Результаты поиска

Treatment of early-stage diabetic nephropathy with Siddha drug Sirupeelai Kudineer: A case series.

Diabetic Nephropathy is one of the major microvascular complications of Diabetes Mellitus, which can be detected in the earlier stage by investigating urinary microalbumin excretion levels and estimating ACR and GFR. Early treatment can delay or prevent the progression of diabetic Nephropathy. Monoherbal Siddha formulation Sirupeelai Kudineer indicated for the complications of Diabetes Mellitus is selected for this Case study. The efficiency of the drug was assessed by measuring the change in renal function throughout the treatment period and the KD QOL assessment. Four patients presented with

Совпадение в полном тексте источника
… The classical presentation of Diabetic Nephropathy is characterized by hyperfiltration and albuminuria in the early phases, which are then followed by a progressive loss of filtration and declined renal function [ 4 ]. … Certain studies reported that albuminuria is a dynamic, fluctuating condition rather than a linearly progressive process [ 20 ]. In cases III and IV, there is a gradual reduction in blood urea and serum creatinine. …

Association Between Cannabinoid Receptor-1 Gene Polymorphism and the Risk of Diabetic Nephropathy Among Patients with Type 2 Diabetes Mellitus.

BackgroundThe cannabinoid receptor 1 (CNR1) gene polymorphism is reportedly associated with components of metabolic syndrome and coronary artery diseases in patients with type 2 diabetes mellitus (T2DM). We investigated whether the common variant rs10493353 polymorphism is associated with diabetic nephropathy (DN) in T2DM patients.Patients and methodsT2DM patients with DN were enrolled as a case group, and patients with only T2DM as a control group. Demographic data and biochemical parameters were collected. The polymerase chain reaction-based restriction fragment length polymorphism technique

Совпадение в полном тексте источника
… factors of T2DM. 7–10 This common polymorphism is associated with risk of T2DM. 11 However, rs10493353 may not be associated with T2DM, but may contribute the genetic risk of diabetic complications, such as coronary artery disease. 12 Animal experiments suggest that the blockade of CNR1 can increase the albuminuria … Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy. Diabetes . 2010;59(4):1046–1054. doi: 10.2337/db09-1336 14. Nam DH, Lee MH, Kim JE, et al. …

Subject index

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… chronic kidney disease and, 28–38 metabolic acidosis of chronic kidney disease and, 978–993 single-pass dialysis with modified CVVH for bilirubin removal, 3:E51 survival of hemodialysis patients and, 565–571 Albumin-creatinine urinary ratio, hormone therapy in postmenopausal women and, 1019–1025 Albuminuria … See Albuminuria Microangiopathic hemolytic anemia, associated with imatinib mesylate, 762–768 β 2 Microglobulin, metabolic acidosis of chronic kidney disease and, 978–993 Microscopic polyangiitis, in newborn with placental transmission of ANCAs, 758–761 Midazolam pharmacokinetics, in CVVH patients …

Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.

Nuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands, including steroid hormones, thyroid hormone, vitamin D, retinoic acid, fatty acids, and oxidative steroids. Upon ligand binding, nuclear receptors form dimer complexes with transcriptional cofactors, which interact with specific DNA sequences in the promoter or enhancer regions of target genes to modulate gene expression. This process plays a crucial role in many physiological processes such as reprodu

Совпадение в полном тексте источника
… NCOA3 deficiency was shown to worsen diabetic kidney disease by exacerbating albuminuria, glomerular sclerosis, and podocyte injury and impairing autophagy. 284 Bile acid, sterol and lipid metabolism Increasing evidence suggests that NRs play critical roles not only in glucose metabolism but also in … in patients with diabetic nephropathyinhibition safely lowers residual albuminuria in patients with diabetic nephropathy 509 ) Diabetic Nephropathy; Chronic Kidney Disease Zemplar (paricalcitol) capsules; Placebo PHASE2 NCT01694160 COMPLETED (There were no statistically significant differences in T50 …

Multiple Myeloma and Kidney Impairment at Diagnosis: A Nephrological Perspective from an Eastern European Country.

Background and Objectives: The clinical presentation and survival factors in patients with myeloma-related kidney impairment (MRKI) at diagnosis remain a topic of ongoing research, given the complex interplay between nephrology and hematology. To date, no studies have specifically reported outcomes for these patients in Eastern Europe. Materials and Methods: We conducted a retrospective, unicentric study of consecutive newly diagnosed patients with MRKI in our tertiary nephrology service in Romania between 2015 and 2020; follow-up extended until 1 September 2022, covering a study period of 90

Совпадение в полном тексте источника
… (arterial hypertension, diabetes mellitus, ischemic heart disease, systemic atherosclerosis), clinical presentation, MM characteristics (type, free light chain level, ratio, serum electrophoresis, marrow plasmacytosis, hemoglobin level, lytic bone lesions), renal characteristics (eGFR, proteinuria, albuminuria … Median proteinuria was 3.3 (IQR 1.3, 6) g/g with a median albuminuria value of 0.27 (IQR 0.11, 0.66) g/g ( Table 1 ). …

Diagnosis and Treatment of AL and ATTR Amyloidosis.

At JADPRO Live Virtual 2020, Beth Faiman, PhD, RN, MSN, APRN-BC, AOCN®, FAAN, and Tiffany Richards, PhD, ANP-BC, AOCNP®, differentiated between AL and ATTR amyloidosis, discussed key considerations in selecting therapy, and identified ways that advanced practitioners can manage the supportive care needs of this patient population.

Совпадение в полном тексте источника
… Patients with kidney involvement may complain of “foamy” urine due to the presence of protein in the urine, and albuminuria is usually greater than 70%. “Of note, there may not be a monoclonal protein in the urine,” said Dr. Richards. …

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy.

Extracellular vesicles (EVs) as membrane structures of cellular origin participating in intercellular communication are involved in the molecular mechanisms of the development of various variants of polyneuropathy. Taking into account the increasing role of the protein corona of EVs and protein-protein interactions on the surface of EVs in the pathogenesis of various diseases, we focused our attention in this review on the role of intravesicular proteins and the protein corona of EVs in the development of chemotherapy-induced polyneuropathy (CIPN). It has been shown that EVs are effectively in

Совпадение в полном тексте источника
… In addition, exosomal miRNAs have been identified in circulating exosomes associated with albuminuria in patients with diabetic nephropathy [ 8 , 9 , 10 ]. … The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy J. Transl. Med. 2019 17 236 10.1186/s12967-019-1983-3 31331349 PMC6647278 11. Li X. Wang J. Qian H. Wu Y. Zhang Z. Hu Z. Xie P. …

Light Chain Amyloidosis.

Light chain (AL) amyloidosis is caused by a usually small plasma-cell clone that is able to produce the amyloidogenic light chains. They are able to misfold and aggregate, deposit in tissues in the form of amyloid fibrils and lead to irreversible organ dysfunction and eventually death if treatment is late or ineffective. Cardiac damage is the most important prognostic determinant. The risk of dialysis is predicted by the severity of renal involvement, defined by the baseline proteinuria and glomerular filtration rate, and by the response to therapy. The specific treatment is chemotherapy targe

Совпадение в полном тексте источника
… The disease manifests with albuminuria, evolving in nephrotic syndrome and progressing to renal failure eventually leading to end-stage renal disease if unrecognized or ineffectively treated. … The onset of cardiac and renal involvement by AL amyloidosis in these subjects can be detected at a pre-symptomatic stage with simple markers, albuminuria and NT-proBNP, that should be part of the follow-up panel of patients with MGUS and abnormal FLC ratio. …

BK and JC polyomavirus co-infection resulting in polyomavirus nephropathy and progressive multifocal leukoencephalopathy at the same time, a case report.

John Cunningham Virus (JCV) and BK Virus (BKV) are the most extensively studied Human Polyomaviruses (HPyVs), primarily associated with Progressive Multifocal Leukoencephalopathy (PML) and BKV Nephropathy (BKVN), respectively. While co-infection with these viruses has been documented in the same disease, simultaneous manifestation in distinct pathologies has not been previously reported. We present the first documented case of concurrent PML and Polyomavirus Nephropathy (PVN) due to reactivation of two different HPyVs, offering new insights into the clinical spectrum of HPyV-related diseases.

Совпадение в полном тексте источника
… Urinalysis revealed no electrolyte imbalances or albuminuria but showed an elevated beta-2-microglobulin at > 4000 mg/L. Given the context of polyomavirus reactivation, further testing confirmed BKV infection, with positive urinary PCR, decoy cells, and positive immunostaining. …

Гистологические и клинические фенотипы диабетической болезни почек: базовый анализ исследования HEROIC.

В качестве неоднородного заболевания все чаще признается диабетическая болезнь почек (ДКД). Наше понимание структурно-функционального взаимодействия, лежащего в основе DKD, ограничено. Целью исследования, проводимого в восточной и северной частях Лондона в области диабета (HEROIC), является выявление перспективных маркеров в различных группах DKD. Мы представляем здесь базовый клинический фенотип когорты, определяют кластеры DKD и оцениваем эффективность оценочных уравнений GFR (eGFR), включая CKD Epi 2021:: У лиц, страдающих диабетом, были набраны специалисты по методам лечения two Высшие поч

Совпадение в полном тексте источника
… The clinical phenotype of DKD is similarly heterogeneous with variation in clinical features (e.g. albuminuria) and progression [ 7 ]. … All participants were deemed to be at moderate or high risk of progression: moderate risk was defined as either a rapidly falling eGFR (>5 ml/min/1.73 m²/year decline in eGFR) or significant albuminuria (albumin:creatinine ration [ACR] >30 mg/mmol); high risk required both. …

Частота обычного кровотечения у пациентов с хроническими почечными заболеваниями: обзор с целью информирования о необходимости ухода.

ЦЕЛЬ РАССМОТРЕНИЯ: Лица, страдающие хроническими заболеваниями почек, лица, проходящие диализную терапию, а также лица, имеющие как почки коренного происхождения, так и почки трансплантации, проходят плановое тестирование крови для регулярного наблюдения и мониторинга ЧКД и его осложнений. Не хватает доказательств, подтверждающих установленную частотность и полезность испытаний, которые в значительной степени основаны на исторической практике и экспертном консенсусе. Хотя раннее выявление и корректировка критических лабораторных значений могут привести к улучшению клинических результатов, анал

Совпадение в полном тексте источника
… The new 2024 KDIGO Guidelines for the management of CKD recommend various frequencies of eGFR screening depending on eGFR and albuminuria category. … year, regardless of albuminuria category. …

Semaglutide: a key medication for managing cardiovascular-kidney-metabolic syndrome.

Recent trials underscore the cardiovascular (CV), renal, and metabolic benefits of semaglutide in individuals with and without type 2 diabetes (T2D). In T2D, semaglutide enhances glycemic control, reduces major adverse CV events (MACE), and slows chronic kidney disease (CKD) progression. The SUSTAIN-6 trial demonstrated a 26% MACE reduction (HR 0.74; 95% CI: 0.58-0.95; p = 0.02) in high CV-risk patients with T2D using semaglutide (0.5 or 1.0 mg weekly). Similarly, the FLOW trial showed a 24% reduction in major kidney disease events (HR 0.76; 95% CI: 0.66-0.88; p = 0.002) with weekly 1.0 mg sem

Совпадение в полном тексте источника
… Across these studies, semaglutide doses of 1.0 and 2.4 mg weekly significantly reduced albuminuria, contrasting with UACR increases in the placebo group [ 105 ]. These reductions were clinically meaningful and provided evidence of semaglutide’s impact on CKD-related parameters over the longer term. … Kidney benefits Semaglutide slows CKD progression, reduces albuminuria, and preserves kidney function in individuals with T2D or obesity. The FLOW trial confirmed a 24% reduction in major kidney events, underscoring its role as a fourth pillar of DKD management. …

Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks.

Primary aldosteronism (PA) is the most common cause of secondary hypertension and is associated with increased morbidity and mortality when compared with blood pressure-matched cases of primary hypertension. Current limitations in patient care stem from delayed recognition of the condition, limited access to key diagnostic procedures, and lack of a definitive therapy option for nonsurgical candidates. However, several recent advances have the potential to address these barriers to optimal care. From a diagnostic perspective, machine-learning algorithms have shown promise in the prediction of P

Noninvasive screening of vancomycin-associated cast nephropathy.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Urine investigations were consistent with tubular injury by disclosing mild proteinuria (urine protein-to-creatinine ratio, 0.1 g/mmol) composed of albuminuria at low levels (urine albumin-to-creatinine ratio, 34 mg/mmol) and elevated retinol-binding protein levels: 3.29 mg/L (normal range, <0.01 mg/ …

Current Advances in RNA Therapeutics for Human Diseases.

Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were recognized as the genetic code containing the necessary information for proper cell functioning. In the years following these discoveries, vast knowledge of the seemingly endless roles of RNA have become better understood. Additionally, many new types of RNAs were discovered that seemed to have no coding properties (non-coding RNAs), such as microRNAs (miRNAs). The discovery of these new RNAs created a new avenue for treating various human diseases. However, RNA is relatively unstable and is degraded fairl

Совпадение в полном тексте источника
… NOX-E36 has completed Phase I clinical trials for the treatment of diabetes and albuminuria ( NCT01547897 ). Increased HbA1c and albumin/creatinine ratio (ACR) are hallmarks of these conditions. … NOX-E36 has been shown to reduce these levels in patients with diabetes and albuminuria [ 51 ] by binding to CCL2, a pro-inflammatory cytokine, with high affinity [ 186 ]. Therefore, this therapeutic drug may have beneficial effects on the treatment of diabetes and related conditions. …

Early dFLC response by C1D7 predicts complete hematologic response in systemic AL amyloidosis.

Daratumumab and bortezomib, the first-line drugs for AL amyloidosis, typically yield a complete hematologic response (CHR) rate of nearly 60% when used in combinations. An early achievement of CHR is crucial in amyloidosis. We retrospectively evaluated the relationship between dFLC (the difference between free light chain) reduction by Day 7 in Cycle 1 (C1D7) and CHR, organ response, and survival in 48 newly diagnosed AL amyloidosis patients receiving daratumumab, bortezomib, and dexamethasone. The CHR rate within six months was 66.7%. Using Receiver Operating Characteristic Curve curve analys

Совпадение в полном тексте источника
… Kimmich CR Terzer T Benner A Dittrich T Veelken K Carpinteiro A Hansen T Goldschmidt H Seckinger A Hose D Jauch A Worner S Beimler J Muller-Tidow C Hegenbart U Schonland SO Daratumumab for systemic AL amyloidosis: prognostic factors and adverse outcome with nephrotic-range albuminuria Blood 2020 135 … 32107537 Kimmich CR, Terzer T, Benner A, Dittrich T, Veelken K, Carpinteiro A, Hansen T, Goldschmidt H, Seckinger A, Hose D, Jauch A, Worner S, Beimler J, Muller-Tidow C, Hegenbart U, Schonland SO (2020) Daratumumab for systemic AL amyloidosis: prognostic factors and adverse outcome with nephrotic-range albuminuria …

Towards an adiposity-related disease framework for the diagnosis and management of obesities.

Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart,

Совпадение в полном тексте источника
… VAT, and not subcutaneous adipose tissue (SCAT), assessed by imaging techniques, is associated with a higher albuminuria prevalence [ 51 ], suggesting a key role of visceral adiposity in this relation [ 52 ]. … Association of subcutaneous and visceral adiposity with albuminuria: The framingham heart study. Obesity. 2011;19:1284–1289. doi: 10.1038/oby.2010.308. 52. Kovesdy CP, Furth SL, Zoccali C. Obesity and kidney disease: Hidden consequences of the epidemic. …

Насколько общим является гиперкортизолизм у пациентов с гипертензией? Факторы риска, эпидемиология и диагностика.

Эндогенный гиперкортизолизм (ЭГК) является недооцененным и клинически значительным фактором гипертонии, особенно резистентной гипертонии. После того, как EHC считается редким субъектом, он теперь воспринимается как спектр избытка кортизола, связанного с неблагоприятными кардиометаболическими результатами и ущербом, причиненным мишени. Недавно проведенные широкомасштабные исследования свидетельствуют о значительном увеличении распространенности ЭГК среди пациентов с устойчивой гипертонией и трудноконтролируемым диабетом, зачастую в отсутствие классических особенностей кушингоида. В настоящем об

Совпадение в полном тексте источника
… EHC is associated with moderately increased albuminuria in Type 2 diabetes mellitus and with increased all‐cause mortality in end‐stage renal disease [ 26 ]. … Overall renal function was poorer in this group, with lower estimated glomerular filtration rates and a greater degree of albuminuria. Adrenal nodules were identified in approximately one quarter of patients with hypercortisolism. …

Chronic Kidney Disease: Strategies to Retard Progression.

Chronic kidney disease (CKD), defined as the presence of irreversible structural or functional kidney damages, increases the risk of poor outcomes due to its association with multiple complications, including altered mineral metabolism, anemia, metabolic acidosis, and increased cardiovascular events. The mainstay of treatments for CKD lies in the prevention of the development and progression of CKD as well as its complications. Due to the heterogeneous origins and the uncertainty in the pathogenesis of CKD, efficacious therapies for CKD remain challenging. In this review, we focus on the follo

Совпадение в полном тексте источника
… Burden of Chronic Kidney Disease by KDIGO Categories of Glomerular Filtration Rate and Albuminuria: A Systematic Review. Adv. Ther. 2021;38:180–200. doi: 10.1007/s12325-020-01568-8. 6. Stevens L.A., Viswanathan G., Weiner G.E. … Rosiglitazone decreases albuminuria in type 2 diabetic patients. Kidney Int. 2007;72:1367–1373. doi: 10.1038/sj.ki.5002516. 63. Sarafidis P.A. Thiazolidinediones and diabetic nephropathy: Need for a closer examination? J. Cardiometab. Syndr. …

Clinical profile of kidney involvement preceding diagnosis of multiple myeloma; a single center experience.

Introduction: The kidneys are involved in significant number of patients with multiple myeloma (MM) who can present with acute or chronic renal failure, nephritic syndrome, non-nephrotic proteinuria or tubular function defects. Objectives: To assess the clinical profile of kidney involvement preceding diagnosis of multiple myeloma Patients and Methods: Renal involvement in 29 cases with MM admitted over an 18-month period to our tertiary care center was retrospectively examined. Diagnosis of MM was confirmed by two or more of the following four features: lytic bone lesions, serum or urine mono

Совпадение в полном тексте источника
… CKD was defined as abnormalities of kidney structure or function, present for >3 months by any of following criteria as per KDIGO guidelines: albuminuria, urine sediment abnormalities, electrolyte and other abnormalities due to tubular disorders, abnormalities detected by histology, structural abnormalities …