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Primary hemiarthroplasty versus conservative treatment for comminuted fractures of the proximal humerus in the elderly (ProCon): a multicenter randomized controlled trial.

BACKGROUND: Fractures of the proximal humerus are associated with a profound temporary and sometimes permanent, impairment of function and q … tiveness. METHODS/DESIGN: A prospective, multi-center RCT will be conducted in nine centers in the Netherlands and Belgium. Eighty patients over 65 years of age, who have sustained a three-or four part, or split head proximal humeral fracture will be randomized between primary hemiarthroplasty and conservative treatment. The primary outcome is the Constant s …

Prevalence of complaints of arm, neck and shoulder among computer office workers and psychometric evaluation of a risk factor questionnaire.

BACKGROUND: Complaints of Arm Neck and Shoulder (CANS) represent a wide range of complaints, which can differ in severity from mild, periodi … g 264 computer office workers of a branch office of the national social security institution in the Netherlands. The MUEQ holds 95 items covering demographic characteristics, in addition to seven main domains assessing potential risk factors with regard to (1) work station, (2) posture during work, (3) quality of break time, (4) job demands, (5) job control, …

[Screening for prostate cancer; a screening program is favored over current opportunistic testing].

In The Netherlands, no national prostate cancer (PCa) screening program exists, despite evidence that screening can reduce mortality and metastasis. Overdiagnosis, a primary concern, is considered too detrimental to justify population-based screening. However, individual early detection through PSA testing is widely practiced, particularly in older men who may derive limited benefit. Variations in patient access to information, health literacy, and general practitioners' screening policies, coupled with high referral rates to secondary care, contribute to inefficiency, overdiagnosis, and socia…

Comparison of DeltaScan® and CAM-ICU for the Assessment of Postoperative Delirium in Patients Undergoing Cardiac Surgery and Cardiac Interventions: A Prospective Observational Pilot Study.

BACKGROUND: Postoperative delirium is frequent among elderly patients and often presents after major surgery or intervention. Validated screening tools should be routinely used to recognise this psychopathological syndrome. Delirium might be associated with systematic changes in brain network organisation, including reduced EEG connectivity. METHODS: This observational single-centre pilot study aimed to evaluate the agreement between DeltaScan® (Prolira BV, Utrecht, The Netherlands) and CAM-ICU screening in detecting postoperative delirium in patients undergoing cardiac surgery or cardiac int…

*Co-Occurrence and Causality Among ADHD, Dyslexia, and Dyscalculia.

ADHD, dyslexia, and dyscalculia often co-occur, and the underlying continuous traits are correlated (ADHD symptoms, reading, spelling, and math skills). This may be explained by trait-to-trait causal effects, shared genetic and environmental factors, or both. We studied a sample of ≤ 19,125 twin children and 2,150 siblings from the Netherlands Twin Register, assessed at ages 7 and 10. Children with a condition, compared to those without that condition, were 2.1 to 3.1 times more likely to have a second condition. Still, most children (77.3%) with ADHD, dyslexia, or dyscalculia had just one con…

Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing.

Neurodegenerative disorders exhibit considerable clinical heterogeneity and are frequently misdiagnosed. This heterogeneity is often neglected and difficult to study. Therefore, innovative data-driven approaches utilizing substantial autopsy cohorts are needed to address this complexity and improve diagnosis, prognosis and fundamental research. We present clinical disease trajectories from 3,042 Netherlands Brain Bank donors, encompassing 84 neuropsychiatric signs and symptoms identified through natural language processing. This unique resource provides valuable new insights into neurodegenera…

Advancements in Cardiovascular Imaging: Substituting Magnetic Resonance Imaging for Contrast-Enhanced Computed Tomography in the Assessment of Patent Ductus Arteriosus.

A male in his seventies was admitted for a patent ductus arteriosus (PDA) closure. We planned a catheter-based closure but avoided pre-procedural contrast-enhanced CT due to his low estimated glomerular filtration rate. Instead, we used magnetic resonance imaging (MRI) (Philips, 3T, Ingenia Elition, Philips Healthcare, Amsterdam, The Netherlands). An MRI of the aorta showed that the PDA was aneurysmal (Krichenko classification, type D). The Qs/Qp ratio via two-dimensional phase-contrast MRI was 1.78. Black blood imaging was used to obtain accurate diameter determination. Black Blood Imaging an…

Sweet Shop Sialagogues: A Sour Solution to Sialolithiasis.

Historically, boiled sweets have been recommended by ear, nose, and throat surgeons for their sialagogue effect in patients with sialolithiasis. This study presents an in vivo analysis of boiled sweets and solutions to determine sialagogue superiority. Six high-street boiled sweets (lemon sherbets, rhubarb sweets, mint humbugs, Werther's Original® (August Storck, Germany), Fox's Glacier Fruits® (Fox's Confectionery, Braunstone, Leicester, United Kingdom), and Chupa Chups® lollipops (Perfetti Van Melle, Breda, Netherlands)) and two solutions (malt vinegar and lemon juice) were compared to two c…

Ergonomic Stressors Among Pregnant Healthcare Workers: Impact on pregnancy outcomes and recommended safety practices.

Workplace environment can have a considerable impact on the physical, psychological and maternal health of pregnant healthcare workers. This article aimed to summarise the impact of work-related ergonomic stressors on pregnancy outcomes for healthcare workers, along with potential interventions to resolve these stressors. A narrative review analysis using the Pearl Growing Strategy was conducted between February 2019 and June 2020 to identify English-language articles published between 2000 and 2020. A total of 89 studies were identified from the SCOPUS (Elsevier, Amsterdam, Netherlands), MEDL…

Dyssynergic defecation may aggravate constipation: results of mostly pediatric cases with congenital anorectal malformation.

BACKGROUND: Most patients with congenital anorectal malformation suffer from mild chronic constipation. To date, it is unclear why a subgrou … use of severe constipation. The study was conducted at the University Medical Center Groningen, The Netherlands. RESULTS: All patients had increased maximum rectal pressure and increased anal sphincter pressure during balloon expulsion and therefore suffered from dyssynergic defecation. CONCLUSIONS: Patients with congenital anorectal malformations may also …

FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma.

Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. Fo … breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P = .000111). These dat …

Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002.

The PEARLS study prospectively monitored selected nosocomial pathogens from 38 centres in 13 European, three Middle Eastern countries and South Africa during 2001-2002. Extended spectrum beta-lactamase (ESBL) production rates among Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp. were 5.4% (142/2609), 18.2% (401/2,206) and 8.8% (204/2,328), respectively, for all study sites. The overall ESBL production rate for the combined Enterobacteriaceae was 10.5% (747/7,143), highest in Egypt, 38.5%, and Greece, 27.4%, and lowest in The Netherlands, 2.0%, and Germany, 2.6%. IEF, PCR and DNA…

Hysterectomy and sexual wellbeing: prospective observational study of vaginal hysterectomy, subtotal abdominal hysterectomy, and total abdominal hysterectomy.

OBJECTIVES: To compare the effects of vaginal hysterectomy, subtotal abdominal hysterectomy, and total abdominal hysterectomy on sexual wellbeing. DESIGN: Prospective observational study over six months. SETTING: 13 teaching and non-teaching hospitals in the Netherlands. PARTICIPANTS: 413 women who underwent hysterectomy for benign disease other than symptomatic prolapse of the uterus and endometriosis. MAIN OUTCOME MEASURES: Reported sexual pleasure, sexual activity, and bothersome sexual problems. RESULTS: Sexual pleasure significantly improved in all patients, independent of the type o…

Spina bifida and parental occupation.

To examine the association between parental occupation and spina bifida in offspring, we conducted a multicenter case-referent study in the Netherlands. Cases were children with spina bifida aperta from nine different hospitals throughout the country; the referent group comprised population-based referents who were randomly drawn from municipal birth registries. All children were born between 1980 and 1992. We collected data using postal questionnaires for both parents with questions about occupational title, industry, daily occupational activities, and a number of potential confounders. We we…

Множественный вариант жесткости склероза в DYSF-ZNF638 связует с нейронной потерей и воспалением.

Был выявлен генетический вариант rs10191329AA, связанный с более быстрым накоплением инвалидности при множественном склерозе (MS). Мы изучили воздействие переносчика Rs10191329AA на MS патологию и флангающие гены дисферлин (DYSF) и белкового цинка 638 (ZNF638) в голландском банке мозга (n = 290) путем сопоставления rs10191329AA (n = 6) с совпадающими rs10191329CC носителями (n = 12). rs10191329A носителями, связанными с более острым аксоном стрессом, снижением нейронной плотности слоя 2 и более высокой долей повреждений пенистыми микроглией. В rs10191329AA спонсоры, обычно выделявшиеся белое в

Совпадение в аннотации оригинала
The genetic variant rs10191329AA has been identified to associate with faster disability accrual in multiple sclerosis (MS). We investigated the impact of rs10191329AA carriership on MS pathology and flanking genes dysferlin (DYSF) and zinc finger protein 638 (ZNF638) in the Netherlands Brain Bank cohort (n = 290) by comparing rs10191329AA (n = 6) to matched…

Delay Discounting and Risk Tolerance in Obsessive Compulsive Disorder: Results From the Global OCD Study.

Although obsessive-compulsive disorder (OCD) features maladaptive decision making, previous research examining economic decision making in O … s to gamble for uncertain rewards when the risk is known. Data were collected in Brazil, India, the Netherlands, South Africa, and the USA as part of the Global OCD study. After controlling for age, sex, education, socioeconomic status, IQ, and site, individuals with OCD did not differ from HC in either delay discounting or risk tolerance. However, patients w …

Huriez syndrome: Additional pathogenic variants supporting allelism to SMARCAD syndrome.

Huriez syndrome (HRZ, OMIM181600) is a rare genodermatosis characterized by scleroatrophic hands and feet, hypoplastic nails, palmoplantar keratoderma, and predisposition to cutaneous squamous cell carcinoma (cSCC). We report herein three HRZ families from Croatia, the Netherlands, and Germany. Deep sequencing followed by Sanger validation, confirmed the presence of germline causative SMARCAD1 heterozygous pathogenic variants. All seven HRZ patients displayed hypohidrosis, adermatoglyphia, and one patient developed cSCC at 32 years of age. Two novel monoallelic germline mutations were identifi…

A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics.

From 2007 through 2010, the Netherlands experienced the largest Q fever epidemic ever reported. This study integrates the outcomes of a multidisciplinary research programme on spatial airborne transmission of Coxiella burnetii and reflects these outcomes in relation to other scientific Q fever studies worldwide. We have identified lessons learned and remaining knowledge gaps. This synthesis was structured according to the four steps of quantitative microbial risk assessment (QMRA): (a) Rapid source identification was improved by newly developed techniques using mathematical disease modelling; …

Variation in serum biomarkers with sex and female hormonal status: implications for clinical tests.

Few serum biomarker tests are implemented in clinical practice and recent reports raise concerns about poor reproducibility of biomarker studies. Here, we investigated the potential role of sex and female hormonal status in this widespread irreproducibility. We examined 171 serum proteins and small molecules measured in 1,676 participants from the Netherlands Study of Depression and Anxiety. Concentrations of 96 molecules varied with sex and 66 molecules varied between oral contraceptive pill users, postmenopausal females, and females in the follicular and luteal phases of the menstrual cycle …

Skipping the pill-free interval: data from a Dutch national sample.

INTRODUCTION: A monthly pill-free interval is unnecessary and many women prefer to have fewer bleeding episodes. METHODS: Eight hundred eighteen oral contraceptive pill (OCP) users reported frequency of skipping the pill-free interval in the online 2011 Sexual Health in the Netherlands Survey. Demographics of women who skipped pill-free intervals regularly were compared to those of women who rarely skipped intervals. RESULTS: 73% of the women have ever skipped pill-free intervals and 38% do so regularly. Women of Dutch or Western origin and non-religious women skip intervals more frequently,…