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Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review.

The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial thromboembolism (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent useful hints for a comprehensive review of the thrombotic issue. A 75-year-old man with advanced rectal cancer treated with fluoropyrimidines suffered two catheter-related VTE events managed according to current guidelines. There was no indication for "extended" anticoagulant therapy for him, but during antithrombotic wash-out and fluoropyrimidines

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… A prophylactic dose of LMWH was administered for 30 days, according to the 2020 ASCO guidelines: “Initial anticoagulation may involve LMWH, UFH, fondaparinux or rivaroxaban” [ 20 ]. The suggested short-term duration is 3 to 6 months. …

Периоперативные соображения для пациентов с множественной миеломой.

Множественная миелома — неизлечимый рак, характеризующийся распространением клональных плазменных клеток, в основном в костном мозге, но вызывающий широкомасштабные системные осложнения. Кроме того, этот рак обычно встречается у пожилых пациентов, которые часто являются слабыми и страдают от многочисленных коморбидов. Общемировая распространенность множественной миеломы неуклонно возрастает, а терапевтические достижения способствуют повышению уровня выживания. Существует несколько осложнений миеломы, о которых анестезиолог должен знать в связи с самим заболеванием, конкретными и подкрепляющими

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… have a substantially elevated risk of thrombosis compared with the general population, making preoperative individualised risk assessment advisable. 10 , 56 Depending on the level of risk, patients may be considered for prophylactic aspirin alone, or in combination with low molecular weight heparin, fondaparinux …

Exploring the Emerging Association Between Immune Checkpoint Inhibitors and Thrombosis.

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but their association with thrombosis presents significant clinical challenges. Patients with cancer already exhibit elevated risks for venous thromboembolism and arterial thrombosis, with treatment modalities like chemotherapy further exacerbating this risk. Emerging evidence suggests that ICIs contribute to thrombotic events through multifactorial mechanisms, including immune dysregulation, T cell activation, endothelial dysfunction, elevated tissue factor expression, and impaired fibrinolysis. Additional risk factors

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… Current guidelines for the acute and long-term management of VTE to prevent recurrence suggest initial anticoagulation with LMWH, unfractionated heparin (UFH), fondaparinux, or rivaroxaban. … Preclinical studies investigating resistance mechanisms to ICIs have implicated factor X in immune escape mechanisms, suggesting a potential role for factor Xa inhibitors such as fondaparinux in enhancing the anti-tumor effects of ICIs [ 109 , 110 ]. …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… contraception: change of user’s profile 2003–2006 PC-234 Development and validation of the socioeconomic impact profile (SEIP)-factor analysis PC-244 Impact on the medical follow-up of inr in a 200-bed geriatric hospital with a computerized control (pharmacist developed) PC-245 Four years experience of fondaparinux …

Short- and Long-Term Prognosis in Hemodynamically Stable Pulmonary Embolism With Unresectable or Metastatic Malignancies: The Role of Performance Status.

BackgroundThe simplified Pulmonary Embolism Severity Index (sPESI) has limitations when evaluating acute pulmonary embolism (PE) in patients with concurrent malignancy. Despite its utility in predicting outcomes among cancer patients, the role of the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in acute PE remains underexplored. This study aims to assess the prognostic significance of ECOG PS ≥ 3 on short- and long-term mortality in acute PE with malignancy, correlating it with the sPESI.Methods and resultsWe retrospectively analyzed 44 hemodynamically stable acute PE patien

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… continuous value) | 1.6 (0.7) | 1.6 (0.9) | 0.83 Presentation setting (in-hospital occurrence) | 13 (46.4%) | 8 (50.0%) | 1.00 Initial treatment | | | Unfractionated heparin | 14 (50.0%) | 11 (68.8%) | 0.34 Direct oral anticoagulants | 13 (46.4%) | 5 (31.3%) | 0.36 Warfarin | 0 (0%) | 0 (0%) | 1.00 Fondaparinux …

Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol.

OBJECTIVES: To assess whether high doses of Low Molecular Weight Heparin (LMWH) (i.e. Enoxaparin 70 IU/kg twice daily) compared to standard … alves) 10. Concomitant double antiplatelet therapy 11. Administration of therapeutic doses of LMWH, fondaparinux, or unfractionated heparin (UFH) for more than 72 hours before randomization; prophylactic doses are allowed 12. Pregnancy or breastfeeding or positive pregnancy test 13. Presence of other severe diseases impairing life expectancy (e.g. patients are …

Cardio-cerebral infarction: a narrative review of pathophysiology, treatment challenges, and prognostic implications.

Cardio-cerebral infarction (CCI) is a rare clinical syndrome characterized by the simultaneous or sequential occurrence of acute myocardial infarction (AMI) and acute ischemic stroke (AIS). Despite its complex pathogenesis and more severe prognosis compared to isolated AMI or AIS, no consensus has been established regarding its definition, classification, epidemiology, treatment protocols, or prognostic management. Current research is largely confined to case reports or small case series, and there are no unified diagnostic or treatment guidelines, nor any expert consensus. Consequently, clini

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… For NSTE-ACS patients not expected to undergo early angiography, fondaparinux is recommended ( 64 ). For AMI patients who develop left ventricular thrombus, oral anticoagulation therapy is indicated. …

Multidisciplinary Care for the Prevention and Treatment of Venous Thromboembolism in Patients with Cancer-Associated Thrombosis (CAT): Impact of Educational Interventions on CAT-Related Events and on Patients' and Clinicians' Awareness.

Cancer is a leading cause of death. Venous thromboembolism (VTE) is an often-overlooked cause of morbidity and mortality in cancer patients that can be readily prevented and treated. Actions are needed to reduce the morbidity and mortality of patients with cancer-associated thrombosis (CAT). There is a need to increase awareness of the impact of CAT on cancer patients' morbidity and mortality, on their quality of life and to understand the importance of more effective preventions and treatments of VTE in cancer patients. Moreover, it is of great importance to systematically assess the risk of

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… Fondaparinux is a valid alternative to LMWH. Unfractionated heparin is an option for patients with severe renal insufficiency [ 15 ]. Thrombocytopenia is common in patients with cancer, especially in those with hematologic malignancies. …

Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis.

BACKGROUND: Cancer-associated thrombosis is a condition associated with high mortality rates, yet limited evidence exists regarding the safety and effectiveness of low-molecular-weight heparin (LMWH) and direct oral anticoagulants (DOACs), focusing on a fixed follow-up period based on clinical practice guideline recommendations. OBJECTIVE: This study aimed to compare the safety and effectiveness of DOACs versus LMWH in patients with cancer-associated thrombosis over a 6-month follow-up period. METHODS: PubMed, Embase, and Cochrane Library databases were systematically searched up to 30 June,

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… period Schrag et al. (2023) [ 49 ] | RCT | USA | EHR from 67 centers | 20161201–20201131 | 6 | Any invasive solid tumor, lymphoma, multiple myeloma, or chronic lymphocytic leukemia | 671 | Median (IQR): 64 (56–70) | 69.1 | Apixaban, dabigatran, edoxaban, or rivaroxaban | Enoxaparin, dalteparin, or fondaparinux …

Профилактика и лечение венозного тромбоэмболия у пациентов с множественной миеломой: руководящие принципы клинической практики от имени Европейской сети миеломы.

Венозный тромбоэмболизм (VTE) является частым осложнением у пациентов с множественной миеломой (MM), что приводит к повышению заболеваемости, смертности, прерыванию лечения и снижению качества жизни. Основные рекомендации включают следующее: Информирование пациентов о риске ВТЕ и признаках/симптомах тромбоза глубокой вены и легочной эмболии. Специализированная помощь. - создание специализированного диагностического и лечебного механизма для профилактики и лечения ВТЕ в амбулаторных условиях. Оценка рисков. Регулярная оценка риска VTE с использованием подтвержденных оценок. Первичная тромбопроф

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… Recommendations We recommend to administer prophylactic doses of LMWH or fondaparinux to patients with active MM and acute medical illness, either hospitalized or receiving care in the primary healthcare setting or at home (Grade 1A) . …

Venous Thromboembolism in Cancer Patients on Simultaneous and Palliative Care.

Simultaneous care represents the ideal integration between early supportive and palliative care in cancer patients under active antineoplastic treatment. Cancer patients require a composite clinical, social and psychological management that can be effective only if care continuity from hospital to home is guaranteed and if such a care takes place early in the course of the disease, combining standard oncology care and palliative care. In these settings, venous thromboembolism (VTE) represents a difficult medical challenge, for the requirement of acute treatments and for the strong impact on an

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… Thus, in cancer patients with established VTE, according to the American Society on clinical Oncology (ASCO) guidelines, initial anticoagulation may involve LMWH, UFH, fondaparinux or rivaroxaban. …

Venous Thromboembolism in Lymphoma: Risk Stratification and Antithrombotic Prophylaxis.

Lymphoma is listed among the neoplasias with a high risk of venous thromboembolism (VTE). Risk factors for VTE appear to differ from risk factors in solid tumors. We review the literature of the last 20 years for reports identifying these risk factors in cohorts consisting exclusively of lymphoma patients. We selected 25 publications. The most frequent studies were analyses of retrospective single-center cohorts. We also included two reports of pooled analyses of clinical trials, two meta-analyses, two analyses of patient registries, and three analyses of population-based databases. The VTE ri

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… Guidelines recommend prophylaxis with LMWH or fondaparinux when creatinine clearance is ≥30 mL/min, or with unfractionated heparin in hospitalized patients with cancer and reduced mobility [ 4 ]. …

A review on how to do hematology consults during COVID-19 pandemic.

The ongoing COVID-19 pandemic is the most trending and talked topic across the World. From its point of origin in Wuhan, China to clinical laboratory at NIH, a mere six-month-old SARS-CoV-2 virus is keeping the clinicians, and scientists busy at various fronts. However, COVID-19 is an emerging and evolving disease and each day brings in more data, new figures, and findings from the field of clinical practice. The role of hematologists has been increasingly recognized during the current pandemic because of several reasons. Most important of them are the characteristic hematological findings of

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… . • Fondaparinux preferred in patient has a history of HIT | Caution: To hold anticoagulation temporarily if platelet count is <30–50 × 109/L or if the fibrinogen is <1.0 g/L • Mechanical thromboprophylaxis, only when chemical treatment is contraindicated B.2.2 | A COVID-19 patient who develop acute …

Артериальный тромбоэмболизм

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Inpatient Medicine

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Fucoidan: An Update on Function, Role in Human Health and Applications.

Fucoidan is a polysaccharide bioactive compound, mainly from brown algae, characterized by multiple biological activities, including anti-inflammatory, anticoagulant, anticancer, antioxidant, antiviral, and cardioprotective properties. In addition, growing scientific evidence supports its epigenetic potential and ability to modulate autophagic mechanisms, two crucial aspects for the treatment and prevention of chronic diseases, such as cancer, inflammation, and aging. For this reason, Fucoidan is a promising candidate for a wide range of applications, both as a bioactive component of drug deli

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… Among these, fucoidan 2,3‐O‐sulfate has been identified as the compound with the greatest inhibitory activity, surpassing in terms of efficacy even Fondaparinux, currently used in therapy (Koike et al. 2021 ). …

Evaluation of the Enhanced Recovery After Surgery (ERAS) Guidance for Patients With Spinal Metastasis.

Surgery continues to remain the most effective treatment for spinal metastasis (SM). As the number of surgeries continues to grow, the need for consensus guidelines for optimal perioperative care is imperative. Enhanced recovery after surgery (ERAS) protocols were created for this purpose. The objective of this study is to review evidence-based ERAS guidelines for SM surgery. A group of multiple experienced spine surgeons was invited to participate in this study. This group identified 19 ERAS items for SM surgery. The principal literature search utilized MEDLINE, Embase, and Cochrane databases

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… In addition to physiotherapy, there were multiple studies that showed that enoxaparin, fragmin, and fondaparinux are effective in preventing screen detected VTE, and prophylactic anticoagulation with low molecular weight heparin in surgically treated patients reduced the risk of DVT. …

When and for Whom Does Intensive Care Unit Admission Change the Prognosis in Oncology?-A Scoping Review.

Background: The intersection between oncology and intensive care has shifted from predominantly end-of-life care to a therapeutic bridge that can preserve anticancer trajectories in carefully selected patients. Yet, criteria separating benefit from futility remain fragmented. Objective: This paper seeks to map contemporary evidence (2015-2025) on outcomes after Intensive Care Unit (ICU) admission in adults with cancer and to identify clinical constellations in which ICU-level care still changes prognosis. Methods: PRISMA-ScR scoping review (PCC framework). PubMed search (2015-2025), dual scree

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… Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer. J. Thromb. Haemost. 2018;16:2492–2500. doi: 10.1111/jth.14317. 12. …

15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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