Результаты поиска

[Efficacy of free perforator flap combined with great toe transplantation in repairing thumb damage combined with thermal crush injuries in the hand].

Objective: To explore the efficacy of free perforator flap combined with great toe transplantation in repairing thumb damage combined with thermal crush injuries in the hand. Methods: This study was a retrospective observational study. From May 2014 to March 2024, seven cases (5 males and 2 females, aged from 25 to 46 years) with thumb injuries combined with thermal crush injuries in hands were admitted to the 988th Hospital of Joint Logistics Support Force of the PLA. After surgical debridement, the thumb defects were classified as grade Ⅱ in 2 cases, grade Ⅲ in 3 cases, and grade Ⅳ in 2 case

Parents seek early intervention services for a two-year-old without autism.

Sam is a 27-month-old boy who you have followed since birth. He lives with his parents in a small resort town approximately 90 miles outside a major city. Both his parents are professionals in their late 30s and have been highly involved in his care since birth. At the 12-month visit, they were concerned about his difficulty regulating. He was not sleeping through the night and had significant difficulty with baths. His physical examination and growth were normal. His eye contact was good, although it was difficult to see him smile. He had 1 or 2 words and was beginning to walk independently.A

Direct Anterior Approach to Hip Resurfacing Arthroplasty.

BACKGROUND: Hip resurfacing arthroplasty remains an appealing option for young and active patients1, but its use has declined because of technical challenges, risks of femoral neck notching, and adverse reactions associated with metal-on-metal bearings, raising concerns regarding long-term implant survival2. Accurate preparation of the femoral head and acetabulum is critical for successful outcomes3. In the present video article, we describe a reproducible technique utilizing preoperative 3D computed tomography (CT)-based planning and patient-specific 3D-printed jigs to optimize femoral head p

Optic neuropathies post-Covid 19 - review.

The Corona virus infection started at the end of 2019 in Wuhan - China and spread rapidly throughout the world, generating the Covid 19 pandemic. The manifestations of the Covid disease were extremely varied, from a simple flu, with fever, cough, weakness, headache, joint pain, up to severe pneumonia, with severe acute respiratory syndrome (SARS-Cov2) and even death. The symptomatology of the disease, the evolution and the complications that appeared varied, depending on the associated pathology - diabetes mellitus (DM), hypertension (HT), the age and the immune status of the patient. Aim: The

[Effect of groove splint fixation on early swelling and blood flow velocity of the injury limb in elderly patients with distal radius fractures].

OBJECTIVE: To observe the effects of groove splint fixation on early hand swelling, blood flow velocity, and clinical function in elderly pa … rsal palmar vein, reduce venous reflux obstruction and swelling of injury limb, alleviate wrist and finger joint stiffness, and improve early clinical efficacy of the affected limb. However, it has no significant impact on clinical function one year after injury.

Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation.

BACKGROUND: Dupuytren's contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence comparing limited fasciectomy with collagenase injection. OBJECTIVES: To compare whether collagenase injection is not inferior to limited fasciectomy when treating Dupuytren's contracture. DESIGN: Pragmatic, two-arm, unblinded, randomised controlled non-inferiority trial with a cost-effectiveness evaluation and nested qualitative and photographic substudies

Proximal Medial Gastrocnemius Release: Surgical Technique.

UNLABELLED: Proximal medial gastrocnemius release (PMGR) is a technique that is performed to relieve tension in the Achilles-calcaneus-plantar system when a biomechanical overload is present1-3. One of the main indications for this technique is recalcitrant plantar fasciitis. This procedure may also be useful in second-rocker metatarsalgia or midportion Achilles tendinitis4. It is considered to be an easy and safe method for achieving good results5-7. DESCRIPTION: PMGR is performed with the patient in the prone position. A thigh tourniquet is not utilized. We prefer to use spinal anesthesia,

Carpal tunnel syndrome.

Carpal tunnel syndrome is one of the most common peripheral neuropathies. It affects mainly middle aged women. In the majority of patients the exact cause and pathogenesis of CTS is unclear. Although several occupations have been linked to increased incidence and prevalence of CTS the evidence is not clear. Occupational CTS is uncommon and it is essential to exclude all other causes particularly the intrinsic factors such as obesity before attributing it to occupation. The risk of CTS is high in occupations involving exposure to high pressure, high force, repetitive work, and vibrating tools.

Long-term follow-up of thalidomide embryopathy: malformations and development of osteoarthritis in the lower extremities and evaluation of upper extremity function.

BackgroundBetween 1959 and 1962, several children with multiple malformations were born after maternal intake of thalidomide during pregnancy, known as thalidomide embryopathy (TE).ObjectivesThe aim of this study was to evaluate the malformations, their long-term effect on the function of the extremities and the development of degenerative osteoarthritis (OA) in the lower extremities.MethodsAll living persons with TE in Sweden were invited to participate in the study. Thirty-one patients were examined clinically as a part of a multi-disciplinary follow-up programme. Evaluation of upper and low

Sclerosing diseases of the skin.

Sclerosing skin diseases comprise a group of distinct dermatological conditions characterized by fibrotic changes that may severely impair patients' quality of life. These conditions often present with cutaneous manifestations and, in some cases, may extend to extracutaneous tissues, potentially resulting in significant morbidity and mortality. This review explores the current understanding of the four most prevalent sclerosing skin diseases - localized scleroderma (morphea), systemic sclerosis (SSc), scleromyxedema, and scleredema adultorum of Buschke - as well as sclerotic conditions induced

Обзор влияния мышечной вибрации на восстановление спасти.

ВВЕДЕНИЕ: В настоящем обзоре анализируются выгоды, связанные с вибрацией мышечных мышц (ВЧ) при лечении спастисти, способствующей углублению понимания и устойчивому улучшению моторных функций. Выводы могли бы способствовать отбору оптимальных протоколов по ТТС, направлять будущие исследования и давать представление о механизмах, с помощью которых ФТС может улучшить моторные функции у лиц, имеющих сенсибилизацию. МЕТОДЫ: Систематический поиск проводился с использованием онлайновых баз данных PubMed, Web of Science и Библиотеки Кокрана. Включая критерии: а) наличие у участников хронической спаст

Quadriceps Coxae-Sparing Modified Posterior Approach to the Hip Joint for Hemiarthroplasty.

BACKGROUND: Various approaches have been described for hip arthroplasty1-3. The posterior approach to the hip remains a popular choice for hemiarthroplasty1. In the classic description, it involves detachment of the short external rotators, which include the quadriceps coxae (QC) (i.e., piriformis, superior gemellus, obturator internus, and inferior gemellus) along with the obturator externus and quadratus femoris (as needed). Since the QC are important for joint stability, detachment during the approach is associated with higher rates of postoperative dislocations4, even following subsequent

Structure, function, and pathology of PHF23.

Plant Homeodomain Finger Protein 23 (PHF23) is a member of the Plant Homeodomain (PHD) finger protein family and has been extensively reported since its discovery. Numerous studies have demonstrated that PHF23 plays a crucial role in various biological processes, such as gene expression regulation, autophagy, and tumorigenesis. Additionally, PHF23 is associated with various diseases including various malignancies, osteoarthritis, and tuberculosis, all of which currently lack effective and targeted treatment options. Therefore, this review systematically summarizes the existing literature on PH

Risk factors for prolonged hospitalization and disease course in osteomyelitis: a single-centre cohort study.

OBJECTIVE: To investigate pathogen epidemiology and clinical characteristics in osteomyelitis patients for optimizing clinical management strategies. METHODS: Confirmed osteomyelitis cases required pathogen isolation with radiological correlation. The cohort included both confirmed (culture-positive) and probable (culture-negative but meeting clinical and radiological criteria) cases, Radiation-induced osteomyelitis, sclerosing osteomyelitis and drug-associated osteomyelitis. Clinical specimens underwent standardized culture and VITEK Compact II or MALDI-TOF MS identification. SPSS 22.0 analy

Оценка функции верхнего лимфа с использованием технологий виртуальной реальности для взрослых с неврологическими расстройствами: систематический обзор.

Справочная информация: Виртуальная реальность (ВП) все чаще изучается в качестве инструмента для оценки состояния верхних конечностей (УЛ) у взрослых с неврологическими расстройствами. Этот обзор обобщает имеющиеся данные оценок UL на основе VR путем анализа их психометрических свойств и потенциальной роли в клинических и исследовательских условиях. Методы: Этот систематический обзор проводился в соответствии с руководящими принципами представления отчетности о систематических обзорах инструментов оценки результатов (PRRISMA-COSMIN) и был в перспективе зарегистрирован в ПРОСПЕРО. Добыча данных

Совпадение в полном тексте источника
… SaeboVR ® SaeboVR ® is a semi-immersive system that combines a commercial SaeboGlove ® Orthosis with motion sensors to track finger joint angles during grasp–release tasks within a virtual environment. …

Mobile phone messaging for preventive health care.

BACKGROUND: Preventive health care promotes health and prevents disease or injuries by addressing factors that lead to the onset of a diseas … of no difference in adverse effects of the intervention, measured as rates of pain in the thumb or finger joints, and car crash rates.None of the studies reported the secondary outcomes of health service utilisation or costs of the intervention. AUTHORS' CONCLUSIONS: We found very limited evidence that in certain cases mobile phone messaging interventions ma …

Atypical bone and synovial metastases from colorectal adenocarcinoma: A case report.

Colorectal cancer (CRC) is a prevalent malignancy globally, ranking third in incidence and second in cancer-specific mortality. Despite advancements in diagnosis and treatment, the incidence of CRC, especially in younger individuals and developing countries, is rising. We present a unique case of a woman initially diagnosed with cecal adenocarcinoma who developed metachronous atypical bone and soft tissue metastases, including involvement of the left knee synovium. This case underscores the diagnostic and therapeutic complexities in managing CRC patients with atypical metastatic disease. The p

Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review.

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a d

RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis.

Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be involved in the pathogenesis of RA. Inhibition of synoviolin activity is a potentially useful therapeutic approach for the treatment of RA. We conducted a high-throughput screen of small molecules to find inhibitors of synoviolin autoubiquitination activity. We identified two classes of small molecules, named LS-101 and

The efficacy and safety of electro-acupuncture for alleviating chemotherapy-induced peripheral neuropathy in patients with coloreactal cancer: study protocol for a single-blinded, randomized sham-controlled trial.

BackgroundColorectal cancer is the most common cancer in Hong Kong. Oxaliplatin-based chemotherapy is a major first-line conventional therapy for advanced and metastatic colorectal cancer. However, oxaliplatin causes chemotherapy-induced peripheral neuropathy (CIPN). Acupuncture has long been used to alleviate limb numbness in Chinese medicine. This study aims to examine the efficacy and safety of acupuncture for alleviating CIPN in patients with colorectal cancer in Hong Kong.Methods/designThis is a single-blinded, randomized, sham-controlled efficacy trial. Eighty-four eligible patients, who