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Non-Chinese herbal medicines for functional dyspepsia.

BACKGROUND: One-third of people with gastrointestinal disorders, including functional dyspepsia, use some form of complementary and alternat … o placebo: Lafonesia pacari (RR 1.52, 95% CI 1.08 to 2.14; 1 study, 97 participants; moderate CoE), Nigella sativa (SMD -1.59, 95% CI -2.13 to -1.05; 1 study, 70 participants; high CoE), artichoke (SMD -0.34, 95% CI -0.59 to -0.09; 1 study, 244 participants; low CoE), Boensenbergia rotunda (SMD -2.22, 95% CI -2.62 to -1.83; 1 study, 160 participants; low …

IL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in rats.

In this study, we investigated possible hepato-protective effects of N. Sativa, P. Ginseng, and C. Sempervirens in Aflatoxin B1 (AFB-1) induced hepatocellular carcinoma rat model. Fifty-four male albino rats were randomly assigned to experimental groups. Alcoholic extracts of aforementioned herbs were administered orally for 28 days at different doses. IL-6, hs-CRP, MDA, SOD and NFE2L2 were determined using ELISA. Histopathological changes in treated groups were examined. Herbal treatment significantly reduced IL-6, hs-CRP, and MDA (P C. Sempervirens 600 and N. Sativa 1000 increased NFE2L2 lev

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… Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 2013;19(16):2529–2536. doi: 10.3748/wjg.v19.i16.2529. 8. Sun B. … Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance. J Physiol Pharmacol. 2016;67(6):801–817. 11. Salem M.L. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. …

Thymoquinone-loaded Nanosized Ethosomal-based Hydrogels: Their Preparation, Characterization, In Vitro, Ex Vivo, and Antimicrobial Evaluation against Staphylococcus aureus.

BACKGROUND: Thymoquinone (TQ) is found in the seeds of Nigella sativa. It has immunomodulatory, antibacterial, anti-inflammatory, antioxidant, astringent, antifungal, and antihistaminic properties, making it a highly valuable compound of interest. However, the use of it as a therapeutic drug is highly challenging because of its poor solubility, low bioavailability, and short-term stability. AIM: The present study focused on a nanosized ethosome formulation of thymoquinone with potent antimicrobial activity against Staphylococcus aureus. METHODS: This study aimed to develop nanosized TQ-loade…

Anti-fibrotic effect of thymoquinone on hepatic stellate cells.

Hepatic stellate cells (HSCs) are the major cell type involved in the production of extracellular matrix in liver. After liver injury, HSCs undergo transdifferentiation process from quiescent state to activated state, which plays an important role in liver fibrosis. Previous studies have shown that thymoquinone (TQ) might have protective effect against liver fibrosis in animal models; however, the underlying mechanism of action is not fully understood. The aim of this study is to examine whether TQ has any direct effect on HSCs. Our results showed that pretreatment of mice with TQ has protecti

Воздействие моделей перорального ухода на профилактику перорального слизистого слизняка, вызванного высокими дозами мельфалана у пациентов, страдающих АЦТ.

Высокодозированные мелфаланы (МЭЛ) в сочетании с аутологической трансплантацией стволовых клеток (ASCT) эффективно лечат множественные миеломы (MM), но часто вызывают оральный слизистой мукосит (OM), влияющий на исход пациента. Цель этого исследования заключается в оценке эффективности усовершенствованной модели орального ухода в деле предотвращения ОМ, вызванного МЭЛ. В этом ретроспективном исследовании были рассмотрены медицинские записи 87 больные с MM, которые прошли ACCT в первой родственной больнице Сокхоуского университета в декабре 2019 и февраль 2022. В соответствии с протоколами о пе

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… Recent studies have mainly focused on pharmacological or mouthwash-based strategies – such as zinc chloride, Nigella sativa oil, or vitamin E–containing formulations – to alleviate chemotherapy-induced OM. [ 8 , 9 ] However, these investigations have primarily addressed the composition of oral rinses … Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia. Biomed Res Int . 2019 ; 2019 : 3619357 . 31781612 10.1155/2019/3619357 PMC6875195 [12] Agha-Hosseini F Pourpasha M Amanlou M Moosavi MS . …

Липидированные мезофорные наночастицы, нагруженные тимокиноном, в качестве нового метода лечения аутоиммунного энцефаломиелита у крыс.

AIMS: Пересечение мозгового барьера (BBB) по-прежнему является серьезной проблемой для доставки терапевтических агентов в центральную нервную систему. Цель этого исследования состояла в том, чтобы оценить потенциал новых наноформуляционных силикатных силиканочастиц (MSN), покрытых липидным двуслойным слоем (LB), с тем чтобы повысить уровень доставки и потенциальное ремиелионирующее воздействие тимокинона (TQ). МЕТОДЫ: Составы характеризовались микроскопией передачи электронов и динамическим рассеиванием света для определения потенциала зета и размера частиц. Экспериментальная аутоиммунная энце

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… Nigella sativa (N. sativa), or the black seed. It treats several conditions naturally [ 17 ]. Thymoquinone (TQ) and N. sativa seed extracts have demonstrated potent curative effects in studies of autoimmune diseases [ 18 ]. … Nigella Sativa as an anti-inflammatory and promising remyelinating agent in the cortex and hippocampus of Experimental autoimmune Encephalomyelitis-induced rats. J Sport Hist Basic Appl Zool. 2014;67(5):182–95. 10.1016/j.jobaz.2014.08.005. 11. …

New targets for the treatment of follicular lymphoma.

The last two decades have witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL). Development of newer treatment approaches have improved the outlook for many individuals with these disorders; however, with these advances come new questions. Given the long-term survival of patients with FL, drugs with favourable side-effect profile and minimal long-term risks are desired. FL is incurable with current treatment modalities. It often runs an indolent course with multiple relapses and progressively shorter intervals of remi

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… E) Thymoquinone as an apoptosis inducing agent for follicular lymphoma Thymoquinone (TQ) (Figure 11 ) is an active constituent of volatile oil of black Nigella sativa seed with biological activities that we have detailed in our recent report [ 105 ]. … Figure 11 Structure of Thymoquinone extracted from Nigella sativa seed . …

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional

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… The preparation of Nigella sativa (belonging to Ranunculaceae family) oil had potent inhibitory effect on cancer cells and its cytotoxicity was through the inhibition of NF-κB signaling pathway ( Agbaria et al., 2015 ). … Apoptotic effect of Nigella sativa on human lymphoma U937 cells . Pharmacogn. Mag. 13 , S628 – S632 . 10.4103/pm.pm_93_17 29142424 PMC5669107 Bai N. He K. Zhou Z. Lai C. S. Zhang L. Quan Z. ( 2010 ). …

Anticancer natural products from the Middle East and North Africa: biodiversity, mechanisms, and translational challenges.

Cancer remains one of the leading causes of morbidity and mortality worldwide, imposing substantial clinical, societal, and economic burdens. Despite major advances in surgical oncology, systemic chemotherapy, radiation therapy, molecularly targeted therapeutics, and immune checkpoint inhibition, contemporary cancer treatment remains constrained by dose-limiting toxicities, intratumoral and intertumoral heterogeneity, and the inexorable emergence of multifaceted drug resistance mechanisms. These persistent therapeutic challenges have reinstated interest in natural products (NPs) as evolutionar

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… | Flavonoids; phenylpropanoids | Flavonoids; phenolics | Angiogenesis models | VEGFR2/EGFR modulation; anti-angiogenic activity | ( 206 ) Ephedra alata | Saudi Arabia | Chlorogenic acid; apigenin | Phenolic acids; flavonoids | Breast; lung cancer | CAIX inhibition; anti-metastatic effects | ( 207 ) Nigella … This chemical convergence across African-tropical and Mediterranean plant life reflects shared biosynthetic responses to analogous environmental pressures rather than phylogenetic proximity.Ethnomedicinal plants like Nigella sativa and Withania somnifera further illustrate the therapeutic and pharmacological …

Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma.

Background and objectivesESC or Ehrlich solid carcinoma is a type of tumor originating from a spontaneous mammary adenocarcinoma in mice. It is a highly aggressive and fast-growing carcinoma that can create a solid mass when inserted under the skin. Its solid, undifferentiated form makes it an ideal model for researching cancer biology, tumor immunology, and testing various anti-cancer treatments. Additionally, arctiin has multiple beneficial properties, such as anti-proliferative, anti-oxidative, anti-adipogenic, and anti-bacterial. This study aimed to explore the potential anti-cancer benefi

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… 10.7759/cureus.41985 PMC10350652 37465088 10 Lack of a significant effect of arctiin on development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats Nutr Cancer Hasumura M Ueda M Onose J Imai T Hirose M 201 208 57 2007 17571954 10.1080/01635580701277585 11 Nigella …

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… Thymoquinone (TQ) is the constituent of Nigella sativa and various other EOs have been found to prevent Dox induced resistance in breast cancer (MCF-7/Dox) cells. … Food Chemistry 2012 132 1 261 267 2-s2.0-84355162777 26434289 10.1016/j.foodchem.2011.10.074 130 Harzallah HJ Grayaa R Kharoubi W Maaloul A Hammami M Mahjoub T Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during …

Evans syndrome: clinical perspectives, biological insights and treatment modalities.

Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive direct anti-human globulin test. It is classified as primary and secondary, with the frequency in patients with autoimmune hemolytic anemia being 37%-73%. It predominates in children, mainly due to primary immunodeficiencies or autoimmune lymphoproliferative syndrome. ES during pregnancy is associated with high fetal morbidity, including severe hemolysis and intracranial bleeding with neurological sequelae and death. The clinical presenta

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… autologous stem cell transplantation has been documented. 150 Additional potential supporting interventions Anecdotic reports suggest that immunological benefits can be gained in patients with autoimmune diseases including SLE and rheumatoid arthritis from simple measures, including oral honey drink and Nigella … internalmedicine.49.2922 151 Hwang-Bo S Kim SK Lee JW Treatment and response of autoimmune cytopenia occurring after allogeneic hematopoietic cell transplantation in children Blood Res 2017 52 2 119 124 28698848 10.5045/br.2017.52.2.119 PMC5503889 152 Kheirouri S Hadi V Alizadeh M Immunomodulatory effect of Nigella …

Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy.

The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is a critical signaling network governing cellular functions such as immune responses, proliferation, and apoptosis. Dysregulation of this pathway is strongly implicated in cancer progression. This review explores the therapeutic potential of natural products, including Curcumin, Resveratrol, Apigenin, and Epigallocatechin Gallate (EGCG), as modulators of the JAK/STAT pathway. These phytochemicals exhibit anticancer activity by inhibiting JAK/STAT phosphorylation, blocking STAT dimerization, and interfering wi

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… Thymoquinone In vitro and in vivo studies Thymoquinone, chemically referred to as 2-methyl-5-isopropyl-1,4-benzoquinone, is a biologically active substance found in black seed ( Nigella sativa ). … Clinical studies Thymoquinone is an active constituent found in Nigella sativa with potent anti cancer activities. A randomized, controlled trial conducted by Cairo University in Egypt evaluated the chemo-preventive effect of thymoquinone on oral potentially malignant lesions. …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Thymoquinone (TQ) Thymoquinone (TQ) is the main phytochemical bioactive constituent found in the volatile oil isolated from the Nigella sativa (black cumin, black seed), which has been used as a traditional medicine in many countries [ 59 , 147 , 148 ]. …

Antioxidant effects of Spirulina platensis (Arthrospira platensis) on cyclophosphamide-induced testicular injury in rats.

Cyclophosphamide (CP) is known to reduce fertility. The protective effects of Spirulina plantesis (SP) against CP-induced testicular toxicity were investigated. Male Wistar rats were categorized into eight groups (n = 7). Four groups of rats were administered CP at a dose of 5 mg in 5 mL distilled water kg-1 per day orally. Two of these groups were received SP (500 and 1000 mg kg-1 per day) orally after CP administration. One of these groups was also received vitamin E (100 mg kg-1 per day) intraperitoneally. A vehicle treated control group, two SP control groups (500 and 1000 mg kg-1 per day)

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… agents were considered useful to decrease oxidative stress. 11 Several studies have shown the beneficial effects of antioxidants on CP induced damages. 12 , 13 Accordingly, in a review study, Afkhami-Ardakani et al . have indicated that more than 20 types of plant compounds and antioxidants such as Nigella …

Cancer Metabolism as a Therapeutic Target and Review of Interventions.

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and

Early follow-up of outpatients with oral anticancer therapy in the ONCORAL multidisciplinary community-hospital program.

BackgroundHealthcare professionals are faced with the new challenges of preventing and managing drug-related problems (DRPs) with oral anticancer therapy (OAT): side-effects, drug-drug interactions (DDIs), non-adherence, or medication errors. This study aims to assess the impact of ONCORAL, a real-life multidisciplinary care plan for cancer patients based on community and hospital follow-up, for the first OAT cycle.MethodsA prospective cohort study was conducted between October 1, 2021 and October 1, 2022 including all outpatients starting OAT treatment. During the first OAT cycle, the program

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… DDI consequence | Oral anticancer drug | Drug or CAM associated | Description of DDI Risk of ↗ OAT concentrations | Dabrafenib Trametinib | Qing Hao (Artemesia Annua) | CYP 3A4 inhibition—↑toxicity of dabrafenib and trametinib | Kalonji ( Nigella sativa ) | Ibrutinib | Herb drug containing Ginger | …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… Anthraquinones Microcarpin Image 125 binds with TMPRSS2 [ 174 ] Anthocyanins Chry-santhemin Image 126 Black grapes RdRp and hACE-2 [ 55 ] Stilbenes δ-Viniferin Image 127 Grapevine leaves M Pro , RdRp and hACE-2 [ 55 ] Iso-gemichalcone Image 128 binds with TMPRSS2 [ 174 ] Lactones Limonin Image 129 Nigella … 125 | | binds with TMPRSS2 | [ 174 ] Anthocyanins Chry-santhemin | Image 126 | Black grapes | RdRp and hACE-2 | [ 55 ] Stilbenes δ-Viniferin | Image 127 | Grapevine leaves | M Pro , RdRp and hACE-2 | [ 55 ] Iso-gemichalcone | Image 128 | | binds with TMPRSS2 | [ 174 ] Lactones Limonin | Image 129 | Nigella …

The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.

BACKGROUND AND AIM: Recently, optimal immune function has become a primary focus of worldwide attention not only in the prevention of chronic disease but also as one strategy to reduce the severity of acute illness. Inflammation, a process largely controlled by the immune system, has long been studied and recognized for its role in chronic disease. Optimizing immune function or managing inflammation using individual nutrients and phytonutrients is not well understood by the average person. Thus, this narrative literature review summarizes many of the more recent findings about how certain nutr

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… MetSyn | Treatment: 15 Placebo: 12 | Bilberry-rich diet (equivalent to 400 fresh bilberries) for 8 weeks | Significant decreases in IL-6, IL-12, CRP, LPS, mRNA expression of C-C motif receptor 2, and monocyte differentiation-associated, and an overall decrease in low-grade inflammation Black seed oil (Nigella …

Plants as a Source of Anticancer Agents: From Bench to Bedside.

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in

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… Thymoquinone Thymoquinone (TQ) is a non-toxic major bioactive ingredient obtained from the essential oil of black seed Nigella sativa L. …