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Microalbuminuria in non-diabetic STEMI: an independent predictor for acute kidney injury.

AIMS: To assess the impact of microalbuminuria on the development of acute kidney injury and to investigate its prognostic role at long term follow-up in 526 consecutive patients with ST elevation myocardial infarction without previously known diabetes. METHODS: Microalbuminuria was measured using immunonephelemetry in the urine collected in the night. RESULTS: Patients with microalbuminuria were older (p = 0.013). They showed higher values of peak glycemia (p = 0.017), peak Tn I (p < 0.001), NT-pro BNP (p = 0.020), ESR (p = 0.003), CRP (p = 0.020), and leukocyte count (p < 0.001). Lower eGF…

Residual daily urine volume association with inflammation and nutrition status in maintenance hemodialysis patients.

BACKGROUND: This study determines the clinical significance of residual renal function (RRF), defined as residual daily urine volume (RDUV), in maintenance hemodialysis (MHD) patients. METHODS: This multi-center study enrolled 704 MHD patients. Geographic, hematological, biochemical, and dialysis-related data were obtained. Values for nutritional and inflammatory markers were analyzed together with RDUV. RESULTS: In total, 670 of 704 patients (95.2%) with HD duration greater than 1 year had abnormal RDUV (<500 ml). Patients with higher RRF were younger, had shorter HD duration, higher preval

Metabolic health in people living with type 1 diabetes in Belgium: a repeated cross-sectional study.

AIMS/HYPOTHESIS: Metabolic abnormalities such as central obesity, insulin resistance, dyslipidaemia and hypertension, often referred to as ' … % in 2022 in women, p<0.0001; 30.4% in 2001 vs 52.1% in 2022 in men, p<0.0001; WHO criteria without albuminuria: 22.3% in 2001 vs 40.6% in 2022 in women, p<0.0001; 25.1% in 2001 vs 49.2% in 2022 in men, p<0.0001; NCEP-ATPIII criteria: 39.9% in 2005 vs 57.2% in 2022 in women, p<0.0001; 40.8% in 2005 vs 60.9% in 2022 in men, p<0.0001; IDF criteria: 43.9% in 200 …

A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study.

BACKGROUND: Intensive treatment (IT) of cardiovascular risk factors can halve mortality among people with established type 2 diabetes but th … 00 person-years; hazard ratio 0.91, 95% CI 0.69 to 1.21) did not differ between groups. At 5 years, albuminuria was present in 22.7% and 24.4% of participants in the IT and RC groups, respectively [odds ratio (OR) 0.87, 95% CI 0.72 to 1.07), retinopathy in 10.2% and 12.1%, respectively (OR 0.84, 95% CI 0.64 to 1.10), and neuropathy in 4.9% and 5.9% (OR 0.95, …

[Is permanent renal function damage possible after hemorrhagic fever with renal syndrome?].

AIM: To investigate the possibility of permanent renal function impairment and other organ lesions following hemorrhagic fever with renal sy … ge, i.e. reduced ability of tubular cells for sodium reabsorption from primary urine. Non-selective albuminuria detected in 11/23 patients indicated permanent lesion of the glomerular basal membrane. Increased beta 2-microglobulin found in 6/23 patients indicated that the lysosomal enzyme level was elevated only in the acute stage of the disease, but may have …

Improving Kidney Disease Care: One Giant Leap for Nephrology.

Nephrology is an ever-evolving field of medicine. The importance of such a discipline is related to the high clinical impact of kidney disease. In fact, abnormalities of kidney function and/or structure are common in the general population, reaching an overall prevalence of about 10%. More importantly, the onset of kidney damage is related to a strikingly high risk of cardiovascular events, mortality, and progression to kidney failure which, in turn, compromises quality and duration of life. Attempts to comprehend the pathogenesis and molecular mechanisms involved in kidney disease occurrence

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… indicated for non-diabetic CKD (eGFR > 20 mL/min) with increased albuminuria (>200 mg/g) [ 15 ]. … Tirzepatide, a dual GLP-1/GIP-RA, was more effective at slowing eGFR reduction and reducing albuminuria than antidiabetic agents such as insulin [ 20 ]. …

Мужской пол и возраст являются независимыми факторами риска для стадии саркопении у пациентов с хронической почечной недостаточностью, не находящихся на гемодиализе.

ОБЪЕКТ: Риск развития саркопении у пожилых людей с хронической почечной недостаточностью (ХПН), не находящихся на диализе, остается спорным. Целью данного исследования было изучить связь между саркопенией, диабетом и ХПН до начала диализа, а также оценить влияние пола и возраста на риск развития саркопении у пожилых пациентов с ХПН до начала диализа. МЕТОДЫ: Участники старше 60 лет были отобраны из сообщества Новой Тайpei, Тайвань. Измеряли силу хватания, массу скелетной мышцы конечностей и время прохождения 6-метровой дистанции. Диагноз саркопении был установлен согласно консенсусу Азиатской

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… Since they defined CKD as eGFR < 60 mL/min/1.73 m 2 or the presence of albuminuria by dipstick test at baseline examination, the participants with CKD had the higher mean eGFR (71.6 mL/min/1.73 m 2 ) and about 96.0% of their participants were CKD I‐IIIa. … Because temporary albuminuria can be detected in several clinical conditions, such as infection, inflammation and urolithiasis, the albuminuria dipstick test was not administered as a reliable indicator for CKD in our study. …

References

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… Prevalence and duration of exercise induced albuminuria in healthy people. Clin Invest Med 2009; 32: E261–265. 183. Leung AK, Wong AH. Proteinuria in children. Am Fam Physician 2010; 82: 645–651. 184. Boger CA, Chen MH, Tin A et al. CUBN is a gene locus for albuminuria. … Albuminuria in children. Curr Opin Nephrol Hypertens 2009; 18: 246–251. 207. Wrong OM, Norden AG, Feest TG. …

Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea.

PURPOSE: While renal impairment is one of the first clinical manifestations of multiple myeloma (MM), declined renal function may conversely be a risk factor for cancers including MM. In this study, we investigated the relationship between chronic kidney disease and MM at a population level. MATERIALS AND METHODS: A total of 9,809,376 adults who participated in a nationwide health screening program and had no MM, cancer or end-stage renal disease at baseline were investigated for incidence of MM. The impact of estimated glomerular filtration rate (eGFR) and random urine dipstick proteinuria,

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… Urine dipstick is an inexpensive screening tool that detects albuminuria, an evidence of glomerular damage, although it has low sensitivity to Bence-Jones protein, a monoclonal immunoglobulin light chain. … These results suggest that low eGFR and albuminuria are either early signs of monoclonal gammopathy, which tends to be unrecognized, or facilitators of MM development. …

Idiopathic Fibrillary Glomerulonephritis: A Case Report Highlighting Diagnostic and Management Challenges.

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by non-branching fibrils within the glomerular basement membrane, often leading to progressive renal dysfunction. Despite advances in diagnostic methods, including DNA-J heat shock protein family member B9 (DNAJB9) immunostaining, the pathogenesis and optimal treatment strategies remain poorly defined. We present the case of a 55-year-old woman with longstanding microscopic hematuria and subnephrotic proteinuria who was diagnosed with idiopathic fibrillary glomerulonephritis (IFGN) following a renal biopsy. Histopat

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… Case presentation A 55-year-old woman with progressive renal dysfunction was evaluated following a prolonged history of microscopic hematuria, subnephrotic proteinuria, and albuminuria. Her serum creatinine was 1.1 mg/dL, and her protein-creatinine ratio was 0.84. … Regular nephrology follow-ups were scheduled every three to six months for serial monitoring of serum creatinine, proteinuria, and albuminuria, with annual kidney function reassessments, including urinalysis and imaging if indicated. …

Диагностическая ценность хронической почечной недостаточности в данных о здоровье за период времени: результаты исследования кохорта взрослых людей пожилого возраста, проживающих в сообществе в Германии.

ЦЕЛЬ: Достаточно подробно изучено не было в общей популяции и в течение времени действительность кодов диагностики ICD-10 для хронической почечной недостаточности (ХПН) в данных о здравоохранении. ПАЦИЕНТЫ И МЕТОДЫ: Мы использовали данные из Берлинской инициативы (BIS), прямого долгосрочного когорта жителей сообщества в возрасте ≥70 лет в Берлине, Германия. С использованием оцененной скорости фильтрации почечной капсулы (eGFR) в качестве эталона мы оценили диагностическую ценность (чувствительность, специфичность, положительный [PPV] и отрицательный прогнозные значения [NPV]) различных кодов

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… Including data for albuminuria and applying a combined CKD definition in accordance with KDIGO guidelines may be subject to further research. … Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Am J Kidney Dis . 2010;56(5):861–871. doi: 10.1053/j.ajkd.2010.05.017 43. Gansevoort RT, Matsushita K, van der Velde M, et al. …

Contemporary Perspectives on Chronic Renal Disorders.

The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting progression and providing personalized diagnostics and therapy. This narrative review highlights the improvements in diagnostic applications of kidney disease and briefly discusses a few notable biomarkers emphasizing the high throughput omics technologies, as wel

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… According to the National Kidney Foundation (NKF), albumin, a protein found in the serum, is estimated by measuring urine albumin and creatinine ratio in patients with kidney failure [ 17 ] albuminuria (> 300 mg/day) and proteinuria (> 150 mg/day). … T., “Albuminuria Is an Appropriate Therapeutic Target in Patients With CKD: The Pro View,” Clinical Journal of the American Society of Nephrology 10, no. 6 (2015): 1079–1088, 10.2215/CJN.11511114. 21. Heerspink H. J. …

Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome.

Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase in the renin-angiotensin system that catalyzes the breakdown of angiotensin II to angiotensin 1-7. We have reported that ACE2 expression in the kidney is reduced in experimental Alport syndrome but the impact of this finding on disease progression has not been studied. Accordingly, we evaluated effects of murine recombinant ACE2 treatment in Col4a3 knockout mice, a model of Alport syndrome characterized by proteinuria and progressive renal injury. Murine recombinant ACE2 (0.5 mg/kg/day) was administered from four to seven weeks o

Diagnosis and referral of patients with AL amyloidosis in Portugal: results from a Delphi panel.

Light chain amyloidosis (AL) is a complex disorder defined by the extracellular deposition of insoluble amyloid fibrils formed by intact or fragmented immunoglobulin light chains, leading to cell dysfunction, rapid organ deterioration, and, ultimately, death. Although the clinical presentation of AL is directly connected to organ involvement, signs and symptoms of AL are frequently nonspecific, misinterpreted, and late recognized. Thus, an early diagnosis combined with effective therapies to cease disease progression and rescue organ function is essential. The aim of this study was to assess t

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… Thus, including biomarkers, such as NT-proBNP, albuminuria, and serum alkaline phosphatase (ALP), in the surveillance of patients with high-risk MGUS contributes to an early diagnosis of AL amyloidosis, even before the establishment of organ damage. Figure 1. … Signs and Symptoms (8) | In patients with albuminuria and cardiac dysfunction (left ventricular hypertrophy with “infiltrative” shiny appearance and interatrial septal thickening) associated with electrocardiogram with low-voltage complexes, I always suspect AL amyloidosis. (9) | AL amyloidosis should …

Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure.

BACKGROUND: Patients with type 2 diabetes mellitus and elevated urinary albumin:creatinine ratio (ACR) have increased risk of heart failure. We hypothesized this was because of cardiac tissue changes rather than silent coronary artery disease. METHODS AND RESULTS: In a case-controlled observational study 130 subjects including 50 ACR+ve diabetes mellitus patients with persistent microalbuminuria (ACR >2.5 mg/mol in males and >3.5 mg/mol in females, ≥2 measurements, no previous renin-angiotensin-aldosterone therapy, 50 ACR-ve diabetes mellitus patients and 30 controls underwent cardiovascular …

[Angiotensin II receptor blockers--evidence along the cardiovascular continuum].

The introduction of Angiotensin II receptor blockers (ARB) in 1995 was another milestone in the pharmacological management of hypertension. … ardial infarction increases the rate of adverse events without improving survival. Increase of microalbuminuria and worsening of diabetic nephropathy is reduced by ARB in patients with diabetes type 2, but an advantage over ACE inhibitors could not be documented. Hypertensive patients with electrocardiographically left ventricular hypertrophy treated with ARB …

Trace proteinuria as a risk factor for cancer death in a general population.

Growing evidence has demonstrated an association between nondialysis chronic kidney disease and cancer incidence, although the association between trace proteinuria and cancer death remains unclear. The aim of this study was to investigate the association between trace proteinuria and cancer death in a community-based population in Japan. This was a prospective cohort study of 377,202 adults who participated in the Japanese Specific Health Check and Guidance System from 2008 to 2011. Exposure was dipstick proteinuria categorized as - (negative), ± (trace), 1 + (mild), or ≥ 2 + (moderate to hea

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… A recent meta-analysis has also demonstrated dipstick-determined protein can predict albuminuria and may help in CKD screening and prognosis 22 . … Mok Y Albuminuria, kidney function, and cancer risk in the community Am. J. Epidemiol. 2020 189 942 950 10.1093/aje/kwaa043 32219380 PMC7443761 8. …

Micro- and Macrovascular Complications in Early-Onset Type 2 Diabetes in Indians: Prevalence and Predictors in a Prospective Cross-Sectional Study.

Introductionand Aims: The prevalence of T2DM is rising among young people, placing them at greater risk for complications. We studied the prevalence and predictors of micro- and macrovascular complications in early-onset diabetes subjects (EOD, MethodsA total of 800 subjects (400 EOD, 400 LOD), matched for gender and diabetes duration, were prospectively recruited and assessed for the prevalence of peripheral neuropathy, retinopathy, nephropathy, and ASCVD. Multivariate logistic regression analyzed predictors of diabetes complications.ResultsThe median age at diagnosis of diabetes was 35 years

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… When albuminuria ranged between 30 and 300 mg/g creatinine, it was classified as moderately high, while it was considered severely high when albuminuria was 300 mg/g creatinine or above. … If there was no other evidence of causes of kidney damage, diabetic kidney disease or nephropathy was clinically diagnosed by the presence of albuminuria and/or a decreased eGFR ( 33 ). …

Prospective Study of Multiparametric Renal MRI for CKD Progression (AFiRM).

IntroductionChronic kidney disease (CKD) has major population health implications, but current imaging approaches provide limited pathophysiological insights. We designed a study to evaluate renal multiparametric magnetic resonance imaging (MRI; mpMRI) as a tool to improve diagnosis, risk stratification, disease monitoring, and therapeutic decision-making in CKD.MethodsThe application of functional renal MRI to improve assessment of CKD (AFiRM study; NCT04238299) is a multicenter, prospective, observational cohort study in people with CKD. Participants underwent renal mpMRI using the harmonize

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… Eligibility Criteria Eligibility criteria are detailed in Table 1 . 25 Participants have CKD with an eGFR of 15 to 59 ml/min per 1.73 m 2 , or if eGFR ≥ 60 ml/min per 1.73 m 2 then with persistent albuminuria (uACR > 30 mg/mmol or urine protein-to-creatinine ratio > 50 mg/mmol). … Optimization of albuminuria-lowering treatment in diabetes by crossover rotation to four different drug classes: a randomized crossover trial. Diabetes Care. 2023;46:593–601. doi: 10.2337/dc22-1699. 5. Neuen B.L., Yeung E.K., Rangaswami J., Vaduganathan M. …

Sex-specific and BMI-specific associations between visceral fat and diabetic kidney disease in patients with diabetes: a large-scale multicentre prospective cohort study.

BACKGROUND: There are few large-scale prospective studies on directly measured visceral fat area (VFA) and diabetic kidney disease, with inc … agnosis was confirmed by an on-site physician at enrollment. Diabetic kidney disease was defined as albuminuria (urinary albumin-to-creatinine ratio ≥3·39 mg/mmol) or estimated glomerular filtration rate less than 60 mL/min per 1·73m2. VFA was measured by bioelectrical impedance analysis. Cox regression analysis was used to evaluate the association between VF …