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Lithium for acute mania.

BACKGROUND: Bipolar disorder is a common condition associated with high morbidity; developing efficacious, safe treatments is therefore esse … ULTS: We found 36 randomised controlled studies comparing lithium with placebo, one of 12 drugs, or electroconvulsive therapy for treatment of acute mania. Studies included male and female participants (n = 4220), of all ages, who all fitted criteria for a manic episode within the context of a diagnosis of bipolar disorder.Risk of bias was variable; 12 studies had a high r …

Bilateral Intertrochanteric Femur Fractures in a Paraplegic Patient: A Case Report.

Bilateral intertrochanteric (IT) femur fractures are rare, and appropriate evaluation and treatment can vary depending on concurrent patient comorbidities. Even less has been described for patients with bilateral IT fractures with pre-existing paraplegia. This case report describes the unique case of a 72-year-old paraplegic female who presented with bilateral IT femur fractures due to a wheelchair accident. The patient was treated with single-stage bilateral cephalomedullary nail fixation so she could effectively transfer to and from the wheelchair with less pain and a greater chance of fract

A Map of the Initiatives That Harmonize Patient Cohorts Across the World.

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… Currently approaching China | Creating a large database of multi-site imaging data and clinical/behavioral/physiological and metadata for analysis of the neural mechanisms and predictors of electroconvulsive therapy-related clinical response | 15 | Yes | 345 | 19–86 | More than a thousand because the … initiative includes diagnostic imaging variables | Patients receiving electroconvulsive therapy Predictors and moderators of cognitive and behavioral therapy outcomes for obsessive-compulsive dissorder | Disease cohorts. …

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder.

BACKGROUND: Many studies have recently been conducted to assess the antidepressant efficacy of glutamate modification in mood disorders. Thi … ate receptor modulators with placebo (pill or saline infusion), other active psychotropic drugs, or electroconvulsive therapy (ECT) in adults with unipolar major depression. DATA COLLECTION AND ANALYSIS: Three review authors independently identified studies, assessed trial quality and extracted data. The primary outcomes were response rate (50% reduction on a standardised …

Repetitive transcranial magnetic stimulation for the treatment of major depressive disorder: an evidence-based analysis.

OBJECTIVE: This review was conducted to assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in the treatment of … S as an option to treat MDD, as an add-on to drug therapy, and, in particular, as an alternative to electroconvulsive therapy (ECT) for patients with treatment-resistant depression. The advantages of rTMS over ECT for patients with severe refractory depression are that general anesthesia is not needed, it is an outpatient procedure, it requires less energy, the simulation …

Association between miR-182 rs76481776 Polymorphism and Antidepressant Treatment Response in Patients with Depression.

ObjectiveThe efficacy of antidepressants is influenced by a combination of genetic, individual, and environmental factors. This study aimed to investigate the association between the miR-182 rs76481776 polymorphism and the response to antidepressant treatment in major depressive disorder (MDD) patients, and its underlying molecular mechanisms.MethodsThis study enrolled 180 MDD patients and 180 healthy controls. The rs76481776 genotype was determined using TaqMan-based qPCR. The severity of depression and treatment response were assessed using the Hamilton Depression Rating Scale (HAMD). The ex

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… The exclusion criteria: comorbidity with severe somatic diseases; presence of other psychiatric disorders; systematic use of psychotropic medications or any antidepressants; history of electroconvulsive therapy or ongoing structured psychotherapy; and known hypersensitivity to study medications. 180 …

A unity of opposites: A prototypical case for the importance of primary-care providers in addressing mental health issues.

Primary-care providers are most often the first point of contact for patients presenting with mental illness. Highly stigmatized and with a litany of other medical issues requiring redress by providers, it may receive inadequate attention, despite its unintuitive consequences. Therefore, the purpose of this case is to demonstrate the potential catastrophic consequences of untreated mental illness by providers. As a result of a serious suicide attempt by a patient afflicted with bipolar disorder, this patient presented with significant blood loss secondary to multiple self-inflicted lacerations

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… After tapering off his medications, the patient became manic, then depressed, and later sought electroconvulsive therapy (ECT). He had received a total of nine rounds of ECT over the course of a month and his last treatment was the day before his suicide attempt. …

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy.

Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons and poses a great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it is of urgent need to explore other potential mechanism to develop a novel approach to delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), the versatile epigenetic regulators re

Using antipsychotic agents in older patients.

OBJECTIVES: Antipsychotics are widely used in geriatric psychiatric disorders. A growing number of atypical antipsychotics are available, ex … epressant alone (77% first line); second-line options were an antidepressant plus an antipsychotic, electroconvulsive therapy (ECT), an antidepressant plus a benzodiazepine, and an antidepressant plus a mood stabilizer. For nonpsychotic major depression with severe anxiety, the experts recommended an antidepressant alone (79% first line) and would also consider adding a be …

Карта знаний транскраниальной магнитной стимуляции бессонницы: библиометрический и визуальный анализ.

Бессонница - это one :: наиболее распространенные нарушения сна, серьезно сказывающиеся на физическом и психическом здоровье человека, снижающие эффективность и бдительность работы и потенциально даже приводящие к несчастным случаям, усугубляющие тем самым экономическое бремя как отдельных лиц, так и общества. Первичное лечение бессонницы включает фармакологическую и нефармакологическую терапию. С учетом потенциальных побочных эффектов, связанных с фармакологической терапией, существует настоятельная необходимость в применении безопасных и эффективных нефармакологических мер. Такие технологии,

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… As illustrated in Figure 6C , the focal point of this field is electroconvulsive therapy, and it also encompasses pharmacological treatments for insomnia accompanied by anxiety and depression. Figure 6 Knowledge graph analysis of keywords. … Furthermore, this study serves to affirm the prevalent research focus in this field, which primarily revolves around electroconvulsive therapy (ECT) and treatments for anxiety and depression. ECT is typically employed when pharmacological interventions are ineffective or not tolerable for patients. …

Cancer therapy-associated Takotsubo cardiomyopathy: A narrative review of mechanisms, drug associations, and clinical implications.

Anticancer therapies have been increasingly associated with Takotsubo cardiomyopathy (TTC). As prior reports remain fragmented across case studies and drug-specific reviews, this paper offers one of the most comprehensive reviews to date of cancer therapy-associated TTC. While classically triggered by emotional or physical stress, TTC has been increasingly associated with chemotherapy and other cancer-directed therapies. This literature review explores the pathophysiology, clinical features, and evolving evidence linking anticancer agents to TTC, with a focus on cytotoxic cancer therapy, hormo

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… This phenomenon is similar to “neurogenic stunned myocardium,” previously observed in patients with acute stroke, seizures, or electroconvulsive therapy. …

Иммунитет в нейромодуляции: исследование нейронных и иммунных путей в расстройствах мозга.

Иммунитет четко регулирует функцию мозга. Она непосредственно участвует в патологических процессах таких нейродегенеративных заболеваний, как болезнь Паркинсона и Альцгеймера, посттравматические заболевания, множественный склероз, травма головного мозга и психические расстройства (большое расстройство организма, серьезное депрессивное расстройство (МДС), расстройства тревожности, расстройства психоза и шизофрения, а также расстройства нервного развития (НРД). Нейромодулирование в настоящее время является одной из ведущих терапевтических стратегий лечения этих расстройств, однако пока мало что

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… Neuromodulation is one of the most important current strategies for many of these disorders- including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), focused ultrasound (FUS), deep brain stimulation (DBS), and valgus …

Drug Repurposing for the Management of Depression: Where Do We Stand Currently?

A slow rate of new drug discovery and higher costs of new drug development attracted the attention of scientists and physicians for the repurposing and repositioning of old medications. Experimental studies and off-label use of drugs have helped drive data for further studies of approving these medications. A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing and drug repositioning to treat depression. In addition to reducing neurotransmitters like epinephrine and serotonin, other mechanisms such as inflammation, insufficient blood supp

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… Electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulus (rTMS) are some noninvasive examples suggested to be beneficial for patients who have already failed at least one antidepressant trial. …

Catgut embedding in acupoints combined with repetitive transcranial magnetic stimulation for the treatment of postmenopausal osteoporosis: study protocol for a randomized clinical trial.

BACKGROUND: To date, the clinical modulation for bone metabolism based on the neuro-bone mass regulation theory is still not popular. The stimulation of nerve systems to explore novel treatments for Postmenopausal osteoporosis (PMOP) is urgent and significant. Preliminary research results suggested that changes brain function and structure may play a crucial role in bone metabolism with PMOP. Thus, we set up a clinical trial to investigate the effect of the combination of repetitive transcranial magnetic stimulation (rTMS) and catgut embedding in acupoints (CEA) for PMOP and to elucidate the c

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… Challenges in comparing the acute cognitive outcomes of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) vs. electroconvulsive therapy (ECT) in major depression: a systematic review. J Psychiatr Res. (2017) 91:14–7. doi: 10.1016/j.jpsychires.2017.03.002, PMID: 35. …

Major depressive disorder and measures of cellular aging: an integrative review.

Major depressive disorder (MDD) affects millions of individuals and causes significant suffering worldwide. It has been speculated that MDD is associated with accelerated aging-related biological and functional decline. To examine the accelerated aging hypothesis, one of the biomarkers under study is leukocyte telomeres, and specifically the measure of telomere length and telomerase activity. This review integrates findings from eleven human studies which evaluated telomere length and telomerase activity, in order to synthesize the state of the current science and to inform the development of

Clinical practice guidelines on addressing cognitive impairment in treatable dementias.

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… The standard of care for treatment of depression, including the need for electroconvulsive therapy, must be followed for depressive cognitive disorder.[ 33 , 34 ] While treatment with antidepressants remains the mainstay of management, certain antidepressants have been found to be more effective for …

Понимание отказа от долгосрочных условий с помощью электронных медицинских записей: обзор скопирования.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Множественные долгосрочные условия (ДТЦ) требуют сложных и продолжительных режимов лечения. Ремиссия в долгосрочных условиях (ДКН) имеет важное значение для понимания динамики заболеваний и оценки эффективности лечения. Электронные медицинские записи (ЭПЧ) все чаще используются для мониторинга клинических результатов, однако вопрос о том, каким образом определяется ремиссия в рамках ЭПЧ, остается неясным. ЦЕЛЬ: Цель настоящего исследования заключалась в обобщении и обобщении предыдущей литературы о том, каким образом ремиссия ЛТК определяется в ЭПЧ.МЕТОДЫ: Систематически

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… Depression Remission of depression was mostly defined as normal scores on validated rating scales such as Patient Health Questionnaire-9 scores of <5 [ 32 , 34 , 36 , 38 , 39 , 42 , 78 ], ≤5 [ 33 , 41 ], <10 (in patients receiving electroconvulsive therapy) [ 37 ], or a 50% decrease from baseline in …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

ObjectiveMajor depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.ResultsBecause of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impair

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… Treatment of affective illness in the elderly with drugs and electroconvulsive therapy. J Geriatr Psychiatry . 1989;22(1):77–112. 100. Montgomery SA. Safety of mirtazapine: a review. Int Clin Psychopharmacol . 1995;10(4):37–45. doi: 10.1097/00004850-199512004-00006 …

АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

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… Antidepressant Response of Electroconvulsive Therapy and Magnetic Seizure Therapy: Response Trajectories by Symptom Clusters Zhi-De Deng*, Shawn McClintock, Mustafa Husain, Sarah Lisanby National Institute of Mental Health, Bethesda, Maryland, United States Background: Electroconvulsive therapy (ECT … Keywords: Electroconvulsive Therapy, Magnetic Seizure Therapy, Factor Analysis, Latent Class Analysis Disclosure: Nothing to disclose. P290. …