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17th Конгресс ЕВНОС: Милан, Италия, 4–6 Июнь, 2026 года

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Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… The Regional Drug Expert Consortium also includes; Eva Andersén-Karlsson, Peter Aspelin, Jonas Bergh, Bo Billing, Peter Ekman, Carl-Gustaf Elinder, Mia von Euler, Johan Franck, Urban Hellgren, Michael Lagerkranser, Lena Lundeberg, Angelica L Hirschberg, Gerd Lärfars, Georgios Panagiotidis, Jan Persson …

Hotspots and trends in multiple myeloma bone diseases: A bibliometric visualization analysis.

Objective: This study aims to explore the research hotspots and trends of multiple myeloma bone disease in the past 20 years by bibliometric visualization analysis. Methods: With the Web of Science Core Collection database as the data source, the relevant publications of multiple myeloma bone disease from 2002 to 2021 are retrieved. These data are analyzed using software CiteSpace 5.8.R3 and Scimago Graphica 1.0.24, together with the Online Analysis Platform of Literature Metrology. Results: A total of 6,168 published research papers, including 4668 articles and 1500 review papers, are include

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… Knowledge mapping of angelica sinensis (oliv.) diels (danggui) research: A scientometric study. Front. Pharmacol. 11, 294. 10.3389/fphar.2020.00294 Lu X., Lu C., Yang Y., Shi X., Wang H., Yang N., et al. (2021). …

From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy.

This review provides a comprehensive analysis of the potential of functional food active ingredients in cancer prevention and therapy. It outlines the multifaceted anticancer mechanisms of bioactive compounds-such as polyphenols, carotenoids, omega-3 fatty acids, phytosterols, alkaloids, isothiocyanates, polysaccharides, phenolic acids, flavonols, and amide-bearing compounds-which include antioxidant and anti-inflammatory activities, induction of apoptosis and autophagy, modulation of the tumor microenvironment, interference with cell cycle regulation and signaling pathways, and regulation of

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… Polysaccharides from Angelica sinensis similarly protected hematopoietic cells from cyclophosphamide toxicity ( 142 ). …

The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises.

BackgroundBreast cancer is a critical threat to human health, and effective targeted agents showing lower systemic toxicity are still lacking. Therefore, exploring new potent therapeutic candidates with a broader safety margin is warranted. Alternative medicine, which has historically been used in traditional Chinese medicine, has played an increasingly prominent role in this area of research. This study introduces Commiphora myrrha (or myrrh) as a potential therapeutic candidate for treating breast cancer patients. Myrrh bioactive extracts have been used traditionally for decades to treat num

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… Analysis of the drug-target-disease network of trichosanthes-angelica sinensis-frankincense-myrrh in the treatment of breast cancer . Eur J Gynaecol Oncol . 2022 ; 43 : 83 - 95 . doi: 10.22514/ejgo.2022.061 38 Ru J Li P Wang J , et al . …

Mechanisms of spinal glial activation in chemotherapy-induced peripheral neuropathy: Focus on microglia and astrocytes.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication in patients with malignant tumors during chemotherapy. The pathological mechanisms of CIPN remain unclear, and effective preventive and therapeutic strategies are still lacking, posing a major challenge in clinical practice. Aberrant activation of spinal glial cells, particularly microglia and astrocytes, is a key pathological hallmark of CIPN. Evidence from multiple animal models supports a causal link between glial activation and CIPN, suggesting that glial cells may serve as potential therapeutic targets. However, ow

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… ceftriaxone (a glutamate transporter upregulator) | [ 44 ] S1P/S1PR1 | Paclitaxe and Bortezomib | Astrocyte | FTY720 | [ 99 , 100 ] TRPV1 | Paclitaxel | Both | Duloxetine, Electroacupuncture treatment | [ 67 , 101 ] | Oxaliplatin | Astrocyte | JI017 (an herb mixture composed of Aconitum carmichaelii , Angelica …

New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

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… Synergistic Inhibition of Glioblastoma Multiforme through an In-Silico Analysis of Luteolin and Ferulic Acid Derived from Angelica Sinensis and Cannabis Sativa: Advancements in Computational Therapeutics. PLoS ONE. 2023;18:e0293666. doi: 10.1371/journal.pone.0293666. 65. …

Abstracts

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Nature-Inspired Strategies in Cancer Management: The Potential of Plant Extracts in Modulating Tumour Biology.

Cancer is a serious group of diseases that is a huge problem on a global scale and is the second most common cause of death. Commonly used therapies do not always lead to the complete elimination of diseased cells or tissues and are also burdened with side effects that reduce the quality of life of patients. Due to these difficulties, new therapeutic approaches are still being sought. In recent years, there has been a return to interest in natural methods of treating various diseases, among which phytochemicals are particularly interesting. This article reviews plant extracts with anticancer p

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… Aqueous extract prepared from eight herbs used in traditional Chinese medicine ( Astragalus membranaceus , Glycyrrhiza uralenisi , Codonopsis pilosula , Angelica sinensis , Citus reticulate , Cimicifuga heracleifolia , Bupleurum chinense , and Atractylodes macrocephala ) has an inhibitory effect on kidney …

miR-135b: A key role in cancer biology and therapeutic targets.

miR-135b, a microRNA, is consistently up-regulated in various cancer tissues and cells, promoting cancer progression. By inhibiting one or more target genes, miR-135b regulates phenotypes such as cancer growth, apoptosis, migration, invasion, drug resistance, and angiogenesis, establishing it as a critical driver of cancer progression. Additionally, miR-135b is regulated by various oncogenes and therapeutic drugs, highlighting its complexity and therapeutic potential. Significant progress has been made in understanding miR-135b's impact on cancer cell behavior, establishing it as a promising b

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… Angelica R. Cavallaro A. Scalia M. Caltabiano R. Privitera G. Biondi A. Di Vita M. Cappellani A. Vasquez E. Lanzafame S. Tendi E. Celeste S. Di Pietro C. Basile F. Purrello M. …

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases.

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs' adoption. This review discusses the pathological development of some BDs, the NP-targeted components, an

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… Imperatorin ( 41 ), a linear furocoumarin derived from remarkable components of traditional Chinese medicine, Angelica archangelica and Peucedanum praeruptorum , enhanced OBG in rat BMMs at 75 µM via activation of RUNX2, COL1A1, and osteocalcin by 5-fold each and by promoting the phosphorylation of Ser473 …

Current Diagnosis and Management of Primary Chylomicronemia.

Primary chylomicronemia (PCM) is a rare and intractable disease characterized by marked accumulation of chylomicrons in plasma. The levels of plasma triglycerides (TGs) typically range from 1,000 - 15,000 mg/dL or higher.PCM is caused by defects in the lipoprotein lipase (LPL) pathway due to genetic mutations, autoantibodies, or unidentified causes. The monogenic type is typically inherited as an autosomal recessive trait with loss-of-function mutations in LPL pathway genes (LPL, LMF1, GPIHBP1, APOC2, and APOA5). Secondary/environmental factors (diabetes, alcohol intake, pregnancy, etc.) often

Repurposing anticancer drugs for the management of COVID-19.

Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded as a global public health emergency. The existing therapeutic options for COVID-19 beyond the intensive supportive care are limited, with an undefined or modest efficacy reported so far. Drug repurposing represents an enthusiastic mechanism to use approved drugs outside the scope of their original indication and accelerate the discovery of new therapeutic options. With the emergence of COVID-19, drug repurposing has been la

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… Conflicts of interest statement Khalid El Bairi, Dario Trapani, Angelica Petrillo, Cécile Le Page, Hanaa Zbakh, Bruno Daniele, Prof. Rhizlane Belbaraka and Prof. Said Afqir have no COI to declare. Prof. …

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines.

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of cli

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… cardiotoxic effects ( Daubney et al., 2015 ). 4.2 Chinese medicine Combination Formula 4.2.1 Qishen Huanwu Capsule Qishen Huanwu Capsule (QSHWC) is a compound preparation mainly composed of Huangqi (Astragalus), Taizishen (Pseudostellaria heterophylla), Chuanxiong (Ligusticum chuanxiong), Danggui (Angelica …

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma.

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosi

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… The compound n -butylidenephthalide (BP, Figure 15 ), isolated from Angelica sinensis , was studied due to the fact that several evidence point to the anticancer activity of this compound [ 188 ]. …

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies.

Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases. Despite being frequently prescribed, MTX's severe multiple toxicities can occasionally limit its therapeutic potential. Intestinal toxicity is a severe adverse effect associated with the administration of MTX, and patients are significantly burdened by MTX-provoked intestinal mucositis. However, the mechanism of such intestinal toxicity is not entirely understood, mechanistic studies demonstrated oxidative stress and inflammatory reactions as key fa

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… Umbelliferone A naturally occurring member of the coumarin family, umbelliferone (UMB) or 7-hydroxycoumarin, is present in a wide variety of plants, including garden angelica, coriander, and carrots (Mazimba 2017 ). …

Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma.

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signalin

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… Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis Life Sciences 2004 75 13 1579 1594 10.1016/j.lfs.2004.03.009 2-s2.0-3142655814 15261763 47 Nwodo J. N. Ibezim A. Simoben C. V. Ntie-Kang F. …

Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects.

Metabolic reprogramming is a fundamental hallmark and a key driver of malignant tumors. By reshaping glucose, lipid, and amino acid metabolism, as well as mitochondrial function, it sustains the abnormal proliferation and survival of tumor cells, making it a crucial target for anti-tumor therapy. Curcumin, a natural multi-target compound, exhibits unique advantages in intervening in tumor metabolic reprogramming due to its low toxicity and broad-spectrum regulatory properties. In various tumor models, it can directly modulate the activity of key glycolytic enzymes, such as hexokinase 2, lactat

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… For instance, Liu et al. constructed a hypoxia-responsive nano-carrier, AAAF (AA/ASP-AZO-Fc), utilizing Angelica sinensis polysaccharide. …

A comprehensive review on pain: Model, target, therapy, and prospect (Review).

Pain serves as both a protective physiological response essential for species survival and a global health issue affecting human well‑being and societal development. The present review systematically summarized and analyzed the research progresses on pain through a multidimensional analytical framework encompassing animal models, molecular targets, therapeutic approaches and future prospects. In animal modeling, neuropathic pain paradigms have evolved from traditional mechanical compression to composite models that combine dynamic displacement and chemical stimulation. Cancer‑induced pain mode