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[Prevalence of congenital dislocation of hip diffusion among the population of Lenkoran and Massaly region in Azerbaijan].

The occurrence of congenital hip dislocation in Lenkoran and Massaly areas of Azerbaijan Republic was studied. The population-genetic assess … ital and genetic diseases in Azerbaijan Republic. The highest prevalence of multiple-factor type of heredity indicates the necessity to control teratogen factors of the environment.

Neurological complications of coeliac disease.

A variety of neurological disorders have been reported in association with coeliac disease including epilepsy, ataxia, neuropathy, and myelo … y of the associated neurological disorders. Other mechanisms proposed include altered autoimmunity, heredity, and gluten toxicity. This review attempts to summarise the literature and suggests directions for future research.

Anatomical observations of the developmental and spondylotic cervical spinal canal in South African blacks and whites.

Cervical vertebral columns (214) of South African black and white cadaver populations were examined and measured to determine the mean midsagittal and transverse diameters of cervical vertebral foramina. Findings reveal that blacks have significantly narrower midsagittal and transverse diameters of their cervical vertebral foramina than do whites. The significance of the findings with particular regard to spondylosis is discussed in some detail. In a discussion on the causes of differences in canal size in the two ethnic groups, the role of heredity and environment was addressed and attention …

"Isolated" hydrocephalus in families of spina bifida and anencephaly: a coincidence?

Hydrocephalus is a frequent complication of spina bifida. We wanted to find out if the risk of isolated hydrocephalus was greater in families with NTD (anencephaly and spina bifida) from 424 families studied between 1975 and 1984 in Brittany. The risk of recurrence of NTD is 1.8% in these families, the risk of hydrocephalus 0.3% which represents a risk three times greater than that of the population at large. This risk seems all the higher if the proband is a spina bifida of the male sex. However, no X-linked heredity can be reasonably assumed in these cases. We conclude that these families pr…

[Porphyrin diseases with particular emphasis on hereditary].

During the last 10 years our knowledge concerning the basis defect in porphyrias has increased so that a better genetic family advice. The f … h the environmental factors. On the basis of the biochemical findings a better understanding of the heredity is possible which is discussed in detail.

Familial risks of hospital-treated spinal stenosis in first-, second-, and third-degree relatives: a nationwide family study.

BACKGROUND CONTEXT: Spinal stenosis (SS) has a multifactorial background. PURPOSE: This nationwide study aimed to determine the familial risks of hospital-treated SS in first-, second-, and third-degree relatives in Sweden. STUDY DESIGN: The Swedish Multigeneration Register was linked to the National Patient Register to investigate the heredity of hospital-treated SS between 1997 and 2018. PATIENT SAMPLE: Offspring born to Swedish-born parents were included. OUTCOME MEASURES: Familial hazard ratios for SS were calculated for relatives of individuals who had a diagnosis of SS compared with …

High risk of adult asthma following severe wheezing in early life.

BACKGROUND: Severe wheezing in early life is associated with an increased risk of asthma during childhood and adolescence. The aim of the pr … 0-fold (adjusted OR 10.0, 95% CI 5.3-18.7), independently of allergic rhinitis, gender, smoking and heredity. Within the cohort, current allergy (aOR 9.6, 95% CI 3.0-31.2) and female gender (aOR 3.2, 95% CI 1.1-9.3) independently increased the risk of adult asthma. Females with current allergy had the highest risk of adult asthma (OR 29.4, 95% CI 5.0-173.3 …

The communication of pharmacogenetic research results: participants weigh in on their informational needs in a pilot study.

In this brief investigation, the informational needs of research participants [n = 62; mothers who had breastfed, taken codeine, and participated in a pharmacogenetic study] were probed during a counselling session in which they received their CYP2D6 pharmacogenetic research results and overall study results. In addition to the standard information, developed by a multidisciplinary team and provided to the participants, 38% of individuals had further questions related to potential adverse effects in babies, future codeine or medication use, heredity, and consequences for policies and programme…

Nasal reconstruction using 20 mg/ml cross-linked hyaluronic acid.

According to American Society for Aesthetic Plastic Surgery (ASAPS), 200,924 people had rhinoplasties in 2005. Patients typically have surgical rhinoplasty to correct unsightly noses resulting from trauma, surgery, or heredity. Several alternatives presently exist for patients considering surgical rhinoplasty. These include injections of botulinum toxins to correct the shape of the nasal tip and the use of various fillers to correct contour and profile defects. This article presents a simple and effective alternative using hyaluronic acid for some patients requiring nasal recontouring. The pro…

[2 clinico-genetic types of primary congenital glaucomas in Slovakia].

The authors present the results of a 20-year follow-up of a group of 125 patients with primary congenital glaucoma. Based on 10 fundamentally different indicators they provided evidence of two clinical forms of primary congenital glaucoma depending on the ethnic origin and type of heredity. In Slovakia is found: a/autosomal recessive hereditary primary congenital glaucoma in the gypsy population with an identified gene locus GLC3A with a different clinical picture, severe course and unfavourable therapeutic results; b/multifactorial primary congenital glaucoma in the remaining population of Sl…

Helicobacter pylori and peptic ulcer disease.

Since William Beaumont's classic description of gastric physiology in 1847, the focus of clinical practice and basic research concerning gastric and duodenal ulcers has centered on the secretion of acid and pepsin. In addition to these well-known factors (largely determined by heredity, age, and oral intake), the search for other agents that alter the mucosal barrier has identified a bacillus, Helicobacter pylori, as a significant agent in the development of chronic gastritis and benign gastric and duodenal ulcers. This review explores the scientific evidence for an important causal role of H.…

Национальное эпидемиологическое обследование слепоты и слабовидения в Китае.

Согласно данным Национального выборочного обследования слепоты и слабовидения, показатель слепоты в Китае составил 0,43%, что было вызвано главным образом катарактой (41,06%), кукурузными заболеваниями (15,38%), трахомой (10,87%) и глаукомой (8,80%), а также низким зрением в Китае 0,58%, из которых основными причинами были катаракта (49,83%), аметропия/амблеопиа (14,98%), трахома (9,55%), кукурузные заболевания (8,48%), чориоретинальные заболевания (6,27%) и т.д. Среди детей в возрасте до 14 лет главной причиной слепоты и слабовидения является наследственность (48,46%). Среди пожилых людей в в

Совпадение в аннотации оригинала
According to the National Sample Survey of Blindness and Low Vision, the prevalence of blindness in China was 0.43%, resulting chiefly from … .27%), etc. Among children under 14 years of age, the leading cause of blindness and low vision was heredity (48.46%). Among elderly of 60 years and over, the leading cause of blindness and low vision was cataract (73.13%).

[Pathogenesis and clinical aspects of atopic dermatitis].

Atopic dermatitis (a. D.) is a chronically relapsing inflammatory disease of the skin caused by a genetically transmitted hypersensitivity to environmental substances. Its pathogenesis is complex and multifactorial: heredity of atopic constitution, disturbances of humoral (hyperimmunoglobulinemia-E) and cellular (defect of suppressor-T-cells) immunity, abnormal vascular reactions and abnormal skin functions. A. D. shows different forms in different age groups: Eczema infantum in infancy, Eczema flexurarum in childhood and Neurodermatitis disseminata and pruriginosa while and after puberty. Typ…

[Ocular myasthenia in sisters (author's transl)].

The case histories of two sisters with ocular infantile myasthenia are reported. The older girl has been suffering from the disease for 11 y … essive mode of transmission. The clinical and genetic heterogeneity of infantile myasthenia and the heredity of the disease are discussed.

Heterogeneity in Waardenburg's syndrome. Report of a family with ocular albinism.

A family had the following manifestations of Waardenburg's syndrome (WS): prominent nasal root, white forelock, premature graying of the hair, freckled pigmentation of pale skin, hypoplastic heterochromia irides, heterochromia of the ocular fundi, congenital sensorineural hearing loss, and autosomal dominant heredity. This family differs from those previously reported in that none of its members showed dystopia of the inner canthi or lower puncta. In addition, four siblings had the combination of hyperopia-estropia-amblyopia, as well as ocular albinism, manifested by foveal hypoplasia and tran…

Patient-reported causes of heart failure in a large European sample.

BACKGROUND: Patients diagnosed with chronic diseases develop perceptions about their disease and its causes, which may influence health beha … mainly smoking), psychosocial (35%, mainly (work-related) stress), and natural causes (32%, mainly heredity). There were socio-demographic, clinical and psychological group differences between the various categories, and large discrepancies between prevalence of physical risk factors according to medical records and patient-reported causes; e.g. 58% had h …

Current Perspectives on Gastric Cancer.

Gastric cancer (GC) is third leading cause of cancer-related death. Only 28.3% of new GC cases survive more than 5 years. Although incidence has declined in the United States, an increase is estimated for 2016. Risk factors include sex (risk is higher in men), Helicobacter pylori infection, heredity, and lifestyle. GC is usually diagnosed between the ages of 60-80 years. Prognosis of GC is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type; diffuse-type GC has worse prognosis. Chemoprevention has been shown to decrease risk, but is currently not …

Update on colorectal cancer. Risk factors, diagnosis, and treatment.

Colorectal cancer is more common in the Western world than in underdeveloped countries. Diet, longevity, heredity, and presence of other bowel diseases may affect the incidence. Diagnosis is based on results of routine laboratory studies and evaluation of the entire large bowel with air-contrast barium enema and colonoscopy. Surgical resection is the primary therapy for colorectal cancer. Postoperative systemic chemotherapy yields poor results, but hepatic artery infusional chemotherapy offers some benefit to patients who have only hepatic metastases. Follow-up evaluation includes physical exa…

[A syndrome: uncombable hair. Observation of 6 members of a family with pili canaliculi, associated with pili torti, progressive alopecia, atopic eczema and hamartomas].

Six members of one family showed the typical clinical picture of uncombable hair (cheveux incoiffables), a syndrome first described by Dupré, Rochiccioli and Bonafé in 1973. In all six cases scanning electron microscopical investigations revealed characteristic morphological hair changes including longitudinal grooves as well as angular or kidney-shaped patterns in cross sections. Genetically the abnormality seems to be of autosomal dominant heredity with incomplete penetrance. In addition to uncombable hair some of our patients showed pili torti, progressive alopecia areata and atopic eczema.…