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Boils at Frictional Locations in a Patient with Hidradenitis Suppurativa.

Dear Editor, Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease. The primary clinical presentation are painful … ted with several courses of oral antibiotics (minocycline, erythromycin, and combination therapy of clindamycin and rifampicine) and surgical treatments: lancing, deroofing, and excisions (2,6). On examination, there were nodules, folliculitis, cysts, and depressed scars in the axillae and groins, including the inner thighs (Figure 1). On the chest, correspon …

Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) therapy. A critical review.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an area of uncovered bone in the maxillo-facial region that did not heal within 8 … rinses in combination with oral systemic antibiotic therapy -penicillin, metronidazole, quinolones, clindamycin, doxycycline, erythromycin- is indicated for Stages I and II of Ruggiero's Staging. The role of hyperbaric oxygen therapy is still unclear but some benefits of this treatment have recently been described in association with discontinuation of BPT an …

Autologous platelet concentrates as adjuvant in the surgical management of medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is an infectious side effect associated with bisphosphonates and monoclonal antibodies (denosumab, immune modulators, and antiangiogenic medications). Adjunctive therapies for the surgical management of MRONJ include autologous platelet concentrates (APCs). These APCs serve as a source of various cells and growth factors that aid tissue healing and regeneration. This review evaluated the use of platelet-rich plasma (PRP), plasma-rich in growth factors (PRGF), and leukocyte- and platelet-rich fibrin (L-PRF) as adjuvant therapies for the surgic

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… References | Number of lesions | Site | Staging AAOMS (specified if different) | Type of intervention | Antibiotic therapy | Follow‐up | Outcome Adornato et al. 22 | 12 | Mandible 8 Maxilla 4 | – | Bone resection + PRP | Clindamycin 300 mg × 4/day for 10 days | 6 m | 10 Complete healing 2 No healing … A liquid chromatography‐tandem mass spectrometry method for the quantification of ampicillin/sulbactam and clindamycin in jawbone, plasma, and platelet‐rich fibrin: application to patients with osteonecrosis of the jaw. J Pharm Biomed Anal. 2023;224:115167. 99. Iacono T. …

Endodontics in Systemically Compromised Patients

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… Adults: 1.0 g IM or IV cefazolin or ceftriaxone Or 600 mg IM or IV clindamycin Children: 50 mg/kg IM or IV cefazolin or ceftriaxone Or 20 mg/kg IM or IV clindamycin within 30 min before the procedure Table 12.3 Antibiotic Prophylactic Regimens for Endocarditis, as recommended by the American Heart … g IM or IV cefazolin or ceftriaxone Or 600 mg IM or IV clindamycin Children: 50 mg/kg IM or IV cefazolin or ceftriaxone Or 20 mg/kg IM or IV clindamycin within 30 min before the procedure Maintaining good oral hygiene and eradicating dental disease is shown to decrease the frequency of bacteremia from …

Treatment of bisphosphonate-related osteonecrosis of the jaws - a report of seven cases.

AIM OF THE STUDY: The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound. MATERIAL AND METHODS: Seven patients with 9 sites of BRONJ stage 2 were included in the study. Perioperative oral antibiotics, surgical debridement and/or sequestrotomy and gentamicin-collagen sponge (Collatamp EG) were used. Postoperative monitoring was carried out for the next 3 months. RESULTS: Three weeks after the surgery, six sites of BRONJ in five patients were treated successfully. In t

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… Quinolones, metronidazole, clindamycin, doxycycline, and erythromycin have been used with success in those patients who are allergic to penicillin. Stage 3: Exposed/necrotic bone in patients with pain, infection and pathologic fracture or extra-oral fistula. … Quinolones, metronidazole, clindamycin, doxycycline and erythromycin have been used in patients allergic to penicillin. These drugs must be administered over a long-term period, which can vary from several months to more than a year. …

Infectious Diseases

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… Polymicrobial ( cefotaxime 2 g IV q8h plus clindamycin 600–900 mg IV q8h [note: clindamycin inhibits toxic protein production], Piperacillin–tazobactam 4.5 g IV q8h, or ampicillin/penicillin G plus ciprofloxacin plus metronidazole). … For polymicrobial infection, cefotaxime plus clindamycin, pipericillin–tazobactam, or ampicillin/penicillin G plus ciprofloxacin/gentamicin plus metronidazole. For Streptococcus , penicillin G plus clindamycin. …

Exploring Nanoherbal Paraboea leuserensis as a Therapeutic Agent in Traumatic Brain Injury: In Silico, and In Vivo Approaches.

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that causes various infections and exhibits antibiotic resistance and virulence factors, requiring alternative therapies. This study aimed to evaluate the effects of nanocurcumin on gene expression of S. aureus isolates from burn wounds in Iraqi patients, focusing on inhibiting resistance and virulence genes. METHODS: From March 2023 to May 2024, burn wound samples from Iraqi patients yielded 110 S. aureus isolates. Identification was conducted by Gram staining, biochemical assays, and culture techniques. Fifty isola

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… resistance, azithromycin, clarithromycin, erythromycin, clindamycin, linezolid, teicoplanin, vancomycin, doxycycline, minocycline, tetracycline, tigecycline, fusidic acid, rifampicin, and trimethoprim/sulfamethoxazole. to assess the profiles related to antibiotic susceptibility and classify these samples … Statistical significance indicators: (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001) Discussion Overall, the results of this study showed 90%, 82%, 80%, 72%, 60%, 32%, and 24% resistance for amoxicillin/clavulanic acid, clindamycin, erythromycin, fusidic acid, clarithromycin, gentamicin, ciprofloxacin …

Infectious Diseases

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… Antibiotics for mild cellulitis ( cephalexin 500 mg PO QID, dicloxacillin 500 mg PO QID, or clindamycin 150–300 mg PO QID × 5–14 days); for systemic toxicity or severe cellulitis ( cefazolin 1–2 g IV q8h, ceftriaxone 1 g IV q24h, nafcillin 1–2 g IV q4–6 h × 7–14 days). … In general, hospital MRSA strains have broader resistance (e.g. clindamycin, trimethoprim–sulfamethoxazole, tetracyclines) than community-associated MRSA strains (CA-MRSA). …

[Analysis of epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with perineal and/or hip burns].

Objective: To explore the epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with … acin and penicillin were both 85.7%, the resistance rates of Enterococcus faecalis to erythromycin, clindamycin, moxifloxacin, and tetracycline ranged from 14.3% to 57.1%, and the resistance rates of Enterococcus faecalis to linezolid, tigecycline, and vancomycin were all 0. The differences were statistically significant between the two groups in terms of gen …

Successful Treatment with Fusidic Acid in a Patient with Folliculitis Decalvans.

Dear Editor, Folliculitis decalvans (FD) is a rare form of primary neutrophilic cicatricial alopecia. It is a highly distressing disease tha … tibiotics are frequently used to treat folliculitis decalvans. Tetracyclines and the combination of clindamycin with rifampicin are the most commonly used (2). However, the disease usually progresses when treatment is stopped. Fusidic acid is an anti-staphylococcal drug with few adverse effects. It is highly bioavailable orally, and has a long plasma half-lif …

Diabetic Ketoacidosis and Necrotizing Soft Tissue Infection.

AUDIENCE: Emergency medicine (EM) residents at all levels of education and medical students on EM rotation. INTRODUCTION: Diabetes is a chr … omycin (or linezolid), 2) either piperacillin/tazobactam, ampicillin/sulbactam, or a carbapenem, 3) clindamycin to decrease toxin production.2,4Initial treatment of DKA is isotonic fluids, and insulin therapy should be withheld until serum potassium levels are obtained since prolonged serum acidosis can drive potassium intracellularly. Patients with serum pot …

A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris.

BACKGROUND: Various treatments for acne vulgaris exist, but little is known about their comparative effectiveness in relation to acne severi … each treatment type were as follows: topical pharmacological - combined retinoid with lincosamide (clindamycin) (44·43%, 95% CrI 29·20-60·02%); oral pharmacological - isotretinoin of total cumulative dose ≥ 120 mg kg-1 per single course (58·09%, 95% CrI 36·99-79·29%); physical - photodynamic therapy (light therapy enhanced by a photosensitizing chemical) (40 …

[Rapid screening and identification of 167 illegally added medicines in herbal tea by ultra high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry].

An accurate mass database and a method based on ultra high performance liquid chromatography-electrostatic field orbitrap high resolution ma … coefficients (r) greater than 0.99. Because pefloxacin, norfloxacin, desloratadine, astemizole and clindamycin had background interference, the method was not suitable for their quantification. Following experiments using three spiked concentrations, the recoveries of the rest 162 compounds were found to be in the range of 66.4%-118.1%, and the relative stan …

Analysis of the microbial species, antimicrobial sensitivity and drug resistance in 2652 patients of nursing hospital.

OBJECTIVE: To understand the microbial species, antimicrobial sensitivity and drug resistance of patients in the nursing hospital, to bring … rate of Staphylococcus aureus to levofloxacin and penicillin are above 90%, the resistance rate to clindamycin and erythromycin are above 80%, the resistance rate to gentamicin is above 70%, and vancomycin and linezolid The sensitivity rate of amine is 100.0%, the sensitivity rate to rifampicin and teicoplanin are above 90%, and the sensitivity to compound s …

[Risk factors and etiological analysis of ventilator-associated pneumonia: three year's cases analysis of intensive care unit in county hospital].

OBJECTIVE: To investigate the risk factors of ventilator-associated pneumonia (VAP) and the distribution and drug resistance of pathogens in … ntoin (NIT), rifampicin (RIF), vancomycin (VAN) and teicoplanin (TEC), while the drug resistance to clindamycin (CLI) and penicillin (PEN) was high (both 80.00%). Most pathogens were multidrug-resistant. The mortality of patients with multidrug resistant bacteria infection was significantly higher than that of non-multidrug resistant bacteria infection [51.85 …

[Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1996)].

The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, sin … he next potent activity with MIC80 of 0.125 microgram/ml. The other drugs except erythromycin (EM), clindamycin (CLDM) and tetracycline (TC) were active against S. pneumoniae tested with MIC80s of 8 micrograms/ml or below. 3) H. influenzae The activities of all drugs were potent against H. influenzae tested with MIC80s of 4 micrograms/ml or below. Cefotiam (C …

[Risk factors and antibiotic use in methicillin-resistant Staphylococcus aureus bacteremia in hospitalized patients at Hacettepe University Adult and Oncology Hospitals (2004-2011) and antimicrobial susceptibilities of the isolates: a nested case-control study].

The aim of this study was to evaluate methicillin-resistant Staphylococcus aureus (MRSA) bacteremia cases who were followed at the Infectiou … resistance rates for ciprofloxacin, rifampin, gentamicin, tetracyclin, cefoxitin, erythromycin and clindamycin were 95%, 95%, 94%, 96%, 98%, 71% and 36%, respectively. All of the isolates were found to be susceptible to trimethoprim-sulfamethoxazole, VAN, TEC, tigecycline, linezolid and daptomycin. Mortality rates in patients who were infected with MRSA stra …

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1995). I. Susceptibility distribution].

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 704 bacterial strains isolated from patients … gentamicin (GM) were active against S. agalactiae. ABPC, cefmenoxime (CMX), IPM, erythromycin (EM), clindamycin (CLDM) and clarithromycin (CAM) showed the highest activities. The MICs for all strains were lower than 0.125 microgram/ml. The MIC90S of the others were 2 micrograms/ml or below. 5. Citrobacter freundii IPM showed the highest activity against C. fr …

Clinical and Histopathological Aspects of MRONJ in Cancer Patients.

Medication-related osteonecrosis of the jaw (MRONJ) is a major complication of bisphosphonate treatment in cancer patients, and its etiology is not completely clarified. The study's goal is to find connections between the clinical and histopathological characteristics of osteonecrosis and bisphosphonates in a cohort of cancer patients who had osteonecrosis treated surgically. The retrospective study includes 51 patients of both sexes, aged 46 to 85 years, who underwent surgical treatment for MRONJ in two oral and maxillofacial surgery clinics (Craiova and Constanța). Demographic, clinical, and

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… Streptococcus anginosus and Escherichia coli were susceptible to azithromycin, cefotaxime, ceftriaxone, clindamycin, and vancomycin. … The antibiogram showed susceptibility of Staphylococcus aureus and Pseudomonas mendocina to penicillin, ceftazidime, ceftriaxone, and ciprofloxacin and resistance to clindamycin. …