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Регулирующие расстройства и качество жизни у пациентов с травматологической и трахеотической каннулой: обзор.

ВВЕДЕНИЕ: Операция по Трахеостомии (TCT) и последующее включение трахеиальной каннулы (TC) сопряжены с рядом физических, коммуникативных и психологических изменений для пациента. В этих клинических ситуациях часто наблюдаются такие расстройства настроения и расстройства, как болезненное беспокойство, депрессия и стресс, что сказывается на качестве жизни (QoL) и процессе реабилитации. Цель этого обзора состоит в изучении исследований, содержащихся в литературе по расстройствам регулирования (АЖД) у пациентов с ТХТ или ТЦ, и того, как это влияет на их QOL в ходе процесса реабилитации. МЕТОДЫ: Ис

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… In Minnesota, USA, sedative medication use increased significantly post‐TCT ( p < 0.001) (Breckenridge et al. 2014 ). In Germany, TCT was associated with longer ICU stays ( p < 0.001) (Blecha et al. 2020 ). … Paul, Minnesota urban area. Country: United States. | To assess whether the placement of TCT lessens anxiety levels in critically ill patients on MV. …

The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.

BACKGROUND: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. METHODS: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardi

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… Cardiac Arrhythmias and Electrocardiographic Abnormalities Arrhythmias and other ECG abnormalities will be based on serial ECGs using Minnesota Code definitions,[ 47 ] which have been used in epidemiological studies and have direct clinical applicability. … Classification of the electrocardiogram for population studies: Minnesota Code. J Electrocardiol. 1969;2(3):305–310. doi: 10.1016/S0022-0736(69)80120-2. Berger K, Ajani UA, Kase CS, Gaziano JM, Buring JE, Glynn RJ, Hennekens CH. …

Identifying Patients With Asymptomatic Hyperparathyroidism by Serum Calcium and Vitamin D Screening in West Bengal, India.

BACKGROUND: Primary hyperparathyroidism (PHPT) is the leading cause of hypercalcemia, with solitary parathyroid adenoma responsible for most cases. Many patients with hyperparathyroidism remain asymptomatic, but early detection and parathyroidectomy can prevent complications such as nephrolithiasis, pancreatitis, and bone and kidney disorders. This study emphasizes the importance of screening for asymptomatic hyperparathyroidism to enable timely intervention. METHODS: Serum calcium and Vitamin D3 levels were screened in 6000 outpatients between March 2021 and September 2022. Patients with kno

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… Global Prevalence and Trends Wermers et al. [ 28 ] conducted a population-based study in Rochester, Minnesota, highlighting a declining incidence of symptomatic PHPT cases alongside a rise in mild and asymptomatic presentations. … JT Jr Fuleihan Gel-H 5353 5361 87 2002 12466320 10.1210/jc.2002-021370 27 Serum calcium survey for hyperparathyroidism: results in 50,000 clinic patients Am J Clin Pathol Boonstra CE Jackson CE 523 526 55 1971 5090209 10.1093/ajcp/55.5.523 28 Incidence of primary hyperparathyroidism in Rochester, Minnesota …

Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies.

Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin-like receptors, NK Group 2 member D (NKG2D), NKG2A/CD94, NKp46, and others, and recognize both foreign and self-antigens expressed by NK-susceptible targets. Recent insights into NK-cell developmental intermediates have translated into a more accurate definition of culture conditions for the in vitro generation and propagation of human NK cells

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… Recently, two GMP-grade NK cells products manufactured at different production assistance for cellular therapies (PACT) facilities were evaluated for homing characteristics, i.e., freshly activated (FA)-NK, used by the Minnesota group, and ex vivo -expanded (Ex)-NK, developed by the Baylor College of … HSCT; phase II | Recruiting | Masonic Cancer Center, University of Minnesota | NCT01370213 6 | CML | NK cells and non-myeloablative HSCT; phase II | Completed (11/14) | M.D. …

Causes of Anemia in Patients Seen in a Rural Community Hematology Clinic.

IntroductionAnemia is a common medical disorder seen in consultation by hematologists. This study was performed to determine the incidence of the etiologies causing anemia in patients referred to the hematologists at Tammy Walker Cancer Center (TWCC) in the rural Kansas community of Salina. An additional goal of the study was to compare the frequencies of different etiologies for anemia in this cohort of patients with those previously reported by four academic medical centers.MethodsA retrospective review of the medical records of 152 patients seen at TWCC between August 2015 and May 2019 was

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… a known hematologic malignancy, cancer chemotherapy, or radiation therapy completed within the previous six months, reported 44% of patients had unexplained anemia after a hematologic workup. 7 Finally, in a study by Ania et al. 8 , the cause of 16% of the anemia in men and women of Olmsted County, Minnesota … Ania et al. 8 | Individuals in Olmstead County, Minnesota older than 65 years old with newly recognized cases of anemia during 1986. Table 6 Comparison of the etiologies of anemia. …

Public parks and physical activity among adolescent girls.

OBJECTIVES: Physical activity may be constrained or facilitated by local environments. The availability of neighborhood facilities for physi … 6 field site areas: Washington, DC, and Baltimore, Maryland; Columbia, South Carolina; Minneapolis, Minnesota; New Orleans, Louisiana; Tucson, Arizona; and San Diego, California. Girls wore accelerometers for 6 days to measure metabolic equivalent-weighted moderate-to-vigorous physical activity, a measure accounting for the volume and intensity of activity. …

Oncolytic viruses on the cusp of success?: proceedings of the 9th International Conference on Oncolytic Virus Therapeutics

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… Masato Yamamoto (University of Minnesota, Minneapolis) screened an Ad library of peptide ligands in the fiber knob and identified a mesothelin-targeted motif (VITNxxx) for pancreatic cancer and a CD133 motif (TYMLxxx) to target cancer stem cells. … Julia Davydova (University of Minnesota, Minneapolis) described an oAd expressing sodium iodine symporter (NIS) that allows infected cancer cells to be imaged with 123 I or killed with 131 I. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 32 States, 2016.

PROBLEM/CONDITION: In 2016, approximately 65,000 persons died in the United States as a result of violence-related injuries. This report sum … orgia, Hawaii, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, and Wisconsin). NVDRS collates information for each death and links deaths tha …

Peritoneal Amyloid as a Presenting Manifestation of AL Amyloid.

Amyloid is a systemic disease characterized by extracellular deposition of misfolded protein. Gastrointestinal and peritoneal deposition of light chain (AL) amyloid is an under-recognized manifestation of this systemic disease, usually as a late sequela. Here we present a case of recently diagnosed AL peritoneal amyloid that presented in the context of recurrent, acute onset abdominal discomfort and was found to have bowel obstruction complicated by perforation in the setting of AL-mediated gastrointestinal tract infiltration and dysmotility.

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… Minnesota: 1950. through 1989 [see comments] 6. Ravichandran S, Law S, Mahmood S, et al. Early relapse is an adverse prognostic marker in systemic immunoglobulin light chain (AL) Amyloid. Leukemia. 2022 Apr;36(4):1180–1184. doi: 10.1038/s41375-021-01497-7. 7. … Minnesota: 1950. through 1989 [see comments]. 21. Kaul A, Slomowitz SJ. Localized amyloid as presentation of light chain multiple myeloma. Proc UCLA Health. 2019;23 22. Simms RW, Prout MN, Cohen AS. The epidemiology of AL and AA amyloid. …

Текущая стратификация и установка множественных миелом и связанные с этим нарушения клональной плазменной клетки.

Клональные расстройства плазменных клеток охватывают целый спектр таких заболеваний, как множественная миелома (ММ), моноклонная гаммопатия неопределённого значения (МГУС), хмельная миелома (МММ), макроглобулиномия Уолденстрёма (ВМ) и амилоидоз иммуноглобулиновой цепи. В MGS, SMM и MM риск развития сильно варьируется и зависит от сложного взаимодействия нагрузки опухоли, цитогенетических аномалий, микроокружающей среды костного мозга и факторов хостинга. Уолденстрёмская макроглобулинемия, хотя она обычно и является бестактной, представляет собой свой собственный спектр молекулярных аномалий и

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… Incidence of AL amyloidosis in Olmsted County, Minnesota, 1990 through 2015. Mayo Clin Proc. 2019;94:465–71. 30713046 10.1016/j.mayocp.2018.08.041 PMC6401262 64. … Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79:1817–22. 1558973 65. …

Elevated Macrophage Migration Inhibitory Factor 1 Is Associated with Left and Right Ventricular Systolic Dysfunction in Heart Failure with Reduced Ejection Fraction.

Background/Objectives: Low-grade systemic inflammation, characteristic of heart failure (HF), is a nonspecific inflammatory syndrome that affects the entire body. Macrophage migration inhibitory factor 1 (MIF-1) is a pro-inflammatory cytokine, a key mediator of the innate immune response, and may serve as a potential biomarker of monocyte homing and activation in HF with reduced and mildly reduced ejection fraction (HFrEF, HFmrEF). Methods: We evaluated 70 hemodynamically stable patients with left ventricular EF (LVEF) < 50% by means of echocardiography and blood sampling. Results: We report s

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… Health-related quality of life was also assessed by applying the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The study adheres to the Declaration of Helsinki. … SD, standard deviation; BMI, body mass index; IQR, interquartile range; HF, heart failure; NYHA, New York Heart Association; 6MWT, six-minute walk distance; MLHFQ, Minnesota Living with Heart Failure Questionnaire; ICM, ischemic cardiomyopathy; NICM, non-ischemic cardiomyopathy; AF, atrial fibrillation …

ICIMH 2022 Abstracts

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Development of an Undiagnosed Mass Registry: Lessons Learned From Our First 100 Patients.

IntroductionThe Undiagnosed Mass Clinic (UMC) at our institution is a clinical and research program created to address gaps in the early diagnostic phase of the cancer care continuum for patients with potential malignant neoplasms. All patients referred to the UMC are invited to participate in the UMC registry, which tracks operational and clinical metrics while maintaining a repository of blood and tissue specimens for future research.MethodsWe conducted a retrospective cohort study of the first 100 patients enrolled in the UMC registry. We analyzed patient demographics, final diagnoses, and

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… This effort began at the Mayo Clinic campus in Scottsdale, Arizona, and was later expanded to our other US campuses in Jacksonville, Florida, and Rochester, Minnesota. … Setting Potential UMC registry participants are identified and recruited from all 3 Mayo Clinic campuses in Arizona, Florida, and Minnesota. Participation at multiple campuses facilitates access to diverse patient populations and improves our study recruitment efforts. …

Monoclonal Gammopathy of Undetermined Significance: Follow-up Patterns in the United States and Concordance With Clinical Practice Guidelines.

OBJECTIVE: To determine follow-up practice patterns of US patients with monoclonal gammopathy of undetermined significance (MGUS) and their concordance with 4 clinical practice guidelines. PATIENTS AND METHODS: In a retrospective analysis of adult patients using the OptumLabs Data Warehouse database, we identified those who had an incident diagnosis of MGUS from January 1, 2006, through December 31, 2013, no history or subsequent diagnosis of lymphoplasmacytic malignancy, and at least 2 years of follow-up. RESULTS: A total of 11,676 patients with MGUS were included in the study. During the f

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… The authors concluded that follow-up of patients with MGUS was inadequate perhaps because of lack of physician awareness of the existing guideline. 13 The only other report, a study published in 2010, included 116 patients with MGUS from southeastern Minnesota. … To overcome this, we estimated the proportion of higher- and lower-risk patients according to the Olmsted County, Minnesota, population data and performed best-case scenario sensitivity analyses and found similar results. 11 Because we did not include patients with MGUS in whom LPM subsequently developed …

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.

STUDY QUESTION: Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins? SUMMARY ANSWER: We i … 8, 1050208, 1075175). L.Y. is funded by Australian Research Council (Grant number DE200100425). The Minnesota Center for Twin and Family Research (MCTFR) was supported in part by USPHS Grants from the National Institute on Alcohol Abuse and Alcoholism (AA09367 and AA11886) and the National Institute on Drug Abuse (DA05147, DA13240, and DA024417). The Women' …

Surveillance for Violent Deaths - National Violent Death Reporting System, 34 States, Four California Counties, the District of Columbia, and Puerto Rico, 2017.

PROBLEM/CONDITION: In 2017, approximately 67,000 persons died of violence-related injuries in the United States. This report summarizes data … ware, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin), four California counties (Los Angeles, …

Pertussis vaccine effectiveness among children 6 to 59 months of age in the United States, 1998-2001.

BACKGROUND: Despite the dramatic pertussis decrease since the licensure of whole-cell pertussis (diphtheria-tetanus toxoids-pertussis [DTP]) … We conducted a case-control study in the Cincinnati, Ohio, metropolitan area, Colorado, Idaho, and Minnesota. PARTICIPANTS: Confirmed pertussis cases among children 6 to 59 months of age at the time of disease onset, with onset in 1998-2001, were included. For each case subject, 5 control children were matched from birth certificate records, according to …

Карта знаний транскраниальной магнитной стимуляции бессонницы: библиометрический и визуальный анализ.

Бессонница - это one :: наиболее распространенные нарушения сна, серьезно сказывающиеся на физическом и психическом здоровье человека, снижающие эффективность и бдительность работы и потенциально даже приводящие к несчастным случаям, усугубляющие тем самым экономическое бремя как отдельных лиц, так и общества. Первичное лечение бессонницы включает фармакологическую и нефармакологическую терапию. С учетом потенциальных побочных эффектов, связанных с фармакологической терапией, существует настоятельная необходимость в применении безопасных и эффективных нефармакологических мер. Такие технологии,

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… Harvard Med Sch, Harvard Medical School; Nanjing Med Univ, Nanjing Medical University; Univ Minnesota, University of Minnesota; Beijing Normal Univ, Beijing Normal University; Hebei Med Univ, Hebei Medical University; Massachusetts Gen Hosp, Massachusetts General Hospital; McGill Univ, McGill University … Health Center | 4 | 0.00 India | 12 | 0.07 | Univ Montreal | 3 | 0.00 Japan | 11 | 0.48 | Hebei Med Univ | 3 | 0.00 Switzerland | 11 | 0.47 | McGill Univ | 3 | 0.00 France | 10 | 0.00 | Shanghai Mental Health Center | 2 | 0.00 Poland | 10 | 0.00 | Mayo Clin | 2 | 0.00 South Korea | 8 | 0.00 | Univ Minnesota …

Final report on North Central Cancer Treatment Group N0877 (alliance): A phase II randomized, placebo-controlled trial of chemoradiotherapy with or without dasatinib for glioblastoma.

BackgroundDasatinib is an oral inhibitor of the Src kinase family, with preclinical data indicating impact on gliomagenesis, tumor invasion, and radiosensitivity.MethodsNorth Central Cancer Treatment Group N0877 is a phase 1 dose escalation and phase II randomized study evaluating the maximum tolerated dose (MTD), safety, and efficacy of dasatinib with radiation and temozolomide (TMZ) for glioblastoma. Following identification of the MTD, adult patients with a histologic diagnosis of glioblastoma were randomized 2:1 between dasatinib given with standard concurrent and adjuvant TMZ, versus plac

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… Daniel Anderson, Regions Hospital, Metro Minnesota Community Oncology Research Consortium, St Louis Park, MN, USA. David Tran, Division of Oncology, Washington University - Siteman Cancer Center, Saint Louis, MO, USA. … Raez; Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, MN; Daniel M. …

A population-based analysis of hematological malignancies from a French-West-Indies cancer registry's data (2009-2018).

BackgroundA worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characteristics of HM in a French West Indies territory, we have performed analysis through Martinique's population-based cancer registry database.MethodsWe included cancer case data, from 2009-2018, coded in strict compliance with international standards set by International Agency for Research on Cancer. We calculated standardized incidence rates, cumulative rate (ages 0-74), and temporal trends for cases and deaths using the global population standard, by sex and five age

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… More recently, a significant and original study used 2012–2017 vital statistics data and cancer mortality data from four states: California, Florida, Minnesota, and New York. … These states provided a balance of West Africans, more common in New York, with East Africans, more common in Minnesota, and African-Caribbean, found mainly in Florida and New York. African-Americans born in the United States showed highest burden of cancer mortality for MM and LAM [ 17 ]. …