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Ранняя интенсивная терапия в сравнении со стратегией эскалации во франко-карибской группе склероза.

ОКРУЖАЮЩАЯ СРЕДА: Данных о стратегии " Эскалация - терапия и ранняя интенсивная терапия " (ЭИТ) при множественном склерозе (МС) не имеется, особенно в афрокарибских случаях, известных своей строгостью. ЦЕЛИ: Оценка эффективности и безопасности этих стратегий применительно к преимущественно афрокарибскому населению, возвращающемуся в атмосферу. МЕТОДЫ: Многоцентральное ретроспективное исследование 195 пациентов с НР, в том числе 66 пациентов на СПЭ, с последующими исследованиями в течение ≥2 лет. ПРИМЕНИТЕЛЬНЫЕ РЕЗУЛЬТАТЫ: Кривые Каплан-Мейер и логарифмическая проверка использовались

Histiocytoid giant cellulitis-like Sweet syndrome at the site of sternal aspiration: A case report and review of literature.

BackgroundGiant cellulitis-like Sweet syndrome (SS) is a rare subtype of SS, and reports of the combined histiocytoid type of pathology are scarce. Here, we report a case of SS with distinctive clinical presentations and which was difficult to distinguish from cellulitis. By sharing this case and a discussion of the related literature in detail, we aim to provide clinicians with new insights into the characteristics of histiocytoid giant cellulitis-like (HGC)-SS and the pathogenesis of SS.Case summaryA 52-year-old male was admitted after experiencing progressive fatigue for 1 mo and tongue swe

Oncology Nursing During a Pandemic: Critical Reflections in the Context of COVID-19.

ObjectivesTo provide a critical reflection of COVID-19 in the context of oncology nursing and provide recommendations for caring for people affected by cancer during this pandemic.Data sourcesElectronic databases, including CINAHL, MEDLINE, PsychINFO, Scopus, professional web sites, and grey literature were searched using Google Scholar.ConclusionNurses are key stakeholders in developing and implementing policies regarding standards of care during the COVID-19 pandemic. This pandemic poses several challenges for oncology services. Oncology nurses are providing a pivotal role in the care and ma

Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies.

Autoimmunity refers to an organism's immune response against its own healthy cells, tissues, or components, potentially leading to irreversible damage to vital organs. Central and peripheral tolerance mechanisms play crucial roles in preventing autoimmunity by eliminating self-reactive T and B cells. The disruption of immunological tolerance, characterized by the failure of these mechanisms, results in the aberrant activation of autoreactive lymphocytes that target self-tissues, culminating in the pathogenesis of autoimmune disorders. Genetic predispositions, environmental exposures, and immun

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… Strachan proposed the “hygiene hypothesis” of allergic disease. This hypothesis posits that decreased exposure to infectious agents, microorganisms, and parasites in early childhood due to modern sanitation practices leads to an under-stimulated immune system. …

Сравнительное исследование между когнитивными фенотипами мальгического энцефаломелита/хронического синдрома утомления и множественным склерозом.

Цель: Когнитивные дефекты являются одним из наиболее распространенных и недействующих симптомов, связанных с синдромом миальгической энцефаломиелита/хронической усталости (ME/CFS). Здесь мы рассматриваем возможность конкретного когнитивного профиля, присущего ME/CFS. Из-за когнитивных недостатков, усталости и боли в обеих патологиях многократный склероз (MS) является соответствующей моделью сопоставления. С этой целью мы провели сравнительное исследование между когнитивными профилями пациентов, имеющих ME/CFS, и пациентов, страдающих MS. Методы: В общей сложности были охвачены 40 пациентов МП/

Effects of a Cognitive Behavioral Digital Therapeutic on Anxiety and Depression Symptoms in Patients With Cancer: A Randomized Controlled Trial.

PURPOSE: Patients with cancer often experience elevated levels of distress. This double-blind, randomized controlled trial compared the impact of an app-based version of cognitive behavioral stress management (CBSM) versus a health education sham app on anxiety and depression symptoms. METHODS: Patients with nonmetastatic (stage I-III) cancer who were receiving or recently completed (≤6 months) systemic treatment were recruited nationwide. The primary outcome of change in anxiety symptoms (PROMIS-Anxiety) over 12 weeks and the top secondary outcome of change in depression symptoms (PROMIS-Dep

Adjuvant A-PRF Application in Patients with Various Stages of Medication-Related Osteonecrosis of the Jaw (MRONJ): Case Series.

Background and Clinical Significance: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of antiresorptive therapies such as Zolendronic acid, used for bone metastases. Its management remains challenging, with outcomes often unpredictable. Platelet-rich fibrin (PRF), rich in growth factors, has been proposed as a potential adjunct to surgical treatment, aiming to promote tissue regeneration and improve patient outcomes. Case Presentation: We reported three clinical cases of MRONJ in patients previously treated with Zolendronic acid. All patients underwent surgical seq

Implementation of a hospital-at-home (HAH) unit for hematological patients during the COVID-19 pandemic: safety and feasibility.

Background"Hospital-at-home" (HAH) programs have been shown to optimize resource utilization, shorten hospitalization and prevent nosocomial infection.MethodsWe retrospectively analysed data regarding implementation of an HAH unit for caring patients with hematological malignancies in our center, during the COVID-19 pandemic.ResultsBetween January and November 2020, 105 patients were treated in the HAH unit for a total of 204 episodes. Nine patients with multiple myeloma (MM) received autologous HSCT (auto-HSCT). Three patients with acute myeloid leukemia (AML) received consolidation therapy,

Risk factors for medication-related osteonecrosis of the jaw and salivary IL-6 IN cancer patients.

INTRODUCTION: Medication-related osteonecrosis of the jaws is a severe complication of the use of antiresorptive and antiangiogenic therapy, with limited treatment options and great impact on patient's quality pf life. OBJECTIVE: The aim of this study was to assess the risk factors associated with medication-related osteonecrosis of the jaws in oncologic patients undergoing bisphosphonate treatment. In addition, salivary levels of interleukin-6, IL-6, were measured to investigate their association with severity and risk of medication-related osteonecrosis of the jaws. METHODS: Case-control s

Время отключения в слоях при мукозите и его ассоциация с системными осложнениями у пациентов с пересадкой гематопоэтических стволовых клеток: выводы из национального исследования в стационаре.

ОБЪЕКТ ИССЛЕДОВАНИЯ: Оральные узловатые мукозные инфекции (ОУМИ) являются частой и серьезной осложнением трансплантации гемопоэтических клеток (ТГК). Определено ли то, что длительное время выписки из больницы, используемое как прокси для увеличенного срока пребывания (СПП), идентифицирует большую системную морбидность у пациентов, которые развивают ОУМИ, остается неясным. Настоящее ретроспективное когортное исследование направлено на оценку, у пациентов с документированным ОУМИ среди получателей ТГК, длительное время выписки независимо связано с увеличением системных осложнений.МЕТОДЫ: Настоящ

Targeted treatments of bone metastases in patients with lung cancer.

Until now ~30-40% of patients with advanced lung cancer develop bone metastases, but as the newer therapies are extending survival, the chance of developing bone metastases increases. Bone metastases cause skeletal-related events (SREs) such as pathologic fractures, spinal cord compression, radiation therapy or surgery to bone, or hypercalcemia, which can have debilitating consequences affecting patients' health-related quality of life (HR-QOL) and performance status (PS). Poor PS then prevents the patients to receive further lines of treatments, which are available today. SREs are associated

A review of evidence supporting amyloid beta reduction as a surrogate endpoint in Alzheimer's disease.

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease driven by pathological depositions of proteins that accumulate over decades. Compelling genetic and neurobiological evidence suggests that amyloid accumulation in the brain initiates and drives early-stage AD. Measurement of fibrillar amyloid has been pivotal to the development and approval of disease-slowing treatments. Various biomarkers of AD pathophysiology provide evidence of target engagement and downstream effects on disease progression, and their use as surrogate endpoints may help identify and expeditiously bring ne

Fractal Dimension Analysis of Mandibular Trabecular Bone in Patients Receiving Antiresorptive Therapy for Osteoporosis and Oncologic Conditions.

Objectives: This study aimed to assess the effects of antiresorptive drugs on mandibular trabecular bone structure in patients with osteoporosis and those receiving antiresorptive therapy for oncologic conditions using fractal dimension (FD) analysis of panoramic radiographs. Additionally, it investigated the influences of age, gender, drug type, administration route, and treatment duration on mandibular trabecular bone structure. Methods: This retrospective cross-sectional study included 73 patients categorized into the following three groups: 23 osteoporosis patients, 25 oncologic patients,

Distress in a Pandemic: Association of the Coronavirus Disease-2019 Pandemic with Distress and Quality of Life in Hematopoietic Stem Cell Transplantation.

The global coronavirus disease 2019 (COVID-19) pandemic has drastically disrupted cancer care, potentially exacerbating patients' distress levels. Patients undergoing hematopoietic stem cell transplantation (HSCT) may be especially vulnerable to this pandemic stress. However, the associations of the COVID-19 pandemic with distress, fatigue, and quality of life (QoL) are not well understood in this population. In a cross-sectional analysis of data from 205 patients undergoing HSCT enrolled in a supportive care trial, we compared baseline pre-HSCT distress symptoms (depression, anxiety, and post

Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome.

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is prevalent in obesity and is associated with many metabolic abnormalities. The relationship between OSAS and bone metabolism is still unclear. The aim of this study was to investigate the relationship between the severity of OSAS and bone metabolic markers. METHODS: A total of 119 obese males were enrolled in this study in spring months from 2015 to 2017. All candidates underwent polysomnography, and their bone mineral density (BMD) and the serum levels of total procollagen type 1 N-terminal propeptide (t-P1NP), N-terminal midfragment of o

Keyword Index for Volume 109

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Bisphosphonate-Related Osteonecrosis of the Jaw and Oral Microbiome: Clinical Risk Factors, Pathophysiology and Treatment Options.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) represents a serious health condition, impacting the lives of many patients worldwide. The condition challenges clinical care due to its complex etiology and limited therapeutic options. A thorough understanding of the pathophysiological and patient-related factors that promote disease development is essential. Recently, the oral microbiome has been implicated as a potential driver and modulating factor of BRONJ by several studies. Modern genomic sequencing methods have provided a wealth of data on the microbial composition of BRONJ lesio

Functional outcomes of cancer patients in an acute inpatient setting at King Fahad Medical City.

[Purpose] Cancer survivors have functional impairments that adversely affect patients' quality of life (QoL). Acute rehabilitation helps to reduce disability and improves QoL in cancer survivors. This study investigated the potential improvement in mobility levels and QoL of cancer patients during acute inpatient physical therapy (PT) from admission to discharge. [Participants and Methods] This was a cross-sectional study conducted at King Fahad Medical City, Riyadh. Acute inpatient cancer survivors (n=99) were assessed at their admission and discharge. The primary outcome measure was the AM-P

Социально-экономические различия в обеспечении выживания многих миелом в Новом Южном Уэльсе Австралия: исследование на тему " Демографический коорт " .

Введение one :: самые высокие показатели заболеваемости миеломой (ММ) в мире, и это бремя, по прогнозам, значительно возрастет в предстоящие десятилетия. Со временем положение в области выживания улучшилось, однако не ясно, в какой степени оно различается по социально-экономическим группам. Здесь мы использовали демографические данные для оценки различий в уровне выживания по социально-экономическим группам и другим прогнозным факторам лиц с MM в Австралии. 2008 и 2019, как указано в регистре рака Нового Южного Уэльса, с последующими мерами по выживанию 2020. Выявленные лица, имеющие первичный

Воздействие причинно-следственных связей между распространенными заболеваниями и провокационными кишечными заболеваниями: исследование по изучению двухнаправленной менделианской случайности.

ЦЕЛИ: Исследования по изучению связей между различными заболеваниями и подстрекательскими кишечными заболеваниями (ИББ) часто ограничиваются путаницей и обратной причиной. Мы стремились оценить потенциальные причинно-следственные связи между широким кругом заболеваний и ИБД, включая болезнь Крона (КД) и язвительный колит (КЮ). МЕТОДЫ: Мы провели всеобъемлющий анализ 104 распространенных болезней и признаков БИ с использованием общего подхода, основанного на обобщенных кратких данных, с использованием метода ОР (МСУГ). Сводные статистические данные о заболеваниях, полученные в рамках общегеноми

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… The hygiene hypothesis posits that early-life exposure to co-evolved microbial agents is critical for the proper development of immunoregulatory circuits, with organisms such as commensal bacteria inducing tolerance through pathways involving toll-like receptor-2 (TLR-2) signaling [ 62 , 63 ]. …