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Efficacy of Transcranial Direct Current Stimulation in Patients with Primary Progressive Aphasia: A Systematic Review and Updated Meta-analysis.

BACKGROUND: Primary progressive aphasia (PPA) is a group of dementias characterized by progressive loss of specific language functions with relative sparing of other cognitive domains. Transcranial direct current stimulation (tDCS) has been introduced as a potential therapeutic option for PPA. We aim to evaluate the efficacy of tDCS in improving cognitive and language functions in patients with PPA. METHODS: PubMed, Embase, Cochrane Library, and Web of Science were searched up to June 2024 to identify randomized controlled studies (RCTs) comparing tDCS vs sham procedure in patients with PPA.

Cardiovascular Events in Lupus Nephritis: A Systematic Review and Meta-Analysis.

INTRODUCTION: Systemic lupus erythematous (SLE) is known to be associated with cardiovascular events (CVEs). However, the incidence of CVE has not been thoroughly investigated in lupus nephritis (LN) patients. In this meta-analysis, we aimed to assess the incidence of CVE in patients with LN. METHODS: We performed a literature search in PubMed, Scopus, and Web of Science database for studies reporting CVE (myocardial infarction [MI], heart failure, cerebrovascular accident [CVA] [i.e., ischemic or hemorrhagic stroke or transient ischemic attack], any cardiovascular- or cerebrovascular-related

Putting the PASC Score to the Test: Clinical vs. Statistical Accuracy in Long COVID Diagnosis.

OBJECTIVE: To validate the RECOVER Post-Acute Sequelae of SARS-CoV-2 infection (PASC) score in a cohort of patients who develop long COVID (LC) or fully recover while iteratively improving the tool's sensitivity and specificity. METHODS: A cross-sectional study in 130 LC patients followed at LC clinics in Baltimore, MD, USA, who met the National Academies of Sciences, Engineering, and Medicine (NASEM) 2024 LC definition, and 60 SARS-CoV-2 exposed but fully recovered individuals. LC participants were required to have at least one neuropsychiatric symptom. Participants completed comprehensive s

Impact of COVID-19-induced psychological distress on sexual quality of life and care delivery among healthcare workers: a scoping review protocol of global evidence.

INTRODUCTION: COVID-19 pandemic affected physical, psychological and social well-being of many individuals, including healthcare workers, who were at the forefront of the pandemic. Thus, the pandemic may have reduced the sexual quality of life of frontline healthcare workers, which in turn could compromise their ability to provide quality healthcare to patients. This scoping review aims to gather and synthesise current available global evidence on the interactions among COVID-19, sexual quality of life and healthcare delivery among healthcare workers. METHODS AND ANALYSIS: The JBI framework f

Association Between Sleep Quality and Academic Performance Among Undergraduate Medical Health Sciences Students: A Cross-Sectional Study.

BACKGROUND: Adequate sleep is crucial for maintaining memory, emotional regulation, mental sharpness, and general health. Students pursuing medical degrees frequently experience interrupted sleep patterns because of rigorous academic workloads and hospital duties, potentially harming both their wellness and educational outcomes. AIM: This study aims to examine how sleep quality influences academic performance in medical and health sciences undergraduates at Batterjee Medical College, Saudi Arabia, in the 2024-2025 academic year. METHODS: A cross-sectional study involving 175 medical students

Safer opioid supply clients' values and preferences: a systematic review and thematic synthesis of qualitative research.

QUESTION: What are the values and preferences of safer opioid supply clients? STUDY SELECTION AND ANALYSIS: We conducted a systematic review of qualitative studies on safer opioid supply client experiences published between January 2016 and August 2024. Searches were conducted across seven databases-MEDLINE, Embase, PsycINFO, CINAHL, EBM Reviews, Web of Science and Scopus-and supplemented with searches in Google Scholar and relevant repositories. Study quality was assessed using the Critical Appraisal Skills Programme. Data analysis was guided by Thomas and Harden's thematic synthesis approac

Barriers and Enablers to WIC Participation: Review of Evidence From Studies Published Between 2019 and 2024.

INTRODUCTION: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) supports low-income mothers and children aged <5 years in the U.S. with nutrition and healthcare resources; however, not all eligible individuals participate. This scoping review aimed to synthesize evidence on factors associated with WIC participation from the perspective of WIC program implementers; WIC participants; and WIC-eligible nonparticipants. METHODS: Qualitative, quantitative, and mixed-methods studies published between March 2019 and December 2024 in peer-reviewed journals were included

Barriers and enablers to centre-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease in low- and middle-income countries: a systematic review.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity in low- and middle-income countries (LMICs). Despite the proven benefits of pulmonary rehabilitation (PR) for patients with COPD, its referral, uptake, and completion rates remain low. This systematic review aimed to identify the barriers and enablers to centre-based PR among patients with COPD in LMICs. METHODS: We searched PubMed, Web of Science, Cumulative Index to Nursing and Allied Health Literature, and Scopus databases from their inception to September 2023 and updated in May 2025. St

Design thinking in cancer care: A systematic literature review.

ObjectiveCancer can have a profound impact on the life of the patient, presenting challenges such as dealing with complex healthcare models and psychological burden. Implementing design thinking (DT) in cancer care can improve the quality of life for patients. Although DT has been used in healthcare, there is limited research highlighting use of DT in cancer care. The objective of this review is to explore the applications of DT within a cancer care context.MethodsWe systematically searched databases (PubMed Central, Scopus, and Medline) for relevant papers published between January 2018 and M

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… Science | Canada | Cancer care | Patient facing Appendix 2: Study objective and results Title | Target condition/System Process | Technique/Intervention Method | Objective of the study | Results | Outcomes Playful strategies to foster the well-being of paediatric cancer patients in the Brazilian … Also Survivor information kit. | To design a provincial support system for high-priority tests for Childhood cancer survivors, informed by principles of implementation science, behavioural science, and design thinking. | Researcher developed a multifaceted intervention using design thinking and behavioural …

Saying YES to Careers in Cancer Research: A Collaborative Model for Evaluating and Improving a Cancer Education and Research Program.

The Case Comprehensive Cancer Center's Youth Enjoy Science (YES) Program is funded by the National Cancer Institute to promote broad interest in pursuing a career in biomedical research via early intervention strategies that inspire student interest, help envision research as a career path, and strengthen practical research and career skills. A major aspect of the YES program is an 8-week immersion into cancer center faculty laboratories to conduct a cancer research project over the summer. The overall goal is to excite students to consider a future career in biomedical research or healthcare

Enhancing physiology learning through group dynamics: outcomes and perceptions of medical students.

BACKGROUND: In health sciences education, active learning strategies are increasingly recognized for their role in enhancing student engagement and competency development. This study explores the impact of a structured group dynamics activity, framed within a desert survival scenario, on decision-making, teamwork, and academic performance among second-year medical students studying renal physiology. METHODS: A mixed-methods design was used involving 195 students, 140 of whom participated in a two-session collaborative activity grounded in physiological knowledge. The intervention emphasized i

Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers.

BACKGROUND: Escalating pyrethroid resistance in malaria vectors highlights the urgency of implementing new control tools incorporating non-pyrethroid molecules. Here, using DNA-based metabolic resistance markers, we assessed the efficacy of the dual active ingredients net Royal Guard against pyrethroids-resistant malaria vectors in Cameroon, establishing its long-term impact on mosquitoes' life traits after exposure. RESULTS: Cone assays revealed low efficacy of Royal Guard against field Anopheles populations. However, analysis of the survival curves revealed that unexposed mosquitoes lived l

How important is the timing and duration of pelvic floor muscle training for preventing postpartum urinary incontinence? a meta-analysis.

BACKGROUND: Postpartum urinary incontinence (PUI) is a common condition that significantly impairs the quality of life for women who have given birth. This meta-analysis aimed to systematically evaluate how the timing and duration of pelvic floor muscle training (PFMT) influence the prevention of PUI. METHODS: To identify relevant studies examining the role of PFMT in preventing PUI, a thorough literature search was conducted across multiple databases up to February 20, 2025. These databases included PubMed, Embase, Web of Science, ClinicalTrials.gov, OVID, Cochrane Library, Wanfang, CNKI, an

Acute pain service for postoperative pain in adults: a network meta-analysis.

BACKGROUND: Postoperative pain significantly impacts patients' quality of life and recovery. Although acute pain services (APS) have been implemented in many hospitals worldwide, no study has directly compared the efficacy of different APS subtypes in managing acute postoperative pain. OBJECTIVE: This network meta-analysis aimed to evaluate the effectiveness of various APS models in alleviating postoperative pain in adults undergoing surgery. METHODS: Four English-language databases (PubMed, Web of Science, Embase, and Cochrane Library) and three Chinese-language databases (CNKI, WANFANG, an

Application of artificial intelligence for nutrient estimation in surface water bodies of basins with intensive agriculture.

Eutrophication is one of the most relevant concerns due to the risk to water supply and food security. Nitrogen and phosphorus chemical species concentrations determined the risk and magnitude of eutrophication. These analyses are even more relevant in basins with intensive agriculture due to agrochemical discharges. However, analyzing these nutrients is labor intensive, as sampling to intercalibration in the laboratory requires considerable financial and human resources. Currently, artificial intelligence allows the modeling of phenomena and variables in various fields. This research focuses

The Intricacies of Polypharmacy and Drug Interactions in Schizophrenia Treatment.

INTRODUCTION: Polypharmacy is frequently practiced in the management of schizophrenia due to its chronic nature, recurrent relapses, and associated comorbidities. While combining psychotropic medications may benefit patients with treatment-resistant symptoms, it poses risks such as drug-drug interactions (DDIs), adverse effects, and reduced medication adherence. The absence of uniform prescribing standards further complicates clinical decision-making. METHODS: This narrative review was conducted using a scoping methodology. Databases including Pub- Med, Scopus, and Web of Science were searche

Virtual reality in adults with respiratory diseases experiencing dyspnoea: a systematic review and meta-analysis.

OBJECTIVES: Our aim was to evaluate virtual reality's effects in dyspnoea's management. METHODS: Information sources: Trials were identified through a systematic search carried out on MEDLINE, Web of Science, Scopus and CINAHL until 17 March 2025. ELIGIBILITY CRITERIA: Eligible studies were controlled trials including adults with dyspnoea associated with respiratory diseases, for whom virtual reality was implemented and compared with another intervention. Risk of bias: Risk of bias (ROB) was assessed using the ROB 2 tool. SYNTHESIS OF RESULTS: The primary outcome was dyspnoea. Secondary out

Cancer-related cognitive impairment in patients with hematologic malignancies after CAR T cell therapy: a systematic review and meta-analysis of prevalence.

PURPOSE: Cancer-related cognitive impairment is one of the symptoms of neurotoxicity among patients receiving chimeric antigen receptor (CAR) T cell therapy. Evidence of the overall estimated prevalence of cancer-related cognitive impairment following CAR T-cell therapy among patients with hematologic malignancies at short-term and long-term follow-ups is lacking. This review aimed to summarize the cognitive functioning status and estimate the prevalence of cancer-related cognitive impairment at follow-up within 1 month, 1 to 12 months, and > 12 months after CAR T cell therapy. METHODS: PubMe

Meta-analysis of maternal exposure to heavy metals (lead, cadmium, mercury, chromium) and adverse pregnancy outcomes.

BACKGROUND: The association of heavy metal exposure with adverse pregnancy outcomes (APOs) remains a subject of debate. The goal of the present study was to analyze the correlation of heavy metals (lead [Pb], cadmium [Cd], mercury [Hg], chromium [Cr]) with APOs. METHODS: A systematic review was carried out across four databases: The Cochrane Library, PubMed, Web of Science, and Embase up to November 19, 2024. Two independent researchers performed the literature screening and data extraction based on predefined eligibility criteria. Then, based on the selected literature, the researchers extra

A meta-analysis of the therapeutic effect of total knee replacement after knee arthroscopic surgery.

PURPOSE: To appraise the influence of knee arthroscopic surgery on subsequent total knee arthroplasty (TKA) through meta-analysis. METHODS: A computer search was implemented from the establishment of the database to August 2023 for literature on the influence of knee arthroscopic surgery on the efficacy of subsequent TKA in Web of Science, PubMed, CNKI, Embase, Cochrane Library, Wanfang, and other databases. Quality assessment, literature screening, and data extraction were enforced according to the exclusion and inclusion criteria, and the methodological quality of the involved literature wa