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Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure.

BACKGROUND: Ischaemic heart disease including heart failure is the most common cause of death in the world, and the incidence of the conditi … 95% CI -0.67 to 0.04; participants = 1617; studies = 6; I2 = 76%; low-quality evidence) and by the Minnesota Living with Heart Failure Questionnaire (MD -0.51, 95% CI -0.78 to -0.24; participants = 1458; studies = 4; I2 = 0%; low-quality evidence) compared with usual care. Death due to pneumonia (N = 1, 3% of PAP group); cardiac arrest (N = 18, 3% of PAP g …

Chronic GVHD after steroid-sensitive, -dependent, and -refractory acute GVHD: incidence and clinical outcomes.

Chronic graft-versus-host disease (cGVHD) is a major limitation to the long-term success of allogeneic hematopoietic cell transplantation (HCT). Our prior study of acute GVHD (aGVHD) defined distinct treatment-response groups based on the response to first-line corticosteroids: steroid-sensitive (SS), steroid-resistant (SR), and steroid-dependent (SD) aGVHDs. We conducted a retrospective, single-institution, cohort study to assess the incidence, risk factors, and clinical outcomes of patients with cGVHD after a previous diagnosis of SS, SD, or SR aGVHD, compared with those with no history of a

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… This study was reviewed and approved by the University of Minnesota institutional review board. Data were retrieved from the UMN BMT database, with supplemental details extracted from the electronic health record. … Demographic and clinical characteristics of aGVHD response groups MDS, myelodysplastic syndrome; MN, Minnesota; MTX, methotrexate. …

Exercise-based cardiac rehabilitation for adults with heart failure.

BACKGROUND: People with heart failure experience substantial disease burden that includes low exercise tolerance, poor health-related qualit … dence) in the short term. Participation in ExCR likely improved short-term HRQoL as measured by the Minnesota Living with Heart Failure (MLWHF) questionnaire (lower scores indicate better HRQoL and a difference of 5 points or more indicates clinical importance; mean difference (MD) -7.39 points, 95% CI -10.30 to -4.77; 21 trials, 22 comparisons, 2699 partic …

Different Clinical Expression of Anxiety Disorders in Children and Adolescents: Assessment and Treatment.

BACKGROUND: Fearful and anxious behaviour is especially common in children, when they come across new situations and experiences. The differ … ears, evaluated with (General Anxiety Scale (GASC), and Eysenck Personality Questionnaire (EPQ). d) Minnesota Multiphasic Personality Inventory (MMPI) profiles obtained for General Anxiety Disorder in 20 young females and 15 males aged 25,7± 5,35 years, and a group with Panic attack syndrome N=15 aged 19,3±4,9 years are presented and discussed by comparison …

Surveillance for Violent Deaths - National Violent Death Reporting System, 27 States, 2015.

PROBLEM/CONDITION: In 2015, approximately 62,000 persons died in the United States as a result of violence-related injuries. This report sum … Colorado, Connecticut, Georgia, Hawaii, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virginia, and Wisconsin). NVDRS collates documents for each death and links deaths that are related (e.g., multipl …

Temporal variation in oral microbiome composition of patients undergoing autologous hematopoietic cell transplantation with keratinocyte growth factor.

IntroductionAutologous hematopoietic cell transplantation (AHCT) is a well-established treatment for lymphoma. Unintended effects of this therapy include oral mucositis (OM) and gastrointestinal toxicities, resulting in poor clinical outcomes. The gut microbiome has been previously linked to transplant toxicities among allogeneic recipients, but little is known about the effects of AHCT on the oral microbiome.MethodsSeven patients with non-Hodgkin or Hodgkin lymphoma undergoing AHCT with palifermin (keratinocyte growth factor) were included. Buccal swab samples were collected at baseline and 1

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… The study was approved by the Institutional Review Board at the University of Minnesota. DNA extraction and PCR amplification Swab tips were cut using flame-sterilized scissors and placed into PowerBead tubes (QIAGEN, Hilden, Germany). … The study was approved by the Institutional Review Board from the University of Minnesota. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication Not applicable. …

Medicaid Formulary Decisions and the Institute for Clinical and Economic Review: Abandoning Pseudoscience in Imaginary Pharmaceutical Pricing Claims.

Medicaid formulary committees and other gatekeepers face a difficult task. On the one hand they can utilize technical expertise in evaluating the real world evidence for clinical, quality of life and resource utilization claims for competing products while on the other hand they may be asked to assess claims built by simulation models for pricing and product access. A common option has been to take modeled claims from third parties such as the Institute for Clinical and Economic Review (ICER) at face value without challenging the model structure, its assumptions and its incremental cost-per-QA

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… Yet the model builders at the University of Minnesota proceed. … As a starting place, consideration could be given to the value assessment framework given in Version 3.0 of the Minnesota formulary submission guidelines 32 . …

Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.

BackgroundThe purpose of this study was to evaluate the activity of Selective Inhibitors of Nuclear Export (SINE) compounds that inhibit the function of the nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and perform a Phase I clinical trial of KPT-335 in dogs with spontaneous cancer to provide a preliminary assessment of biologic activity and tolerability.Methods and findingsCanine tumor cell lines derived from non-Hodgkin lymphoma (NHL), mast cell tumor, melanoma and osteosarcoma exhibited growth inhibition and apoptosis in response to nanomolar concentrations o

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… Clinical Trial Eligibility This clinical trial was approved by the Ohio State University (OSU) Veterinary Medical Center (VMC) Clinical Research Advisory Committee and the OSU IACUC; IACUC approval was also obtained at University of Minnesota and Texas A&M University. … The Clinical Investigation Center of the University of Minnesota College of Veterinary Medicine (Kathy Stuebner and Amber Winter) assisted with case management at the University of Minnesota; Mitzi Lewellen assisted with sample coordination and database management at the University of Minnesota. …

Real-World Evaluation of Talquetamab for the Treatment of Relapsed/Refractory Multiple Myeloma (RRMM): An International Myeloma Working Group Immunotherapy Registry Real-World Analysis.

Talquetamab is a GPRC5D × CD3 bispecific antibody approved for relapsed/refractory multiple myeloma (RRMM). This is the first real-world study to comprehensively report muco-cutaneous toxicities, infections, and efficacy of talquetamab in 151 patients across five countries with the longest follow-up reported enabling better efficacy and toxicity estimates. The median age was 64 years; high-risk cytogenetics were present in 42%; ECOG ≥ 2 in 22%; 12% had creatinine clearance < 30; and 55% would not have met MonumenTAL-1 eligibility. Patients received a median of 6 prior lines of therapy, 53% wer

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… Nadine Abdullah, Mayo Clinic, Rochester, Minnesota, USA Niels Abildgaard, Odense University Hospital, Odense C, DENMARK Ingerid Abrahamsen, Oslo University Hospital, Oslo, NORWAY Melissa Alsina, H. … Kaufman, Emory University School of Medicine, Atlanta, Georgia, USA Kihyun Kim, Samsung Medical Center and Sungkyunkwan University School of Medicine, Suwon, SOUTH KOREA Amrita Krishnan, City of Hope Medical Center, Newport Beach, California, USA Shaji Kumar, Mayo Clinic, Minnesota, USA Chara Kyriakou …

Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients.

BackgroundBoth human and veterinary cancer chemotherapy are undergoing a paradigm shift from a "one size fits all" approach to more personalized, patient-oriented treatment strategies. Personalized chemotherapy is dependent on the identification and validation of biomarkers that can predict treatment outcome and/or risk of toxicity. Many cytotoxic chemotherapy agents, including doxorubicin, base their mechanism of action by interaction with DNA and disruption of normal cellular processes. We developed a high-resolution/accurate-mass liquid chromatography-mass spectrometry DNA screening approac

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… Additionally, the authors would like to extend thanks to the nurses at the University of Minnesota Veterinary Medical Center who collected the blood samples from the patients, to Romel P. … Funding This research was funded in part by the University of Minnesota Small Companion Animal Grant awarded to KW. BZ is supported by the National Heart, Lung, and Blood Institute, grant 1R01HL151740, the St. …

Fertility preservation trends, perspectives, and reflections in gender diverse adults across the life course.

STUDY QUESTION: What is the fertility preservation (FP) utilization rate among transgender and gender diverse (TGD) patients at the Transgen … akers' fees for lectures or presentations from Mount Sinai, University of Washington, University of Minnesota, University of Rochester, Cincinnati University, the National Institutes of Health, Duke University, Wake Forest University, the Patient Centered Outcomes Research Institute, Johns Hopkins University; travel support from the Association for Clinical …

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years - Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022.

PROBLEM/CONDITION: Autism spectrum disorder (ASD). PERIOD COVERED: 2022. DESCRIPTION OF SYSTEM: The Autism and Developmental Disabilities Monitoring Network is an active surveillance program that estimates prevalence and characteristics of ASD and monitors timing of ASD identification among children aged 4 and 8 years. In 2022, a total of 16 sites (located in Arizona, Arkansas, California, Georgia, Indiana, Maryland, Minnesota, Missouri, New Jersey, Pennsylvania, Puerto Rico, Tennessee, Texas [two sites: Austin and Laredo], Utah, and Wisconsin) conducted surveillance for ASD among children a…

Identifying Body Awareness-Related Brain Network Changes after Cognitive Multisensory Rehabilitation for Neuropathic Pain Relief in Adults with Spinal Cord Injury: Delayed Treatment arm Phase I Randomized Controlled Trial.

BACKGROUND: Neuropathic pain after spinal cord injury (SCI) is notoriously hard to treat. Mechanisms of neuropathic pain are unclear, which … ier: NCT04706208. FUNDING: AIRP2-IND-30: Academic Investment Research Program (AIRP) University of Minnesota School of Medicine. National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR002494; the Biotechnology Research Center: P41EB015894, the National Institute of Neurological Disorders & Stroke Institu …

Surveillance for Sickle Cell Disease - Sickle Cell Data Collection Program, Two States, 2004-2018.

PROBLEM/CONDITION: Sickle cell disease (SCD), an inherited blood disorder affecting an estimated 100,000 persons in the United States, is as … ta source as probable cases. In 2019, nine states (Alabama, California, Georgia, Indiana, Michigan, Minnesota, North Carolina, Tennessee, and Virginia) were funded as part of an SCDC capacity-building initiative. The newly funded states developed strategies for SCD case identification and data linkage similar to those used by California and Georgia. As of 2 …

Exercise-based cardiac rehabilitation for adults with heart failure.

BACKGROUND: Chronic heart failure (HF) is a growing global health challenge. People with HF experience substantial burden that includes low … important improvement in short-term disease-specific health-related quality of life may be evident (Minnesota Living With Heart Failure questionnaire - 17 trials, 18 comparisons (1995 participants): mean difference (MD) -7.11 points, 95% CI -10.49 to -3.73; low-quality evidence). Pooling across all studies, regardless of the HRQoL measure used, shows there …

Osteoprotective Roles of Green Tea Catechins.

Osteoporosis is the second most common disease only secondary to cardiovascular disease, with the risk of fracture increasing with age. Osteoporosis is caused by an imbalance between osteoblastogenesis and osteoclastogenesis processes. Osteoclastogenesis may be enhanced, osteoblastogenesis may be reduced, or both may be evident. Inflammation and high reactive oxygen enhance osteoclastogenesis while reducing osteoblastogenesis by inducing osteoblast apoptosis and suppressing osteoblastic proliferation and differentiation. Catechins, the main polyphenols found in green tea with potent anti-oxida

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… The Minnesota Green Tea Trial was a 12-month randomized, double-blind, placebo-controlled clinical trial with 937 50–70 years old postmenopausal women to treated placebo or GTE containing 843 mg (−)-epigallocatechin-3-gallate [ 145 , 146 ]. … In the Minnesota Green Tea Trial, 800 mg EGCG daily was used for one year. It is unknown whether this dose is suitable for protecting bone health. …

Disparities in Preconception Health Indicators - 
Behavioral Risk Factor Surveillance System, 2013-2015, and Pregnancy Risk Assessment Monitoring System, 2013-2014.

PROBLEM/CONDITION: Preconception health is a broad term that encompasses the overall health of nonpregnant women during their reproductive y … told by a health care provider that they had hypertension ranged from 19.2% (Mississippi) to 7.0% (Minnesota). INTERPRETATION: Preconception health risk factors and health-promoting indicators varied by age group, race/ethnicity, insurance status, and reporting area. These disparities highlight subpopulations that might benefit most from interventions tha …

Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment.

There is considerable biologic plausibility to the hypothesis that genetic variability in pathways involved in insulin signaling and energy homeostasis may modulate dietary risk associated with colorectal cancer. We utilized data from 2 population-based case-control studies of colon (n = 1,574 cases, 1,970 controls) and rectal (n = 791 cases, 999 controls) cancer to evaluate genetic variation in candidate SNPs identified from 9 genes in a candidate pathway: PDK1, RP6KA1, RPS6KA2, RPS6KB1, RPS6KB2, PTEN, FRAP1 (mTOR), TSC1, TSC2, Akt1, PIK3CA, and PRKAG2 with dietary intake of total energy, car

Mayo Clinic Hematology Fellowship for Advanced Practice Providers.

Advanced practice providers (APPs), including nurse practitioners (NPs) and physician assistants (PAs), are part of a growing cancer care workforce. Current hematology-specific education provided by most graduate NP and PA school educations is limited. Mayo Clinic School of Health Sciences launched a hematology-specific fellowship in 2018 to provide APPs with the skills and knowledge required to deliver high-quality specialty care in hematology and blood and marrow transplant (BMT). The fellowship curriculum was developed based on a needs-based assessment study as well as the qualitative repor

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… The project included a retrospective review of the 5-year APP workforce data and a prospective web-based survey of current APP employees in hematology and BMT at three Mayo Clinic sites (Rochester, Minnesota; Scottsdale, Arizona; and Jacksonville, Florida). … They are fully licensed APPs with the privilege to prescribe and bill under the regulation by the State of Minnesota during the fellowship training. Upon completion of each rotation, the preceptors provide feedback and evaluate the clinical performance of the fellows. …