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Case report of a tibial fracture in a patient suffering from gout: An atypical site, the importance of differential diagnosis.

We present the case of a 60-year-old man with a history of severe tophaceous gout with polyarticular involvement who came to the emergency room due to direct trauma to the right forearm and knee. The knee X-ray and CT scan showed a lateral tibial plateau fracture characterized by the presence of a lytic bone lesion. The presence of a solid neoplasm was ruled out and a CT-guided biopsy was performed. Histological evaluation revealed findings typical for an advanced intraosseous gout. As there was no significant risk of progression of the lytic lesion, the fracture site was treated conservativel

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… Curr Rheumatol Rep 23 2021 71 10.1007/s11926-021-01035-5 34259946 2 Neogi T Jansen TLTA Dalbeth N Fransen J Schumacher HR Berendsen D 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Ann Rheum Dis 74 2015 1789 1798 10.1136 … Lee JK Park YC Pathological fracture of the femoral neck due to tophaceous gout: an unusual case of gout Hip Pelvis 31 2019 238 241 10.5371/hp.2019.31.4.238 31824879 PMC6892900 17 Kasper IR Juriga MD Giurini JM Shmerling RH Treatment of tophaceous gout: when medication is not enough Semin Arthritis Rheum …

Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.

Fibromyalgia (FM) is a chronic non-inflammatory disorder mainly characterized by widespread musculoskeletal pain, fatigue, sleep disturbance … identifying the most plausible diseases in the specific case. This article discusses prevalent non-rheumatological conditions commonly observed in the general population that can manifest with clinical features similar to primary FM. Given their frequent inclusion in the differential diagnosis of FM patients, the focus will be on elucidating the distin …

Mechanisms of bone pain: Progress in research from bench to bedside.

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with va

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… Rheum. Dis. 2011;70:60–67. doi: 10.1136/ard.2010.131904. 114. Kwoh CK. OSTEOARTHRITIS clinical relevance of bone marrow lesions in OA. Nat. Rev. Rheumatol. 2013;9:7–8. doi: 10.1038/nrrheum.2012.217. 115. Laslett LL, et al. … Semin Arthritis Rheum. 2007;37:69–80. doi: 10.1016/j.semarthrit.2007.01.007. 137. Park WM, Kim K, Kim YH. Effects of degenerated intervertebral discs on intersegmental rotations, intradiscal pressures, and facet joint forces of the whole lumbar spine. Comput. Biol. …

Adverse Reaction to COVID-19 mRNA Vaccination in a Patient With VEXAS Syndrome.

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a rare genetic disorder originating from a somatic mutation in the hematopoietic stem cells. This syndrome was first described in 2020 and carries many clinical features that other conditions cannot explain. Widespread autoinflammation is the primary process the disease presents, with high morbidity and mortality in those who show signs of bone marrow failure. Treatment is complex, and response to current therapies is poor. Long-term prognosis carries a mortality of 50%. In addition, the advancement of new-generation

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… Ann Rheum Dis. 2019;78:1296–1304. doi: 10.1136/annrheumdis-2019-215213. 13. Tocilizumab in VEXAS relapsing polychondritis: a single-center pilot study in Japan. Kirino Y, Takase-Minegishi K, Tsuchida N, Hirahara L, Kunishita Y, Yoshimi R, Nakajima H. … Ann Rheum Dis. 2021;80:1501–1502. doi: 10.1136/annrheumdis-2021-220876. 14. Tocilizumab for the treatment of adult-onset Still's disease. Castañeda S, Martínez-Quintanilla D, Martín-Varillas JL, García-Castañeda N, Atienza-Mateo B, González-Gay MA. …

Эффективность и безопасность иммуноадсорбции как спасательной терапии подстрекательских миопатий: доклад three - обзор дел и литературы.

Идиопатическая воспалительная миопатия (МИМ) резюмирует редкие, системные аутоиммунные условия, характеризующиеся главным образом провокационным повреждением скелетной мышцы. Несмотря на то, что мышечные мышцы повреждены в первую очередь, эти заболевания, связанные с IIM, связаны с другими органами, включая кожу, легкие, верхний желудочно-кишечный тракт, суставы и сердце. Несмотря на то, что многие пациенты адекватно реагируют на иммунодепрессивное лечение, некоторые пациенты развивают быстро прогрессивные и устойчивые к лечению жизнестойкие курсы. Для лечащего врача ИИМ является сложным делом

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… Arthritis Rheum 2008 ; 58 : 3593 – 3599 . 18975333 10.1002/art.23963 14 Hay EM Bacon PA Gordon C , et al . The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus . … Ann Rheum Dis 2022 ; 81 : 1486 – 1487 .36008130 21 Miller FW Leitman SF Cronin ME , et al . Controlled trial of plasma exchange and leukapheresis in polymyositis and dermatomyositis . N Engl J Med 1992 ; 326 : 1380 – 1384 . 1472183 10.1056/NEJM199205213262102 22 Weeding E Tiniakou E . …

Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study.

Aim of the studyThe purpose of this study is to demonstrate that Chinese herbal medicine is beneficial for survival improvement in patients with multiple myeloma.Materials and methodsWe performed a 1:1 propensity score-matched cohort study to analyze patients with multiple myeloma diagnosed between January 1, 2002, and December 31, 2012, through the Taiwanese National Health Insurance Research Database. Patients who received Chinese herbal medicine therapy from the initial date of diagnosis of multiple myeloma to December 31, 2012, were included in the Chinese herbal medicine group. Patients w

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… The 3 most frequently prescribed Chinese herbal formulas and single herbs were Shu-Jing-Huo-Xue-Tang, Ban-Xia-Xie-Xin-Tang and Du-Huo-Ji-Sheng-Tang, and Tian-Hua-Fen ( Trichosanthes kirilowii Maxim.), Da-Huang ( Rheum officinale Baill.) and E-Zhu ( Curcuma kwangsiensis S.G.Lee & C.F.Liang), respectively … person-days | n | Frequency of mortality | HR (95% CI) Crude a | Adjusted b Non-Chinese herbal medicine group | | 156 | 96 | 1 (reference) | 1 (reference) Single-herb products Tian-Hua-Fen | Trichosanthes kirilowii Maxim. | 8,703 | 105 | 32 | 0.29 (0.19-0.43) *** | 0.29 (0.20-0.44) *** Da-Huang | Rheum …

Clinical development of neridronate: potential for new applications.

Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget's disease of bone (PDB). A characteristic property of neridronate is that it can be administered both intravenously and intramuscularly, providing a useful system for administration in homecare. In this review, we discuss the latest clinical results of neridronate administration in OI and PDB, as well as in osteoporosis and other conditions. We will focus in particular on the latest evidence of the effect of neridronate on treatment of complex regional pain syndrome type I.

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… Clin Exp Rheum. 2002;20(1):55–58. 24. Walsh JP, Ward LC, Stewart GO, et al. A randomized clinical trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget’s disease of bone. Bone. 2004;34(4):747–754. doi: 10.1016/j.bone.2003.12.011. 25. … Ann Rheum Dis. 1997;56:201–204. doi: 10.1136/ard.56.3.201. 41. Varenna M, Zucchi F, Ghiringhelli D, et al. Intravenous clodronate in the treatment of reflex sympathetic dystrophy syndrome. A randomized, double blind, placebo controlled study. J Rheumatol. 2000;27:1477–1483. 42. …

New and Emerging Biological Therapies for Myasthenia Gravis: A Focussed Review for Clinical Decision-Making.

Myasthenia gravis (MG) is a rare autoimmune disease characterised by exertion-induced muscle weakness that can lead to potentially life-threatening myasthenic crises. Detectable antibodies are directed against specific postsynaptic structures of the neuromuscular junction. MG is a chronic condition that can be improved through therapies, but to date, not cured. Standard treatment has been unchanged for decades and includes symptomatic treatment with acetylcholine-esterase inhibitors and disease-modifying treatment with steroids, steroid-sparing immunosuppressants and thymectomy. Overall, a rel

Primary neuroendocrine lung tumor presenting with acute ileal obstruction. Case report.

INTRODUCTION: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently identified, somatic mutation-driven, a … s. Multiple unsuccessful attempts were made to wean and replace steroids with disease-modifying antirheumatic drugs. Following genetic confirmation of VEXAS, tocilizumab therapy was initiated. CONCLUSION: Due to the rapidly progressive nature of VEXAS and associated high mortality, early diagnosis is critical. This case highlights the importance of con …

Percutaneous vertebroplasty in patients with osteoportic vertebral body fractures.

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… Arthritis Rheum. 1998;41:171–175. doi: 10.1002/1529-0131(199801)41:1<171::AID-ART21>3.0.CO;2-5. 10. Lin Edward P, Ekholm Sven, Hiwatashi Akio, Westesson Per-Lennart. Vertebroplasty: Cement Leakage into the Disc Increases the Risk of New Fracture of Adjacent Vertebral Body. …

Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics.

BackgroundRheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF) share a common pathogenic mechanism, but the underlying mechanisms remain ambiguous. Our study aims at exploring the genetic-level pathogenic mechanism of these two diseases.MethodsWe carried out bioinformatics analysis on the GSE55235 and GSE213001 datasets. Machine learning was employed to identify candidate genes, which were further verified using the GSE92592 and GSE89408 datasets, as well as quantitative real-time PCR (qRT-PCR). The expression levels of TOP2A in RA and IPF in vitro models were confirmed using West…

Систематический обзор: цифровые биомаркеры усталости от хронических заболеваний.

В рамках этого систематического обзора изучается взаимосвязь между цифровыми биомаркерами, измеряемыми с использованием изношенных устройств, и усталостью у пациентов с хроническими заболеваниями. Исследования, включенные в этот обзор, были посвящены лицам с заболеваниями или заболеваниями 13 широких категорий: множественный склероз (MS); ревматоидный артрит (RA); хроническая обструктивная легочная болезнь (COPD); длинный COVID; рак; синдром хронической усталости (CFS); саркоидоз легких; болезнь Паркинсона; хронический инсульт; хроническое воспалительное ревматическое заболевание (CIRD); болез

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This systematic review explores the relationship between digital biomarkers, measured using wearable devices, and fatigue in patients with chronic diseases. Studies included in this review focused on individuals with diseases or conditions in 13 broad categories: multiple sclerosis (MS); rheumatoid arthritis (RA); chronic obstructive pulmonary disease (COPD)…

MicroRNAs in Aseptic Loosening of Prosthesis: Pathophysiology and Potential Therapeutic Approaches.

OBJECTIVES: Aseptic loosening (AL) is one of the leading causes of total joint arthroplasty (TJA) revision. Discovering the roles of microRNAs (miRNA/miR) in ontogenesis and osteolysis has attracted more attention to diagnosing and treating bone disorders. This review aimed to summarize miRNA biogenesis and describe the involvement of miRNAs in AL of implants. METHODS: A detailed search was carried out on scientific search engines, including Google Scholar, Web of Science, and PubMed, to find appropriate papers related to subjects. The search process was performed using the following keywords

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… Arthritis Rheum. 2013;65:1530–1540. doi: 10.1002/art.37948. 56. Rossi M, Pitari MR, Amodio N, et al. miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease. … Arthritis Rheum. 2011;63(5):1281–8. doi: 10.1002/art.30281. 76. Mizoguchi F, Izu Y, Hayata T, et al. Osteoclast‐specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem. 2010;109(5):866–75. doi: 10.1002/jcb.22228. 77. …

A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease defined by the production of autoantibodies and involves multiple organs and systems. Although there are reports on SLE, data on its pathogenesis is limited.MethodsUsing R language software, we constructed a competing endogenous RNA (ceRNA) network. We then utilized the Search Tool for Recurring Instances of Neighbouring Genes (STRING) and cytoHubba databases to generate a protein-protein interaction (PPI) network, which led to the identification of hub genes. The top two hub genes with the highest Maximal Clique Centrality

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… Ann Rheum Dis 2014;73:138-42. 10.1136/annrheumdis-2012-202099 31. Cheng X, Xu X, Chen D, et al. Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer. Biomed Pharmacother 2019;110:473-81. 10.1016/j.biopha.2018.11.082 32. Wang Z, Li B, Zhou L, et al. … Ann Rheum Dis 2015;74:1293-301. 10.1136/annrheumdis-2013-204228 37. Orme JJ, Du Y, Vanarsa K, et al. Leukocyte Beta-Catenin Expression Is Disturbed in Systemic Lupus Erythematosus. PLoS One 2016;11:e0161682. 10.1371/journal.pone.0161682 38. Kong J, Li L, Zhimin L, et al. …

The Treatment Gap in Osteoporosis.

Worldwide, there are millions of people who have been diagnosed with osteoporosis, a bone disease that increases the risk of fracture due to low bone mineral density and deterioration of bone architecture. In the US alone, there are approximately ten million men and women diagnosed with osteoporosis and this number is still growing. Diagnosis is made by measuring bone mineral density. Medications used for the treatment of osteoporosis are bisphosphonates, denosumab, raloxifene, and teriparatide. Recently, romosozumab has been added as well. In recent years, a number of advances have been made

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… Arthritis Rheum. 2013;65:294–298. doi: 10.1002/acr.21796. 63. Benedek T.G. History of the development of corticosteroid therapy. Clin. Exp. Rheumatol. 2011;29:5–12. 64. DeMartini F., Grokoest A.W., Ragan C. Pathological fractures in patients with rheumatoid arthritis treated with cortisone. … Rheum. Dis. 1995;54:66–68. doi: 10.1136/ard.54.1.66. 72. Hart S.R., Green B. Osteoporosis prophylaxis during corticosteroid treatment: Failure to prescribe. Postgrad. Med. J. 2002;78:242–243. doi: 10.1136/pmj.78.918.242. 73. Neogi T., Allison J.J. …

Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip.

Fine-needle aspiration biopsy of the abdominal fat pad is considered to be a minimally invasive procedure for diagnosing systemic amyloidosis. However, this procedure is sometimes difficult and can be dangerous for elderly patients whose abdominal fat layer is thin because of malnutrition. In such cases, alternative diagnostic methods are required. We report three elderly patients with heart failure complicated by malnutrition. In all cases, electrocardiogram showed low voltage in the limb leads and a pseudoinfarct pattern in the chest leads, and echocardiography showed left ventricular wall t

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… Arthritis Rheum. 1989;32(1):82–85. doi: 10.1002/anr.1780320114. 4. Masouye I. Diagnostic screening of systemic amyloidosis by abdominal fat aspiration: an analysis of 100 cases. Am J Dermatopathol. 1997;19(1):41–45. doi: 10.1097/00000372-199702000-00008. 5. Guy CD, Jones CK. … Arthritis Rheum. 2006;54(6):2015–2021. doi: 10.1002/art.21902. 8. Dhingra S, Krishnani N, Kumari N, Pandey R. Evaluation of abdominal fat pad aspiration cytology and grading for detection in systemic amy-loidosis. Acta Cytol. 2007;51(6):860–864. doi: 10.1159/000325861. 9. …

Виром ДНК связан с аутоиммунными заболеваниями и COVID-19.

Аберрантная иммунная реакция на вирусные патогены способствует патогенезу, но наше понимание патологических иммунных реакций, вызванных вирусами в вироме человека, особенно в масштабе населения, остается ограниченным. Мы проанализировали наборы данных о последовательности целых генов 6,321 Японцы, включая пациентов с аутоиммунными заболеваниями (псориаз вульгарис, ревматоидный артрит (RA), системный волшебный эритематос (SLE), легочный альвеолярный протеиноз (PAP) или множественный склероз) и коронавирусное заболевание 2019 (В тыс.COVID-19) или здоровый контроль. Систематическая количественная

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Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by vi … ets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, …

The JAK/STAT signaling pathway: from bench to clinic.

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pat

Diagnostic Performance of Machine Learning for Systemic Lupus Erythematosus: Systematic Review and Meta-Analysis.

BACKGROUND: Early and accurate diagnosis of systemic lupus erythematosus (SLE) and its organ involvement is essential. Previous reviews of machine learning (ML) in SLE combined heterogeneous tasks and validation strategies and may have overinterpreted model performance. OBJECTIVE: This study evaluated the diagnostic performance of ML and deep learning (DL) models for 3 clinically distinct SLE-related tasks: SLE classification or diagnosis, lupus nephritis (LN) diagnosis, and neuropsychiatric systemic lupus erythematosus (NPSLE) discrimination. We also assessed methodological quality and certa

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… Barbhaiya M Zuily S Naden R et al 2023 ACR/EULAR antiphospholipid syndrome classification criteria Ann Rheum Dis Oct 2023 82 10 1258 1270 doi 10.1136/ard-2023-224609 Medline 37640450 11. … Tian J Zhang D Yao X Huang Y Lu Q Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study Ann Rheum Dis Mar 2023 82 3 351 356 doi 10.1136/ard-2022-223035 Medline 36241363 PMC9933169 64. …

Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system.

INTRODUCTION: Systemic autoimmune diseases (SADs) are a significant burden on the healthcare system. Understanding the complexity of the peripheral immunophenotype in SADs may facilitate the differential diagnosis and identification of potential therapeutic targets. METHODS: Single-cell mass cytometric immunophenotyping was performed on peripheral blood mononuclear cells (PBMCs) from healthy controls (HCs) and therapy-naive patients with rheumatoid arthritis (RA), progressive systemic sclerosis (SSc), and systemic lupus erythematosus (SLE). Immunophenotyping was performed on 15,387,165 CD45+ …