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Thrombosis in Neuromuscular Medicine: Current Evidence, Unmet Needs, and Future Directions.

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is an important but under-recognised complication in neuromuscular diseases. In adults, emerging epidemiological data suggests increased VTE occurrence in conditions such as Amyotrophic Lateral Sclerosis, myotonic dystrophy, myasthenia gravis, inflammatory neuropathies, inflammatory myopathies, and POEMS syndrome. This heightened risk reflects not only disease-related immobility but also disorder-specific biological mechanisms, including inflammation, endothelial dysfunction and cardiomyopathy-related stasis.

Совпадение в полном тексте источника
… Based on that indirect evidence, the panel recommends pharmacologic prophylaxis with prophylactic-dose unfractionated heparin, low-molecular-weight heparin, or fondaparinux as first-line therapy, with intermittent pneumatic compression (IPC) used when bleeding risk precludes anticoagulation. …

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

Совпадение в полном тексте источника
… Heparin-induced thrombocytopenia (HIT) : Therapeutic anticoagulation with an alternative parenteral anticoagulant to heparin, such as argatroban, bivalirudin, danaparoid, and fondaparinux, should be administered in the acute phase of HIT, and depending on the presence of thrombosis, treatment should …

A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors.

The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challenging to treat because of their fast development and early metastases. The treatment of these patients must not be jeopardized, and they must be protected as much as possible from the continuous spread of the COVID-19 infection. Initially identified in December 2019 in Wuhan, China, the contagious coronavirus illness 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (S

Совпадение в полном тексте источника
… Entrectinib | –10.57 Osi-027 | –10.50 MK3207 | –10.97 Rimegepant | –10.77 Bolazine | –10.47 Paritaprevir, Simeprevir and Velpatasvir | Below –10.0 | S-protein | Anti-SARS-CoV-2 activity | [ 61 ] Nucleocapsid protein 2’-O-ribose MTase Gonadorelin | –9.40 | RBD-ACE2 | Inhibiting the virus infection | [ 62 ] Fondaparinux …

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus.

BackgroundThe COVID-19 pandemic has created enormous challenges for the clinical management of patients with hematological malignancies (HMs), raising questions about the optimal care of this patient group.MethodsThis consensus manuscript aims at discussing clinical evidence and providing expert advice on statements related to the management of HMs in the COVID-19 pandemic. For this purpose, an international consortium was established including a steering committee, which prepared six working packages addressing significant clinical questions from the COVID-19 diagnosis, treatment, and mitigat

Совпадение в полном тексте источника
… Patients hospitalized with a confirmed diagnosis of COVID-19 should receive prophylaxis of thromboembolic events using LMWH or fondaparinux, or even unfractionated heparin, if critically ill with a significantly reduced kidney function. …

16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends.

Antiphospholipid syndrome (APS), an acquired autoimmune thrombophilia, is characterised by thrombosis and/or pregnancy morbidity in association with persistent antiphospholipid antibodies. The 16th International Congress on Antiphospholipid Antibodies Task Force on APS Treatment Trends reviewed the current status with regard to existing and novel treatment trends for APS, which is the focus of this Task Force report. The report addresses current treatments and developments since the last report, on the use of direct oral anticoagulants in patients with APS, antiplatelet agents, adjunctive ther

Совпадение в полном тексте источника
… Other treatment options may include an increased target INR range, standard treatment dose low-molecular-weight heparin (LMWH), fondaparinux if VKA/LMWH are not suitable, or the addition of antiplatelet therapy. …

ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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EHA Guidelines on Management of Antithrombotic Treatments in Thrombocytopenic Patients With Cancer.

In cancer patients, thrombocytopenia can result from bone marrow infiltration or from anticancer medications and represents an important limitation for the use of antithrombotic treatments, including anticoagulant, antiplatelet, and fibrinolytic agents. These drugs are often required for prevention or treatment of cancer-associated thrombosis or for cardioembolic prevention in atrial fibrillation in an increasingly older cancer population. Data indicate that cancer remains an independent risk factor for thrombosis even in case of thrombocytopenia, since mild-to-moderate thrombocytopenia does n

Совпадение в полном тексте источника
… Furthermore, the upfront combination of UFH and LMWH should be avoided and substituted by fondaparinux 2.5 mg for the indication of non-ST elevation MI (NSTEMI) and 2000 IU UFH should be used for diagnostic transradial cardiac catherization only. …

Oral Communication abstracts

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Abstract

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Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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Abstract

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Proceedings of the RAMI Intern Section Meeting.

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions

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In vitro расширила человека CD4+CD25+ регуляционные T клетки, подавляющие распространение Т клеток.

Регулирующие Т клетки (Tregs) оказались критически важными в балансе между автоиммунизацией и терпимостью и были связаны с несколькими аутоиммунными заболеваниями человека. Однако небольшое число трегов в периферии крови ограничивает их терапевтический потенциал. Поэтому мы разработали протокол, который позволит расширить "Трегз" при сохранении их подавляющей активности. Мы изолировали клетки CD4+CD25 hi от человеческой периферической крови и расширили их in vitro в присутствии anti-CD3 и anti-CD28 Магнитные кситы и высокие концентрации внешнего интерлейкина (IL) -2. Траги были эффективно расш

:: 45th Ежегодное совещание Европейского общества по трансплантации крови и костного мозга: Врачи - сессия плаката.

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Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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Резюме книги для 27th Конгресс Европейской ассоциации гематологии

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