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Enhanced Visualization Methods for First Transurethral Resection of Bladder Tumour in Suspected Non-muscle-invasive Bladder Cancer: A Health Technology Assessment.

BACKGROUND: Bladder cancer begins in the innermost lining of the bladder wall and, on histological examination, is classified as one of two … se new technologies to improve patient outcomes following first TURBT. The use of NBI in diagnostic cystoscopy was out of scope for this health technology assessment. METHODS: We performed a systematic literature search of the clinical evidence from inception to April 15, 2020. We searched for randomized controlled trials (RCTs) that compared the outcomes o …

Case Report: Primed dendritic cell immunotherapy for multiple solid tumors.

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard

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… During hospitalization for colitis, the patient was found to have microhematuria on cystoscopy, and transurethral resection of bladder tumor revealed invasive high-grade, T2b urothelial carcinoma of the bladder, with a high proliferation index (Ki-67 at 90%). …

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.

Fibroblast growth factors (FGFs) orchestrate a variety of cellular functions by binding to their transmembrane tyrosine-kinase receptors (FGFRs) and activating downstream signalling pathways, including RAS/MAPK, PLCγ1, PI3K, and STATs. In the last ten years, it has become clear that FGF signalling is altered in a high proportion of bladder tumours. Activating mutations and/or overexpression of FGFR3 are common in urothelial tumours with low malignant potential and low-stage and -grade urothelial carcinomas (UCs) and are associated with a lower risk of progression and better survival in some su

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… One of the major challenges in the management of these tumours is their propensity to recur, therefore requiring frequent and often life-long surveillance with cystoscopy and urine cytology. …

Radiomics models to predict bone marrow metastasis of neuroblastoma using CT.

BACKGROUND: Bone marrow is the leading site for metastasis from neuroblastoma and affects the prognosis of patients with neuroblastoma. However, the accurate diagnosis of bone marrow metastasis is limited by the high spatial and temporal heterogeneity of neuroblastoma. Radiomics analysis has been applied in various cancers to build accurate diagnostic models but has not yet been applied to bone marrow metastasis of neuroblastoma. METHODS: We retrospectively collected information from 187 patients pathologically diagnosed with neuroblastoma and divided them into training and validation sets in

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… An artificial intelligence system for the detection of bladder cancer via cystoscopy: a multicenter diagnostic study. J Natl Cancer Inst. 2022;114(2):220–227. 10.1093/jnci/djab179 28. Ji GW, Zhang YD, Zhang H, Zhu FP, Wang K, Xia YX, et al. …

Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… The procedure consists of 20–30 injections into the bladder wall via cystoscopy under local anesthesia. Repeat injections are required every 6–9 months. …

2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

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Robotic-assisted single-site abdominal cerclage in the bicornuate uterus patient with cervical insufficiency.

OBJECTIVE: To demonstrate the surgical techniques for improving safety in robotic-assisted abdominal cerclage in patients with bicornuate ut … remain securely tied and in the correct position. Hemostasis was assured. Both a hysteroscopy and a cystoscopy were done after the completion of the cerclage to ensure that no tape or sutures were seen within the cervical canal or the uterine cavity. None were observed. MAIN OUTCOMES MEASURES: The success criteria for the surgery were identified as the pati …

Post-Transplant Cyclophosphamide for the Prevention of Graft-vs.-Host Disease in Allogeneic Hematopoietic Cell Transplantation: A Guide to Management for the Advanced Practitioner.

Cyclophosphamide remains a critical component to haploidentical transplant conditioning regimens. Post-transplant cyclophosphamide (PTCy) emerged as an effective component of graft-vs.-host disease (GVHD) prophylaxis in the nonmyeloablative haploidentical bone marrow transplant setting. The relative ease of administration compared with ex vivo manipulations and efficacy in reducing GVHD has led to increasing PTCy use in transplant centers around the world. The role of PTCy has expanded to haploidentical transplantation with myeloablative conditioning regimens and peripheral blood progenitor ce

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… Serious cases may require continuous bladder irrigation, cystoscopy to remove clots, percutaneous nephrostomy placement for persistent hydronephrosis, or installation of topical therapies (prostaglandins, alum, formalin, aminocaproic acid, glutamine). …

Curcumin as a complementary treatment in oncological therapy: a systematic review.

PurposeCurcumin, the active ingredient in turmeric, is employed by numerous cancer patients to support conventional cancer therapy. This systematic review aims to summarize the existing clinical evidence and to provide an overview of the potential benefits and risks associated with curcumin supplementation.MethodsIn January 2024, we conducted a systematic search of five electronic databases (Embase, Cochrane, PsycInfo, CINAHL, and Medline) using a complex search strategy. We included randomized controlled trials on the use, effectiveness, and potential harm of additional curcumin therapy in ad

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… Tumor response (complete clinical response to CTx, cystoscopy by blinded, independent urologist) 4 weeks after end of treatment 2. CTx-induced nephrotoxicity (CTCAE) 3. Hematologic toxicity (CTCAE) | 1. … Studies showed no difference between a nanocurcumin and a placebo group in increase of apparent diffusion coefficient values in diffusion-weighted MRI three months after RTx ( p = 0.574; [ 42 ]) and tumor downstaging to pT0 in cystoscopy 4 weeks after end of treatment (50% vs. 30.8%, p = 0.417; [ 28 …

Exploiting artificial intelligence in precision oncology: an updated comprehensive review.

Precision oncology considers the genetic makeup of both the tumor and the cancer patient, medical history, clinical metadata, lifestyle and environmental factors. Thus, adoption of precision cancer medicine mandates sophisticated integrative analysis. Being a master in sorting and solving the puzzle pieces, artificial intelligence (AI)-powered frameworks emerged to fill the gap via executing multimodal analysis and generating meaningful outputs. Herein, we systematically discussed the opportunities and challenges of exploiting AI-assisted models in preclinical cancer research and in clinical o

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… To diagnose bladder cancer, urologists rely on two fundamental tests: cystoscopy and cytology [ 119 ]. Many patients abandon cystoscopy given its invasive nature. …

Proceedings of the CIMAGO Congress - Environment, Genetics and Oncobiology in the 21st Century - Challenges and Opportunities.

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… In fact, cystoscopy and cytology are still standards for bladder cancer detection. It is critical for the development of less invasive and reliable diagnostic techniques for bladder cancer, other than cystoscopy and cytology. …

Creative Arts Therapy for Anxiety, Depression, and Quality of Life in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BackgroundCancer is a significant psychological burden for patients. Previous evidence syntheses suggest creative arts therapies (CATs) may improve psychological outcomes, but are limited by heterogeneity in intervention types, study designs, and outcomes, and the lack of a certainty of evidence assessment.AimsWe conducted a robust systematic review and meta-analysis of current randomized trial literature to explore the efficacy of CATs in improving anxiety, depression, and quality of life in cancer patients.MethodsWe searched PubMed, Embase, and PsycInfo databases for peer-reviewed randomized

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… C., et al., “Music From Noise‐Canceling Headphones is Beneficial Against Anxiety in Male Bladder Cancer Patients Undergoing Follow‐Up Cystoscopy: A Prospective Randomized Trial,” Urologia Internationalis 108, no. 5 (October 2024): 414–420, 10.1159/000539312. 49. Chuang C. H. and Chen C. …

Imaging of abdominal and pelvic infections in the cancer patient.

Infections are the most commonly encountered complications in patients with cancer. The classical signs and symptoms of infections are often not present in this patient population, which makes the diagnosis more challenging. Host factors play a major role in the development and prognosis of infections in cancer patients; these can be related to the underlying type of malignancy (solid organ versus hematological), tumor burden, anatomic obstruction, altered integrity of barriers (skin or mucosa), treatment-related factors (from chemotherapy, radiation treatment, surgery, interventional procedur

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… Cystoscopy confirmed tumor replacing the entire base of bladder, including trigone and bilateral ureters, with pathology consistent with colorectal adenocarcinoma. …

KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.

The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach and guideline recommendations are based on systematic reviews of relevant studies that included critical appraisal of the quality of the evidence and the strength of recommendations. However, m

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… CHAPTER 7: PREDONATION HEMATURIA Evaluation 7.1: Donor candidates should be assessed for microscopic hematuria. 7.2: Donor candidates with persistent microscopic hematuria should undergo testing to identify possible causes, which may include: Urinalysis and urine culture to assess for infection Cystoscopy …

Health-related quality of life domains relevant to people in Europe undergoing cancer treatment: a systematic review of qualitative research.

PurposeTo identify and synthesize evidence from European qualitative studies on cancer-related quality of life outcomes, needs, experiences, preferences, and concerns of people undergoing cancer treatment in the last decade.MethodsSystematic review ( https://www.crd.york.ac.uk/PROSPERO , CRD42024575065) of European studies using qualitative methodology, assessing constructs related to HRQoL, and involving adults receiving cancer treatment. The search was performed in PubMed and Scopus from January 2013 to July 2024. Titles, abstracts, and full texts screening, data extraction and risk of bias

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… treatment to six months thereafter | -Insecurity -Coping Stewart 2023 [ 56 ]Ireland | Phenomenology Semi-structured interviews | n = 10 Range: 59–84 yrs 30% women Active surveillance Bladder | To investigate the lived experience of non-muscle invasive bladder cancer patients attending surveillance cystoscopy …

Gossypol and Its Natural Derivatives: Multitargeted Phytochemicals as Potential Drug Candidates for Oncologic Diseases.

Despite the vast amounts of research and remarkable discoveries that have been made in recent decades, cancer remains a leading cause of death and a major public health concern worldwide. Gossypol, a natural polyphenolic compound derived from the seeds, roots, and stems of cotton (Gossypium hirsutum L.), was first used as a male contraceptive agent. Due to its diverse biological properties, including antifertility, antiviral, antioxidant, antibacterial, antimalarial, and most notably antitumor activities, gossypol has been the subject of numerous studies. Nevertheless, no systematic review has

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… Diagnostic workup includes urine cytology and cystoscopy, which is the gold standard for diagnosis and staging [ 83 , 84 ]. …

Abstracts of the 12th European Cytogenomics Conference 2019 : Salzburg, Austria. 6-9 July 2019

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Свет в диагностике, терапии и хирургии.

Легкие и оптические методы оказывают глубокое воздействие на современную медицину, и в настоящее время в клинической практике используются многочисленные лазеры и оптические устройства для оценки состояния здоровья и лечения заболеваний. Последние достижения в области биомедицинской оптики позволили использовать все более сложные технологии, в частности технологии, которые объединяют фотонику с нанотехнологией, биоматериалами и генной инженерией. В настоящем Обзоре мы вновь обращаемся к основам взаимодействия легкой материи, описываем применение света в визуализации, диагностике, терапии и хир

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… For example, blue-light cystoscopy with fluorescent labelled CD47 antibodies enabled the detection of bladder cancer in ex vivo specimens 131 , and neoplastic colorectal polyps in humans were detected through fluorescent peptides targeting c-Met 132 . …

Уникальные диагностические и терапевтические функции порфиринов и фтальокянинов в области фотодинамической терапии, визуализации и термостимы.

Порфиринические молекулы играют уникальную тераностическую роль в лечении болезней; они используются для отображения, обнаружения и лечения различных форм заболевших тканей, в том числе в связи с возрастной маркулярной дегенерацией и рядом различных видов рака. В настоящее время основное внимание уделяется клинической съемке опухолей; целенаправленной доставке фотосенитеров и потенциалу фотоэнцедентов в мультимодальных биомедицинских наноплатформах. В настоящем Обзоре подчеркиваются роли порфириновых молекул в области съемки и пдта, а также исследования по совершенствованию их селективного пог

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… In a phase III trial, comparing transurethral guided resection using ALA verses white light cystoscopy, 61.5% of the patients in the PPIX fluorescence endoscopy group were tumour-free at the follow-up assessment in comparison to only 40.6% in the white light group 243 . …

Abstracts from the 6th Annual Conference of Emirates Society of Internal Medicine (ESIM) 2025.

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