Результаты поиска

Genetic variations of prostate stem cell antigen (PSCA) contribute to the risk of gastric cancer for Eastern Asians: a meta-analysis based on 16792 individuals.

The associations between polymorphisms of prostate stem cell antigen (PSCA-rs2294008C>T and -rs2976392G>A) and gastric cancer (GC) risk for Eastern Asians have been commonly studied, but the results were conflicting. The aim of the present study was to further assess the associations by the method of meta-analysis. The databases of Medline, Embase and CNKI (up to May 25th, 2011) were retrieved to identify eligible case-control studies. Odds ratio (OR) and 95% confidence interval (95%CI) were used to present the strength of the associations. In total, eight case-control studies in seven article…

Recognising symptoms of breast cancer as a reason for delayed presentation in Asian women--the psycho-socio-cultural model for breast symptom appraisal: opportunities for intervention.

INTRODUCTION: Advanced presentation of breast cancer and the problem of late diagnosis is well documented. Patient delay beyond three months has been shown to reduce survival. This paper aims to explore the experience of Malaysian women presenting with advanced breast cancer with regards to their interpretation of breast symptoms. METHOD: Purposive sampling of 19 breast cancer patients presenting with delayed treatment and/ or advanced cancer diagnosed within two years at the University Malaya Medical Centre, Kuala Lumpur were carried out. In-depth interviews were conducted using a self-devis

Effect of spot size and fluence on Q-switched alexandrite laser treatment for pigmentation in Asians: a randomized, double-blinded, split-face comparative trial.

BACKGROUND: Q-switched laser treatment for pigment disorders commonly leads to postinflammatory hyperpigmentation (PIH) in Asians. OBJECTIVES: To evaluate the effect of spot size and fluence on Q-switched alexandrite laser (QSAL) treatment for pigmentation in Asians. METHODS: Ten patients with freckles, 18 with lentigines, and 8 with acquired bilateral nevus of Ota-like macules (ABNOM) received 1 session of QSAL treatment for a 3-mm spot on one cheek and a 4-mm spot on the other cheek. The lowest fluences to achieve a visible biologic effect were chosen. RESULTS: The patients with freckles …

Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX-4 treatment in Asian patients with colorectal carcinoma.

Xeroderma pigmentosum group D (XPD) participates in DNA unwinding during nucleotide excision repair, which may alter the efficacy of platinum-based chemotherapy. We analyzed the influence of codon 751 Lys-->Gln polymorphism of XPD on its protein expression levels, clinico-pathological features, and outcome of 188 Chinese patients with metastatic colorectal carcinoma (CRC) that had been treated with first-line Oxaliplatin + Leucovorin + 5-Fluorouracil (FOLFOX-4) chemotherapy. The results showed that in comparison with Caucasian populations, a remarkably lower prevalence of Lys/Gln genotype was …

Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis.

INTRODUCTION: Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians. To examine the associations of these SNPs with OA in East Asian populations and to evaluate their global significance, we conducted two case-control studies in 955 Chinese and 750 Japanese patients. METHODS: We genotyped the previously implicated SNPs rs585017 (in RHOB) and rs4720262 (in TXNDC3) in patients with primary symptomatic knee OA with radiographic confirmation and in matched contr…

Genotype frequencies at codon 129 of the prion protein gene in Brazil: Implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations.

A polymorphism at codon 129 of the prion protein gene has been shown to confer genetic susceptibility to prion diseases, and to influence the epidemic course of variant Creutzfeldt-Jakob disease. We employed a PCR-endonuclease digestion-based assay to investigate this genetic trait in Brazil, and then compared our results to previously published data from several European and Asian countries.

Electron microscopic investigations on stages of dog piroplasms cultured in vitro: Asian isolates of Babesia gibsoni and strains of B. canis from France and Hungary.

Stages obtained from two Asian Babesia gibsoni-isolates cultured in vitro were studied by means of transmission electron microscopy and compared to strains of B. canis cultured in vitro. While the developmental stages of the latter preserved their shape in culture, many of the initially small stages of the B. gibsoni strains grew considerably and often looked rather similar to B. canis.

An examination of current control strategies for Asian schistosomiasis in the Dongting lake region of China. II. A five year follow-up survey on Qingshan island.

In 1995-1996 we conducted an epidemiological survey in two communities (1656 individuals) on Qingshan island, Hunan province P.R. China, in order to determine the efficacy of current control strategies since their upgrading in 1991. In 1996, the overall prevalence for Schistosoma japonicum, Ascaris lumbricoides, Ancylostoma duodenale, and Trichuris trichiura had decreased moderately since 1991. The age-specific prevalence for S. japonicum for each of the representative age groups decreased slightly, but there was a significant reduction in these prevalences for the 5-9 (P < 0.01), 55-59 (P < 0

The effects of collectivistic and authority-based green advertising on green purchasing behavior for apparel among gen Z and Y Asian consumers in an emerging market.

The purpose of this study is to investigate the effects of collectivistic and authority-based green advertising on actual green purchasing behavior for apparel among Gen Z and Gen Y consumers in an emerging market. By conceptually uniting the stimulus-organism-response model with the theory of planned behavior, data were collected through a robust two-stage survey from 197 Vietnamese consumers to minimize consistency bias and specifically address the intention-behavior gap prevalent in environmental communication research. Results indicate a significant direct association between culturally ad

The burden of nasopharyngeal carcinoma in countries of the Association of Southeast Asian Nations (ASEAN), 1990-2023: findings from the Global Burden of Disease Study 2023.

BACKGROUND: Nasopharyngeal carcinoma (NPC) remains a major cancer burden in parts of Asia, particularly in the Association of Southeast Asian Nations (ASEAN). However, the burden and trends within ASEAN have not been comprehensively explored. METHODS: We extracted data on incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of NPC in ASEAN from the Global Burden of Disease Study (GBD) 2023. We summarized absolute counts, crude rates, and age-standardized rates, and quantified temporal trends using estimated annual percentage changes (EAPCs). Analyses were stratified by…

Development of the sterile insect technique as a control strategy for the Asian citrus psyllid: determining the number of sterile individuals needed to suppress the growth of wild populations.

Controlling the Asian citrus psyllid (ACP), Diaphorina citri, is key to preventing spread of huanglongbing, a disease that has decimated citrus industries worldwide. One promising control method is the Sterile Insect Technique (SIT). This involves rearing large numbers of a target pest, sterilizing them using radiation, and releasing them into the field to compete with wild conspecifics for mating, ultimately suppressing population growth. The success of SIT is largely influenced by 3 factors: (i) ensuring released insects are sufficiently sterile such that mating between wild and sterile indi…

Asian Flu in Milan, 1957. A brief history of the first pandemic occurred after the discovery of Influenza A virus and its impact in a large Italian city.

Asian flu emerged in southern China in the last months of 1956 and after reaching Singapore and Hong spread in the rest of the world. Phylogenetic studies subsequently revealed that the new virus, called H2N2, was the product of a reassortment of a H1N1 strain circulating in humans with an avian strain that contributed polymerase subunit 1 (PB1), hemagglutinin and neuraminidase coding genes. The peak of the epidemic in most European countries occurred in autumn 1957. Compared to the Spanish flu, mortality was significantly lower, with an estimated number of two million deaths and case-fatality…

An Integrative Morphological and Genomic Analysis With a Refined Fluorescence In Situ Hybridization (FISH) Threshold and Novel Kinase Fusions in a Large Asian Cohort of Spitzoid Neoplasms.

Differentiating atypical Spitz tumors (ASTs) from true Spitz melanomas (SMs) and conventional melanomas with spitzoid features (MSFs) remains a formidable diagnostic challenge. Because current molecular epidemiological data are overwhelmingly derived from Caucasian cohorts, the genomic landscape of Asian populations remains largely unexplored. To elucidate the molecular progression landscape and refine the diagnostic criteria, we performed a comprehensive multimodal analysis-integrating histomorphology, immunohistochemistry, multiprobe fluorescence in situ hybridization (FISH), and targeted RN…

The epidemiology and burden of injury in countries of the Association of Southeast Asian Nations (ASEAN), 1990-2021: findings from the Global Burden of Disease Study 2021.

BACKGROUND: Injuries are among the top causes of mortality and disability in southeast Asia. Although injury prevention is a key health priority in the Post-2015 Health Development Agenda of the Association of Southeast Asian Nations (ASEAN), the focus was placed solely on road injuries. The absence of a broader recognition of injury burden and trends hinders future intervention efforts. This study aims to provide a comprehensive analysis of the burden and epidemiological trends of all injuries across ASEAN countries. METHODS: In this analysis of the Global Burden of Disease, Injuries, and Ri…

Safinamide as an adjunct to levodopa monotherapy in Asian patients with Parkinson's disease experiencing early wearing-off: a pooled analysis of the J-SILVER and KEEP studies.

BACKGROUND: Limited trials are evaluating the efficacy of monoamine oxidase B inhibitors as an adjunct to levodopa monotherapy for early wearing-off in Parkinson's disease (PD). We evaluated the efficacy and safety of safinamide in patients with fluctuating PD treated with levodopa monotherapy. METHODS: This pooled analysis used data from the J-SILVER and KEEP studies and targeted patients with PD experiencing wearing-off who received safinamide as adjunct to levodopa monotherapy. Efficacy endpoints were mean changes in 39-item Parkinson's Disease Questionnaire (PDQ-39), Movement Disorder Soc

Бремя множественной миеломы в азиатских странах 1990 в адрес 2021 и прогнозирование тенденций 2050:: анализ, основанный на Глобальном исследовании бремени болезней 2021.

Множественная миелома (ММ) создает растущую угрозу для здоровья населения во всем мире, причем региональные различия в бремени болезней становятся все более заметными. Являясь самым густонаселенным континентом, Азия переживает быстрые демографические и социально-экономические изменения и играет решающую роль в формировании эволюционной траектории глобального бремени ММ. Цель этого исследования заключается в оценке бремени болезней, связанных с множественной миеломой в азиатских странах. 1990 в адрес 2021Данные этого исследования были получены на основе исследования глобального бремени болезней

Совпадение в аннотации оригинала
BackgroundMultiple myeloma (MM) poses a growing challenge to global public health, with regional disparities in disease burden becoming incr … ectory of the global MM burden. This study aims to assess the disease burden of multiple myeloma in Asian countries from 1990 to 2021.MethodsThe data of this study were derived from the Global Burden of Disease Study 2021 database. We conducted a systematic analysis of the disease burden of MM in Asia from 1990 to 2021, covering four core dimensions: in …

Disease burden of infertility in five East Asian countries from 1990 to 2021 and prediction for 2050: An analysis of the Global Burden of Disease study 2021.

BACKGROUND: With the development of society, fertility seems to have become a public health issue in East Asian countries. At present, there is insufficient attention to infertility, especially male infertility. Understanding the burden and trends of infertility in men and women aged 20-49 years in East Asia is essential for fertility issues. METHOD: The related data in China, Democratic People's Republic of Korea, Japan, Mongolia and Republic of Korea, was extracted from the Global Burden of Disease (GBD) Study 2021 including prevalence, disability-adjusted life-year (DALY), age-standardized…

The impact of Asian-Indian criteria for higher body mass index and preservative solutions on haemolysis of stored red blood cells: A prospective observational study.

INTRODUCTION: The quality of packed red blood cells (PRBC) is influenced by various factors such as the collection and processing method, storage conditions, type of bag materials used, anticoagulant properties, and donor characteristics. Studies have indicated that haemolysis in stored RBC bags is linked to male sex, older age, high haemoglobin count, and increased body mass index (BMI). The study's primary objective was to investigate whether a high BMI, as per Asian Pacific criteria among donors, is associated with an elevated haemolysis rate in stored RBC. Additionally, the study aimed to …