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Computed tomography-based conventional imaging features and texture analysis characteristics of chemotherapy drug-related acute pancreatitis.

PurposeChemotherapy drug-related acute pancreatitis (CDRAP) is a rare adverse event that poses significant challenges to clinicians. This study aimed to describe plain computed tomography (CT)- and contrast-enhanced computed tomography (CECT)-based conventional imaging features and texture analysis characteristics of CDRAP.MethodsA total of 62 patients with initial clinical and/or biochemical evidence of pancreatitis and 34 patients with normal pancreatic manifestations who underwent CT during chemotherapy were retrospectively included. The diagnosis of CDRAP was established based on clinical,

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… Her2+ breast cancer treatment and cardiotoxicity: monitoring and management . Breast Cancer Res Treat . ( 2019 ) 177 : 237 – 50 . doi: 10.1007/s10549-019-05303-y 31165940 PMC6661020 12. Simons-Linares CR Elkhouly MA Salazar MJ . Drug-induced acute pancreatitis in adults: an update . …

The UK's Early Access to Medicines Scheme 10 years on: an evaluation using publicly available data.

ObjectivesTo investigate the drugs and indications that have passed through the UK's Early Access to Medicines Scheme (EAMS) to date, the type of evidence the regulator considers when accepting a drug into the EAMS, and potential risks to patients.DesignAnalysis of publicly available data: MHRA Public Assessment Reports; Electronic Medicines Compendium database; interactive Drug Analysis Profiles database; Eudravigilance database.SettingUnited Kingdom.ParticipantsThe 51 'scientific opinions' available on the MHRA website in June 2024.Main outcome measuresPublic Assessment Reports, pharmacovigi

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… Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity . Front Physiol 2017 ; 8 ( SEP ): 1 – 15 . 28955244 10.3389/fphys.2017.00668 PMC5601077 43 Li Z Mirams GR Yoshinaga T , et al. …

Management of cytotoxic chemotherapy in patients undergoing dialysis: a still unresolved issue of onconephrology.

The incidence of tumors increases significantly in individuals with chronic kidney disease (CKD), particularly among those undergoing dialysis. This dialysis-associated condition not only impacts therapy but also influences the prognosis of oncological patients, contributing to heightened mortality rates related to both cancer and non-cancer causes. Importantly, it stands as a primary factor leading to suboptimal utilization of therapies. Dosage adjustment for many types of chemotherapy is a necessity in patients with kidney impairment. However, due to a lack of comprehensive knowledge about t

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… Zhang et al. contribute valuable insights into drug-specific risks, emphasizing the heightened vulnerability of dialysis patients to myelotoxicity induced by cisplatin and carboplatin, the increased risks of cardiotoxicity with doxorubicin and epirubicin, and the potential for hemorrhagic cystitis with …

Review of BCL2 inhibitors for the treatment of Waldenström's macroglobulinaemia and non-IgM lymphoplasmacytic lymphoma.

Lymphoplasmacytic lymphoma (LPL) is a relatively rare form of indolent B-cell non-Hodgkin's lymphoma, termed Waldenström's macroglobulinaemia (WM) in the presence of an IgM paraprotein. Although traditionally treated with combination chemoimmunotherapy, the management is evolving in the era of targeted molecular therapies including Bruton's tyrosine kinase inhibitors (BTKi). However, intolerance and refractoriness to BTKi mean newer agents are required, and the prognosis of so-called quadruple-refractory patients is poor. BCL2 is an anti-apoptotic, pro-survival protein that promotes lymphoma c

Peripheral Neuropathy During Concomitant Administration of Proteasome Inhibitors and Factor Xa Inhibitors: Identifying the Likelihood of Drug-Drug Interactions.

Backgrounds: Proteasome inhibitors (PI) cause toxic peripheral neuropathy (PN), which is one of the dose-limiting adverse events of these treatments. Recent preclinical studies find that factor Xa inhibitor (FXaI), rivaroxaban, promotes PN in animals receiving oxaliplatin. Cancer patients can receive combined therapy of PI and FXaI. This study aimed to identify and characterize the interaction signals for the concomitant use of PI and FXaI resulting in PN. Methods: Reports from the United States FDA Adverse Event Reporting System (FAERS) were extracted from the first quarter of 2004 to the fir

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… Unfortunately, PIs play a role in producing cardiotoxicity and neurotoxicity. Peripheral neuropathy (PN) is one of the major dose-limiting adverse events (AE) of PIs ( Schlafer et al., 2017 ; Gavazzoni et al., 2018 ). …

Therapeutic education and physical activity are feasible and safe in hematologic cancer patients referred to chemotherapy: results of a randomized controlled trial.

PurposeAlthough over 60% of patients with hematologic cancer report distressing fatigue, they often do not receive recommendations on fatigue management strategies. The aim of this pilot study was to estimate the feasibility of therapeutic education and physical activity (TEPA) by measuring the patients' adherence to this multidimensional intervention. The secondary aim was to estimate the impact of TEPA on clinical outcomes.MethodsPatients with hematologic cancer participated in this single-center, open-label, randomized controlled trial. The control group (CG) received two educational group

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… Moreover, physical deconditioning is highly prevalent in individuals with hematologic malignancies, as it also derives from side effects of treatments, such as cardiotoxicity, neurotoxicity, or cachexia, and from the widespread belief that the patient should rest in order to cope with CRF [ 6 ]. …

Protocol for Care After Lymphoma (CALy) trial: a phase II pilot randomised controlled trial of a lymphoma nurse-led model of survivorship care.

IntroductionLymphoma is the sixth most common cancer diagnosed in Australia and internationally. Owing to the aggressive nature of the disease and intensity of treatment, survivors face long-term effects that impact on quality of life. Current models of follow-up post-treatment fail to address these complex issues. Given that 74% of patients with lymphoma cancer now survive 5 years beyond diagnosis and treatment, it is important to address this gap in care.AimTo determine self-reported informational and practical needs, anxiety, depression, stress, coping and empowerment at baseline, 3 and 6 m

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… Aust J Cancer Nurs 2013 ; 14 : 7 – 12 . 10 Aleman BM , van den Belt-Dusebout AW , De Bruin ML Late cardiotoxicity after treatment for Hodgkin's lymphoma . …

Novel therapeutic agents in clinical trials: emerging approaches in cancer therapy.

Novel therapeutic agents in clinical trials offer a paradigm shift in the approach to battling this prevalent and destructive disease, and the area of cancer therapy is on the precipice of a trans formative revolution. Despite the importance of tried-and-true cancer treatments like surgery, radiation, and chemotherapy, the disease continues to evolve and adapt, making new, more potent methods necessary. The field of cancer therapy is currently witnessing the emergence of a wide range of innovative approaches. Immunotherapy, including checkpoint inhibitors, CAR-T cell treatment, and cancer vacc

Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles.

Peptide-drug conjugates (PDCs) are modular, targeted therapeutics composed of a homing peptide linked to a cytotoxic or modulating drug payload via a cleavable/non-cleavable linker. PDCs utilize peptide targeting to enhance the delivery of potent drugs to tumors, providing advantages such as superior tissue penetration, reduced immunogenicity, and simpler manufacture compared to antibody-drug conjugates (ADCs). A comparison of PDCs versus ADCs highlights that PDCs' small size (~1-3 kDa) enables deeper tumor penetration and faster clearance, whereas ADCs (~150 kDa) benefit from prolonged circul

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… Topoisomerase Inhibitors Dox, a potent anthracycline, is frequently associated with severe cardiotoxicity and myelosuppression due to its lack of tumor specificity. 67 Dox is often linked via acid-sensitive hydrazone or amide bonds to facilitate drug release in acidic tumor compartments. … This selective release mechanism results in significantly enhanced intracellular drug accumulation, reduced cardiotoxicity, and superior antitumor efficacy compared to free Dox. …

A Narrative Review on the Antitumoral Effects of Selected Mediterranean Plant Products from Southern Italy.

Natural products are a valuable source of bioactive compounds with established roles in oncology. Their structural diversity and ability to target multiple cancer-related pathways make them promising candidates for anticancer drug development. Increasing preclinical and clinical data highlight their potential not only to exert direct antitumor effects but also to enhance patient tolerance to conventional therapies by reducing side effects and improving treatment adherence. The Mediterranean region, known for its biodiversity and traditional dietary habits, provides a rich array of natural comp

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… Adverse effects such as fatigue, myelosuppression, nausea, vomiting, neuropathy, cardiotoxicity, and alopecia often reduce patients’ quality of life and lead to treatment discontinuation [ 5 , 6 ]. …

Exploiting Nanomedicine for Cancer Polychemotherapy: Recent Advances and Clinical Applications.

The most important limitations of chemotherapeutic agents are severe side effects and the development of multi-drug resistance. Recently, the clinical successes achieved with immunotherapy have revolutionized the treatment of several advanced-stage malignancies, but most patients do not respond and many of them develop immune-related adverse events. Loading synergistic combinations of different anti-tumor drugs in nanocarriers may enhance their efficacy and reduce life-threatening toxicities. Thereafter, nanomedicines may synergize with pharmacological, immunological, and physical combined tre

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… A liposome-based DOX-TRAIL system was used to treat GMB induced with U87 cells to overcome the TRAIL short half-life, DOX cardiotoxicity, and MDR [ 76 ]. Liposome-DOX+liposome-TRAIL showed increased anticancer activity compared with the liposomes loaded with the single drugs alone. … Studies in mice bearing ovarian or breast cancer showed that DOX uploaded in EVs displays decreased cardiotoxicity and an improved therapeutic effect [ 176 , 177 ]. EVs carrying CIS significantly enhance the cytotoxic effect against drug-resistant A2780/DDP cells [ 178 ]. …

Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy.

Cancer is one of the primary causes of worldwide human deaths. Most cancer patients receive chemotherapy and radiotherapy, but these treatments are usually only partially efficacious and lead to a variety of serious side effects. Therefore, it is necessary to develop new therapeutic strategies. The emergence of nanotechnology has had a profound impact on general clinical treatment. The application of nanotechnology has facilitated the development of nano-drug delivery systems (NDDSs) that are highly tumor selective and allow for the slow release of active anticancer drugs. In recent years, veh

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… and head and neck | [ 154 , 155 ] Gemzar (Gemcitabine) | Polyketal NPs and lipid polymer hybrid; | Pancreas, breast, ovary, and lung | [ 156 , 157 ] Fang et al. found that Dox-loaded dextran-based nanocarriers are an effective drug delivery system for the treatment of malignant lymphoma with reduced cardiotoxicity … Adverse cardiac effects of cancer therapies: Cardiotoxicity and arrhythmia. Nat. Rev. Cardiol. 2020;17:474–502. doi: 10.1038/s41569-020-0348-1. 29. Zhang C.-L., Huang T., Wu B.-L., He W.-X., Liu D. Stem cells in cancer therapy: Opportunities and challenges. …

Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention.

Multi-factorial mitochondrial damage exhibits a "vicious circle" that leads to a progression of mitochondrial dysfunction and multi-organ adverse effects. Mitochondrial impairments (mitochondriopathies) are associated with severe pathologies including but not restricted to cancers, cardiovascular diseases, and neurodegeneration. However, the type and level of cascading pathologies are highly individual. Consequently, patient stratification, risk assessment, and mitigating measures are instrumental for cost-effective individualized protection. Therefore, the paradigm shift from reactive to pred

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… Similarly, 7,8-DHF improved cardiac function and inhibited cardiac injury mediated by increased OPA1 protein expression, Akt activation, OXPHOS, and mitochondrial membrane potential dysregulation in doxorubicin-induced cardiotoxicity in Kunming mice and H9c2 cells [ 127 ]. … Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation Free. Radic. Biol. Med. 2019 130 557 567 10.1016/j.freeradbiomed.2018.11.024 30472367 128. Wu B. Lin J. Luo J. …

Organic Nanoparticles in Progressing Cardiovascular Disease Treatment and Diagnosis.

Cardiovascular diseases (CVDs), the world's most prominent cause of mortality, continue to be challenging conditions for patients, physicians, and researchers alike. CVDs comprise a wide range of illnesses affecting the heart, blood vessels, and the blood that flows through and between them. Advances in nanomedicine, a discipline focused on improving patient outcomes through revolutionary treatments, imaging agents, and ex vivo diagnostics, have created enthusiasm for overcoming limitations in CVDs' therapeutic and diagnostic landscapes. Nanomedicine can be involved in clinical purposes for CV

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… Liposomal doxorubicin attenuates cardiotoxicity via induction of interferon-related DNA damage resistance. Cardiovasc. Res. 2020;116:970–982. doi: 10.1093/cvr/cvz192. 70. Ho D., Lynd T.O., Jun C., Shin J., Millican R.C., Estep B.K., Chen J., Zhang X., Brott B.C., Kim D.W., et al. …

Emerging Trends in Diagnostic Radiology: Integrating Advanced Imaging Modalities for Early Detection, Clinical Monitoring, and Prognostic Evaluation of Multisystem Internal Medicine Disorders.

Diagnostic radiology has progressed from basic X-ray imaging to a highly advanced, multimodality discipline that integrates high-resolution structural techniques, functional and molecular imaging, and computational analytics. This review synthesizes emerging trends in diagnostic radiology with a particular focus on their relevance to multisystem internal medicine disorders. The historical evolution of imaging is outlined, from early radiographs to computed tomography (CT), magnetic resonance imaging (MRI), and hybrid platforms such as positron emission tomography-computed tomography (PET-CT) a

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… Moreover, cardiac MRI is also becoming a growing trend and is becoming more popular as a tool to assess cardiotoxicity of chemotherapy, and it is a sensitive method of longitudinal surveillance [ 9 ]. …

Physical health outcomes and step cadence improvements: a digital physical activity intervention in cancer survivors.

BackgroundCancer survivors experience symptoms that can often be managed with moderate-to-vigorous physical activity. Most studies are short, small, and in-person, limiting scalability. This study evaluated a 12-month digital moderate-to-vigorous physical activity intervention and its impact on long-term physical health outcomes in a large sample of cancer survivors.MethodsThis 2-arm trial was embedded within the Cancer Prevention Study-3 prospective cohort study and included survivors with cancers associated with physical inactivity. Eligible participants were randomly assigned to a digital m

Detection of potential complications in cancer survivors after chemotherapy and development of a regional care network: the PASCA feasibility study.

Complications are often poorly identified and managed in cancer survivors after treatment and restoring their initial quality of life remains a challenge, particularly in a context of unequal access to care nationwide. The PASCA "Parcours de Santé au cours du Cancer [in English: healthcare pathways with cancer]" feasibility study was conducted in the Léon Bérard Comprehensive Cancer Center (Lyon, France) to assess the feasibility of a complications detection program, in cancer survivors who have received intensive chemotherapy. An initial network of physicians and healthcare professionals was

Автономная трансплантация стволовых клеток с помощью гематопоиетической гематомии для множественных склерозов в Соединенном Королевстве: A 20-year Ретроспективный анализ деятельности и гематологических результатов Британского общества трансплантации крови и мозга и клеточной терапии (BSBMTCT).

Автологическая трансплантация стволовых клеток (AHSCT) была разработана в качестве средства лечения множественных склерозов (MS) с тех пор. 1995. Соединенное Королевство one :: из наиболее активных стран Европы, осуществляющих АХСХТ для НР. Мы сообщаем об опыте Соединенного Королевства в области AHSCT для MS 364 :: пациенты, имеющие MS, которые лечатся AHSCT между 2002 и 2023. Мы представляем данные о смертности, связанной с трансплантацией (ТМР), осложнениях и эффективности АХСПП, определяемых расширенной шкалой показателей инвалидности (ЭДСС) в условиях бесперебойного выживания (ПФС) 2 годы

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… early in the transplant course, mainly starting during conditioning before the aplastic phase and potentially related to reduced cardio‐respiratory reserve in patients with advanced MS compounded by conditioning regimens (such as cyclophosphamide‐ATG) that induce significant fluid retention and direct cardiotoxicity …

Prognostic impact of resistance to bortezomib and/or lenalidomide in carfilzomib-based therapies for relapsed/refractory multiple myeloma: The Kyoto Clinical Hematology Study Group, multicenter, pilot, prospective, observational study in Asian patients.

BackgroundCombinatory strategies with carfilzomib (CFZ), a second-generation proteasome inhibitor, plus dexamethasone (DEX) with or without lenalidomide (LEN) have shown promising efficacy for patients with relapsed/refractory multiple myeloma (RRMM) in pivotal clinical trials. However, their effects on patients who were resistance to bortezomib (BTZ) and/or LEN have not been fully evaluated in a daily practice setting.AimsTo evaluate the real-world efficacy and safety of CFZ-based treatments; that is, CFZ with LEN plus DEX (KRD therapy) and CFZ with DEX (KD therapy), in Asian patients, we con

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… Cardiotoxicity associated with carfilzomib: systematic review and meta‐analysis . Leuk Lymphoma . 2018 ; 59 ( 11 ): 2557 ‐ 2569 . 29465266 10.1080/10428194.2018.1437269 43 Facon T , Niesvisky R , Mateos V , et al. …

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Osteonecrosis of the femoral head (ONFH) is a debilitating disease that is closely associated with the clinical application of high-dose glucocorticoids. Elevated oxidative stress contributes to the pathophysiological changes observed in ONFH. The lack of effective treatments besides surgical intervention highlights the importance of finding novel therapeutics. Our previous studies demonstrated that D7, a cyclic polypeptide, enhances the adhesion, expansion, and proliferation of bone marrow mesenchymal stem cells (BMSCs). Therefore, in this study, we investigated the therapeutic effects of D7

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… FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT Cell Death & Differentiation 2020 27 2 540 555 31209361 10.1038/s41418-019-0372-z PMC7206111 30 Zhang Z. D. Yang Y. J. Liu X. W. …