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Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… Mentha spicata and M. piperita have been found to be effective in overcoming these emetic conditions (chemotherapy-induced nausea and vomiting, CINV) along with the reduction of expenditure on treatment in the cancer patients undergoing chemotherapy [ 107 ]. … spicata and Mentha piperita in chemotherapy-induced nausea and vomiting ecancermedicalscience 2013 7 1, article 290 2-s2.0-84873336018 10.3332/ecancer.2013.290 PMC3562057 23390455 108 Maddocks-Jennings W Wilkinson JM Cavanagh HM Shillington D Evaluating the effects of the essential oils Leptospermum …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… . ## Mentha longifolia; Cuminum cyminum; Zataria multiflora; Pimpinella anisum . … Compared to the extract of Mentha haplocalyx , shallot extract showed a better toxic effect on larvae, which is illustrated in Figure 2i ( 40 ). Furthermore, one study indicated that shallot extract could have potential use as a symbiotic agent. …

The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises.

BackgroundBreast cancer is a critical threat to human health, and effective targeted agents showing lower systemic toxicity are still lacking. Therefore, exploring new potent therapeutic candidates with a broader safety margin is warranted. Alternative medicine, which has historically been used in traditional Chinese medicine, has played an increasingly prominent role in this area of research. This study introduces Commiphora myrrha (or myrrh) as a potential therapeutic candidate for treating breast cancer patients. Myrrh bioactive extracts have been used traditionally for decades to treat num

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… receptor MOL001107 | β-cedrene | Progesterone receptor MOL001109 | β-thujene | Progesterone receptor MOL001114 | 2-[(1R)-2,2,3-trimethyl-1-cyclopent-3- enyl]ethanal | Progesterone receptor MOL001115 | cis-Verbenol | Progesterone receptor MOL001116 | pinocarvone | Progesterone receptor MOL001117 | p-mentha … -1,5-dien-8-ol | Progesterone receptor MOL001118 | p-mentha-1(7)-dien-8-ol | Progesterone receptor MOL001120 | myrtenal | Progesterone receptor MOL001129 | l-Verbenone | Progesterone receptor MOL001136 | 1,2-epoxyfurano-10(15)-germacren-6-one | Progesterone receptor MOL001137 | 4,7-dimethoxy-5-methyl-coumarin …

The Liver in Systemic Illness

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… Fournier B, Giostra E, Mentha G. Three cases of liver transplantation for type I familial amyloid polyneuropathy. Transplant Proc. 1997;29:2416. doi: 10.1016/s0041-1345(97)00428-4. 161. Garcia-Herola A, Prieto M, Pascual S. …

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells.

Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence after standard first-line treatment (reductive surgery and chemotherapy). New treatments and adjunct therapies are needed. In ovarian cancer, as in other cancers, the immune response, particularly cytotoxic (CD8+) T cells are correlated with a decreased risk of recurrence. As well as completely new antigen targets resulting from DNA mutations (ne

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… proliferation in cancer cell lines | Cyanidin 3-glucoside pelargonidin 3-glucoside | [ 165 , 166 ] Davidson’s plum | Davidsonia pruriens | Antioxidant | Naringenin Hesperetin delphinidin 3-sambubioside cyanidin 3-sambubioside peonidin 3-sambubioside petunidin 3-sambubioside | [ 164 , 166 ] Native river mint | Mentha … Identification and quantification of phenolics in australian native mint (mentha australis r. Br.) Food Chem. 2016;192:698–705. doi: 10.1016/j.foodchem.2015.07.032. 163. Konczak I., Roulle P. …

Is Camphor the Future in Supporting Therapy for Skin Infections?

The aim of this review is to present the potential application of camphor-a bicyclic monoterpene ketone-in the prevention of skin infections. Skin diseases represent a heterogeneous group of disorders characterized by prolonged symptoms that significantly diminish the quality of life. They affect the dermis, the epidermis, and even subcutaneous tissue. They very often have a bacterial or fungal background. Therapy for dermatological skin disorders is difficult and long-term. Therefore, it is important to find a compound, preferably of natural origin, that (i) prevents the initiation of this in

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… Chemical Composition and Synergistic Potential of Mentha pulegium L. and Artemisia Herba Alba Asso. Essential Oils and Antibiotic against Multi-Drug Resistant Bacteria. Molecules. 2022;27:1095. doi: 10.3390/molecules27031095. 25. Gahlot R., Nigam C., Vikas Kumar G., Yadav H., Anupurba S. … Chemical Composition of Mentha Pulegium and Rosmarinus Officinalis Essential Oils and Their Antileishmanial, Antibacterial and Antioxidant Activities. Microb. Pathog. 2017;111:41–49. doi: 10.1016/j.micpath.2017.08.015. 108. Mohammed H.A., Al-Omar M.S., Aly M.S.A., Hegazy M.M. …

Platelet proteome and tumor dormancy: can platelets content serve as predictive biomarkers for exit of tumors from dormancy?

Although tumor dormancy is highly prevalent, the underling mechanisms are still mostly unknown. It is unclear which lesions will progress and become a disseminated cancer, and which will remain dormant and asymptomatic. Yet, an improved ability to predict progression would open the possibility of timely treatment and improvement in outcomes. We have recently described the ability of platelets to selectively uptake angiogenesis regulators very early in tumor growth, and proposed their use as an early marker of malignancy. In this review we will summarize current knowledge about these processes

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… Fuhrmann-Benzakein E., Ma M.N., Rubbia-Brandt L., Mentha G., Ruefenacht D., Sappino A.P., Pepper M.S. Elevated levels of angiogenic cytokines in the plasma of cancer patients. Int. J. Cancer. 2000;85:40–45. doi: 10.1002/(SICI)1097-0215(20000101)85:1<40::AID-IJC7>3.0.CO;2-L. 74. …

Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities.

Liver cancer is the sixth most commonly occurring cancer and costs millions of lives per year. The diagnosis of hepatocellular carcinoma (HCC) has relied on scanning techniques and serum-based markers such as α-fetoprotein. These measures have limitations due to their detection limits and asymptomatic conditions during the early stages, resulting in late-stage cancer diagnosis where targeted chemotherapy or systemic treatment with sorafenib is offered. However, the aid of conventional therapy for patients in the advanced stage of HCC has limited outcomes. Thus, it is essential to seek a new tr

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… New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy J Clin Oncol 2009 27 446 452 19064965 10.1200/JCO.2008.18.8151 25 Merani S Majno P Kneteman NM Berney T Morel P Mentha …

The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors.

Background: The emergence of multidrug-resistant organisms (MDROs) is a global public health issue, severely hindering clinicians in administering appropriate antimicrobial therapy. Drug repurposing is a drug development strategy, during which new pharmacological applications are identified for already approved drugs. From the viewpoint of the development of virulence inhibitors, inhibition of quorum sensing (QS) is a promising route because various important features in bacterial physiology and virulence are mediated by QS-dependent gene expression. Methods: Forty-five pharmacological agents,

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… Anti-Quorum Sensing Activity of 12 Essential Oils on chromobacterium violaceum and Specific Action of cis-cis-p-Menthenolide from Corsican Mentha suaveolens ssp. Insularis Molecules 2018 23 2125 10.3390/molecules23092125 30142938 PMC6225197 101. Hendrix A.S. Spoonmore T.J. Wilde A.D. Putnam N.E. …

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

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… peritoneal cancers | Sodium selenite pentahydrate vs. vehicle vs. standard care Chemotherapy-induced peripheral neuropathy-essential oil intervention | NCT03449303 | Augusta University | NA | NS | Breast cancer | Eoi (10% dilution of Curcuma longa , Piper nigrum , Pelargonium asperum , Zingiber officinale , Mentha …

Карвацоль Ойл как нейропоохранный агент: обзор дизайна исследований и последних достижений.

Нейродегенеративные заболевания в основном воспринимаются как болезни стареющего населения, однако сегодня в день эти заболевания представляют угрозу для населения всех возрастных групп, несмотря на значительное улучшение качества жизни. Согласно сообщениям, почти все основные масла (ЭО) обладают определенными нейрозащитными способностями и на протяжении столетий использовались в качестве добавок к хорошему психическому здоровью. Этот обзор свидетельствует о терапевтическом потенциале одного такого монотерпенового фенола, карвакрула (CV), который может быть использован в качестве основного тер

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… CV is present in the EOs of various plants native to China, such as Mosla chinensis Maxim, Thymus vulgaris L, Piper nigrum L, and Mentha haplocalyx Briq [ 75 , 76 ]. …

Bioactivity of the Genus Turnera: A Review of the Last 10 Years.

Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Amo

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers.

Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is present in the essential oils of various plants. It has diverse applications and can be found in household items, including foods, cosmetics, and cleaning supplies. Over the past three decades, it has also been investigated for its potential anticancer activity. Clinical trials with an oral POH formulation administered to cancer patients failed to realize therapeutic expectations, although an intra-nasal POH formulation yielded encouraging results in malignant glioma patients. Based on its amphipathic nat

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… Common synonyms of POH are perilla alcohol, perillol, and p-mentha-1,8-dien-7-ol, among others. Its IUPAC name is (4-prop-1-en-2-ylcyclohexen-1-yl)methanol. It is a terpene (or, more accurately, a terpenoid, as it is a terpene modified by derivatization through the addition of a hydroxyl group). …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Granules | Scrophulariae Radix extract, Rehmanniae Radix extract, Ophiopogonis Radix extract, Panacis Quinquefolii Radix extract, Dextrin, Stevia sugar | G20230352 Xinzhu Nutritional Brand Di Huang Xuan Shen Tablets | Rehmanniae Radix, Scrophulariae Radix, Fritillariae Thunbergii Bulbus, Moutan Cortex, Menthae …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

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… acid, silicon dioxide, magnesium stearate, dicalcium phosphate, microcrystalline cellulose | ( 151 ) Turmix tablet | 300 mg curcumin plus 5 mg piperine | ( 113 ) Turmix mouthwash | C. longa dry extract 0.1% w/v standardized to 95% curcumin (tetrahydrocurcumin) along with thymol, eucalyptol, clove oil, mentha …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Moreover, it can be obtained from other plants, including Sesbania grandifolra , Cajanus cajan , Apium graveolens , Platycodon grandiflorum , Mentha spicata , and Perilla frutescens [ 233 ]. Different extraction techniques have been developed to extract luteolin from plants. …

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Emergency Care

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Неделя ГЭЭ 2017 Презентации на плакате

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