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Fisetin as an Antiviral Agent Targeting the RNA-Dependent RNA Polymerase of SARS-CoV-2: Computational Prediction and In Vitro Experimental Validation.

SARS-CoV-2 continues to evolve into immune-evasive variants, and although vaccination remains the cornerstone of prevention, the search for antiviral molecules targeting conserved viral enzymes remains essential. The RNA-dependent RNA polymerase (NSP12) is a central component of coronavirus replication, and natural polyphenols have been recurrently proposed as modulators of viral polymerases. Among these compounds, Fisetin has been reported to interact with multiple viral and cellular pathways, yet its direct antiviral activity against SARS-CoV-2 remained largely unexplored. Here, we first ana…

Process optimization for development of black carrot (Daucus carota ssp. Sativus Var. Atrorubens alef) wine with improved sensorial and physicochemical attributes.

UNLABELLED: Fruits and vegetables are vital to our dietary intake, providing essential vitamins and minerals, crucial for overall health and well-being. This study investigated the feasibility of producing wine from black carrots, a fruit rich in polyphenols. The physicochemical properties of black carrot juice were analyzed, and its fermentation process using Brewer's yeast (Saccharomyces cerevisiae) was evaluated. The quality of the resulting black carrot wine was assessed. A comprehensive evaluation encompassing physicochemical and sensory characteristics was conducted over intervals of 0, …

Antiviral activity of curcumin against Israeli acute paralysis virus in Apis mellifera: Screening and mechanistic study.

The Israeli acute paralysis virus (IAPV), widespread in honeybee (Apis mellifera) colonies, causes paralysis, tremors, and eventual mortality, while strongly associated with colony collapse disorder (CCD). Currently, there are no widely approved antiviral therapies for IAPV infection; however, several natural compounds have shown promising antiviral efficacy. In this study, we evaluated the effects of eight natural compounds (myrcene, citral, menthol, chlorogenic acid, resveratrol, curcumin, quercetin, and tea polyphenols) on IAPV-infected honeybees. Bees were artificially or naturally infecte…

Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches.

Diabetic retinopathy (DR) is a common and severe microvascular complication of diabetes, leading to vision impairment and blindness, particu … ls, and enhancing antioxidant defenses hold promise. Various natural antioxidant compounds, such as polyphenols (e.g., epigallocatechin-3-gallate, quercetin, resveratrol) and carotenoids (e.g., lutein, zeaxanthin), have demonstrated potential in reducing oxidative stress and improving retinal health in DR models. Moreover, activation of the Nrf2 and SIRT1 pat …

Influence of dietary components on the gut microbiota of middle-aged adults: the gut-Mediterranean connection.

BACKGROUND: A plant-focused, healthy dietary pattern, such as the Mediterranean diet enriched with dietary fiber, polyphenols, and polyunsaturated fats, is well known to positively influence the gut microbiota. Conversely, a processed diet high in saturated fats and sugars negatively impacts gut diversity, potentially leading to weight gain, insulin resistance, and chronic, low-grade inflammation. Despite this understanding, the mechanisms by which the Mediterranean diet impacts the gut microbiota and its associated health benefits remain unclear. METHODS: This retrospective, observational st…

On the road to sustainability - application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review.

The growing interest in green-synthesized metallic nanoparticles reflects a global shift toward sustainable, eco-friendly technologies in bi … ts, fungi, or bacteria, offers a sustainable alternative by leveraging natural reducing agents like polyphenols and flavonoids. These bioactive compounds not only facilitate nanoparticle formation but also improve stability and biological efficacy, making them ideal for dental applications such as caries prevention, endodontic disinfection, and periodontal re …

Botany, traditional uses, phytochemistry, pharmacology, processing, and applications of Cibotium barometz (L.) J. Sm.: A review.

Cibotium barometz (L.) J. Sm. (C. barometz), an ancient fern has a long history as a natural medicine in China, India, Vietnam, and other co … z have shown that over 100 compounds have been isolated from the plant, including phenylpropanoids, polyphenols, flavonoids, terpenoids, steroids, polysaccharides, and other compounds. Modern pharmacological studies have also confirmed that C. barometz has anti-osteoporosis activity, anti-microorganism activity, anti-osteoarthritis activity, anti-cancer activ …

Microbial Biotransformation of Chicory by Bacteroides fragilis: In Vitro Implications for Obesity-Related Psoriasis.

Obesity, a global health crisis, is linked to chronic low-grade inflammation and an increased risk of developing various chronic diseases, including psoriasis. Probiotics, postbiotics, and fermented foods have shown promise in combating inflammation and obesity. This study aimed to develop and characterize a chicory extract fermented with Bacteroides fragilis (C-B. fragilis) and its supernatant (phyto-postbiotic supernatant, PPS) as potential treatments for obesity, inflammation, and psoriasis. Polyphenols, organic acids, and amino acids were identified in the metabolic profile of C-B. fragili…

Design and synthesis of natural antibacterial derivatives for ocular tuberculosis: a comprehensive review.

Ocular tuberculosis (TB) is an underrecognized extrapulmonary manifestation of Mycobacterium tuberculosis (M. tuberculosis) infection that c … ed drug delivery. Phytochemicals such as, plant-derived alkaloids, flavonoids, terpenoids, quinone, polyphenols, and saponins offer promising antibacterial scaffolds, which can be optimized for ocular bioavailability and safety through structural modification, prodrug strategies, and hybridization with other bioactive moieties. Advanced drug delivery systems, …

Therapeutic impact of Citrus paradisi peel extract on muscular trichinellosis: an in vivo study.

Trichinellosis is a parasitic zoonosis caused by a nematode parasite of the Trichinella (T.) genus. It poses significant public health issues due to limited effective and safe treatment options, especially for the muscle-encysted larval stage. Citrus paradisi (C. paradisi), with its high content of flavonoids and polyphenols, has been recorded to possess anti-parasitic properties and numerous therapeutic applications. The present work aimed to assess the efficacy of C. paradisi extract peel extract as a therapeutic agent, either alone or combined with albendazole (ABZ), against T. spiralis in …

Mitochondrial-targeted injectable hydrogel for periodontitis therapy via oral immunity and flora regulation.

The therapy of chronic periodontitis poses a perennial challenge due to its intricate etiology, specific bacterial involvement, and the pres … ffectively mediates the targeted clearance of mitochondrial reactive oxygen species (mtROS) through polyphenols, restores mitochondrial function, and disrupts the free radical cycle of inflammation. As a microbiome modulator, it effectively suppressed pathogenic bacterial overgrowth, restored oral gingival microbiota balance in rats, and created a favorable s …

Formulation and evaluation of therapeutic antimicrobial citrus and Manuka honey creams with aloe vera, mint essential oil, and Indian costus.

Honey has long been recognized for its antimicrobial properties, attributed to components such as polyphenols and biodefense proteins. Among honey types, Manuka honey, rich in methylglyoxal, and citrus honey, abundant in flavonoids and bioactive enzymes, exhibit potent antimicrobial activity. This study aims to enhance the antimicrobial and antibiofilm efficacy of Manuka and citrus honey by incorporating natural additives-aloe vera, Indian costus, and mint essential oil-into cream formulations. Two emulsion types, aerosil fumed silica-based and arabic gum-based, were prepared and optimized usi…

Иммуно-питательная терапия в экспериментальном аутоиммунном энцефаломиелите: перевод в систему управления множественным склерозом.

Множественный склероз (MS) — хроническое аутоиммунное расстройство, характеризующееся дегенерацией миелин в центральной нервной системе (CNS), приводящее к значительным неврологическим расстройствам. Поражает примерно 2,8 миллиона человек во всем мире и имеет многофакторную аэтологию, связанную с генетической предрасположенностью и экологическими факторами, в частности с влиянием на питание. В настоящем обзоре рассматривается новая область иммунотерапии в качестве новаторского подхода к регулированию экспериментального аутоиммунного энцефаломиелита (EAE), широко признанного животного образца M

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disorder characterised by myelin degeneration in the central nervous system (CNS), leading t … We highlight the therapeutic potential of key nutritional components, such as omega-3 fatty acids, polyphenols, and vitamins A and D, which have been shown to modulate immune responses and promote neuroprotection. These nutrients exert their effects by regulating cytokine profiles, enhancing regulatory T-cell (Treg) differentiation, and maintaining blood-bra …

An introduction to antibacterial materials in composite restorations.

The longevity of direct esthetic restorations is severely compromised because of, among other things, a loss of function that comes from the … uld otherwise have in mouth rinses. This review focuses specifically on natural compounds, of which polyphenols are the most abundant category. The authors examined attempts at using these either as pretreatment or incorporated directly into restorative material as a step toward fulfilling a long-recognized need for restorations that can combat or prevent sec …

Visulization of peroxynitrite variation for accurate diagnosis and assessing treatment response of hepatic fibrosis using a Golgi-targetable ratiometric fluorescent probe.

Hepatic fibrosis (HF) is caused by persistent inflammation, which is closely associated with hepatic oxidative stress. Peroxynitrite (ONOO-) … used for ratiometric monitoring the Golgi ONOO- fluctuations and screening of ONOO- inhibitors from polyphenols in living cells. Meanwhile, using Golgi-PER as a probe, the overexpression of Golgi ONOO- in HF and the treatment response of HF to the screened rosmarinic acid were precisely visualized for the first time. Furthermore, the screened RosA has a remar …

Effects of natural products on angiogenesis in melanoma.

Melanoma is the most aggressive form of skin cancer and originates from genetic mutations in melanocytes. The disease is multifactorial, but … nowledge Infrastructure databases. According to summarizes 27 natural products including alkaloids, polyphenols, terpenoids, flavonoids, and steroids that effectively inhibit angiogenesis in melanoma. In addition to these there are 15 crude extracts that can be used as promising agents to inhibit angiogenesis, but their core components still deserve further i …

Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a prevalent health concern, encompassing a wide spectrum of liver-related disorders. Insulin resistance, a key pathophysiological feature of MASLD, can be effectively ameliorated through dietary interventions. The Mediterranean diet, rich in whole grains, fruits, vegetables, legumes, and healthy fats, has shown promising results in improving insulin sensitivity. Several components of the Mediterranean diet, such as monounsaturated fats and polyphenols, exert anti-inflammatory and antioxidant effects, thereby reduci…

New Insights into the Anti-Oomycete Mechanisms of a Leaf Extract from Glycyrrhiza glabra Against Pseudoperonospora cubensis.

Cucurbit downy mildew, caused by Pseudoperonospora cubensis, is responsible for high economic losses worldwide in cucumber production. Synth … nfestation rates were reduced between 73 and 96%. F1 contained three previously reported antifungal polyphenols: glabranin, pinocembrin, and licoflavanon. Here, we report an additional new compound, naringenin. Furthermore, F5 is found here to show some protective effects against P. cubensis, based on either direct fungicidal or indirect effects via the host …

Nutritional and bioactive properties and antioxidant potential of Amaranthus tricolor, A. lividus, A viridis, and A. spinosus leafy vegetables.

Climate change results in continuous warming of the planet, threatening sustainable crop production around the world. Amaranth is an abiotic … tent of iron, copper, sodium, boron, molybdenum, zinc, β-carotene and carotenoids, vitamin C, total polyphenols (TP), RSP (DPPH), and RSP (ABTS+) was determined in Amaranthus viridis (AV). On the other hand, A. spinosus (AS) was found to have the highest content of protein, fat, dietary fiber, manganese, molybdenum, and total flavonoids (TF). In A. tricolor ( …

Therapeutic potential of virgin coconut oil in mitigating sodium benzoate- model of male infertility: Role of Nrf2/Hmox-1/NF-kB signaling pathway.

OBJECTIVES: Male infertility is a major public health issue due to increased prevalence, so there is an urgent need for a therapeutic solution. The search for a natural dietary substance that could modulate redox balance and inflammation and protect testicular function is in demand. Virgin Coconut Oil (VCO) has found use in the treatment of diabetes, and cancer owing to the presence of polyphenols. However, there is a dearth of information on its effect on testicular toxicity. The present study investigated VCO as a possible treatment for testicular toxicity in the Sodium Benzoate (SB) model o…