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VOGT-KOYANAGI-HARADA-LIKE UVEITIS FOLLOWED BY MELANOMA-ASSOCIATED RETINOPATHY WITH FOCAL CHORIORETINAL ATROPHY AND CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH METASTATIC CUTANEOUS MELANOMA.

PURPOSE: To report a case of Vogt-Koyanagi-Harada-like uveitis followed by melanoma-associated retinopathy with focal chorioretinal atrophy and subsequent choroidal neovascularization in a patient with metastatic cutaneous melanoma. METHOD: Case report. Main outcome measures include external photography, anterior segment photography, ophthalmoscopic examination, fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography, optical coherence tomography angiography, and electroretinography. RESULTS: A 68-year-old man with a history cu…

Altitudinal field defects and retinal nerve fibre degeneration in optic nerve lesions.

Altitudinal visual field defects in five cases with optic nerve lesions due to optic glioma, compression, and trauma are correlated to retinal nerve fibre degeneration, recorded with ophthalmoscopy and photography in red-free light. In one case the optic nerve was damaged at operation. Repeated fundus photography was used to record the evolution of descending optic atrophy. The results suggest that the findings in funduscopic examination of the retinal nerve fibre layer should be cautiously judged and the method cannot replace careful perimetry in cooperative patients.

The thickness of the aging human lens obtained from corrected Scheimpflug images.

Commonly, measurements of lens thickness are performed using A-scan ultrasonography or slitlamp Scheimpflug photography. Both techniques have their drawbacks in the study of presbyopia: ultrasonography requires the velocity of sound in the lens which may change with age, whereas Scheimpflug photography requires knowing the refractive index of the lens to enable correction of the photographs for the distortion due to the refraction of the cornea and lens. By combining Scheimpflug photography and axial optical eye-length measurements, we were able to individually correct the Scheimpflug images f…

Feasibility of a Nonmydriatic Ocular Fundus Camera in an Outpatient Neurology Clinic.

OBJECTIVE: To determine the feasibility of nonmydriatic fundus photography in the neurology outpatient setting and to record frequency of clinically relevant fundus findings. METHODS: Over 5 weeks, fundus photographs were obtained using a nonmydriatic fundus camera in both eyes of adult patients attending our general neurology and headache clinics. A neurologist, who had received 15 minutes of training on the use of the camera, took the photographs. Quality of photographs was graded. Photographs were reviewed by 2 neuro-ophthalmologists. Treating neurologists completed a survey on the use of …

Telemedicine approach to screening for severe retinopathy of prematurity: a pilot study.

PURPOSE: To evaluate the use of remote reading of digital retinal photographs in the diagnosis of severe (referral-warranted) retinopathy of prematurity (ROP) during longitudinal screening for ROP. STUDY DESIGN: Prospective, longitudinal cohort study. SUBJECTS: Forty-four consecutive premature infants at risk for ROP. METHODS: All infants were examined longitudinally, over a series of examinations, by indirect ophthalmoscopy (gold standard) and digital photography using the RetCam-120 Digital Retinal Camera (Massie Research Laboratories Inc., Dublin, CA) equipped with an ROP lens. Images we…

A historic photomicrograph of a parasite (Trichomonas vaginalis).

Knowing that Alfred Donné was the discoverer of an important human parasite, and finding that he was also a pioneer of photomicrography, it occurred to me that his parasite might well have become a subject of his photography. It was a simple matter to confirm that this was indeed the case. The parasite he discovered was Trichomonas vaginalis; and, in collaboration with Foucault, Donné made a photomicrograph showing several protozoan parasites lying among vaginal epithelial cells. His publication of an engraved image of the photomicrograph in 1845, was a landmark in the history of photography a…

Combined Rotating Ultra-High-Resolution Spectral Domain OCT and Scheimpflug Imaging for In Vivo Corneal Optical Biopsy.

PURPOSE: This article introduces the Pentacam® Cornea OCT (optical coherence tomography). This advanced corneal imaging system combines rotating ultra-high-resolution spectral domain OCT with sub- 2-micron axial resolution and Scheimpflug photography. The purpose of this study is to present the first experience with the instrument and its potential for corneal diagnostics, including optical biopsy. METHODS: In this prospective study, the Pentacam® Cornea OCT was used to image the corneas of seven patients. The novel wide-angle pericentric scan system enables optimal OCT imaging performance fo…

Optical Coherence Tomography Versus Optic Disc Photo Assessment in Glaucoma Screening.

PRÉCIS: Optical coherence tomography (OCT) and optic disc photography present valuable but distinct capabilities for glaucoma screening. OBJECTIVE: This review article examines the strengths and limitations of OCT and optic disc photography in glaucoma screening. METHODS: A comprehensive literature review was conducted, focusing on the accuracy, feasibility, cost-effectiveness, and technological advancements in OCT and optic disc photography for glaucoma screening. RESULTS: OCT is highly accurate and reproducible but faces limitations due to its cost and less portable nature, making widespr…

Validating Techniques for Measurement of Cutaneous Neurofibromas: Recommendations for Clinical Trials.

OBJECTIVE: To assess the reliability and variability of digital calipers, 3D photography, and high-frequency ultrasound (HFUS) for measurement of cutaneous neurofibromas (cNF) in patients with neurofibromatosis type 1 (NF1). BACKGROUND: cNF affect virtually all patients with NF1 and are a major source of morbidity. Reliable techniques for measuring cNF are needed to develop therapies for these tumors. METHODS: Adults with NF1 were recruited. For each participant, 6 cNF were assessed independently by 3 different examiners at 5 different time points using digital calipers, 3D photography, and …

Physical Activity and the Development of Substance Use Disorders: Current Knowledge and Future Directions.

PURPOSE: To evaluate the diagnostic accuracy of smartphone corneal photography in detecting corneal opacities in a community-based setting. METHODS: A case-control, diagnostic accuracy study was nested in a cluster-randomized trial of a corneal ulcer prevention intervention in Nepal. Smartphone corneal photography was performed annually on community members self-reporting a potential risk factor for a corneal infection. Corneal photographs were graded for the presence or absence of an opacity. All cases with an opacity on smartphone photography and an equal number of controls were invited for…

Современный подход к диагностике диабетической ретинопатии

В этой статье рассматриваются инновационные методы диагностики диабетической ретинопатии, поскольку распространение сахарного диабета и его осложнений продолжает расти. Новые методы сосредоточены на раннем обнаружении заболеваний. Технологические новшества, такие как телеофтальмология, смартфонная фотография, искусственный интеллект с глубоким обучением или широкополосная фотография, могут повысить диагностическую точность и ускорить лечение. В ходе обзора в качестве перспективных решений для дистанционного офтальмологического обслуживания рассматриваются телеоптальмология и ручная фотография.

Совпадение в аннотации оригинала
This article reviews innovative diagnostic approaches for diabetic retinopathy as the prevalence of diabetes mellitus and its complications continue to escalate. Novel techniques focus on early disease detection. Technological innovations, such as teleophthalmology, smartphone-based photography, artificial intelligence with deep learning, or widefield photog…

In vitro and in vivo release characteristics of Tacrolimus (FK506) from an episcleral drug-delivery implant.

PURPOSE: To investigate the in vitro and in vivo release characteristics of Tacrolimus (FK506) from an episcleral drug-delivery implant. ME … ined by liquid chromatographic-tandem mass spectrometry. Ocular toxicity was evaluated by slit-lamp photography, fundus photography, intraocular pressure (IOP), and histology. RESULTS: The implants released Tacrolimus in a biphasic pattern for 96 h in the in vitro study. The release kinetics were not dependent on the drug concentrations. The in vivo study sh …

Simplifying the Diagnosis of Vertical Diplopia: Is It Skew or Not?

Ocular tilt reaction (OTR) and trochlear nerve palsy (TNP) can induce cyclotorsion. We aimed to assess the utility of fundus photography in distinguishing between these disorders. The database of a neuro-ophthalmology hospital-based clinic was retrospectively searched for patients referred for new-onset vertical diplopia between 2020 and 2023. Medical data were collected, and the angle between the optic disc and fovea was measured using ImageJ software to quantify torsion. Distinct torsional patterns were identified between the groups. OTR was characterized by variable, often conjugate torsion…

Multimodal Analysis of the Retinal Manifestations of Tuberous Sclerosis Complex: A Case Series.

BACKGROUND AND OBJECTIVE: We used a multi-modal imaging approach including fundus fluorescein angiography (FFA) to assess the retinal lesions in tuberous sclerosis complex (TSC) and evaluate their correlation with intracranial tuber burden on magnetic resonance imaging (MRI). PATIENTS AND METHODS: Participants with TSC underwent bilateral fundus photography, optical coherence tomography (OCT), infrared (IR) imaging, and FFA. Participants' most recent MRI brain scans were analyzed to determine intracranial tuber load. RESULTS: Nine participants were included. OCT identified all retinal astroc…

A health economic pilot study comparing two diabetic retinopathy screening strategies.

To compare two screening strategies for diabetic retinopathy (DR), and to determine the health-economic impact of including optical coherence tomography (OCT) in a regular DR screening. This cross-sectional study included a cohort of patients (≥ 18 years) with type 1 or 2 diabetes mellitus (T1D or T2D) from a pilot DR screening program at Oslo University Hospital, Norway. A combined screening strategy where OCT was performed in addition to fundus photography for all patients, was conducted on this cohort and compared to our existing sequential screening strategy. In the sequential screening st…

Non-invasive quantification of corneal vascularization using anterior segment optical coherence tomography angiography.

The presence of corneal vascularization (CV) interferes with the angiogenic and immune privilege of the cornea, risking rejection in eyes following keratoplasty. Pre-operative (lymph)-angioregression is a promising therapeutic approach, but objective monitoring by non-invasive CV imaging is needed. The purpose of this study was to investigate anterior-segment optical coherence tomography angiography (AS-OCTA) for CV visualization and quantification, and to show its superiority over slit-lamp photography in high-risk eyes scheduled for keratoplasty. This institutional pilot study included 29 ey…

The role of imaging in the prevention of wrong-site surgery in dermatology.

Wrong-site surgery in dermatology often results from inaccurate identification of a skin cancer biopsy site. Factors making biopsy-site identification difficult include background actinic damage, delays from biopsy to surgery, and lack of photographic documentation. While other methods exist for biopsy-site identification, photography is the most helpful tool available. Although modern technology has made high-quality photographic equipment ubiquitous and easy to use, photography for biopsy-site identification continues to be underutilized. The authors recommend that photographic documentation…

Choroidal neovascularization in Bardet-Biedl syndrome.

PURPOSE: To describe a case of choroidal neovascularization in a young patient with genetically-proven Bardet-Biedl syndrome. METHODS: Case description with fundus and anatomical photography and optical coherence tomography. PATIENTS: Single patient case description. RESULTS: Fundus photography and optical coherence tomography reveal the presence of previously-active choroidal neovascularization. Anatomical, historical, and genetic evidence confirm Bardet-Biedl syndrome in this individual. DISCUSSION: Choroidal neovascularization accompanying this syndrome has not been reported. Herein we …

Macular Features in X-Linked Retinoschisis Patients.

OBJECTIVE: To describe the frequency and prevalence of macular features in X-linked retinoschisis (XLRS) patients using optical coherence tomography (OCT) and fundus photography, with attention to inter-eye asymmetry. DESIGN: Retrospective consecutive case series. SUBJECTS: Thirty-three male patients (66 eyes) with genetically confirmed XLRS evaluated at a tertiary pediatric retina clinic between 2013 and 2024. METHODS: Fundus photography and macular OCT images were graded independently by 2 masked reviewers for macular schisis, cystoid spaces (with layer localization), macular atrophy, spo…

Vascular Regression After Pinguecula Excision and Conjunctival Autograft Using Fibrin Glue.

OBJECTIVES: To determine the change in local vascularization after pinguecula excision and conjunctival autograft secured with fibrin glue at 12 months. METHODS: Thirty-one eyes of 31 patients which underwent excision and conjunctival autografting with fibrin glue were retrospectively reviewed. Anterior segment photography was obtained before and after the surgery. Cosmetic outcome was evaluated by patient self-grading (five-point scale; excellent (5), good (4), acceptable (3), poor (2), and very poor (1)), and medical evaluation of treatment outcome was based on subjective evaluation of vasc…