bavachin suppresses proliferation of laryngopharyngeal cancer by regulating the STAT3 and MAPK signaling pathways.

Purpose: The present study aimed to explore the underlying antitumor effects of bavachin on laryngopharyngeal cancer in-vitro and in-vivo. Methods: Tu212 and FaDu cells were cultured in the incubator. Cells were treated with 0.1% DMSO (control group) and different concentrations of bavachin (experimental groups) for exploring the results of proliferation and apoptosis. We revealed the underlying mechanism of bavachin on laryngopharyngeal cancer through western blotting, qRT-PCR assay and immunofluorescence staining. Results: Bavachin could suppress the proliferation and migration of laryngopha

Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models.

Waldenström macroglobulinemia (WM) is a rare and currently incurable neoplasm of IgM-expressing B-lymphocytes that is characterized by the occurrence of a monoclonal IgM (mIgM) paraprotein in blood serum and the infiltration of the hematopoietic bone marrow with malignant lymphoplasmacytic cells. The symptoms of patients with WM can be attributed to the extent and tissue sites of tumor cell infiltration and the magnitude and immunological specificity of the paraprotein. WM presents fascinating clues on neoplastic B-cell development, including the recent discovery of a specific gain-of-function

Clinical management and therapeutic development for the rare disease rhabdomyosarcoma.

Rhabdomyosarcoma (RMS) is a rare disease that arises from skeletal muscle mainly affects children and adolescents. Patients with RMS have diverse symptoms and prognosis based on tumor sizes, tumor anatomical locations, histological subtypes of the tumors and genetic testing of paired-box-forkhead box O1 (PAX-FOXO1) fusion gene. The 4 subtypes of RMS include embryonal RMS (eRMS), alveolar RMS (aRMS), spindle cell/sclerosing RMS (scRMS) and pleomorphic RMS (pRMS). Treatment for RMS patients remains challenging due to its heterogeneous nature. Thus, a combinatory approach is likely to warrant bet

Совпадение в полном тексте источника
… First, CDK1-cyclin B1 phosphorylates N-MYC at Ser54. Then serine-threonine kinase glycogen synthase kinase 3β (GSK3β) recognizes N-MYC (pSer54) and phosphorylates it at Thr50 subsequently triggering protein phosphatase 2A (PP2A)-dependent dephosphorylation of Ser54. …

Molecular Mechanisms of Symptom Fluctuations in Malignant Tumor Patients: Stable by Day and Severe at Night.

Patients with malignant tumors often experience fluctuations in the severity of their symptoms depending on the time of day. In traditional Chinese medicine, symptoms are said to follow a pattern of "mild in the morning, stable by day, worsening in the evening, and severe at night." This article investigates the circadian chronobiology of symptoms and examines their molecular pathophysiology. Evidence suggests that disruptions in core circadian clock genes, such as BMAL1 and PER, along with the dysregulation of cellular metabolic pathways, immune responses, and endocrine functions, synergistic

Совпадение в полном тексте источника
… On the other hand, p53 upregulates the expression of its key downstream target gene p21 while downregulating the cell cycle protein cyclin B1. … As a potent cyclin-dependent kinase inhibitor (CDKI), p21, in conjunction with reduced cyclin B1, causes cell cycle arrest at the G2/M phase, preventing the abnormal proliferation of damaged cells 27 . …

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials.

Curcuminoids are bioactive polyphenols, mainly extracted from Curcuma longa (turmeric), and have received much attention due to their pleiotropic anticancer properties. Recent evidence suggests that curcumin and analogs prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF-kB pathways, resulting in the induction of apoptosis, prevention of proliferation, and suppression. In addition to these processes, curcumin has been shown to enhance the efficacy of the conventional anti-cancer modalities such as radiation and chemotherapy. By suppressing the expres

Совпадение в полном тексте источника
… The current study also proves that curcumin selectively induced cell cycle arrest of glioma cells in the G2/M phase, which is due to the reduction in the expression of CDK1 and cyclin B1 (Banik et al. 2020 ). … For instance, curcumin has been described to reduce cyclin B1 and CDK1, which directly affect tumor growth and exhibit G2/M cell cycle arrest (Banik et al. 2020 ). …

Keyword Index for Volume 88

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Pterostilbene in the Management and Treatment of Multiple Myeloma.

Multiple Myeloma is a malignancy of the plasma cells of the bone marrow. This cancer rapidly becomes refractory to many of the currently available chemotherapeutic regimens used against it, requiring an alternative option or supplementary therapy. Pterostilbene is a naturally occurring compound in a variety of commonly consumed plants that exhibits strong antioxidant properties and, lately, has shown increasing activity as an anti-neoplastic compound. A review of the literature published since 2015 on Google Scholar and PubMed was conducted, with a focus on randomized controlled trials and an

Clinical evaluation and outcome in heart failure patients receiving chemotherapy with different anti-cancer agents.

BACKGROUND: The optimal strategy for modern chemotherapy should be based on a comprehensive approach for cancer patients with cardiovascular diseases. Therefore, cardio-oncology has received increasing attention owing to the cardiotoxic effects of anti-cancer therapies. OBJECTIVES: We aimed to evaluate the clinical characteristics and outcomes of patients with heart failure (HF) who received chemotherapy compared with those of a matched cohort with HF who did not receive chemotherapy, using real-world HF data. METHODS: This study was based on the Diagnosis Procedure Combination (DPC) databas

Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing lo

Functional genomics for breast cancer drug target discovery.

Breast cancer is a heterogeneous disease that develops through a multistep process via the accumulation of genetic/epigenetic alterations in various cancer-related genes. Current treatment options for breast cancer patients include surgery, radiotherapy, and chemotherapy including conventional cytotoxic and molecular-targeted anticancer drugs for each intrinsic subtype, such as endocrine therapy and antihuman epidermal growth factor receptor 2 (HER2) therapy. However, these therapies often fail to prevent recurrence and metastasis due to resistance. Overall, understanding the molecular mechani

Совпадение в полном тексте источника
… TOPK phosphorylates and then binds to cdk1/cyclin B1 and protein regulator of cytokinesis 1 (PRC1) on microtubules during mitosis to promote cytokinesis [ 78 ]. … Overall, these findings suggest that TOPK functions as an essential mitotic kinase through phosphorylation depending on the regulation of substrates involved in cytokinesis, including the p47/p97 complex, histone H3, cdk1/cyclin B1, and PRC1. …