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Measuring Frailty Using Patient-Reported Outcomes (PRO) Data: A Feasibility Study in Patients with Multiple Myeloma.

PURPOSE: The objective of this retrospective study was to determine the feasibility of measuring frailty using patient responses to relevant EORTC QLQ-C30 items as proxy criteria for the Fried Frailty Phenotype, in a cohort of patients with Relapsed/Refractory Multiple Myeloma (RRMM). METHODS: Data were pooled from nine Phase III randomized clinical trials submitted to the FDA for regulatory review between 2010 and 2021, for the treatment of RRMM. Baseline EORTC QLQ-C30 responses were used to derive a patient-reported frailty phenotype (PRFP), based on the Fried definition of frailty. PRFP wa

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… (Q3) Low physical activity (typically measured by Kcals expended per week using the short version of the Minnesota Leisure Time Activity Questionnaire) | 0 or 1 | Were you limited in doing either your work or other daily activities? … For instance, in addition to clinical measurements like grip strength and gait speed, the original Frief Frailty Phenotype involves calculating kilocalories of energy expended using the Minnesota Leisure Time Activity instrument [ 23 ]. …

Humoral Responses After SARS-CoV-2 mRNA Vaccination and Breakthrough Infection in Cancer Patients.

ObjectiveTo evaluate the magnitude of humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines in patients with cancer receiving active therapies.Patients and methodsPatients 18 years or older in whom SARS-CoV-2 spike antibody (anti-S Ab) levels were measured after 2 doses of SARS-CoV-2 mRNA vaccines were included. Patients with prior coronavirus disease 2019 (COVID-19) infection or receiving other immunosuppressive therapy were excluded.ResultsAmong 201 patients who met the criteria, 61 were immunocompetent, 91 had a hematologic malignancy

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… Patients and Methods Patient Selection We conducted a retrospective cross-sectional study of patients 18 years or older who had SARS-CoV-2 spike antibody (anti-S Ab) tests performed after 2 doses of SARS-CoV-2 mRNA vaccines between 12 and 90 days at the 3 Mayo Clinic sites in Minnesota, Florida, and …

Реналь-лимитированный амилоидный лайт-чаин (Ламбда) Амилоидоз, представленный как Моноклональная Гаммопатия Ренального Значения: доклад по делу.

Моноклональная гаммопатия почечной значимости (MGRS) охватывает почечные заболевания, вызываемые нефротоксичными моноклональными иммуноглобулинами, производимыми небольшими клонами B-клеток или плазменными клонами, которые не отвечают критериям явной гематологической злокачественности. Ренал амилоидный светоцепный (AL) амилоидоз — признанное повреждение в диапазоне MGRS. Мы сообщаем о случае 66-year-old Женщина с нефротическим синдромом и почечной дисфункцией, связанными с моноклональными лямбдами. Биопсия реала подтвердила амилоидоз AL (ламбда), в то время как анализ костного мозга и системна

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… Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Kyle RA, Linos A, Beard CM, Linke RP, Gertz MA, O'Fallon WM, Kurland LT. https://doi.org/10.1182/blood.V79.7.1817.1817 . Blood. 1992;79:1817–1822. 4. …

Целые пищевые рационы на основе растений являются практически осуществимыми при автоматическом воздействии на организм человека и связаны с модификацией микробиома в зависимости от дозы.

Целые пищевые рационы, основанные на кратком планете, могут представлять собой целенаправленный подход к смягчению последствий нарушения микробиома и улучшению последствий для пациентов, проходящих аутологическую трансплантацию гематопоиетических клеток (auto-HCT) в случае множественной миеломы, в которой кишечный дисбиоз связан с более низким уровнем выживаемости. Мы провели одностороннее клиническое испытание в нашем центре, в ходе которого участники прошли автоHCT (n = 22) получили свежее, заранее подготовленное, растительное питание 5 Недели, охватывающие кондиционирование, нейтрализацию и

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… Metabolism) 10 for calorie (30 kcal/kg per day) and protein (1.5 g/kg per day) recommended minimums for this patient group, and 24-hour dietary recall survey data were analyzed using the Nutrition Data System for Research software version 2024, developed by the Nutrition Coordinating Center, University of Minnesota … , Minneapolis, Minnesota; and (2) diet quality was assessed using the Healthy Eating Index-2020 (HEI-2020), modeled as a function of time and the intake of delivered meals. …

Geographic and Racial Disparities in Access to Chimeric Antigen Receptor-T Cells and Bispecific Antibodies Trials for Multiple Myeloma.

ImportanceThe use of chimeric antigen receptor-T cell (CAR-T) therapy and bispecific antibodies in multiple myeloma is expanding, with encouraging early results. It is unknown if the current geographic distribution of CAR-T therapy and bispecific antibodies in multiple myeloma allows access for patients in need, especially for Black populations, which have a higher incidence of multiple myeloma.ObjectiveTo investigate if the current geographic distribution of CAR-T cell therapy and bispecific antibodies for multiple myeloma allows equitable access for Black patients with multiple myeloma.Desig

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… multiple myeloma were performed at the University of Arkansas for Medical Sciences (1283 transplantations), MD Anderson Cancer Center in Texas (1182 transplantations), City of Hope in California (1158 transplantations), Emory University in Georgia (1146 transplantations), and Mayo Clinic Rochester in Minnesota …

Current Status of Gene Engineering Cell Therapeutics.

Ex vivo manipulations of autologous patient's cells or gene-engineered cell therapeutics have allowed the development of cell and gene therapy approaches to treat otherwise incurable diseases. These modalities of personalized medicine have already shown great promises including product commercialization for some rare diseases. The transfer of a chimeric antigen receptor or T cell receptor genes into autologous T cells has led to very promising outcomes for some cancers, and particularly for hematological malignancies. In addition, gene-engineered cell therapeutics are also being explored to in

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… Judes Children’s Research Hospital; UAMS, University of Arkansas for Medical Sciences; UB, University of Bologna; UMinn, University of Minnesota; UPMC, University of Pittsburgh Medical Center . … Reference | Center | Clinicaltrials.gov identifier | Product | Indication | Outcome | Toxicity ( 133 ) | University of Gdansk | Phase I | Expanded donor polyclonal Tregs | GvHD ( n = 2) | Safe, decreased use of immunosuppression for cGvHD, temporary impact on aGvHD | ( 144 ) | University of Minnesota …

Research trends and hotspots of CAR-T cell therapy for acute lymphoblastic leukemia: A bibliometric analysis.

This study aims to analyze the global research patterns and emerging trends in CAR-T cell therapy for ALL through a bibliometric analysis. Publications were retrieved from the Web of Science Core Collection database. The bibliometric analysis utilized VOSviewer, CiteSpace, and the R package "bibliometrix" to visualize collaborations, keyword co-occurrences, and emerging research trends. A total of 844 articles from 253 journals by 6,459 authors across 44 countries were analyzed, showing an annual growth rate of 40.08%. The USA (372 articles, 38,065 citations) and China (275 articles, 5,636 cit

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… Prominent labeled nodes include univ penn, mem sloan kettering canc ctr, harvard med sch, columbia univ, univ calif san francisco, univ cincinnati, univ minnesota, univ colorado, johns hopkins sch med, massachusetts gen hosp, univ texas md anderson canc c and a dense group including tongji univ, zhejiang … Prominent labeled nodes include univ penn, mem sloan kettering canc ctr, harvard med sch, columbia univ, univ calif san francisco, univ cincinnati, univ minnesota, univ colorado, johns hopkins sch med, massachusetts gen hosp, univ texas md anderson canc c and a dense group including tongji univ, zhejiang …

Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis.

The lungs represent the most common site of metastasis for osteosarcoma (OS). Despite our advances in developing targeted therapies for treating solid malignancies, broad acting chemotherapies remain the first line treatment for OS. In assaying the efficacy of approved therapeutics for non-OS malignancies, we previously identified the histone deacetylase 1 and 2 (HDAC1 and 2) inhibitor, romidepsin, as effective for the treatment of established lung metastatic OS. Yet, romidepsin has noted toxicities in humans and so here we aimed to define the primary mechanisms through which HDAC1/2 mediate O

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… All cell lines were periodically tested and determined to be mycoplasma free (R&D Systems, Minneapolis, Minnesota, Cat#: CUL001B). All human cell lines were validated by short tandem repeat (STR Moffitt genomics core) and mouse cell lines via IDEXX BioAnalytics within the last 6 months. … Phospho-kinase array blotting using Proteome Profiler Human Phospho-Kinase Array Kit was performed with cell lysates as per kit instructions (R&D Biosystems, Minneapolis, Minnesota, Cat#: ARY003C) and detected using Odyssey Fc Imaging System (LI-COR). …

Ferret coronavirus-associated diseases.

A novel coronavirus of ferrets was first described in 1993. This coronavirus caused an enteric disease called epizootic catarrhal enteritis (ECE). Recently, a ferret systemic coronavirus (FRSCV)-associated disease was discovered. This new systemic disease resembles the dry form of feline infectious peritonitis (FIP) and has been reported in the United States and Europe. This article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret FIP-like disease.

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… antioxidants like vitamins A, C, and E may also be helpful. 26 One possible side effect from vitamin C supplementation is the formation of calcium oxalate uroliths. 82 Calcium oxalate was the third most common ferret urolith and accounted for 10.5% of all the ferret uroliths analyzed at the University of Minnesota … Quantitative analysis of 4468 uroliths retrieved from farm animals, exotic species, and wildlife submitted to the Minnesota Urolith center: 1981–2007 Vet Clin North Am Small Anim Pract 39 2008 65 78 10.1016/j.cvsm.2008.09.005 19038651 Acknowledgments Dr Murray would like to thank the pathologists ( …

Design and Rationale of Prolonged Nightly Fasting for Multiple Myeloma Prevention (PROFAST): Protocol for a Randomized Controlled Pilot Trial.

BACKGROUND: Obesity is an established, modifiable risk factor of multiple myeloma (MM); yet, no lifestyle interventions are routinely recommended for patients with overweight or obesity with MM precursor conditions. Prolonged nightly fasting is a simple, practical dietary regimen supported by research, suggesting that the synchronization of feeding-fasting timing with sleep-wake cycles favorably affects metabolic pathways implicated in MM. We describe the design and rationale of a randomized controlled pilot trial evaluating the efficacy of a regular, prolonged nighttime fasting schedule among

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… Concordant with these findings, a more recent analysis of patients with MGUS identified through a population-based screening study in Olmstead County, Minnesota, between 1995 and 2003 observed that having a BMI ≥25 was also associated with increased progression to MM or other plasma cell or lymphoid … Body mass index associated with Monoclonal Gammopathy of Undetermined Significance (MGUS) progression in Olmsted County, Minnesota. Blood Cancer J. 2022;12(4):67. doi: 10.1038/s41408-022-00659-9. doi: 10.1038/s41408-022-00659-9.10.1038/s41408-022-00659-9 14. …

Unraveling Obesity and Multiple Myeloma: Insights from Epidemiology and Molecular Mechanisms.

Purpose of reviewThe global incidence of obesity has risen dramatically in recent decades, with consequent detrimental health effects. Extensive studies have demonstrated that obesity significantly affects the risk, prognosis, and progression of various cancers, including multiple myeloma (MM). As an established modifiable risk factor for both MM and its precursor stages -monoclonal gammopathy of unknown significance (MGUS) and smoldering MM (SMM)- the association between obesity and disease onset has become a compelling area of research. This review presents a comprehensive overview of the cu

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… exhibited increased abdominal fat CSA and fat metabolic activity versus MGUS patients | Potential misinterpretation of abdominal fat activity due to peristalsis and respiration Different imaging protocols and equipment Kleinstern et al. 2022 [ 38 ] | Cohort study | Patients residing in Olmsted County, Minnesota … Body mass index associated with monoclonal gammopathy of undetermined significance (MGUS) progression in Olmsted County, Minnesota. Blood Cancer J. 2022;12:67. …

Why pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translation.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting toxicity of cancer treatment, yet reliable biomarkers to predict individual susceptibility remain lacking. Germline genetic variation has been widely investigated as a potential contributor to CIPN risk; however, the consistency and clinical utility of these associations remain unclear. We performed a systematic review of genetic association studies evaluating CIPN across neurotoxic chemotherapies. PubMed, Embase, Web of Science, and the Cochrane Library were searched (April 2025) for human studies assessing germline

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… Stephanie Huang , University of Minnesota Twin Cities, United States Reviewed by: Yuting Shan , University of Minnesota, United States Suneeta Modekurty , SANJEEVANI AI LLC, United States Lydia Hach , University of Minnesota Twin Cities, United States Data availability statement The original contributions …

Receipt of Selected Preventive Health Services for Women and Men of Reproductive Age - United States, 2011-2013.

PROBLEM/CONDITION: Receipt of key preventive health services among women and men of reproductive age (i.e., 15-44 years) can help them achie … ences. This report uses PRAMS data for 2011-2012 from 11 states (Hawaii, Maine, Maryland, Michigan, Minnesota, Nebraska, New Jersey, Tennessee, Utah, Vermont, and West Virginia). The National Health Interview Survey (NHIS) is a nationally representative survey of noninstitutionalized civilians in the United States. NHIS collects data on a broad range of hea …

Разработка интерактивной прикладной программы биоразведки для оценки декстерности пальцев.

ЦЕЛЬ: Точная оценка функции пальца имеет решающее значение для контроля за ежедневной деятельностью рук. Однако для оценки различных задач, связанных с использованием пальцев, не хватает специализированных цифровых приложений. Цель этого исследования заключается в разработке индивидуального прикладного программного обеспечения цифрового биоразведки для оценки декситеритности пальцев. МЕТОДЫ: Мы разработали цифровую программу биоразведки, совместимую с смартфонами и таблетками, которая позволяет 3-min испытание на декстерминацию пальцев, измерение скорости и точности для каждого пальца и каждог

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… Additionally, the Minnesota Manual Dexterity Test, 13 and the O'Connor Tweezer Test, 14 assess precision and control in the manipulation of small objects. …

Оценка понижательного риска при множественном склерозе с использованием результатов, о которых сообщают пациенты, и износимых показателей походок.

Падение людей с множественным склерозом (pwMS) ведет к заболеваемости и расходам. ЦЕЛЬ: Определение клинических параметров, связанных с водопадами. МЕТОДЫ: Eighty-six PCMS завершены обследования осенних осадков, времяd 25-foot Пройдите (T25FW) и анализ движения с помощью устройств Clario Opal. Были разработаны модели логистической регрессии. Результаты: Средний возраст 54.5 годы (дальность 21-73), 62% (В тыс.53) были женщинами. Включена группа 58% с вращением50) и 42% с прогрессивным НР36). Лица, сообщившие о сокращении в прошлом году, были старше (средний возраст) 58 vs. 52.5, р = .03) и имел

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… Methods Patient identification This study was approved by the Institutional Review Board of Mayo Clinic, Rochester, Minnesota (Institutional Review Board 08-007846), and all patients gave written consent for the use of their medical records and gait analysis for research purposes. …

AL Amyloidosis: The Effect of Maintenance Therapy on Autologous Stem Cell Transplantation Outcomes.

BackgroundAutologous stem cell transplantation (ASCT) remains an effective treatment option for many patients with systemic light chain (AL) amyloidosis. While maintenance post ASCT in multiple myeloma is now standard, the decision to utilize maintenance in AL amyloidosis remains largely unexplored. The present study aims to determine the prognostic significance of utilizing maintenance therapy following ASCT and assess the impact of fluorescent in situ hybridization (FISH) abnormalities, bone marrow plasma cell burden (BMPC), and degree of organ involvement on this decision.Methods and result

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… Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989 Blood 1992 79 1817 1822 10.1182/blood.V79.7.1817.1817 1558973 2. Gertz M.A. Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment Am. J. …

Oral cancer therapy: policy implications for the uninsured and underinsured populations.

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… A total of 26 states have enacted oral chemotherapy access laws: Oregon (2008), Indiana (2009), Iowa (2009), Hawaii (2009), District of Columbia (2009), Vermont (2010), Connecticut (2010), Kansas (2010), Colorado (2010), Minnesota (2010), Illinois (2011), New Mexico (2011), Texas (2011), New York (2011 …

Характеристики и результаты вторичных гематологических магнатов после аутологической трансплантации стволовых клеток в случае множественной миеломы.

Автологическая трансплантация стволовых клеток (auto-SCT) по-прежнему является важной основой в многократной терапии миэломы (MM); вместе с тем существует повышенный риск развития второй первичной халатности, включая вторую гематологическую халатность (SHM). Мы провели ретроспективное исследование пациентов с MM, которые прошли авто-SCT в нашем учреждении между 1990 и 2022 и впоследствии разработан SHM. Среди 3401 пациентов с MM, которые прошли авто-SCT, 110 (В тыс.3.2%) разработан SHM [терапия, связанная с опухолью миэлоида (t-MN) = 98; острая лимфоболическая лейкемия в клетке B (t-B-ALL) = 1

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… This study was approved by the institutional review board at Mayo Clinic, Rochester, Minnesota. MDS was risk stratified based on the Revised International Prognostic Scoring System (IPSS-R)[ 13 ] and molecular IPSS (IPSS -M) was used when next generation sequencing (NGS) data was available[ 14 ]. … Acknowledgements Research reported in this publication was supported by NIH grant P30CA077598 utilizing the Biostatistics and Bioinformatics Core shared resource of the Masonic Cancer Center, University of Minnesota and by the National Center for Advancing Translational Sciences of the National Institutes …

Тенденции в области смертности, связанной с множественной миеломой в Соединенных Штатах, 1999-2023.

Несмотря на значительные терапевтические достижения, большое число миелом (ММ) по-прежнему является важным фактором смертности от рака в Соединенных Штатах. Понимание долгосрочных моделей смертности имеет важное значение для разработки справедливых стратегий в области клинического и общественного здравоохранения. 1999-2023 для оценки связанных с MM смертей среди взрослых ≥25 Годы. Коэффициенты смертности, скорректированные с учетом возраста, рассчитывались на основе прямой стандартизации 2000 Население США. Временные тенденции были изучены с использованием регрессии " Compoint " для

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… 6059 | 15.49 | 7.22 (6.27 to 8.16) | 5.08 (4.46 to 5.71) | -0.87 (-1.27 to -0.47)* Massachusetts | 239 | 259 | 6241 | 8.37 | 5.51 (4.81 to 6.21) | 4.23 (3.71 to 4.75) | -1.40 (-1.76 to -1.04)* Michigan | 390 | 455 | 10727 | 16.67 | 6.29 (5.66 to 6.91) | 5.12 (4.64 to 5.60) | -0.98 (-1.31 to -0.66)* Minnesota … were observed predominantly in the Southeastern and parts of the Midwestern United States, including Mississippi, Alabama, Georgia, South Carolina, Tennessee, Ohio, and Pennsylvania, while relatively lower AAMRs were found in Western and Northern states such as Alaska, Utah, Colorado, Washington, and Minnesota …

Bridging the Gap in AL and ATTR Cardiac Amyloidosis: Integrating Histopathology, Biomarkers, and Multimodal Imaging for Subtype-Specific Diagnosis.

Cardiac amyloidosis (CA) represents an increasingly recognized but historically underdiagnosed cause of restrictive cardiomyopathy and heart failure. CA is now understood to be more prevalent, particularly in older adults, as advancements in imaging and biomarker technologies have improved detection. The disease results from the misfolding of precursor proteins, primarily immunoglobulin light chains (in light chain (AL) amyloidosis) or transthyretin (in transthyretin (ATTR) amyloidosis), into insoluble fibrils that deposit in myocardial tissue. These deposits cause structural and functional ca

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… Incidence of AL Amyloidosis in Olmsted County, Minnesota, 1990 through 2015. Mayo Clinic Proceedings . 2019;94:465–471. doi: 10.1016/j.mayocp.2018.08.041. [16] Muchtar E, Buadi FK, Dispenzieri A, Gertz MA. … Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood . 1992;79:1817–1822. [41] Koike H, Katsuno M. The Ultrastructure of Tissue Damage by Amyloid Fibrils. Molecules (Basel, Switzerland) . 2021;26:4611. doi: 10.3390/molecules26154611. …