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Medicinal plants used to induce labour during childbirth in western Uganda.

Traditional medicine usage in rural Ugandan population for day-to-day health care needs is close to 90%. Women and children form the bulk of the people reliant on herbal medicine. This study was undertaken to document how ethnomedical folklore aids childbirth in rural western Uganda by conducting field surveys, discussions and interviews with the resource users (mothers) and health providers (traditional birth attendants). Health surveys revealed that over 80% of childbirths are conducted at home by using herbal remedies in Bushenyi district. Seventy-five plants have been recorded for usage in…

Sleeping sickness in Uganda: a thin line between two fatal diseases.

OBJECTIVE: To determine, through the use of molecular diagnostic tools, whether the two species of parasite that cause human African trypanosomiasis have become sympatric. DESIGN: Blood sampling of all available patients between June 2001 and June 2005 in central Uganda and between July and September 2003 in northwest Uganda and analysis of subcounty sleeping sickness records in Uganda between 1985 and 2005. SETTING: Sleeping sickness treatment centres in central and northwest Uganda and in south Sudan. PARTICIPANTS: Patients presenting at the treatment centres and diagnosed as having sleep…

Factors associated with self-reported HIV testing among men in Uganda.

This study examined rates and predictors of self-reported HIV testing and willingness to test among married men aged 15-59 in Uganda. The data are nationally representative and drawn from the 2000-01 Uganda Demographic and Health Survey. The results of multiple regression analyses indicate that knowledge about AIDS, a history of paying for sex, spousal communication about HIV prevention, secondary or higher education, household wealth, and neighbourhood knowledge of a test site are associated with an increased likelihood of HIV testing. The higher the frequency of injection use in the past 3 m…

Factors influencing sexual partner referral for sexually transmitted diseases in Uganda.

BACKGROUND AND OBJECTIVE: Patient-based partner referral has limited effectiveness. We studied factors associated with sexual partner referral among patients with sexually transmitted diseases (STDs) with a view of suggesting remedial action. GOAL: To examine the role of psychosocial variables vis-a-vis other variables in predicting sexual partner referral. STUDY DESIGN: A cross-sectional interview survey with 507 patients with STDs at an STD clinic in Kampala, Uganda. Multivariate analyses were used to identify independent predictors of sexual partner referral. RESULTS: Forty-two percent o…

Adolescents, sexual behaviour and HIV-1 in rural Rakai district, Uganda.

OBJECTIVES: To describe the epidemiology of HIV-1 infection among adolescents aged 13-19 years, in rural Rakai district, Uganda. STUDY DESIGN: Baseline survey and 2-year follow-up (1990-1992) of adolescents in a population-based, open rural cohort. METHODS: Annual enumeration and behavioral/serological survey of all consenting adolescents aged 13-19 years at recruitment, residing in 31 randomly selected community clusters. RESULTS: At baseline, of 909 adolescents present in study clusters, 824 (90.6%) provided interview data and serological samples. No adolescents aged 13-14 years were HIV-…

Complications of Ascaris lumbricoides infection: case reports from south western Uganda.

Two cases of intestinal obstruction due to Ascaris lumbricoides infection are reported from Ishaka Adventist Hospital, in south western Uganda. One was a male aged two and a half years and another was a female aged twenty. They were both treated surgically with good results. A review of the literature also revealed that intestinal obstruction due to A. lumbricoides is a common complication, though other surgical and nutritional complications also seem to be common, they are less reported.

Estimating price and expenditure elasticities of demand for cigarettes, beer and soda in Uganda: evidence from eight waves of the Uganda National Panel Survey using the Deaton approach.

OBJECTIVE: To estimate the most up-to-date price and expenditure elasticities of demand for cigarettes, beer and soda in Uganda to inform the optimal design of health taxes and contribute to reducing the burden of non-communicable diseases while increasing government tax revenue. METHODS: We used eight waves of the nationally representative Uganda National Panel Survey (2005/2006–2019/2020) and applied the Deaton demand framework, which exploited spatial price variation while correcting for quality substitution and measurement error in unit values. We adjusted the basic model for possible bia…

Meningitis diagnosis, treatment, and outcomes in rural, northern Uganda: 2015-2024.

Meningitis affects over 2.5 million people worldwide, primarily within resource-limited regions of the meningitis belt of Africa. In 2017, we implemented a cryptococcal meningitis (CM) diagnosis and treatment program (CM-DTP) designed to improve CM outcomes. In 2021, a meningitis diagnosis and treatment program (MEN-DTP) began to include all etiologies of meningitis to assess the impact of expanded diagnosis and treatment of meningitis. We conducted a retrospective study utilizing clinical records from 1443 adult patients admitted to Lira Regional Referral Hospital (LRRH) over three time perio

Mapping tsetse fly connectivity in Uganda with machine learning landscape genetics.

INTRODUCTION: Tsetse flies (genus Glossina ) are biting insects that transmit human and animal trypanosomiases across sub-Saharan Africa, and sustainable vector control depends on understanding dispersal barriers and reinvasion routes. Despite major progress toward elimination, Uganda remains at risk for both human forms of the disease ( Trypanosoma brucei gambiense and T. b. rhodesiense ) and planners still lack reliable maps of tsetse movement and reinvasion risk. METHODS AND RESULTS: We address this gap with machine-learning landscape genetics and species distribution models, integrating e…

Epidemiology of Sudan ebolavirus disease cases in Uganda, January-April, 2025.

OBJECTIVES: On January 30, 2025, the Ministry of Health, Uganda (MoH), announced an outbreak of Sudan ebolavirus disease (SVD). We describe the epidemiological characteristics and transmission dynamics of the SVD outbreak in Uganda during January-April, 2025. METHODS: SVD cases were identified using MoH case definitions and were classified as confirmed if positive on RT-qPCR or probable if an SVD-related death was reported with epidemiological linkage but without laboratory confirmation. Cases were identified through contact tracing, community and health facility alerts, and active search. Da…

Целенаправленные метагеномии обнаруживают скрытую эпидемию ветрянки при наблюдении за Мпоксом в Уганде.

В регионах, где одновременно циркулирует вирус обезьянопокс (MPXV) и вирус варицелла-зостер (VZV), частичное совпадение клинических проявлений может осложнить клиническую диагностику. Во время вспышки MPXV, объявленной в Уганде в июле 2024 года, симптоматические подозрительные случаи показали, что ПЦР отрицателен для Mpox. Чтобы определить причину симптомов, мы использовали метагеномическую последовательность с целевой панелью Вирального наблюдения в 284 негативных образцах MPXV. VZV был определен в качестве основного патогена в 86% негативных случаев MPXV, что говорит о параллельном всплеске

Совпадение в аннотации оригинала
In regions where both monkeypox virus (MPXV) and varicella zoster virus (VZV) are co-circulating, overlapping clinical manifestations can complicate clinical diagnosis. During the MPXV outbreak declared in Uganda in July, 2024, symptomatic suspected cases tested PCR negative for Mpox. To determine the cause of symptoms, we employed metagenomic sequencing wit…

Antimicrobial Activity of Actinomycetes Isolated From Hot Springs in Western Uganda.

INTRODUCTION: Actinomycetes are Gram-positive filamentous bacteria belonging to the phylum Actinobacteria. This study aimed to isolate and characterize Actinomycetes from Ugandan hot springs and evaluate their antimicrobial activity against pathogenic microorganisms. MATERIALS AND METHODS: A total of 30 Actinomycetes isolates were retrieved from two major hot springs in Uganda and identified using morphological and molecular techniques, including PCR amplification of the 16S rRNA gene and whole-genome sequencing. Antimicrobial activity was assessed against Staphylococcus aureus, Escherichia c…

Determinants maintaining healthcare personnel's motivation during COVID-19 pandemic in Uganda.

BACKGROUND: Maintaining the physical and psychological well-being of healthcare workers (HCWs) is crucial for health system resilience. In sub-Saharan Africa, particularly Uganda, HCWs faced significant challenges during the coronavirus disease 2019 (COVID-19) pandemic, compounded by pre-existing resource constraints. This study investigated challenges faced by HCWs at a designated COVID-19 hospital ('the Hospital') and explored determinants of maintaining healthcare personnel's motivation during the COVID-19 pandemic in Uganda. METHODS: A facility-based cross-sectional study was conducted at…

Neonatal Hyperbilirubinemia in Uganda: Mechanisms, Clinical Consequences, and Health-System Challenges.

OBJECTIVE: Neonatal hyperbilirubinemia is a prevalent condition characterized by elevated serum bilirubin levels, affecting approximately 50 … , clinical outcomes, and interventions in low- and middle-income countries (LMICs), with a focus on Uganda. Exclusion criteria included case reports, non-English studies, and articles without primary data. RESULTS: The condition arises from an imbalance between bilirubin production and elimination, influenced by immature liver function, increased red bl …

Pregnancy outcomes following surgical repair of female genital fistula in Uganda.

BACKGROUND: Women developing genital fistula and undergoing fistula repair in sub-Saharan Africa and South Asia are largely of reproductive … t within 10 years following genital fistula repair, recruited from six fistula repair facilities in Uganda. We described sociodemographic characteristics, spontaneous abortion (pregnancy loss <20 weeks gestational age), and stillbirth (intrauterine fetal death at ≥20 weeks gestational age) and determined factors associated with these outcomes using logis …

Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda.

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease endemic to many regions of Africa, the Middle East, Southeast Asia and the Balkans. Caused by the CCHF virus (CCHFV), CCHF has been a recognized cause of illness in Uganda since the 1950s and recently, more intensive surveillance suggests CCHFV is widely endemic within the country. Most surveillance has been focused on the Ugandan cattle corridor due to the risk of CCHFV exposure associated with livestock practices. Here we evaluated the seroprevalence of CCHFV in several Southern Ugandan communities outside the cattle corridor com…

Human papillomavirus infection and vaccination among young females in rural Uganda.

Cervical cancer is the most common cancer in Uganda. In 2015, a national human papillomavirus (HPV) vaccination program was initiated, targeting girls aged 10 years. To provide a pre-vaccination baseline to monitor HPV vaccine effectiveness, first-void urine (FVU) samples were collected from females aged 16-21 years in the General Population Cohort (GPC) in South-East Uganda, between 2019 and 2023. HPV vaccination status was obtained from questionnaires and vaccination cards. FVU samples were tested for 28 HPV types using Allplex HPV28. Among 1009 participants, 28 type prevalence was 33%, and …

Cancer patterns in Arua district, Uganda: a hospital-based retrospective study.

INTRODUCTION: Cancer is the second leading cause of mortality with over 19 million cases and 10 million deaths worldwide. Available data on cancer patterns in Uganda are through modelling of data from two population-based cancer registries (PBCRs) representing only about 10% of the cancer situation in Uganda. This study sought to determine the common types of cancer among adults and children in Arua District over a 5-year period (2017-2021). METHODS: Retrospective cohort chart review and 'catchment population approach' were employed. All newly diagnosed cancer patients from Arua between 2017 …