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New developments in immunotherapy for SCLC.

Small cell lung cancer (SCLC) is an aggressive form of neuroendocrine neoplasm known for its striking initial response to treatment, followed by fast relapse and refractoriness in response to additional lines of therapy. New advances in immunotherapy are paving the way for more effective treatment strategies and have promising results with early clinical trial data. While SCLC rarely harbors actionable mutations, the receptor DLL3 is extensively present in SCLC, making it a potential target for immunotherapy. Three emerging therapeutic options include bispecific T cell engagers targeting DLL3,

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… Other possible adverse effects include neutropenia, infection, and cardiotoxicity. 27 28 However, one major advantage for BiTE molecules (particularly in fast-growing cancers such as SCLC) is the ability to be used “off the shelf”. …

Ixazomib-Lenalidomide-Dexamethasone for the Treatment of Replaped/ Refractory Multieloma: Венгерский анализ реального мира.

Справочная информация/задачи: Несмотря на терапевтические достижения, решение проблем, связанных с рецидивированием/изъятием множественных миеломы (RRMM), по-прежнему сопряжено с трудностями. Для пациентов со слабой, комординируемой, ограниченной мобильностью или в тех случаях, когда предпочтение лечения и доступность лекарств являются ключевыми факторами, всеоральный режим ixazomib-lenalidomide-dexamethasone (IRd) предлагает практическую альтернативу. Методы: Мы провели многоцентральное ретроспективное исследование пациентов RRMM, лечившихся IRd в Венгрии 1 Январь 2020 и 30 Июнь 2025. Результ

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… Balancing the Risk of Cardiotoxicity Outcomes in Treatment Selection for Multiple Myeloma: A Retrospective Multicenter Evaluation of Ixazomib, Lenalidomide, and Dexamethasone (IRd) Versus Carfilzomib, Lenalidomide, and Dexamethasone (KRd) eJHaem 2025 6 e70038 10.1002/jha2.70038 40297748 PMC12036692 …

Изучение неврологических неблагоприятных реакций протеиновых ингибиторов в системе отчетности УЛХ о неблагоприятных явлениях.

ЦЕЛЬ: Бортезомиб, карфилзомиб и ixazomib являются протеозными ингибиторами (ИП), используемыми для лечения множественной миэломы (ММ). Мы провели всеобъемлющий фармакологический анализ их нейротоксичности с использованием Системы отчетности о неблагоприятных явлениях управления продуктами питания и лекарствами (FAERS), включая не только периферическую нейротоксичность, но и центральную нейротоксичность, с тем чтобы дать ориентиры для безопасного и рационального клинического использования. Мы получили отчеты о негативной реакции ПИ во время Q1 2004 с Q2 2025 из базы данных FAERS. С помощью стат

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… Proteasome inhibitor-related cardiotoxicity: mechanisms, diagnosis, and management . Curr. Oncology Reports 22 ( 7 ), 66 . 10.1007/s11912-020-00931-w 32514632 Xu Y. L. Zhao W. H. Tang Z. Y. Li Z. Q. Long Y. Cheng P. ( 2019 ). …

Artificial intelligence enabled interpretation of ECG images to predict hematopoietic cell transplantation toxicity.

AbstractArtificial intelligence (AI)-enabled interpretation of electrocardiogram (ECG) images (AI-ECGs) can identify patterns predictive of future adverse cardiac events. We hypothesized that such an approach would provide prognostic information for the risk of cardiac complications and mortality in patients undergoing hematopoietic cell transplantation (HCT). We retrospectively subjected ECGs obtained before HCT to an externally trained, deep-learning model designed to predict the risk of atrial fibrillation (AF). Included were 1377 patients (849 autologous [auto] HCT and 528 allogeneic [allo

A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for denosumab.

BACKGROUND: Denosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab to better understand toxicities. METHODS: The FAERS data base data from Q1 of 2010 to Q3 of 2023 was chosen. The definition of Medical Dictionary for Regulatory Activities (MedDRA) was dependent on preferred terms (PTs) and system organ class (SOCs). Following the removal of duplicate reports, a disproportionality analysis was conducted to iden

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… Cardiotoxicity induced by immune checkpoint inhibitors: a pharmacovigilance study from 2014 to 2019 based on FAERS . Front. Pharmacol. 12 , 616505 . 10.3389/fphar.2021.616505 33643048 PMC7907652 Cummings S. R. San Martin J. McClung M. R. Siris E. S. Eastell R. Reid I. R. ( 2009 ). …

CAR-T cell therapy for multiple myeloma: a practical toolkit for treatment in Brazil.

IntroductionChimeric antigen receptor T (CAR-T) cell therapy is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) that is a multi-step process involving various stakeholders. Appropriate education on the practical logistics is therefore paramount to ensure treatment success.MethodsA group of key opinion leaders met to explore the key elements of setting up and running a CAR-T center in Brazil. For each step in the CAR-T cell therapy process, the experts agreed on basic requirements, gave their key recommendations from practical experience, and considered any remainin

Suicide, other externally caused injuries, and cardiovascular disease within 2 years after cancer diagnosis: A nationwide population-based study in Japan (J-SUPPORT 1902).

BackgroundThis study aimed to investigate the risk of death by suicide, other externally caused injuries (ECIs), or cardiovascular disease for patients with cancer.MethodsWe used data from the National Cancer Registry, which include the entire population in Japan. Patients diagnosed with cancer from January 1 to December 31, 2016 were included, and their follow-up period was set to 2 years. The standardized mortality ratio (SMR) of death by suicide, other ECIs, and cardiovascular disease was calculated compared with the general population. Multivariate Poisson or negative binomial regression a

The Khorana score and venous and arterial thrombosis in patients with cancer treated with immune checkpoint inhibitors: A Danish cohort study.

BackgroundThrombosis is common among patients with cancer. Primary thromboprophylaxis guided by the Khorana score is endorsed by guidelines but recommendations rely mainly on data from patients treated with chemotherapy.ObjectivesTo explore if the Khorana score could risk stratify patients with cancer treated with immune checkpoint inhibitors according to risk of venous and arterial thrombosis.Patients/methodsThe study population and Khorana score were defined using administrative Danish health registries. The primary outcome was 6-month risk of venous thromboembolism after initiation of check

New proteasome inhibitors in the treatment of multiple myeloma.

The treatment of patients with relapsed and/or refractory multiple myeloma has improved considerably in the last 15 years, after the introduction of proteasome inhibitors and immunomodulatory drugs. The first clinical trials with new proteasome inhibitors have produced exciting results, particularly those comparing triplet regimens with standard doublet regimens, with a gain in progression-free survival accompanied by an acceptable safety profile and either similar or better health-related quality of life. New proteasome inhibitors hold the potential to fill unmet needs in multiple myeloma man

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… Cardiotoxicity of the anticancer therapeutic agent bortezomib. Am J Pathol. 2010;176(6):2658–2668. doi: 10.2353/ajpath.2010.090690. 36. Rosenthal A., Luthi J., Belohlavek M., Kortum K.M., Mookadam F., Mayo A. Carfilzomib and the cardiorenal system in myeloma: an endothelial effect? …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Sessions (O009-O155).

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Гут микробиота и ее влияние на ось Гут-Брэйна в сравнении с пациентами, страдающими химиотерапией, и данными о безраковых методах контроля в вычислительной перспективе рака груди.

Рак груди (БК) по-прежнему является одной из основных причин связанных с раком заболеваний и смертности среди женщин во всем мире. Традиционное лечение включает хирургию, радиацию, гормональную терапию и химиотерапию, но эти методы часто сталкиваются с трудностями из - за изменчивости реакции пациента и неблагоприятных последствий. В рамках этого исследования изучалась взаимосвязь между разнообразием кишечного микробиома, составом общины и анализом путей развития у женщин, проходящих химиотерапию в Британской Колумбии (Время лечения - DT), по сравнению с мерами по борьбе с раком (КФК). Использ

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… Acute side effects encompass nausea, alopecia, fatigue, infections, and weight loss, whereas chronic side effects include cardiotoxicity, peripheral neuropathy, cognitive impairment, fertility issues, and secondary malignancies [ 8 ]. …

Результаты октогенарских пациентов с множественной миеломой, лечившихся вне клинических исследований, с упором на терпимость и эффективность лечения.

Справочная информация: Данные о результатах лечения октогенианских пациентов с множественными миеломами (ММ), особенно при лечении за пределами клинических исследований, являются недостаточными. Цели и методы: MM pts ≥ 80 годы, лечение в ТАМСК с первой терапией между 2010 и 2023, были рассмотрены. Были проанализированы характеристики и результаты. Результаты: общее число 101 ПТ, из которых 54 мужчин с средним возрастом 84 годы80-98), были включены. Среди них 67.4% :: имел индекс коморбности Charlson ≥5, 37% имели ISS-3 (Международная система сборки) и 20% имели Revised-ISS-3. В нашем исследова

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… Most frequent documented AEs ≥ grade 3 included infections (22%), neutropenia (18%—resulting in grade ≥ 3 neutropenic fever in 5%), thrombocytopenia (10%), cardiotoxicity (3%), hypotension (1%), neuropathy (1%), rash (1%), and diarrhea (1%). …

Fucoidan: An Update on Function, Role in Human Health and Applications.

Fucoidan is a polysaccharide bioactive compound, mainly from brown algae, characterized by multiple biological activities, including anti-inflammatory, anticoagulant, anticancer, antioxidant, antiviral, and cardioprotective properties. In addition, growing scientific evidence supports its epigenetic potential and ability to modulate autophagic mechanisms, two crucial aspects for the treatment and prevention of chronic diseases, such as cancer, inflammation, and aging. For this reason, Fucoidan is a promising candidate for a wide range of applications, both as a bioactive component of drug deli

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… “Autophagy and Mitophagy in the Context of Doxorubicin‐Induced Cardiotoxicity.” Oncotarget 8, no. 28: 46663–46680. 10.18632/oncotarget.16944. Lähteenmäki‐Uutela, A. , Rahikainen M., Camarena‐Gómez M. T., Piiparinen J., Spilling K., and Yang B.. 2021. … “Fucoidan From Fucus vesiculosus Attenuates Doxorubicin‐Induced Acute Cardiotoxicity by Regulating JAK2/STAT3‐Mediated Apoptosis and Autophagy.” Biomedicine & Pharmacotherapy 130: 110534. 10.1016/j.biopha.2020.110534. Zhang, L. , Hao J., Zheng Y., et al. 2018. …

Advancing Cancer-Targeted Nanotherapies with Tumor Homing Peptides.

The development of smart nanoparticles for precision medicine in anticancer drug delivery and controlled release has the potential to revolutionize cancer treatment. This progress is driven by expanding body of preclinical and early clinical studies on anticancer nanoparticles. Despite these advancements, a critical challenge remains achieving a selective and efficient tumor accumulation, along with effective extravasation and deep tissue penetration of nanoparticles into the tumor parenchyma. Affinity targeting strategies using ligands such as homing peptides and antibodies leverage molecular

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… 5-Fluorouracil, Gemcitabine | Inhibit DNA/RNA synthesis, preventing cell proliferation | Mucositis, immunosuppression, hepatotoxicity, pulmonary toxicity (e.g., with gemcitabine) | Anthracyclines | Doxorubicin, Epirobicine, Daunorubicin | DNA intercalation, free radical generation | Dose-dependent cardiotoxicity … Nevertheless, these “precision” therapies have some drawbacks like on-target toxicities (e.g., rash with EGFR inhibitors), hypertension with VEGF blockers and off-target effects (e.g., cardiotoxicity, hepatotoxicity) that can still limit their clinical use. …

Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.

BackgroundMCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role in tumor maintenance and survival and can act as a resistance factor to multiple anticancer therapies. Herein, we describe the generation and characterization of the highly potent and selective MCL-1 inhibitor ABBV-467 and present findings from a first-in-human trial that included patients with relapsed/refractory multiple myeloma (NCT04178902).MethodsBinding of ABBV-467 to human MCL-1 was assessed in multiple cell lines. The ability of ABBV-467 to induce tumor growth inhibition was investigated in xen

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… Written informed consent was obtained from all patients; the informed consent materials included a note of potential cardiotoxicity as evidenced by class effects of other MCL-1 inhibitors. The first patient on study was recruited on May 19, 2020, and the study completion date was June 22, 2021. … Concerns about cardiotoxicity in patients who have received MCL-1 inhibitor treatment have recently been reported. …

Progress and challenges in the treatment of cardiac amyloidosis: a review of the literature.

Cardiac amyloidosis is a restrictive cardiomyopathy determined by the accumulation of amyloid, which is represented by misfolded protein fragments in the cardiac extracellular space. The main classification of systemic amyloidosis is determined by the amyloid precursor proteins causing a very heterogeneous disease spectrum, but the main types of amyloidosis involving the heart are light chain (AL) and transthyretin amyloidosis (ATTR). AL, in which the amyloid precursor is represented by misfolded immunoglobulin light chains, can involve almost any system carrying the worst prognosis among amyl

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… effective, especially in patients who were not exposed to other proteasome inhibitor agent and common noted adverse events being represented by nausea, skin disorders, fatigue, and diarrhoea. 79 However, there is evidence for secondary cardiac structural damage consistent with Type I chemotherapy‐induced cardiotoxicity … Ixazomib cardiotoxicity: a possible class effect of proteasome inhibitors. Am J Hematol 2017; 92: 220–221. 81. Wechalekar AD, Goodman HJ, Lachmann HJ, Offer M, Hawkins PN, Gillmore JD. Safety and efficacy of risk‐adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosis. …

The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.

Cardiac amyloidosis (CA) represents a growing etiology of heart failure (HF) and arrhythmogenesis, driven by the intramyocardial deposition of aberrantly folded proteins, notably immunoglobulin light chains (AL) and transthyretin (ATTR). This infiltrative process compromises myocardial compliance and disrupts the cardiac conduction system, leading to a diverse spectrum of dysrhythmias. The escalating prevalence of CA, particularly within geriatric demographics and individuals with plasma cell dyscrasias, underscores the imperative for refined diagnostic and therapeutic paradigms. The considera

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… Atrial dysfunction and thrombus formation remain key contributors to cardioembolic stroke risk.[ 4 , 8 ] Positron emission tomography (PET) studies reveal abnormal coronary flow reserve in conjunction with microvascular amyloid.[ 9 , 10 ] In AL-CA, direct light chain cardiotoxicity further exacerbates … Thus, AL-CA pathophysiology reflects a dual mechanism of restrictive infiltration and direct cardiotoxicity [ Table 1 and Figure 2 ].[ 4 , 7 ] Table 1 Pathophysiology of arrhythmias in cardiac amyloidosis AV: Atrioventricular, VT: Ventricular tachycardia, VF: Ventricular fibrillation, AF: Atrial fibrillation …

Целевые стратегии лечения рака цвета кожи: изучение использования аптемеров и золотых нанопчастей.

Рак цвета кожи (КЗК) является второй ведущей причиной смертности от рака и является причиной ~10% из всех случаев рака. По оценкам, во всем мире случаи, связанные с КПР 1.9 million и 930,000 смертями в 2022. Несмотря на расширение доступа к обследованиям и лечению в рамках КПР, ожидается, что показатели смертности резко возрастут в районах с низким уровнем ресурсов, что подчеркивает настоятельную необходимость принятия новаторских мер по лечению в рамках КПР. Текущая химиотерапия создает проблемы, такие, как плохая биодоступность, резистентность к многочисленным лекарствам и негативные побочны

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… However, AuNPs facilitate cellular uptake through passive targeting and localize into non-target cells, leading to systemic side effects such as neurotoxicity, cardiotoxicity and mucositis [ 26 ]. … The formulation reduced cardiotoxicity, gastrointestinal toxicity, alopecia and extravasation necrosis in patients [ 66 , 67 ]. In 2015, Onivyde, liposomes loaded with irinotecan, was approved for the treatment of advanced pancreatic adenocarcinoma. …

LncRNA NEAT1 restrains the malignant biological characteristics of acute myeloid leukemia via regulating CTCF/CXCR2 axis.

Acute myeloid leukemia (AML) is notorious in the field of hematology for its poor efficacy, frustrating prognosis, and it is prone to refractory or relapsed conditions. Previous studies in our team have shown that some Long noncoding RNAs (lncRNAs) and chemokine receptors play key regulatory roles in AML. The findings of this study demonstrated that the expression of NEAT1 was atypically low in both clinical AML specimens and AML cell lines. Overexpression of NEAT1 was capable of attenuating the malignant biological characteristics of AML cells, including inhibiting the malignant proliferation

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… Konstantinidis I Tsokkou S Grigoriadis S Cardiotoxicity in acute myeloid leukemia in adults: A scoping study Cancers (Basel) 2024 16 13 2474 10.3390/cancers16132474 39001536 PMC11240574 Konstantinidis I, Tsokkou S, Grigoriadis S, et al. … Cardiotoxicity in acute myeloid leukemia in adults: A scoping study. Cancers (Basel). 2024;16(13):2474. 10.3390/cancers16132474. 39001536 10.3390/cancers16132474 PMC11240574 27. …

Oncolytic virus therapy in the elderly: immune frailty, challenges, and perspectives.

With global aging accelerating, cancer incidence among older adults is rapidly increasing. Individuals aged ≥65 years now represent 64% of new cancer cases and 71.3% of cancer-related deaths worldwide. This population exhibits a distinct immune imbalance-driven by tumor-induced immunosuppression, immunosenescence, and inflammaging-which contributes to poor tolerance of standard therapies and suboptimal outcomes with PD-1/PD-L1 inhibitors. As an emerging immunotherapeutic strategy, oncolytic viruses (OVs) selectively infect tumor cells, induce immunogenic cell death (ICD), and activate the cGAS

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… For cardiotoxicity, the combination of abatacept (CTLA-4-Ig) and ruxolitinib has shown promise in reversing ICI-induced myocarditis ( 98 – 100 ). … Immune checkpoint inhibitors and cardiotoxicity: A comparative meta-analysis of observational studies and randomized controlled trials . …