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'Targeted top down' approach for the investigation of UTI: A 10-year follow-up study in a cohort of 1000 children.

INTRODUCTION: Investigations following urinary tract infection (UTI) aim to identify children who are prone to renal scarring, which may be … current UTIs; three underwent endoscopic treatment of VUR; one had a PUV resection; one underwent a cystoscopy; three had a pyeloplasty for pelvi-ureteric junction obstruction; and one had a ureteric reimplantation for vesico-ureteric junction obstruction. After initial investigations and management, 936 patients were discharged from the UTI clinic: 47 of th …

Polypoid/papillary cystitis: a series of 41 cases misdiagnosed as papillary urothelial neoplasia.

Polypoid cystitis and its more chronic phase papillary cystitis, which results as a reaction to injury to the bladder mucosa, is a benign le … after bladder/ureter carcinoma treatment, long-term urinary stents, and colovesicular fistulas. At cystoscopy, lesions were variably described as polypoid, trabeculations, bullous polyps, and diffuse erythema and edema. The locations of polypoid cystitis were bladder (n=34), ureteral orifice (n=2), urethra (n=2), renal pelvis (n=2), and undesignated (n=1). …

Paclitaxel-hyaluronic acid for intravesical therapy of bacillus Calmette-Guérin refractory carcinoma in situ of the bladder: results of a phase I study.

PURPOSE: Carcinoma in situ represents high grade anaplasia of the bladder mucosa. Intravesical immunotherapy with bacillus Calmette-Guérin is the gold standard treatment for patients with carcinoma in situ. Patients with carcinoma in situ refractory to bacillus Calmette-Guérin are candidates for major surgery such as radical cystectomy. We identified the maximum tolerated dose and the recommended dose, and evaluated the safety profile of paclitaxel-hyaluronic acid bioconjugate given by intravesical instillation to patients with carcinoma in situ refractory to bacillus Calmette-Guérin. MATERIA

Давление может быть серьезно повышено при инъекции детруса ботулиновым токсином А.

ВВЕДЕНИЕ: Токсин ботулинового токсина А (BONT/A-DI) используется у пациентов с избыточным мочевым пузырем (OAB) или нейрогеническим мочевым пузырем в результате множественных склерозов (MS) или повреждения спинного мозга. Эта процедура, как правило, проводится под местной анестезией. Мы изучили влияние BONT/A-DI на кровяное давление, наиболее важный автономный параметр для бодрых пациентов, в качестве потенциального фактора риска сердечно-сосудистых заболеваний.МАТЕРИАЛ & МЕТОДЫ: Пациенты с OAB или спонтанно опустошающие с нейрогенной детрозной активностью (NDO) из-за MS, в которых BONT/A-DI п

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… Cystoscopy was then performed with a rigid 21 Char. Instrument from Wolf Endoscopes (Richard Wolf GmbH, Knittlingen, Germany). The injection needles varied and were marginally different in needle size and length (22–27 gauge, 4–5 mm needle length). …

Unusual Prostate-Specific Membrane Antigen (PSMA) Splenic Uptake in a Patient With Prostate Cancer.

There are many benefits to early detection of prostate cancer, including improved survival rates, less invasive treatment options, and better quality of life. Apart from traditional tests and imaging (including the prostate-specific antigen (PSA) test, digital rectal exam, biopsy, computed tomography (CT), and magnetic resonance imaging (MRI)), an imaging technique called prostate-specific membrane antigen positron emission tomography (PSMA PET) is more specific and sensitive, targeting PSMA expressed by prostate cancer cells on their surface. This case report describes a 62-year-old male with

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… MRI = magnetic resonance imaging The patient underwent cystoscopy, urethral dilation, and MRI fusion prostate biopsies. …

Unusual case of amyloidosis presenting as a jejunal mass.

Amyloidosis constitutes a heterogeneous group of disorders of protein misfolding that can involve different organ systems. The disease can occur either in a systemic or localised manner that is well known to involve the gastrointestinal (GI) tract. GI amyloidosis can present with a wide range of symptoms including diarrhoea, bleeding and obstruction. This case illustrates a patient with localised jejunal amyloid light chain disease that was diagnosed serendipitously during a workup for haematuria. Our patient was otherwise asymptomatic, but this case underscores the importance of considering a

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… Outcome and follow-up At a 2-week follow-up, he was again treated for a urinary tract infection and had a normal cystoscopy. …

Case report: Immune-mediated meibomian gland dysfunction following pembrolizumab therapy for advanced urothelial carcinoma.

Ocular immune-related adverse events are a relatively rare complication of immune checkpoint inhibitors. Common ocular toxicities range from dry eyes to inflammatory uveitis and ocular myasthenia gravis. Here, we present the case of a 55-year-old woman with recurrent urothelial carcinoma of the ureter after initially being managed with neoadjuvant cisplatin-based chemotherapy and surgical resection. She was treated with pembrolizumab which was complicated by immune-mediated pneumonitis after the eighth cycle, which was managed with a prolonged steroid course. The patient also developed red eye

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… She underwent cystoscopy which identified tumor arising from the right ureteral orifice. …

DNA Methylation Cancer Biomarkers: Translation to the Clinic.

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with focal hypermethylation of numerous 5'-cytosine-phosphate-guanine-3' (CpG) islands, often spanning gene promoters and first exons. Many of these epigenetic changes occur early in tumorigenesis and are highly pervasive across a tumor type. This allows DNA methylation cancer biomarkers to be suitable for early detection and also to have utility across a range of areas relevant to cancer detection and treatment. Such tests are also simple in

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… The gold standard for diagnosis is cystoscopy and cytology; urinary tests have yet to achieve comparable specificity or sensitivity. However, monitoring for recurrence could be safer and cost effective if the non-invasive test had a high NPV ( Witjes et al., 2018 ). … AssureMDx™ for Bladder Cancer (MDxHealth) is a urine assay that excludes bladder cancer diagnosis based on a negative result (99% NPV), leading to 77% reduction in diagnostic cystoscopies, resulting in lower diagnostic costs and reduced patient burden ( van Kessel et al., 2017 ). …

Редкий случай конъюнктурного уринотракса и миэломатного плеурального эфлюмилия.

ВВЕДЕНИЕ: миэломатное плевральное эфилирование (МПЭ) представляет собой редкое осложнение множественной миеломы, происходящее в < 1% - случаи, связанные с плохим прогнозом. Еще одной редкой причиной плевральной эфлуции является утечка мочи в плевральную полость, как правило, из-за обструктивной урпатии или травмы. Несмотря на то, что оба условия в индивидуальном порядке являются редкими, об их параллельных случаях ранее не сообщалось. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: 81-year-old У человека с рецидивированной множественной миеломой были диспнея, гематурия и острая почечная недостаточность. Воображение вы

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… Cystoscopy was done that showed an inflamed bladder with old clots, but no active bleeding or visible tumors were identified. …

Metastatic primary duodenal adeno-carcinoma responding to metronomic oral cyclophosphamide chemotherapy.

Primary adenocarcinoma of duodenum is a very rare tumour with a prevalence of only 0.3 to 1% of among all the tumours of gastrointestinal tracts. Localised tumours, if resected have good prognosis but those with metastates entails a poor prognosis, where generally palliation may be the only feasible option. Low dose continous cytotoxic treatment or metronomic chemotherapy prevents neoangiogenesis and chemoresistance thereby, provides excellent symptom relief and palliation in many advanced heavily pretreated solid malignancies. It offers as an affordable, less toxic therapy with moderate to go

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… The only toxicity the above patient experienced was mild dysuria, however, on cystoscopy revealed no obvious abnormality. Hence, maintenance of such a therapy after initiation by an oncologist can be undertaken by a palliative care physician. …

Photodynamic versus white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer: PHOTO RCT.

BACKGROUND: Around 7500 people are diagnosed with non-muscle-invasive bladder cancer in the UK annually. Recurrence following transurethral … S: Photodynamic diagnosis-guided transurethral resection of bladder tumour and standard white-light cystoscopy transurethral resection of bladder tumour. MAIN OUTCOME MEASURES: The primary clinical outcome measure was the time to recurrence from the date of randomisation to the date of pathologically proven first recurrence (or intercurrent bladder cancer d …

Myelomatous ascites and pleural effusion in relapsed multiple myeloma.

Extramedullary multiple myeloma is seen in advanced and aggressive disease and occurs due to plasma cell infiltration of sites other than the bone marrow. Myelomatous ascites or pleural effusion is seen in less than 1% of cases and can be differentiated from infectious etiologies based on fluid cytology.

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… Concurrently, his serum creatinine levels rose dramatically from 0.86 to 2.63 mg/dl and evolved to acute renal insufficiency necessitating a cystoscopy to place a ureteral stent. …

Developments in Point-of-Care Diagnostic Technology for Cancer Detection.

Cancer is the cause of death for one in seven individuals worldwide. It is widely acknowledged that screening and early diagnosis are of vital importance for improving the likelihood of recovery. However, given the costly, time-consuming, and invasive nature of the many methods currently in use, patients often do not take advantage of the services available to them. Consequently, many researchers are exploring the possibility of developing fast, reliable, and non-invasive diagnostic tools that can be used directly or by local physicians at the point-of-care. Herein, we look at the use of estab

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… | Cancer Biomarker | POC Device | Clinical Capabilities | Test Duration | Sample | Company Prostate | PSA | PSA Semi-quantitative rapid test | 4 ng/mL | 15 min | WB, S or P | CTK Biotech Bladder | Nuclear matrix protein 22 (NMP 22) | Alere NMP22 ® BLADDERCHEK ® | 99% Sensitivity when combined with cystoscopy … For bladder cancer diagnosis, to improve upon the gold-standards of cytology (which suffers from low sensitivity) and cystoscopy (which is an uncomfortable invasive procedure), researchers are developing a microfluidic device to isolate and examine exosomes present in urine [ 27 ]. …

Post-sampling mortality and non-response patterns in the English Cancer Patient Experience Survey: Implications for epidemiological studies based on surveys of cancer patients.

BackgroundSurveys of the experience of cancer patients are increasingly being introduced in different countries and used in cancer epidemiology research. Sampling processes, post-sampling mortality and survey non-response can influence the representativeness of cancer patient surveys.MethodsWe examined predictors of post-sampling mortality and non-response among patients initially included in the sampling frame of the English Cancer Patient Experience Survey. We also compared the respondents' diagnostic case-mix to other relevant populations of cancer patients, including incident and prevalent

Bladder preservation in non-metastatic muscle-invasive bladder cancer (MIBC): a single-institution experience.

The aim of this study is to access the feasibility, toxicity profile, and tumour outcome of an organ preservation curative approach in non-metastatic muscle-invasive bladder cancer. A retrospective analysis was conducted on patients affected by M0 bladder cancer, who refused cystectomy and were treated with a curative approach. The standard bladder preservation scheme included maximal transurethral resection of bladder tumour (TURBT) and combination of radiotherapy and platin-based chemotherapy, followed by endoscopic evaluation, urine cytology, and instrumental evaluation. Thirteen patients f

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… Two months after the completion of chemoradiotherapy, endoscopic evaluation (cystoscopy or TURBT), and urine cytology were performed. During concomitant chemoradiotherapy, none of the patients developed acute G3–G4 urinary or gastroenteric toxicity. …

Healthcare Resource Utilization and Cost Burden of BCG-Treated Non-Muscle Invasive Bladder Cancer Patients in Germany: A Retrospective Claims Analysis.

BackgroundIntermediate and high-risk non-muscle-invasive bladder cancer (NMIBC) is typically managed with transurethral resection of the bladder tumour (TURBT) followed by intravesical Bacillus Calmette-Guérin (BCG) immunotherapy; however, NMIBC patients can become refractory or unresponsive to BCG treatment, and/or progress to muscle-invasive bladder cancer (MIBC). Healthcare resource utilization (HCRU) and costs in these patient populations are high.MethodsA retrospective longitudinal cohort design of adult (≥18 years) patients with bladder cancer and BCG treatment (01/01/2012-31/12/2017) wa

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… Introduction Bladder cancer (BC) is the most frequently occurring malignancy of the urinary tract. 1 The main symptom of BC is haematuria, and the disease is diagnosed by a cystoscopy, and biopsy confirmed by a transurethral resection of the bladder tumour (TURBT). 2 , 3 BC can be divided into muscle-invasive …

Твердая неэптическая гипераммония, связанная с уреаплазмой парвума и инфекциями гомини Микопласмы в двойном иммунозапугивании женщины, представляющей как предполагаемый перитональный карциноматоз.

Острая гипераммония, не связанная с гепатической гипераммонией, является редким, но потенциально опасным для жизни заболеванием у пациентов, страдающих иммунокомпромиссной болезнью. Виды Ureaplasma и Mycoplasma являются быстродействующими врожденными организмами, которые генерируют аммиак и могут вызывать распространенную культурно-отрицательную инфекцию. Мы сообщаем о случае 63-year-old Женщина, получающая двойную биологическую терапию, оклелизумаб от множественных склерозов и секукинуумаб от псориаза, которая имела историю стерильности пюрии и симптомов мочи ниже. В течение двух месяцев ее с

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… She underwent cystoscopy and left ureteral stent placement; diffuse erythema of the bladder wall was noted intraoperatively, and renal pelvic urine was sterile. Her condition did not improve, and she developed bilious vomiting, food intolerance, and rising inflammatory markers. …

Царская нейромодия для нейрогенного Нижнего Уринарного тракта, Боул и Сексуальная дисфункция у пациентов с множественным склерозом: экспериментальное испытание.

АИСЮ: Мы представляем результаты two- Экспериментальное исследование с применением огнестрельного оружия для оценки целесообразности проведения двухзвукового выборочного контролируемого испытания (РКТ) с целью оценки эффективности нейромодуляции (СНМ) у пациентов с множественным склерозом (МС), страдающих нейрогеническим расстройством нижних мочевых путей (НЛУТД). МЕТОДЫ: Учитываемые темы с рефрактным NLUTD и EDS < 5 Прошла стадию испытания SNM. Те, кто показывают больше, чем 50% - усовершенствование переменных мочевого пузыря, получение имплантируемых импульсных генераторов (ИПГ) и произвольн

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… Eligible subjects underwent a complete neuro‐urological investigation including a 3‐day bladder diary (BD), questionnaires of patient related outcome measures (PROMs), uroflowmetry, post‐void residual measurement (PVR), cystoscopy and imaging of the kidneys to assess baseline characteristics ( Baseline …

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research

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… Cystoscopy | Not available | A cystoscope is inserted into the urethra to visualize the lower urinary tract. | Effective in identifying prostatic enlargement, urethral and bladder inflammation, and some urological cancers, but this method is not available for mice. … There is a distinction between histological and clinical prostatitis: histological prostatitis is identified in histological tissue sections, while clinical prostatitis is diagnosed by physical examination, urinalysis, imaging, cystoscopy, or patient questionnaire (for example, The National Institute …

The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review.

The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial thromboembolism (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent useful hints for a comprehensive review of the thrombotic issue. A 75-year-old man with advanced rectal cancer treated with fluoropyrimidines suffered two catheter-related VTE events managed according to current guidelines. There was no indication for "extended" anticoagulant therapy for him, but during antithrombotic wash-out and fluoropyrimidines

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… In August 2018, due to positive urine cytology, the patient underwent a bladder cystoscopy, which documented a bulky lesion on the posterior wall of the bladder, subsequently resected using TURB. …