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Progress in Research on Stem Cells in Neonatal Refractory Diseases.

With the development and progress of medical technology, the survival rate of premature and low-birth-weight infants has increased, as has t … therapy may open up the possibility of treating such neonatal diseases. This review summarizes the Исследование progress on stem cells and exosomes derived from stem cells in neonatal refractory diseases to provide new insights for most Исследованиеers and clinicians regarding future treatments. In addition, the current challenges and perspectives in stem cell th …

[Research on pretreatment methods for cystine determination in milk powder].

OBJECTIVE: To establish a rapid, accurate and safe pretreatment method for the determination of cystine in milk powder. METHODS: Samples were oxidized at 50 ℃ for 10 min after adding performic acid, and then the reaction was terminated with ethanol as oxidation terminator. The reaction solution was concentrate to dryness by vacuum centrifugation at 50 ℃. The residue was hydrolyzed at 145 ℃ for 4 h after adding 15 mL hydrochloric acid(6 mol/L). Quantitatively transfer the hydrolysate to 25 mL volumetric flask, rinsing with water, and dilute to volume. A proper amount of hydrolysate was concent

[Research advances in imaging techniques related to the diagnosis of pneumoconiosis].

Occupational pneumoconiosis (hereinafter referred to as pneumoconiosis) is the most harmful occupational disease in China. According to the … e technology as auxiliary imaging examination methods have shown different diagnostic values in the Исследование of auxiliary diagnosis of pneumoconiosis. This paper summarizes the advantages and problems in the application of various kinds of imaging techniques, which provides a direction for the future Исследование of imaging techniques related to the diagnosis …

[Research advances on the role and mechanism of microRNA in hypertrophic scar].

Hypertrophic scar (HS) affects the function and beauty of patients, and brings a heavy psychological burden to patients. However, the specific pathogenesis mechanism of HS in molecular biology level is not yet clear, and this disease is still one of the clinical diseases difficult to prevent and cure. MicroRNA (miR) is a family of single-stranded endogenous noncoding RNAs that can regulate gene expression. The abnormal transcription of miR in hypertrophic scar fibroblasts can affect the transduction and expression of downstream signal pathway or protein, and the exploration of miR and its down

[Research advance on structure and function of amides in Zanthoxylum plants].

Zanthoxylum belongs to the Rutaceae family, and there are 81 Zanthoxylum species and 36 varieties in China. Most of the Zanthoxylum plants are used as culinary spice. In recent years, scholars in China and abroad have carried out in-depth Исследование on Zanthoxylum plants, and found that the peculiar numbing sensation of Zanthoxylum plants originates from amides. It is also determined that amides are an important material basis for exerting pharmacological effects, especially in anti-inflammatory analgesia, anesthesia and other aspects. In this paper, 123 amides in 26 Zanthoxylum plants and their…

[Research progress in quality control of Bufonis Venenum in preparations].

Bufonis Venenum, an animal medicinal material, is widely used for treating cardiovascular diseases and pain induced by rheumatics or maligna … of Bufonis Venenum in other preparations are low or even absent. Therefore, it is urgent to conduct Исследование on the improvement of quality standards for the preparations containing Bufonis Venenum. This study retrieved the reports focusing on the quality evaluation and quality control of the preparations containing Bufonis Venenum from CNKI, PubMed, and We …

Radiometals in Imaging and Therapy: Highlighting Two Decades of Research.

The present article highlights the important progress made in the last two decades in the fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based positron emission tomography, single photon emission computerized tomography, and radionuclide therapy are illustrated in terms of their production routes and ease of radiolabeling. Applications in clinical diagnostic and radionuclide therapy are considered, including human studies under clinical trials; their current stages of clinical translations and findings are summarized. Because the metalloid astatine is used for

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… On other hand, 186 Re is most commonly produced in apparent specific activity of 111–148 GBq/mg at the Missouri Research Nuclear Reactor [ 261 ]. Table 18 Clinical applications of 188 Re-labeled radiopharmaceuticals. … In the last two decades, Исследование efforts have facilitated the development of 213 Bi-based peptide conjugates for PRRT study. …

Research progress of siVEGF complex and their application in antiangiogenic therapy.

Vascular endothelial growth factor (VEGF) is an important factor in the development of some diseases such as tumors, ocular neovascular disease and endometriosis. Inhibition of abnormal VEGF expression is one of the most effective means of treating these diseases. The resistance and side effects of currently used VEGF drugs limit their application. Herein, small interfering RNA for VEGF (siVEGF) are developed to inhibit VEGF expression at the genetic level by means of RNA interference. However, as a foreign substance entering the organism, siVEGF is prone to induce an immune response or mismat

Research Letter: Rate of BPPV in Patients Diagnosed With Concussion.

OBJECTIVE: The purpose of this study was to investigate the incidence of benign paroxysmal positional vertigo (BPPV) specifically among patients with dizziness in the rehabilitation phase of concussion recovery and to provide evidence regarding the importance of BPPV assessment in physical therapy concussion evaluations. SETTING: Outpatient neurologic rehabilitation center at a suburban comprehensive rehabilitation hospital. PARTICIPANTS: Fifty patients diagnosed with concussion and referred to vestibular physical therapy with complaints of dizziness were tested for BPPV within their first 3

The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss.

Recurrent pregnancy loss (RPL) is both mental and physical health problem affecting about 1-5% of women of childbearing age. The etiology of … d highly variable clinical presentation. Therefore, the genetic factors of RPL still need plentiful Исследование to obtain a more accurate understanding of its pathogenesis and to provide more detection means for the screening and prevention of RPL.

Research Progress on the Immune-Inflammatory Mechanisms of Posttraumatic Epilepsy.

Posttraumatic epilepsy (PTE) is a severe complication arising from a traumatic brain injury caused by various violent actions on the brain. The underlying mechanisms for the pathogenesis of PTE are complex and have not been fully defined. Approximately, one-third of patients with PTE are resistant to antiepileptic therapy. Recent Исследование evidence has shown that neuroinflammation is critical in the development of PTE. This article reviews the immune-inflammatory mechanisms regarding microglial activation, astrocyte proliferation, inflammatory signaling pathways, chronic neuroinflammation, and …

[The progress of clinical Исследование and treatment of monocular elevation deficiency].

Monocular elevation deficiency (MED) is a functional defect in upward eye movement caused by paralysis, restriction, or a combination of fac … ification, and available surgical options for MED, aiming to provide valuable insights for clinical Исследование and treatment.

Basic Исследование on curcumin in cervical cancer: Progress and perspectives.

Curcumin is a polyphenolic substance extracted from plants such as Curcuma longa, Curcuma zedoaria, and radix curcumae, and it has attracted … t cervical cancer and may become a novel antitumor drug in the future, opening up new ideas for the Исследование of curcumin in the field of antitumor. There is a lack of systematic reviews on the mechanism of action of curcumin against cervical cancer. Therefore, this study is a review of the literature based on the mechanism of action of curcumin against cer …

Advances in Исследование on cell models for skeletal muscle atrophy.

Skeletal muscle, the largest organ in the human body, plays a crucial role in supporting and defending the body and is essential for movement. It also participates in regulating the processes of protein synthesis and degradation. Inhibition of protein synthesis and activation of degradation metabolism can both lead to the development of skeletal muscle atrophy, a pathological condition characterized by a decrease in muscle mass and fiber size. Many physiological and pathological conditions can cause a decline in muscle mass, but the underlying mechanisms of its pathogenesis remain incompletely

A comprehensive review on the Исследование progress of PTP1B inhibitors as antidiabetics.

Diabetes mellitus (DM) is a serious global health concern affecting over 500 million people. To put it simply, it is one of the most dangerous metabolic illnesses. Insulin resistance is the root cause of 90% of all instances of diabetes, all of which are classified as Type 2 DM. Untreated, it poses a hazard to civilization since it can lead to terrifying consequences and even death. Oral hypoglycemic medicines presently available act in a variety of ways, targeting various organs and pathways. The use of protein tyrosine phosphatase 1B (PTP1B) inhibitors, on the contrary, is a novel and effect

A new era for myelin Исследование in Neurofibromatosis type 1.

Evidence for myelin regulating higher-order brain function and disease is rapidly accumulating; however, defining cellular/molecular mechanisms remains challenging partially due to the dynamic brain physiology involving deep changes during development, aging, and in response to learning and disease. Furthermore, as the etiology of most neurological conditions remains obscure, most Исследование models focus on mimicking symptoms, which limits understanding of their molecular onset and progression. Studying diseases caused by single gene mutations represents an opportunity to understand brain dys/fu…

After a century of nisin Исследование - where are we now?

It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in the same year that penicillin was first desc … ons in the biomedical field. This review will discuss the latest progress in these aspects of nisin Исследование.

The current state and future of T-cell exhaustion Исследование.

'Exhaustion' is a term used to describe a state of native and redirected T-cell hypo-responsiveness resulting from persistent antigen exposu … act of different microenvironmental signals and cell interactions have now become an active area of Исследование. Finally, we discuss what the future holds for the analysis of this physiological condition and, given the diversity of ways in which exhausted cells are now being generated, propose the adoption of a unified approach to clearly defining exhaustion …

[Research progress in the pathologic mechanism of temporomandibular joint osteoarthritis].

Temporomandibular joint osteoarthritis (TMJOA) is a kind of degenerative lesion in temporomandibular joint disorders. The pathogenesis of TM … epigenetic regulation, which may become potential therapeutic targets of TMJOA. In this paper, the Исследование progress on the pathologic mechanism of TMJOA in recent years is reviewed to provide a basis for finding new therapeutic targets of TMJOA.