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New strategies and perspectives on managing IgA nephropathy.

IgA nephropathy is an inflammatory renal disease characterised by the deposition of IgA in the glomerular mesangium and is the most commonly reported primary glomerulonephritis worldwide. Thirty to forty percent of patients with the disease develop progressive renal function decline, requiring renal replacement therapy within two decades of diagnosis. Despite this, accurate individual risk stratification at diagnosis and predicting treatment response remains a challenge. Furthermore, there are currently no disease specific treatments currently licensed to treat the condition due to long standi

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… Maeng Y Kim M Park J Cho C Oh H Sung WJ Glomerular and tubular C4d depositions in IgA nephropathy: relations with histopathology and with albuminuria Int J Clin Exp Pathol 2013 6 5 904 910 23638222 PMC3638101 103. …

Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections.

Hepatitis B virus (HBV) infections affect approximately 296 million people around the world, and the prevalence of any past or present HBV infection during the years 2015-2018 was as high as 4.3%. Acute HBV infection often presents with nonspecific symptoms and is usually self-limited, but 5% of patients can have persistent infections leading to chronic HBV infection and the risk of turning into chronic HBV infection is significantly higher in babies with vertical transmission (95%). Patients with chronic HBV infection are usually asymptomatic, but 15 to 40% of chronic HBV carriers develop cir

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… Patients with HBV-MN present with massive proteinuria, often exceeding 3.5 g/day, due to podocyte injury and loss of membrane anionic charge, resulting in albuminuria. …

Carfilzomib in multiple myeloma: unraveling cardiac toxicities - from mechanisms to diagnosis and management.

The survival rates of patients with hematological malignancies such as multiple myeloma have improved with advances in cancer treatment. However, the risk of cardiovascular disease associated with novel therapeutic agents, including proteasome inhibitors (PIs), is becoming increasingly evident. PIs act on proteasome peptidases, leading to cell cycle arrest or apoptosis. Carfilzomib (CFZ), an intravenously administered irreversible PI, exhibits pronounced cardiovascular toxicity that is characterized by heart failure, hypertension, arrhythmia, and ischemic heart disease (IHD). This review focus

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… Estimated glomerular filtration rate, albuminuria, and adverse outcomes: an individual-participant data meta-analysis . Jama 330 ( 13 ), 1266 – 1277 . 10.1001/jama.2023.17002 37787795 PMC10548311 Gregersen H. Peceliunas V. Remes K. Schjesvold F. Abildgaard N. Nahi H. ( 2022 ). …

Kidney Disease and Hematopoietic Stem Cell Transplantation.

Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for patients with hematologic malignancies and certain solid tumors and nonmalignant hematologic conditions. Both AKI and CKD occur commonly after HSCT and are associated with significant morbidity and mortality. AKI and CKD in this setting may result from direct effects of the transplant or be caused by pretransplant bone marrow conditioning regimens and/or nephrotoxic agents administered in the post-transplant period. In this article, we review the epidemiology, risk factors, etiologies, pathophysiology, diagnos

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… acute TA-TMA • Anemia • High LDH • Low eGFR Definitive • Kidney biopsy CNI nephropathy | After 3 mo | • Progressive kidney failure • Hypertension • Proteinuria | • Chronic CNI therapy • Exclusion of other causes (infections, glomerular disease) • Kidney biopsy (confirmation) NS | Median 20.5 mo | NS • Albuminuria …

Clinical approaches to osteoporosis in patients with chronic kidney disease: A comprehensive review.

Chronic kidney disease (CKD) induces secondary osteoporosis, characterized by an imbalance between bone formation and resorption due to kidney dysfunction; the result is a reduction in both bone mineral density and quality. This condition is compounded by disruption of bone metabolic turnover, abnormalities in bone microstructure and collagen cross-linking, and compromised bone quality, all of which contribute to increased bone fragility. Reduced kidney function is complicated by secondary hyperparathyroidism, which exacerbates bone fragility. Managing osteoporosis in patients with CKD is chal

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… In particular, proteinuria (urinary protein levels >0.15 g/gCr, or albuminuria >30 mg/gCr) is considered significant. …

Immunotherapeutic approaches for systemic lupus erythematosus: early overview and future potential.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Current SLE therapies include immunosuppressants, antimalarial drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids, but these treatments can cause substantial toxicities to organs and may not be effective for all patients. In recent years, significant progress has been made in the treatment of SLE using immunotherapy, including Benlysta and Saphnelo. These advances in immunotherapy hold promise for SLE patients, providing new therapeutic options that may offer better clinical benefit and effectiveness. S

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… Additionally, the clinical beneficial effects including reduced albuminuria level were observed in refractory LN patients who had RTX infusion reaction after treatment with ofatumumab at a dose of 700 mg two weeks apart [ 57 ]. …

What the Intensivists Need to Know About Critically Ill Myeloma Patients

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… MIDD is most commonly kappa subtype, while AL amyloidosis tends to be lambda; both tend to be associated with predominant albuminuria unlike cast nephropathy. …

Selected abstracts from the XXXVIII National Congress of the Italian Society of Hypertension (SIIA)

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POSTER PRESENTATIONS

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Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.

The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The "coagulome" as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis. Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbio

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… Moreover, a direct relation was observed between platelet-derived extracellular vesicles and the degree of albuminuria in these patients. 65 Subsequent mechanistic studies in a mouse model for diabetic nephropathy demonstrated that the platelet P2Y12 inhibitor ticagrelor could counteract disease progression … by lowering albuminuria, mesangial matrix expansion, macrophage infiltration, and fibrosis. 66 Future studies with selective platelet inhibitors such as GLP-1 analogues 67 could well augment our therapeutic options in progressive ischemia-associated diseases of the kidney. …

The Role of Irisin and Physical Activity in Breast Cancer.

BACKGROUND/AIM: Irisin, a myokine released during physical activity, has been proposed as a mediator of exercise's protective effects against breast cancer (BC). This review underscores the critical role of irisin in mediating the anticancer effects of exercise and its potential application in BC prevention and prognosis. MATERIALS AND METHODS: Studies published up to 2025 were identified in PubMed, Scopus, and Web of Science databases. Data from experimental models, clinical trials, and observational studies were analyzed with emphasis on exercise-induced irisin secretion and its effects on

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… Based on ELISA measurements, serum mean Ir levels increased with the severity of albuminuria in T2DM patients. This ranges irisin as a candidate biomarker ( 166 ), but assay variability means its predictive/clinical utility remains unvalidated. …

Membranous nephropathy: pathogenesis and treatments.

Membranous nephropathy (MN), an autoimmune disease, can manifest at any age and is among the most common causes of nephrotic syndrome in adults. In 80% of cases, the specific etiology of MN remains unknown, while the remaining cases are linked to drug use or underlying conditions like systemic lupus erythematosus, hepatitis B virus, or malignancy. Although about one-third of patients may achieve spontaneous complete or partial remission with conservative management, another third face an elevated risk of disease progression, potentially leading to end-stage renal disease within 10 years. The i

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… clinical symptoms MN, is a chronic progressive kidney disease that usually has an insidious onset and is asymptomatic in the early stages or with only slight limb edema. 117 , 118 The clinical symptoms of most adult patients, whether primary or secondary MN, present mostly nephrotic syndrome, including albuminuria …

Фармакологическая модуляция CXCL12/CXCR4/ACKR3 для нейродисфункций — обзор.

Аксис CXCL12/CXCR4/ACKR3 является важным для развития и гомеостаза мозга. Нарушение регуляции CXCL12 или его рецепторов связано с различными расстройствами ЦНС, связанными с нарушениями нейропластичности, нейроинфляцией, нейродегенерацией и опухолями мозга. Эта сигнальная система представляет собой привлекательную целевую точку для терапии, и значительные усилия привели к разработке и применению специфических фармацевтических модуляторов для нейропатологий. Хотя фармацевтическая модуляция CXCR4 в последние десятилетия была активно изучена, целевой ACKR3 только недавно выделилась как критически

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… Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia. 2009;52(11):2445–54. 10.1007/s00125-009-1493-6. 71. D. C. E, et al. …

Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system.

ObjectiveThe objective of this study was to describe the prevalence of obesity, obesity-related conditions (ORCs), and antiobesity medication (AOM) eligibility and prescribing practice among eligible patients in a large health care system.MethodsIn this cross-sectional analysis of the multicenter Mass General Brigham health care system (Boston, Massachusetts) spanning 2018 to 2022, adults eligible for AOMs (BMI ≥ 30 kg/m2 or BMI 27-29.9 kg/m2 with ≥1 ORC) were identified. Among those AOM-eligible, the prevalence of prescriptions for AOMs approved for long-term weight management was evaluated.R

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… Effects of semaglutide on albuminuria and kidney function in people with overweight or obesity with or without type 2 diabetes: exploratory analysis from the STEP 1, 2, and 3 trials . …

The Application of Aptamer and Research Progress in Liver Disease.

Aptamers, as a kind of small-molecule nucleic acid, have attracted much attention since their discovery. Compared with biological reagents such as antibodies, aptamers have the advantages of small molecular weight, low immunogenicity, low cost, and easy modification. At present, aptamers are mainly used in disease biomarker discovery, disease diagnosis, treatment, and targeted drug delivery vectors. In the process of screening and optimizing aptamers, it is found that there are still many problems need to be solved such as the design of the library, optimization of screening conditions, the tr

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… Menne J, Eulberg D, Beyer D, Baumann M, Saudek F, Valkusz Z, Więcek A, Haller H, Emapticap Study Group C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria. Nephrology Dialysis Transplantation. 2017;32(2):307–315. doi: 10.1093/ndt/gfv459. 54. …

Effects of Expanded Hemodialysis with Medium Cut-Off Membranes on Maintenance Hemodialysis Patients: A Review.

Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most prevalent modality of renal replacement therapy, uses the principle of semipermeable membranes to remove solutes and water in the plasma of patients with kidney failure. With the evolution of hemodialysis technology over the last half century, the clearance of small water-soluble molecules in such patients is adequate. However, middle molecules uremic toxins are still retained in the plasma and cause cardiovascular events, anemia, and malnutrition, which significantly contribute to poor quality of life and h

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… Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin. J. Am. Soc. Nephrol. 2012;7:1938–1946. doi: 10.2215/CJN.03500412. 77. Modaresi A., Nafar M., Sahraei Z. Oxidative stress in chronic kidney disease. Iran. J. Kidney Dis. 2015;9:165–179. 78. …

Экстракорпоральные стратегии свободного освещения и гемоглозы в эпоху эффективной антимиеломной терапии.

Повреждение реналов затрагивает до половины пациентов с недавно поставленным диагнозом множественной миеломы, и примерно 2-4% из них требуют диализа при презентации, чаще всего из-за нефропатии легкой цепи. У этих пациентов восстановление почек связано со скоростью и величиной сокращения свободных световых цепей (SFLC) в наблюдательных группах - ассоциации, которая в основном отражает гематологическую реакцию на химиотерапию; постепенное преимущество удаления циркулирующих SFLC с помощью экстракорпоральных средств остается неопределенным, и эта повествование построена вокруг этого вопроса в ны

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… The IMWG recommendations incorporate this diagnostic distinction; a renal biopsy should be considered in the presence of non-selective proteinuria with prominent albuminuria, or when involved sFLC concentrations are relatively low (e.g., <500 mg/L). …

Amyloids and the Heart: An Update.

Amyloids consist of fibrils that can be formed by a large variety of different precursor proteins. In localized amyloidosis, amyloids accumulate at the production site with a single organ being affected, whereas in systemic amyloidosis several organs are affected, with the heart being the most common, followed by the kidneys, liver, and the nervous system. The two most frequent systemic amyloidosis types affecting the heart in the vast majority (>95%) of cases are immunoglobulin light chain (AL) amyloidosis and transthyretin (TTR) amyloidosis (ATTR amyloidosis). Patients with amyloid cardiopat

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… Albuminuria or alkaline phosphatase should also be determined in AL amyloidosis due to the frequent involvement of kidneys and liver. 3.3. …

Aptamer Therapeutics in Cancer: Current and Future.

Aptamer-related technologies represent a revolutionary advancement in the capacity to rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA oligonucleotides, aptamers mimic small, protein-binding molecules and exhibit high binding affinity and selectivity. Although their molecular weight is relatively small-approximately one-tenth that of monoclonal antibodies-their complex tertiary folded structures create sufficient recognition surface area for tight interaction with target molecules. Additionally, unlike antibodies, aptamers can be readily chemically synthesize

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… Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes Diabetologia 2009 52 2445 2454 10.1007/s00125-009-1493-6 19707743 162. Marasca R. Maffei R. …

Evolution of Molecular Targeted Cancer Therapy: Mechanisms of Drug Resistance and Novel Opportunities Identified by CRISPR-Cas9 Screening.

Molecular targeted therapy has revolutionized the landscape of cancer treatment due to better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a major challenge in clinical settings that hinders continuous clinical benefits for cancer patients. In this regard, unraveling the mechanisms of drug resistance may identify new druggable genetic alterations for molecularly targeted therapies, thus contributing to improved therapeutic efficacies. The recent rapid development of novel methodologies including CRISPR-Cas9 screening technology and patient-derived models

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… The Relationship Between Neutrophil-to-Lymphocyte Ratio and Albuminuria in Type 2 Diabetic Patients: A Pilot Study . Arch Med Sci ( 2016 ) 12 ( 3 ): 571–5 . doi: 10.5114/aoms.2016.59931 PMC4889692 27279850 147 Lovly CM Shaw AT . …