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Predictors of atrial fibrillation freedom postablation with the pentaspline pulsed field ablation catheter: Subanalysis of the ADVENT Study.

BACKGROUND: Pulsed field ablation (PFA) has proven to be at least noninferior to thermal ablation for paroxysmal atrial fibrillation (AF). Predictors of AF freedom for PFA have not yet been described. OBJECTIVE: The purpose of this study was to identify clinical and procedural predictors of treatment success in paroxysmal AF patients treated with the pentaspline PFA catheter. METHODS: ADVENT (Randomized Controlled Trial for Pulsed Field Ablation versus Standard of Care Ablation for Paroxysmal Atrial Fibrillation) was a prospective randomized trial comparing PFA to thermal ablation with cente…

Safety, Effectiveness, and Clinical Workflow with a Balloon-Based Pulsed Field Ablation System: A Single-Center Experience.

A balloon-based pulsed field ablation (PFA) system with tissue proximity and mapping integration is currently undergoing clinical study. The initial 47 cases performed by a single operator identified important procedural workflow and system features that allow for the efficient adoption of this new catheter ablation technology resulting in an average procedure time including a 20 minute waiting period of 106.4 ± 21.1 minutes, with an average of 18.2 ± 3.1 applications per patient. This initial clinical study experience demonstrated this PFA system was safe and acutely effective in pulmonary ve…

Outcomes With Pulsed Field Ablation Versus Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation: A Meta-Analysis.

BACKGROUND: Pulmonary vein isolation is a standard therapy for paroxysmal atrial fibrillation (AF). Pulsed field ablation (PFA) has emerged as a novel approach aiming to improve efficacy and safety over conventional thermal ablation (CTA) (radiofrequency and cryoballoon). This meta-analysis evaluated outcomes of PFA versus thermal ablation in paroxysmal AF. METHODS: Electronic databases were searched through May 2025 for randomized controlled trials (RCTs) and observational studies that compared the efficacy and safety of PFA versus CTA. The primary outcome was AF recurrence. Summary estimate…

Early Assessment of the Environmental Impact of Pentaspline Pulsed Field Ablation and Cryoablation in the Treatment of Paroxysmal Atrial Fibrillation.

BACKGROUND: Atrial fibrillation (AF) affects 2% to 4.5% of the population. Catheter ablation, a key strategy for paroxysmal AF management, can be achieved through radiofrequency (RFA), cryoablation (CBA), or pulsed field ablation (PFA). While clinical outcomes are well studied, their environmental impact remains underexplored. OBJECTIVES: This study modeled the environmental impact of CBA and PFA ablation techniques in Europe, aiming to provide evidence to guide sustainable practices in AF treatment. METHODS: An early environmental analysis compared pentaspline PFA (Farapulse system, Boston …

Efficacy and Drug-Related Complications of Anticholinergic Drugs for Vagal Reaction Prevention During Pulsed Field Ablation.

BACKGROUND: Vagal responses (VR) are frequently observed during pulmonary vein isolation (PVI) with pulsed field ablation (PFA). OBJECTIVES: The aim of this study was to compare the effectiveness of 2 different anticholinergic (AC) medications, namely glycopyrrolate (GLY) or atropine (ATP), for VR prophylaxis in patients undergoing PVI via a pentaspline PFA catheter. METHODS: Consecutive patients with atrial fibrillation undergoing first-time PVI with PFA were prospectively enrolled at 4 centers between April 2023 and March 2024. Intravenous GLY 0.2 mg (Group GLY) or ATP 1 mg (Group ATP) wer…

Multifactorial Determinants of Pulsed Radiofrequency Treatment Outcomes in Meralgia Paresthetica: A Focus on Obesity, Comorbidities, and Technical Variables.

BACKGROUND: Meralgia paresthetica (MP) is the second most common nerve entrapment. AIMS: This study aimed to investigate the impact of obesity, comorbidities, and technical variables on treatment outcomes following ultrasound-guided pulsed radiofrequency (PRF) neuromodulation of the lateral femoral cutaneous nerve (LFCN) in MP over a 6-month period. SETTING AND METHODS: In this retrospective cohort study, 30 MP patients who underwent PRF of the LFCN and were followed for at least 6 months were analyzed. Treatment response was defined as a Douleur Neuropathique 4 (DN4) score <4 at 6 months. O…

Pulsed-Field Ablation-Induced Coronary Vasospasm for Atrial Tachycardia Originating From the Lateral Tricuspid Annulus.

BACKGROUND: Pulsed-field ablation (PFA) is a novel nonthermal technique that achieves myocardial ablation with high tissue selectivity and fewer complications than conventional thermal methods. Coronary vasospasm has been increasingly reported with the Farawave catheter, but data on the PulseSelect system are limited. CASE SUMMARY: A 67-year-old man with paroxysmal atrial fibrillation and atrial tachycardia (AT) underwent catheter ablation. Pulmonary vein isolation was successfully achieved with the PulseSelect system. Subsequent mapping localized the AT to the lateral tricuspid annulus. Radi…

Neuroendocrine mechanisms responsible for elevated gonadotrophin-releasing hormone and luteinising hormone pulses in polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despit … ch in animal models has rapidly advanced our understanding of the neural mechanisms underlying GnRH pulse generation with the identification of KNDy cells-a unique cell population in the hypothalamus expressing the neuropeptides kisspeptin, neurokinin B and dynorphin. As a result, therapeutics targeting KNDy cell signaling have emerged as a promising av …

Safety and feasibility of percutaneous pulsed electrical field ablation in multiple organs: A multi-center retrospective study☆.

PURPOSE: To assess the safety and feasibility of Pulsed Electrical Fields (PEF) ablation in various organs and patient populations. MATERIALS AND METHODS: This multi-center, retrospective study collected data from five academic medical centers on patients undergoing percutaneous PEF ablation, with a minimum of 30 days follow-up. Parameters assessed included demographics, treatment specifics, immediate adverse events, and survival rates. Procedures used CT or ultrasound guidance with a 19-gauge insulated needle and PEF probe. RESULTS: This study included 155 patients with a mean age of 60.7 y…

Intense Pulsed Light Combined with Low Level Blue and Red Light Therapy for Demodex-Associated Blepharitis.

PURPOSE: Demodex-associated blepharitis is a chronic disease of the lid accounting for over 60% of all blepharitis. Although several therapies have been employed to address Demodex mites' infestation, there is no universal consensus about the most effective strategy. Purpose of this study was to evaluate the efficacy of combined intense pulsed light (IPL) and low-level light therapy (LLLT) in the treatment of Demodex-associated blepharitis and associated ocular surface disease (OSD). PATIENTS AND METHODS: Medical records of patients with Demodex-associated blepharitis resistant to first-line …

Периферальная нейромодуляция в синдроме спастити-плюс: воздействие импульсной радиочастоты на тонические и больные расстройства при множественном склерозе.

ВВЕДЕНИЕ: Синдром Спастити-Плюс (СФС) при множественном склерозе (МС) представляет собой группу симптомов, включая спастику, нейропатическую боль, спазмы и дисфункцию мочевого пузыря. Эти проявления могут ухудшиться после травмы или операции. Пульсированная радиочастотная (РВЧ) предлагает минимально инвазивную нейромодуляционную стратегию, которая могла бы дополнить стандартное лечение. Мы сообщаем о случае 56-летней женщины со вторичным прогрессивным MS (EDSS 6.5), разработавшей SPS после гип-артопластики. Несмотря на многократную фармакологическую терапию (баклафен, опиоиды, набиксимолы), бо

Совпадение в аннотации оригинала
INTRODUCTION: Spasticity-Plus Syndrome (SPS) in multiple sclerosis (MS) represents a cluster of symptoms including spasticity, neuropathic pain, spasms, and bladder dysfunction. These manifestations may worsen after trauma or surgery. Pulsed radiofrequency (PRF) offers a minimally invasive neuromodulation strategy that could complement standard treatments. …

Using single and double laser pulses on the molecular Ni4@C48H36 system to design integrated nanospintronic units.

The accomplishment of long-distance spin transfer scenarios between several magnetic centers is a big challenge for building and supporting … accomplished within the subpicosecond regime. The impact of the propagation direction of the laser pulse by switching their polar and the azimuthal angles in spherical coordinates on the spin dynamics processes is analyzed. Double laser pulses with time delay δt ≥ 200 × FWHM yield in a realistic magnetic field gradient selectively a lateral resolution, …

Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps.

Transcranial pulsed current stimulation (tPCS) is a noninvasive brain stimulation technique that has aroused considerable attention in recent years. This review aims to provide an overview of the existing literature on tPCS, examine the scope and nature of previous research, investigate its underlying mechanisms, and identify gaps in the literature. Searching online databases resulted in 36 published tPCS studies from inception until May 2023. These studies were categorized into three groups: human studies on healthy individuals, human studies on clinical conditions, and animal studies. The fi…

Atrial Fibrillation Ablation During Hospitalization for Acute Heart Failure: Feasibility and Role of Pulsed Field Ablation.

INTRODUCTION: Atrial fibrillation (AF) can cause or aggravate heart failure (HF). Catheter ablation (CA) is an effective treatment for AF. T … ventricular ejection fraction (LVEF) of 25 [23, 28]%. Thermal CA was performed in 14 patients, and pulsed field ablation (PFA) in 32 patients. Procedure time was significantly shorter with PFA compared to thermal CA (77 [57, 91] vs. 166 [142, 200] minutes, p < 0.001). Fluoroscopy time was longer with PFA (9.5 [7.6, 12.0] vs. 3.9 [2.9, 6.0] minutes, p < …

Feasibility study on atrial fibrillation ablation with pulsed field ablation and concomitant occlusion of the left atrial appendage.

AIMS: Atrial fibrillation (AF) ablation and left atrial appendage occlusion (LAAO) are increasingly performed as individual procedures. Pulsed field ablation (PFA) has significantly reduced procedure duration and may be advantageous for the combined approach. METHODS AND RESULTS: We have launched a programme for simultaneous AF ablation using PFA and LAAO for patients qualifying for both treatments and excluding those with a complex anatomy. We compare procedure duration and fluoroscopy time against individual procedures (either AF ablation or LAAO alone), all performed by the same operators …

Quantitative and qualitative assessment of evaporative dry eye post intense pulsed light therapy, a prospective study.

PURPOSE: This study aimed to determine the effect of intense pulsed light (IPL) treatment on meibomian gland disease. SETTINGS AND DESIGN: This is a prospective interventional study. METHODS: Seventy eyes of patients with dry eye disease undergoing three sessions of IPL therapy, 15 days apart, were included. Each patient completed the dry eye questionnaire (SPEED) for symptomatic assessment. Dry eye evaluation tests were performed, including Schirmer's 1 test, meiboscopy, noninvasive tear break-up time (NIBUT) and interferometry. These tests were repeated before each IPL session. STATISTICA…

Combined low-dose isotretinoin and long-pulsed nd: YAG laser in the treatment of post-acne erythema.

Post-acne erythema (PAE) is a bothering skin condition that emerges from inflammatory acne and persists after its resolution. It is characterized by telangiectasia and erythematous macules. the role of 1064-nm Nd: YAG when combined with low-dose isotretinoin in the acne erythema treatment. forty-eight PAE patients were involved in the study. They were divided into two groups; group (A) patients administering a low dose of oral isotretinoin (10 mg/day) and underwent a total of six two-week interval sessions of 1064 ND-YAG laser treatment, group (B) patients administering a low dose of oral isot

Pulsed Field vs Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation: Recurrent Atrial Arrhythmia Burden.

BACKGROUND: The ADVENT randomized trial revealed no significant difference in 1-year freedom from atrial arrhythmias (AA) between thermal (radiofrequency/cryoballoon) and pulsed field ablation (PFA). However, recent studies indicate that the postablation AA burden is a better predictor of clinical outcomes than the dichotomous endpoint of 30-second AA recurrence. OBJECTIVES: The goal of this study was to determine: 1) the impact of postablation AA burden on outcomes; and 2) the effect of ablation modality on AA burden. METHODS: In ADVENT, symptomatic drug-refractory patients with paroxysmal …

Clinical efficacy of 595 nm pulsed dye laser in combination with supramolecular salicylic acid in the treatment of rosacea.

OBJECTIVE: This research was aimed at ascertaining the clinical effects of 595 nm pulsed dye laser (PDL) in combination with supramolecular salicylic acid (SSA) in the treatment of rosacea. METHODS: Eighty-four patients with rosacea were selected, of which 42 patients treated with PDL alone were considered as the control group, and 42 patients treated with 595 nm PDL in combination with 30% SSA were regarded as the observation group. The treatment continued for 4 months in the two groups. Clinical symptom scores, skin barrier function indicators, serum inflammatory factors, Acne⁃QOL scores an…