Результаты поиска

Association of Methamphetamine and Opioid Use With Nonfatal Overdose in Rural Communities.

IMPORTANCE: Overdoses continue to increase in the US, but the contribution of methamphetamine use is understudied in rural communities. OBJ … ities in 10 states (Illinois, Kentucky, New Hampshire, Massachusetts, North Carolina, Ohio, Oregon, Vermont, West Virginia, and Wisconsin). Participants included rural PWUD who reported any past-30-day injection drug use or noninjection opioid use to get high. A modified chain-referral sampling strategy identified seeds who referred others using drugs. Da …

Modeling Oxygen Saturation Targets, Mortality, and Retinopathy Among Extremely Preterm Infants.

IMPORTANCE: According to the Neonatal Oxygenation Prospective Meta-Analysis, a higher oxygen saturation as measured by pulse oximetry (Spo2) … TING, AND PARTICIPANTS: This decision analytical modeling study used US national birth data and the Vermont Oxford Network database (2019-2023), incorporating gestational age (GA) and 16 performance subgroups (based on quartiles of center-specific mortality and retinopathy risks), to simulate an annual birth cohort of infants born extremely preterm (GA 23 …

Early postnatal dexamethasone therapy for the prevention of chronic lung disease.

OBJECTIVE: To test the hypothesis that early postnatal dexamethasone will reduce the incidence of death or chronic lung disease (CLD) in ventilated extremely low birth weight premature infants. DESIGN: Multicenter randomized double-blinded controlled clinical trial. SETTING: A total of 42 neonatal intensive care units in the Vermont Oxford Network. PARTICIPANTS: Infants weighing 501 to 1000 g were eligible for enrollment at 12 hours of age if they needed assisted ventilation, had received surfactant replacement therapy, were physiologically stable, had no obvious life-threatening congenital…

Results of an intervention for individuals and families with BRCA mutations: a model for providing medical updates and psychosocial support following genetic testing.

: Providing medical management updates and long-term support to families with hereditary cancer syndromes in rural areas is a challenge. To address this, we designed a one-day retreat for BRCA1/2 carriers in our region. The retreat included educational updates about medical management, genetic privacy and discrimination, and addressed psychological and family issues. Evaluations completed at the conclusion of the retreat were overwhelmingly positive with requests for a similar event in the future. The impact of this retreat on a variety of health behaviors was assessed. Eligible participants c

Medicaid Retention After Transition to Medicare Among Adults With Expansion Coverage.

IMPORTANCE: When becoming eligible for Medicare, adults previously covered by Medicaid expansion are typically required to meet an asset tes … expansion by January 2018, of which 6 states (Arizona, Connecticut, Delaware, New York, Oregon, and Vermont) plus Washington, DC, waived the MSP asset test. Analyses were conducted between May 2024 and February 2026. EXPOSURE: States without vs states with the MSP asset test. MAIN OUTCOMES AND MEASURES: MSP or any Medicaid coverage 1 year after Medicare …

Variation in Performance of Neonatal Intensive Care Units in the United States.

IMPORTANCE: Hospitals use rates from the best quartile or decile as benchmarks for quality improvement aims, but to what extent these aims a … birth weight of 501 to 1500 g born from January 1, 2005, to December 31, 2014, and cared for at 756 Vermont Oxford Network member NICUs in the United States were evaluated. Logistic regression models with empirical Bayes factors were used to estimate standardized morbidity ratios for each NICU. Each ratio was multiplied by the overall network rate to calc …

Variation in HIV Transmission Behaviors Among People Who Use Drugs in Rural US Communities.

IMPORTANCE: People who use drugs (PWUD) continue to be at risk of HIV infection, but the frequency and distribution of transmission-associated behaviors within various rural communities is poorly understood. OBJECTIVE: To examine the association of characteristics of rural PWUD with HIV transmission behaviors. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, surveys of PWUD in rural communities in 10 states (Illinois, Kentucky, New Hampshire, Massachusetts, North Carolina, Ohio, Oregon, Vermont, West Virginia, and Wisconsin) were collected January 2018 through March 2020 and…

Red Blood Cell Transfusion Characteristics and Morbidity or Mortality in Very-Low-Birth-Weight Infants.

IMPORTANCE: Few studies have evaluated whether modifiable aspects of red blood cell (RBC) transfusions are associated with recipient outcome … medical record data linking blood donor and component data to infants were obtained and linked with Vermont Oxford Network outcome data, with additional outcome review by site. The analysis was completed in January 2026. EXPOSURES: RBC transfusion and transfusion characteristics, evaluated up to the first outcome event. MAIN OUTCOMES AND MEASURES: The p …

Implementing potentially better practices to improve neonatal outcomes after reducing postnatal dexamethasone use in infants born between 501 and 1250 grams.

OBJECTIVE: The purpose of this article is to describe how a neonatal intensive care unit (NICU) was able to reduce substantially the use of postnatal dexamethasone in infants born between 501 and 1250 g while at the same time implementing a group of potentially better practices (PBPs) in an attempt to decrease the incidence and severity of chronic lung disease (CLD). METHODS: This study was both a retrospective chart review and an ongoing multicenter evidence-based investigation associated with the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative (NIC/Q 2000). …

Reduced Nicotine Cigarettes and E-Cigarettes in High-Risk Populations: 3 Randomized Clinical Trials.

IMPORTANCE: Prohibiting the sale of commonly preferred e-cigarette flavors (eg, fruity and sweet) to discourage use among youths poses a ris … cal trials were conducted for 16 weeks from October 2020 through November 2023 at the University of Vermont, Brown University, and Johns Hopkins University. Participants were adults who smoked daily and were not planning to quit in the next 30 days. These participants were from 3 at-risk populations: those with affective disorders, exemplifying mental ill …

Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage: 3 Randomized Clinical Trials.

IMPORTANCE: This study is part of a programmatic effort evaluating the effects of reducing nicotine content of cigarettes to minimally addictive levels. OBJECTIVE: To examine whether very low-nicotine-content (VLNC) cigarettes decrease smoking rates and dependence severity among smokers with psychiatric disorders or socioeconomic disadvantage. DESIGN, SETTING, AND PARTICIPANTS: These 3 randomized clinical trials were performed at the University of Vermont, Brown University, and Johns Hopkins University between October 2016 and September 2019. Participants received 12 weeks of exposure to stu…

National Trends in the Provision of Human Milk at Hospital Discharge Among Very Low-Birth-Weight Infants.

IMPORTANCE: Human milk confers important health benefits to very low-birth-weight (VLBW) infants (≤1500 g). The extent to which the use of h … s' gestation or with a birth weight of 401 to 1500 g, who were cared for at 802 US hospitals in the Vermont Oxford Network from January 1, 2008, to December 31, 2017. The US census region was categorized as West, Midwest, Northeast, and South (reference). Maternal race/ethnicity was categorized as non-Hispanic white (reference), non-Hispanic black, Hispan …

Гуманистический подход к совершенствованию: подход, основанный на постоянном склерозе и постоянном повышении качества сотрудничества в области координации.

Множественный склероз (MS) является дорогостоящим, хроническим, сложным заболеванием, которое требует индивидуализации ухода на системном уровне для достижения лучших результатов. Авторы описывают осуществляемое при поддержке тренеров мероприятие по совершенствованию качества (QI) в рамках постоянного сотрудничества в области QI (MS-CQI), которое представляет собой исследование по вопросам охраны здоровья в рамках многоцентральной системы обучения (LHS) в целях улучшения результатов MS (2018-2022 годы). МЕТОДЫ: Авторы разработали при поддержке тренера программу " QI " в рамках систем

Совпадение в полном тексте источника
… ER, emergency room; MGH, Massachusetts General Hospital; MS, multiple sclerosis; PwMS, people with MS; UVM, University of Vermont; UVMMC, University of Vermont Medical Center. … ; UVMMC, University of Vermont Medical Center. …

Assisted Reproductive Technology Surveillance - United States, 2014.

PROBLEM/CONDITION: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART a … of ART-conceived infants who were low birthweight was 8.9% (range: 3.2% in some states to 16.1% in Vermont) among singletons and 55.2% (range: 38.5% in Delaware to 77.8% in Alaska) among twins; the corresponding percentages of low birthweight infants among all infants born were 6.3% for singletons (range: 4.6% in Alaska, North Dakota, and Oregon to 9.5% …

Alcohol use, intentions to reduce consumption, and perceived motivations and barriers among cancer survivors.

PurposeTo characterize alcohol use patterns, awareness of alcohol's oncologic risks, and efforts and intentions to reduce consumption among cancer survivors in New Hampshire and Vermont.MethodsCross-sectional survey of 471 cancer survivors aged ≥21 years enrolled in two state-wide, online panels. Participants reported their current or former alcohol use, completed the Alcohol Use Disorders Identification (AUDIT), and replied to a series of items regarding any efforts to reduce consumption and related motivations and barriers.ResultsAmong 471 survivors, 34.2% of which had an alcohol-related can…

Исследование in vitro токсикологических механизмов финолимода (S)-фосфата в камерах HEPG2.

Fingolimod (FTY720) — первый модератор рецептора фингозина-1-фосфата (S1P), утвержденный Администрацией продовольствия и лекарств США для лечения множественных склерозов. Активная форма FTY720 (S)-P действует в качестве мощного агониста рецептора S1P, что ведет к его нижнему регулированию на поверхности клеток, снижению активности и прекращению внутриклеточной сигнализации, зависимой от фингозина. Повышенные уровни фермента печени, клинически значимая травма печени и острая недостаточность печени наблюдались у пациентов, прошедших курс лечения с помощью FTY720 (S)-P, что требует дополнительног

Совпадение в полном тексте источника
… The absorbance was measured at 450 nm using a microplate reader (Biotek, Epoch, Vermont, USA). Result was expressed as U/mg protein. The protein content was measured with the Pierce BCA protein assay kit (Thermo Scientific, USA). … The absorbance was measured at 405 nm using a microplate reader (Biotek, Epoch, Vermont, USA) and the results were expressed as U/mg protein. The protein content was measured with the Pierce BCA protein assay kit (ThermoFisher Scientific, USA). …

Implementing guidelines to prevent cancer associated thrombosis: how can we do better?

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Similarly, in 2 studies in the community practice setting that deployed an implementation model developed at the University of Vermont, we found that although the risk assessment can be relatively straightforward to address, the actual prescribing of prophylaxis is more difficult and remained at only … Figure Prevention of VTE in ambulatory patients with cancer: Best practices and future directions Figure Prevention of VTE in ambulatory patients with cancer: Best practices and future directions To this end, we are uploading the current University of Vermont program to the common community library …

Emerging trends and disparities in mortality due to coexisting non-Hodgkin's lymphoma and respiratory infections: A U.S. nationwide retrospective analysis from 1999 to 2020.

Non-Hodgkin lymphoma (NHL) patients are highly susceptible to respiratory infections due to immunosuppression from both the disease and its treatments. Understanding mortality trends and disparities in this population is crucial for improving care and reducing the burden of coexisting conditions. This study analyzed death certificates from the Center of Disease Control Wide-Ranging Online Data for Epidemiologic Research database for individuals aged ≥ 25 years who died between 1999 and 2020 with both NHL and respiratory infections. Age-adjusted mortality rates (AAMRs) and annual percent change

Совпадение в полном тексте источника
… State-wise distribution AAMR values varied significantly by state, ranging from 8.9 in the District of Columbia to 21.2 in Vermont. … Geographic trends revealed higher AAMR in the Midwest (15.8), particularly in states like Vermont (21.2), and in non-metropolitan areas (16.5) compared to urban regions (13.6), with both seeing a significant increase in mortality after 2018. …

Диагностическая задержка и неправильное диагностирование симптомов, сообщенных пациентами с множественным склерозом, участвующими в исследовательской работе.

РУКОВОДЯЩИЕ ПРИНЦИПЫ: Данные групп исследований свидетельствуют о том, что задержка с диагностикой множественных склерозов (MS) уменьшилась параллельно с пересмотром диагностических критериев MS, однако в других исследованиях этот вывод не был повторен. Последние данные свидетельствуют о неправильной диагностике первоначальных симптомов НР, что часто приводит к задержкам в диагностике. ЦЕЛИ: В ходе этого обследования была проведена оценка задержки с диагностикой и неправильной диагностики в реестре пациентов с НР. МЕТОДЫ: Участники завершили исследование в период с 12 ноября 2021 года по 22 де

Совпадение в полном тексте источника
… This specific study was also reviewed and approved by the University of Vermont Institutional Review Board, and an additional electronic consent for survey participants was obtained. Results Participant characteristics There were 428 participants. … Contributor Information Andrew J Solomon, Larner College of Medicine at the University of Vermont, Department of Neurological Sciences, Burlington, VT, USA. Sarah M Weinstein, Department of Epidemiology and Biostatistics, College of Public Health, Temple University, Philadelphia, PA, USA. …