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A survey of Исследованиеers' attitudes to preregistration in animal Исследование reveals multiple perceived barriers to adoption.

Preregistration is arguably one of the most promising and potentially impactful Open Science practices. Defined as the a priori registration of study designs and analysis plans, preregistration has long been established as standard practice in clinical human Исследование and is increasingly taken up in other fields of science. Despite growing evidence suggesting that preregistration can mitigate questionable Исследование practices, and the existence of two platforms targeting animal studies, preregistration has remained uncommon in animal Исследование. In light of a "reproducibility crisis" and calls for …

Research Evolution and Frontiers in Glial Scar and Spinal Cord Injury Research: A Bibliometric Perspective.

INTRODUCTION: Glial scars play a key role in the pathophysiology of spinal cord injury. This study aims to systematically analyze global Исследование trends and advances on glial scars in spinal cord injury through bibliometric methods. METHOD: A comprehensive literature search was performed in the Web of Science Core Collection. Bibliometric analysis using VOSviewer, CiteSpace, and the R package Bibliometrix evaluated publication output, citation patterns, author and institutional contributions, international collaboration, journal impact, keyword co-occurrence, and emerging Исследование themes. RE…

Research gaps for children who are HIV-exposed but uninfected: outcomes of a Исследование prioritisation workshop.

Globally, 16 million children are HIV-exposed but uninfected (HEU), with health disparities when compared with children who are HIV-unexposed. To identify current challenges, a Исследование prioritisation exercise was conducted through an online survey and in-person workshop with diverse stakeholders, with the aim of identifying the top ten scientific priorities related to children who are HEU. Among 104 survey respondents (46% from Africa; 37% from Europe; 15% from the region of the Americas; and 2% from South-East Asia), 271 Исследование questions were submitted. Workshop attendees (n=35) refined an…

Interdisciplinary Исследование on periodontitis and depression: a bibliometric analysis of Исследование trends, hotspots and future directions.

BACKGROUND: Periodontitis, a chronic inflammatory disease affecting nearly 50% of the global population, has been increasingly linked to dep … ), "oral health" (n = 47) and "stress" (n = 37) were the most frequent keywords, reflecting current Исследование hotspots. Through the time map analysis of keyword clustering, we found that the Исследование hotspots gradually changed from "risk factors", "chronic periodontitis" and "psychosocial factors" to "inflammation", "Alzheimer's disease" and "smoking" and o …

Ethical challenges in sensitive Исследование: a reflective narrative on managing the clinician-Исследованиеer dual role.

BACKGROUND: Conducting sensitive Исследование in healthcare settings often presents complex ethical challenges, particularly when clinicians assume a dual role as Исследованиеers. This dual role, while providing valuable insight, can lead to ethical dilemmas when professional responsibilities intersect with Исследование obligations, especially in resource-limited and culturally sensitive environments. This reflective narrative explores these ethical tensions through the lens of a qualitative study involving men living with advanced prostate cancer and their family caregivers. METHOD: The study employed a …

The development of Liver Research Cymru, a new partnership to increase hepatology Исследование activity in Wales.

BACKGROUND: The incidence and severity of liver disease in the United Kingdom have increased over the last 20 years. Many patients present w … e the deprivation gradient and reduce health inequalities are urgently required. METHODS: Clinical Исследование has an enormous role to play both in terms of identifying the true scale of this challenge, where current gaps exist, and to identify the optimal early detection strategies and their implementation. We therefore established Liver Research Cymru (LRC …

Пробелы в области глобальных исследований в области здравоохранения применительно к мпоксу: анализ исследовательской деятельности и имеющихся данных.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: С декабря 2022 года число случаев заболевания мпоксом в Демократической Республике Конго (ДРК) возросло беспрецедентными темпами. Мы указали на необходимость систематического картирования активного исследовательского ландшафта и фактических данных, оценки их соответствия как местным, так и глобальным приоритетам в области научных исследований, с тем чтобы можно было получать информацию о срочно необходимых инвестициях в научные исследования в поддержку усилий по реагированию. МЕТОДЫ: Мы провели картографический обзор глобального финансирования исследований и международны

Совпадение в аннотации оригинала
BACKGROUND: Since December 2022, human cases of mpox in the Democratic Republic of the Congo (DRC) have risen at unprecedented rates. We identified a need for systematic mapping of the active Исследование landscape and evidence, assessing their alignment with both local and global Исследование priorities, to inform urgently needed Исследование investments to support res…

Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research.

The concept of vulnerability in bioethics was first referenced in 1979, when the Belmont Report highlighted the need for special consideration of certain populations in the application of its general principles of respect for persons, beneficence, and justice in Исследование with human participants. Since then, a body of literature has emerged regarding the content, status, and scope, as well as ethical and practical implications of vulnerability in biomedical Исследование. The social history of HIV treatment development has at various points reflected and actively influenced bioethics' debate on vuln…

International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India.

The Malaria Evolution in South Asia (MESA) International Center of Excellence for Malaria Research (ICEMR) conducted Исследование studies at multiple sites in India to record blood-slide positivity over time, but also to study broader aspects of the disease. From the Southwest of India (Goa) to the Northeast (Assam), the MESA-ICEMR invested in Исследование equipment, operational capacity, and trained personnel to observe frequencies of Plasmodium falciparum and Plasmodium vivax infections, clinical presentations, treatment effectiveness, vector transmission, and reinfections. With Government of India …

Gambling disorder in the UK: key Исследование priorities and the urgent need for independent Исследование funding.

Gambling in the modern era is pervasive owing to the variety of gambling opportunities available, including those that use technology (eg, online applications on smartphones). Although many people gamble recreationally without undue negative effects, a sizeable subset of individuals develop disordered gambling, which is associated with marked functional impairment including other mental health problems, relationship problems, bankruptcy, suicidality, and criminality. The National UK Research Network for Behavioural Addictions (NUK-BA) was established to promote understanding of, Исследование into,…