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A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy.

PurposeChemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy.MethodsRandomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over th

Полуструктурированный клинический интервью для оценки компульсивного сексуального поведения (SSCI-CSB): Развитие, надежность и валидность.

Цели Оценка компульсивного сексуального поведения (КСП) требует тонких подходов к оценке, идеально через клинические интервью. Однако ни одно из нескольких доступных клинических интервью для КСП не продемонстрировало сильные психометрические свойства. Чтобы решить эту проблему, мы разработали Semi-Structured Clinical Interview for the assessment of CSB (SSCI-CSB), интервью, которое собирает информацию о проявлениях, симптомах и клиническом течении КСП. Цель этого исследования состояла в том, чтобы проанализировать его надежность и обоснованность в выборке пациентов, нуждающихся в лечении некон

Neurofeedback Reduces P300 Amplitudes to Intensely Emotive Pictures in Depressed Cancer Patients.

Objective. Electroencephalographic neurofeedback (EEG NF) or its effects on event-related potentials (ERPs) in quantitative EEG have not yet been systematically studied in cancer patients. The aim of this study was to investigate the emotional arousal and valence effects on the event-related P300 in a visual oddball paradigm by an individualized EEG alpha and theta/beta NF intervention in cancer patients and survivors (N = 18, age between 31 and 73 years). Methods. ERPs to low and high arousal target stimuli with either emotional positive or negative content and depressive state were obtained

Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study.

While nurses report challenges with the manual administration of large-volume subcutaneous drugs, these challenges and potential solutions are not captured in the literature. In this cross-sectional study, 45 nurses with experience administering large-volume subcutaneous biologics completed an 18-item survey about preferences for syringes vs. on-body delivery systems. 100% responded that an on-body delivery system seemed easy to learn and use and preferable to syringes. In a drug delivery scenario including comprehensive administration details and assuming equivalent safety and efficacy, 97.78

Exploring Barriers and Facilitators to Engagement of an Online Acceptance and Commitment Therapy Intervention for Cancer Survivors With Chronic Painful Chemotherapy-Induced Peripheral Neuropathy: Qualitative Interview Study.

BackgroundOnline self-management interventions for cancer survivors are increasingly being used, but engagement is often difficult for patients. Given the importance of engagement for intervention effectiveness, identifying patient-reported barriers and facilitators is essential.ObjectiveThe aim of this study was to qualitatively examine barriers and facilitators influencing engagement with an online self-management intervention, offered with or without guidance, for cancer survivors experiencing chronic painful chemotherapy-induced peripheral neuropathy (CIPN).MethodsPatients who took part in

Falls among geriatric cancer patients: a systematic review and meta-analysis of prevalence and risk across cancer types.

BackgroundFalls represent a significant health concern among the older adults, particularly geriatric cancer patients, due to their increased susceptibility from both age-related and cancer treatment-related factors. This systematic review and meta-analysis aimed to synthesize global data on the prevalence and risk of falls in this population to inform targeted fall prevention strategies.MethodsFollowing PRISMA 2020 guidelines, we conducted a comprehensive search of PubMed, Embase, and Web of Science up to October 2024. Articles were screened using Nested Knowledge software by two independent

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… Predictors of falls among community-dwelling older adults with cancer: results from the health and retirement study. Support Care Cancer. 2014;22:479–85. 26. Childs DS, Yoon HH, Eiring RA, Jin Z, Jochum JA, Pitot HC, Jatoi A. …

Patient preferences for triple-class-exposed relapsed or refractory multiple myeloma treatment: a discrete-choice study.

AimsTo quantify patient preferences for attributes of novel treatments for triple-class-exposed (TCE) relapsed and/or refractory multiple myeloma (RRMM).MethodsUsing a discrete-choice experiment, we elicited preferences for 7 attributes: objective response rate (ORR), overall survival (OS), all-grade cytokine release syndrome risk, all-grade immune effector cell-associated neurotoxicity syndrome risk, serious infection risk (grade 3+), treatment administration, and initial hospitalization requirements.ResultsOS was the most important attribute (conditional relative importance [CRI] 32.0% for a

Effects of web-based interventions on cancer caregivers’ burden and quality of life: A systematic review and meta-analysis

Abstract Objectives As cancer incidence and survival rates rise, caregivers responsible for providing diverse support face increased burden and reduced quality of life (QoL). Although research on web-based interventions for this group is expanding, the impact of these interventions on caregiver burden and QoL remains unclear. This study aims to investigate the effects of web-based interventions on the caregiver burden and QoL of caregivers of patients with cancer. Methods Searches were conducted in PubMed, Web of Science, Cochrane Library, CINAHL, Embase, and PsycINFO from database inception t

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… It is influenced by factors such as long caregiving duration, caregiver retirement, lack of supplemental health insurance, older caregiver age, low-income level, high work requirements, high patient dependency, and high subjective stress (Akter et al. 2023 ; Karimi Moghaddam et al. 2023 ). …

A Glimpse into the Epidemiology of Geriatric Cancers in India: Report from the Indian Population Based Cancer Registries.

IntroductionIndian population is aging and the cancer rates are rising. Older adults (OAs)(≥60 years) with cancer require specialized care. However, data on geriatric cancer epidemiology is scarce.MethodsThe study compiled the geriatric cancer data from the published reports(2012-2014) of Indian population-based cancer registries(PBCRs).ResultsOf the 1,61,363 cancers registered in the Indian PBCRs, 72,446(44.9%) occur in OAs, with 21,805(30.1%), 18,349(25.3%), 14,645(20.2%), and 17,647(24.4%) occurring in 60-64, 65-69, 70-74, and ≥75year age groups. The truncated incidence rates for OAs are 55

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… In India, most geriatric cancer reports include patients ≥ 60 years of age due to the retirement age, the age cut-off for governmental schemes, and the average life expectancy [ 10 - 12 ]. …

Experience of life quality from patients with aplastic anemia: a descriptive qualitative study.

BackgroundDespite the increasing incidence of aplastic anemia in China, few studies have explored its effect on the patients' quality of life from the perspective of these patients. In fact, patients with aplastic disorder live with the disease for a long time, and need to face a variety of difficult realities, including multiple disease symptoms and drug side effects, heavy burden of medical costs, difficulties in social reintegration, and negative emotional distress. Therefore, this study used descriptive qualitative research to explore the direct and rich quality-of-life experiences of pati

Treatment preferences of patients with relapsed or refractory multiple myeloma in the United States, United Kingdom, Italy, Germany, France, and Spain: results from a discrete choice experiment.

IntroductionNewer treatment options for relapsed/refractory multiple myeloma (RRMM) with efficacy and safety profiles that differ from traditional therapies have facilitated personalized management strategies to optimize patient outcomes. In the context of such personalized management, understanding how treatment characteristics influence patients' preferences is essential. This study assessed patients' preferences for RRMM treatment attributes and determined trade-offs between potential benefits, administration procedures, and adverse effects.MethodsPatients' preferences were evaluated using

Experiences and preferences for psychosocial support: a qualitative study exploring the views of patients with chronic haematological cancers.

OBJECTIVES: Patients with chronic haematological cancers are often treated on a relapsing-remitting pathway, which may extend for many years. Such diagnoses are associated with uncertainties that often cause anxiety and distress, meaning patients (and families) are susceptible to potentially prolonged emotional difficulties, across the cancer journey. Experiences and preferences regarding psychosocial needs and support over time are relatively unexplored, which this study aimed to address. SETTING AND DESIGN: Set within the UK's Haematological Malignancy Research Network (an ongoing populatio

Показания пациентов с множественными миеломными пациентами, прошедшими курс лечения в соответствии со стандартом ухода Idecabtagen Vicleucel.

Idecabtagen vicleucel (ide-cel) был первым утвержденным УЛХ химериком антиген-рецептором Т-клектором для пациентов с множественным миэломой (RRMM). Это было первое исследование для оценки результатов, сообщаемых пациентами (ПИО) среди пациентов, получающих идицель в стандарте медицинского обслуживания (ЗСО). Перспективно оцениваемое качество жизни, связанное со здоровьем (HRQOL), и симптомы, связанные с предвыпуском (исходным уровнем) и днем (D)90 После вливания. Базовые ассоциации ПРО, имеющие характеристики пациентов, средние изменения ПРО и время для стабильных изменений оценивались с помощ

Methods for measuring financial toxicity after cancer diagnosis and treatment: a systematic review and its implications.

Patients experiencing financial distress as a side-effect of cancer are not only reported in the United States, but also in third-party payer healthcare systems in Europe. Since validated survey instruments are a prerequisite for robust and comparable results, we aimed to compile and classify available instruments to enable both a better understanding of the underlying construct of financial toxicity and to facilitate further studies that are adjustable to various healthcare systems. We did a systematic literature search on studies that provide data on perceived cancer-related financial distre

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… While in the United States, due to a lack of general security systems, private assets must compensate the loss of income in most cases, in European social security systems other compensation benefits such as sick pay or reduced pension payments through early retirement play a major role. …

Perceived social support and associations with health-related quality of life in young versus older adult patients with haematological malignancies.

BackgroundThis study compared the perceived social support of young and older adult cancer patients, examining possible influencing factors as well as associations with health-related quality of life.MethodsA total of 179 young patients (18-39 years) and 200 older adult patients (> 70 years) with haematological malignancies completed questionnaires on their perceived social support (ISSS-8, scales: Positive Support and Detrimental Interactions, range 0-16) and health-related quality of life (EORTC QLQ-C30). Tests for mean differences, correlations and regression analyses to determine associate

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… Patients who participated in that study had to meet the following criteria: (1) age > =70 years (due to the lack of a fixed age limit for older adult patients, the age limit based on gerontological age concepts [ 27 ], the time of transition to retirement), (2) manifestation of haematological cancer …

A noticeable difference? Productivity costs related to paid and unpaid work in economic evaluations on expensive drugs.

Productivity costs can strongly impact cost-effectiveness outcomes. This study investigated the impact in the context of expensive hospital drugs. This study aimed to: (1) investigate the effect of productivity costs on cost-effectiveness outcomes, (2) determine whether economic evaluations of expensive drugs commonly include productivity costs related to paid and unpaid work, and (3) explore potential reasons for excluding productivity costs from the economic evaluation. We conducted a systematic literature review to identify economic evaluations of 33 expensive drugs. We analysed whether eva

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… For instance, if most of the patients receiving an intervention are above retirement age, productivity losses related to paid work may be negligible. Note, however, that this is not the case for losses related to unpaid work. …

World Trade Center Health Program: First Decade of Research.

The terrorist attacks on 11 September 2001 placed nearly a half million people at increased risk of adverse health. Health effects research began shortly after and continues today, now mostly as a coordinated effort under the federally mandated World Trade Center (WTC) Health Program (WTCHP). Established in 2011, the WTCHP provides medical monitoring and treatment of covered health conditions for responders and survivors and maintains a research program aimed to improve the care and well-being of the affected population. By 2020, funds in excess of USD 127 M had been awarded for health effects

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… FDNY responders are a cohort of active or retired members of the FDNY (e.g., firefighters and emergency medical systems providers) who participated for at least one day in rescue and recovery efforts at any of the former WTC sites (primarily Ground Zero). … Of these, 173 remained either on medical leave or light duty or were pending a disability retirement evaluation nearly a year later [ 17 ]. Spirometry, taken before and after the attacks revealed significant declines in lung function in exposed firefighters shortly following the attacks [ 18 ]. …

Health behaviour abilities profiles in patients with haematological malignancies and its influencing factors: a cross-sectional survey.

ObjectivesTo identify the latent profiles of health behaviour abilities among patients with haematological malignancies and to explore the underlying population heterogeneity and influencing factors.DesignA cross-sectional study conducted between October and December 2024.SettingData were collected from three provincial hospitals in China.ParticipantsA total of 486 hospitalised patients were recruited.Outcome measuresData were collected using a demographic questionnaire, the Sense of Coherence Scale-13, the Perceived Social Support Scale and the Self-rated Abilities for Health Practices Scale.

Social support and care burden in family caregivers of patients with hematologic malignancies: a parallel mediation model of coping strategies.

ObjectiveWith the rising incidence of hematologic malignancies (HMs) in recent years, caregivers of HMs patients have increasingly emerged as a significant factor affecting the treatment of these conditions. This study aimed to explore the association of coping strategies on the relationship between care burden and social support among family caregivers of HMs patients.MethodologyA questionnaire survey was conducted involving 207 family caregivers of hospitalized HMs patients in a tertiary hospital in Dalian from October 2023 to May 2024 and 200 valid responses were collected. We used hierarch

Proactive Identification and Digital Mental Health Intervention for the Treatment of Depression Among Individuals With Likely Incurable Cancer: A Pilot Randomized Clinical Trial.

BackgroundAlthough depression is prevalent and has significant consequences among individuals living with likely incurable cancer (ILLIC), optimal methods of identifying and treating depression in this population remain unknown.AimsTo evaluate a paradigm of (1) proactive identification (ID) (i.e., remotely and asynchronously from clinical encounters) of depression among ILLIC and (2) digital mental health intervention (DMHI) for depression treatment.MethodsIn this decentralized randomized clinical trial, ILLIC with elevated depressive symptoms were proactively identified using electronic healt