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The prevalence of antifungal agents administration in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective study.

BackgroundInvasive fungal infections (IFIs) are chief infectious complications in patients undergoing hematopoietic stem cell transplantation (HSCT). However, the diagnosis of fungal infections is difficult, and often empiric treatment initiates. Since there is no data available on the prevalence of antifungal drugs administration in allogeneic HSCT recipients in Iran, we decided to conduct this study.MethodsThis study was a retrospective review of records of patients who received allogeneic HSCT in the Hematology-Oncology, Bone Marrow Transplantation center at Shariati Hospital in Tehran, bet

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… This was probably due to the unavailability of micafungin, and anidulafungin and restricted availability of caspogungin in Iran. Additionally, the cost of the latter drug was not covered by the medication insurance systems at the time of the study. …

Infectious Diseases

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Molecular diagnostics in cancer patients with suspected respiratory mold infections.

Invasive fungal infections (IFIs), including aspergillosis and mucormycosis, are serious complications in cancer patients. Reliable detection of etiologic agents is challenging but important for optimal patient management. In a prospective multicenter study, we compared fungal detection by culture, specific and unspecific qPCRs, and fluorescence in situ hybridization (FISH) targeting Aspergillus and Mucorales in bronchoalveolar lavage fluid (BALF) and serum of adult cancer patients with suspected fungal pneumonia. In subgroups of patients, fungal DNA was amplified from serum. We evaluated 210

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… characteristics of included patients and the subgroup with proven or probable mold infection a a ALL, acute lymphogenous leukemia; NHL, non-Hodgkin’s lymphoma; CLL, chronic lymphocytic leukemia; GvHD, graft vs host disease; CT, computed tomography. b Voriconazole, posaconazole, isavuconazole, caspofungin, anidulafungin …

Evaluation of the Effect of Loratadine versus Diosmin/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial.

Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin/hesperidin on neuropathy induced by vinca alkaloids. Patients were randomized into one of three groups as follows: group 1 was the control group, group 2 received 450 mg diosmin and 50 mg hesperidin combination orally twice daily, and group 3 received loratadine 10 mg orally once daily. Subjective scores (numeric pain rating scale, douleur neuropathique 4, and functional assessme

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… If antifungal therapy is necessary, an echinocandin (for example, micafungin, caspofungin, or anidulafungin) could substitute for the azoles [ 45 ]. 2.6. …

A noticeable difference? Productivity costs related to paid and unpaid work in economic evaluations on expensive drugs.

Productivity costs can strongly impact cost-effectiveness outcomes. This study investigated the impact in the context of expensive hospital drugs. This study aimed to: (1) investigate the effect of productivity costs on cost-effectiveness outcomes, (2) determine whether economic evaluations of expensive drugs commonly include productivity costs related to paid and unpaid work, and (3) explore potential reasons for excluding productivity costs from the economic evaluation. We conducted a systematic literature review to identify economic evaluations of 33 expensive drugs. We analysed whether eva

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… Drotrecogin-alfa | Severe sepsis Natalizumab | Crohn’s disease, multiple sclerosis Cetuximab | Colon cancer Ranibizumab | Macular degeneration Abatacept | Rheumatoid arthritis Voriconazole | Invasive aspergillosis, invasive candidiasis Methyl aminolevulinate | Skin cancer Panitumumab | Colorectal cancer Anidulafungin …

Infectious Diseases

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Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhu GM-CSF) as Adjuvant Therapy for Invasive Fungal Diseases.

BackgroundSargramostim (yeast-derived, glycosylated recombinant human granulocyte-macrophage colony-stimulating factor [rhu GM-CSF]) augments innate and adaptive immune responses and accelerates hematopoietic recovery of chemotherapy-induced neutropenia. However, considerably less is known about its efficacy as adjunctive immunotherapy against invasive fungal diseases (IFDs).MethodsThe clinical courses of 15 patients with pediatric malignancies and IFDs treated adjunctively with sargramostim at a single institution were analyzed in a retrospective cohort review. Further, a systematic review of

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… Wisconsin) [ 43 ] | 15 yo M | ALL (B cell) | Invasive sinopulmonary fungal infection ( Conidiobolus coronatus ) | Yes | Yes (prior voriconazole, micafungin) | Sargramostim 250 µg/m 2 /d, then 100 µg/m 2 TIW for maintenance; increased to 250 µg/m 2 /d when neutropenic | Granulocyte transfusions, HBOT, LAmB, anidulafungin …

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved the treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drug classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.

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… have been recommended [ 93 ] c Itraconazole, voriconazole, and posaconazole are more potent inhibitors of cytochrome P450 3A4 isoenzymes than fluconazole and may significantly decrease the clearance of several agents used to treat cancer d All three agents in the class (micafungin, caspofungin, and anidulafungin …

A review on clinical cases of rare mold infections and their antifungal treatment strategies.

In recent years, with the growing population of immunocompromised individuals, infections caused by rare environmental molds have become increasingly prevalent and clinically significant. Due to frequent misdiagnosis and difficult clinical management, the overall disease burden of such infections poses a major challenge in clinical practice. This article aims to fill the knowledge gap by reviewing cases of rare mold infections from January 2020 to February 2026, analyzing the susceptible populations, identification techniques, antifungal susceptibility testing, and antifungal treatment strateg

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… . ‡ AMB, amphotericin B; L-AMB, liposomal amphotericin B; ABLC, amphotericin B lipid complex; VRC, voriconazole; FLC, fluconazole; ITR, itraconazole; MCF, micafungin; CPN, caspofungin; POS, posaconazole; TBF, terbinafine; ISA, isavuconazole; NTM, natamycin; 5-FC, flucytosine; MCZ, miconazole; ANI, anidulafungin …

Critically Ill Immunosuppressed Host

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… less attractive either because the patient has received fluconazole prophylaxis or because molds are suspected. 28 , 38 , 39 The toxicity profile of amphotericin B, even in its liposomal form, has led many clinicians to prefer voriconazole or one of the echinocandins (i.e., caspofungin, micafungin, or anidulafungin …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… Treatment of Systemic Mycoses Treatments for these severe systemic fungal infections include systemic azole agents (itraconazole, fluconazole, voriconazole, isavuconazole, and posaconazole), echinocandins (caspofungin, micafungin, anidulafungin, rezafungin), antimetabolites (flucytosine) or polyene …

COVID-19 Therapeutic Options Under Investigation.

Since its emergence in China in December 2019, COVID-19 has quickly spread around the globe causing a pandemic. Vaccination or the development of herd immunity seems the only way to slow down the spread of the virus; however, both are not achievable in the near future. Therefore, effective treatments to mitigate the burden of this pandemic and reduce mortality rates are urgently needed. Preclinical and clinical studies of potential antiviral and immunomodulatory compounds and molecules to identify safe and efficacious therapeutics for COVID-19 are ongoing. Two compounds, remdesivir, and dexame

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… Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection . 10.31219/osf.io/urxwh Dhama K. Sharun K. Tiwari R. Dadar M. …

FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021-2025): Pharmaceutical Use, Trends and Synthetic Approaches.

The amide functional group remains a cornerstone of medicinal chemistry, serving as an indispensable scaffold in the design of modern therapeutics. This review presents an analysis of FDA-approved drugs (small molecules and peptides with MW ®), amides form the structural backbone of peptidomimetics, enabling high-affinity binding to a viral protease. In precision oncology, as seen with adagrasib (Krazati®), the amide acts as a critical, metabolically stable linker that positions a covalent warhead for selective inhibition of a mutant kinase. This analysis underscores that amide's unique combin

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… It is a cyclic hexapeptide echinocandin antifungal analog of anidulafungin, characterized by a unique choline aminal ether moiety at the C5 ornithine position. It is a semi-synthetic drug. …

NAPCON 2025 – Best Original Research Abstracts

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Abstracts cont.

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Inpatient Medicine

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… These include caspofungin, micafungin, and anidulafungin. Amphotericin B is given less often due to the risk of nephrotoxicity. Both the echinocandins and the azoles are better tolerated than amphotericin B formulations. Candidemia requires treatment with antifungal agents. …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions

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Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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