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Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis.

Accurate assessment of progression and disease course in multiple sclerosis (MS) is vital for timely and appropriate clinical intervention. The gradual transition from relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS) is often diagnosed retrospectively with a typical delay of three years. To address this diagnostic delay, we developed a predictive model that uses electronic health records to distinguish between RRMS and SPMS at each individual visit. To enable reliable predictions, conformal prediction was implemented at the individual patient level with a confidence of 93%. Our

Неблагоприятное событие во время случайных клинических испытаний для Множественной миеломы.

ВАЖНОСТЬ: Лечение раком может приводить к обременительным токсичным последствиям, которые оказывают глубокое воздействие на качество жизни пациентов. В докладах о клинических испытаниях, направленных на то, чтобы подчеркнуть эффективность испытуемого лечения, могут использоваться субъективные или минимизированные термины для описания негативных явлений (АЭ). ЦЕЛЬ: Оценить модели представления данных по ПВ в ходе многократных клинических испытаний на миеломе (ММ), опубликованных в период между 2015 и на раннем этапе 2023. DESIGN, SETTING, И УЧАСТНИКИ: Для этого когортного исследования были найд

Feasibility of a tailored and virtually supported home exercise program for people with multiple myeloma using a novel eHealth application.

INTRODUCTION: eHealth exercise interventions have the unique ability to leverage the benefits of in-person programming (tailoring and supervision) with the benefits of home programming (flexibility). There may be a role for eHealth-delivered exercise for people with multiple myeloma (MM), as exercise tailoring and supervision are critical for successful outcomes due to the significant impacts/risks of myeloma-related side effects. The purpose of this study was to determine the safety, feasibility, and preliminary efficacy of a 12-week virtually supported eHealth exercise program. METHODS: Par

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… Minimal clinically important difference in 30 s sit-to-stand test after pulmonary rehabilitation in patients with COPD. Eur Respir J 2018; 52: OA5199. 62. Ishigaki EY, Ramos LG, Carvalho ES, et al. … Minimal clinically important difference in the physical, emotional, and total symptom distress scores of the Edmonton symptom assessment system. J Pain Symptom Manage 2016; 51: 262–269. …

2023 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Montréal, Canada, 19 March–April 1 2023: Posters

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A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy.

PurposeChemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy.MethodsRandomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over th

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… Minimal clinically important differences in the EORTC QLQ-C30 and Brief Pain Inventory in patients undergoing re-irradiation for painful bone metastases. Qual Life Res. 2018;27:1089-1098. 23. Wong K, Zeng L, Zhang L, et al. … Minimal clinically important differences in the Brief Pain Inventory in patients with bone metastases. Support Care Cancer. 2013;21:1893-1899. 24. Yost KJ, Eton DT. Combining distribution- and anchor-based approaches to determine minimally important differences: the FACIT experience. …

Advances in neoadjuvant therapy for locally advanced head and neck squamous cell carcinoma (Review).

PURPOSE: Identifying factors that affect recovery or restoration of neurological function is a key goal of rehabilitation in neurology and ophthalmology. One such factor can be prolonged mental stress, which may be not only the consequence of nervous system damage but also a major risk factor, or cause, of neural inactivation. Using the visual system as a model of neural injury, we wished to study how patients' stress and personality profiles correlate with vision recovery as induced by therapy with alternating current stimulation (ACS) in patients with optic nerve damage. METHODS: Personalit

Е-постеры.

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… In a series of three multivariable logistic regressions, LTJR was shown to provide 4.0 times greater odds of achieving the minimal clinical symptom state in disability and pain (ODI < 20%, NRS back and leg pain < 2) and 3.6 and 2.6 times greater odds of achieving minimal clinically important difference …

A new era in the management of spinal metastasis.

Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy. Consequently, main

Health-related quality of life in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation: results from the randomized phase III ALCYONE trial.

BACKGROUND: In the phase III ALCYONE trial, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) significantly improved overall response rate and progression-free status compared with VMP alone in transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM). Here, we present patient-reported outcomes (PROs) from ALCYONE. METHODS: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item (EORTC QLQ-C30) and EuroQol 5-dimensional descriptive system (EQ-5D-5L) questionnaire were administered at baseline, every 3 months (year 1) a

Efficacy of a nonsurgical treatment regimen in patients with bisphosphonate-related osteonecrosis of the jaws in Saudi Arabia.

ObjectivesThe objective of this study was to evaluate the effectiveness of a nonsurgical treatment regimen in the long-term control of necrotic areas of the jaws and pain in such patients.MethodsA total of 96 patients suffering from the disease were included in this study. All patients received nonsurgical treatment regimen for 10 days, and repeated every 3 months for 2 years. The size of the osteonecrotic lesions was measured and the pain level was self-assessed with a visual analog scale.ResultsThe patients showed a statistically significant (F = 16.1; p ConclusionsThis conservative nonsurgi

Прогнозирующее значение динамического мониторинга состояния минимальных остаточных заболеваний у пациентов с множественной миеломой: исследование реального мира.

Фон: Минимальное остаточное заболевание (МВД) является установленным прогнозным фактором в миеломе (ММ), однако значение динамических изменений MRD до и после аутологической трансплантации стволовых клеток (ASCT) остается неясным. Методы: Ретроспективный анализ 335 Недавно диагностировали пациентов MM, прошедших первичную ACCT. Общий показатель выживаемости (ОС) и выживаемости без прогрессирования (ПФС) оценивался с использованием метода Kapan-Meier и сопоставлялся с использованием теста log-rk. Для оценки коэффициентов опасности (HR) и 95% Интервал доверия (CI), коррекция с учетом клинических

Minimally Invasive Pedicle Screw Fixation Combined with Percutaneous Kyphoplasty Under O-Arm Navigation for the Treatment of Metastatic Spinal Tumors with Posterior Wall Destruction.

ObjectiveTo evaluate the safety and efficacy of O-arm-guided minimally invasive pedicle screw fixation combined with percutaneous kyphoplasty for metastatic spinal tumors with posterior wall destruction.MethodsPatients who underwent minimally invasive pedicle screw fixation combined with percutaneous kyphoplasty for pathological vertebral fractures with posterior wall defects from January 2015 to December 2017 were followed up for 1 year. Visual analogue scale (VAS), SF-36 scores, middle vertebral height, posterior vertebral height, and the accuracy of pedicle screws were assessed preoperative

Rapid Fire Presentations

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… Maximum medical improvement (MMI) was defined as the time point where more than 90% of the cohort achieves minimal clinically important difference (MCID) for both ODI and PROMIS score reports. Descriptive and inferential statistics were performed. …

Устные доклады

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Электронные постеры

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Эффективность транскраниального прямого тока (tDCS) на нейропсихиатрических Симптомах в множестве склерозов (MS) - обзор и понимание возможных механизмов действий.

Введение: Нейропсихиатрические симптомы, такие, как депрессия и беспокойство, являются значительным бременем для пациентов с множественным склерозом (МС). Их патофизиология сложна и еще не до конца понятна. Существует срочная потребность в неинвазивных методах лечения, которые непосредственно нацелены на мозг и помогают пациентам с склерозом. Одним из таких возможных способов лечения является транскраниальная стимуляция прямого тока (TDCS) - популярный и эффективный метод неинвазивной стимуляции мозга. Методы: В рамках этого механистического обзора изучается эффективность ТДСС в лечении депрес

MRD negativity: considerations for older adults with multiple myeloma.

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Mass spectrometry-based proteomics and metabolomics in multiple myeloma: a systematic review of prognostic biomarkers and minimal residual disease monitoring.

INTRODUCTION: Current multiple myeloma (MM) risk stratification, anchored on the Revised International Staging System (R-ISS), provides a static snapshot of disease but fails to capture its dynamic biological evolution, functional tumor-microenvironment crosstalk, and real-time treatment response. Mass spectrometry (MS)-based proteomic and metabolomic profiling has emerged as a high-sensitivity tool for both novel biomarker discovery and minimal residual disease (MRD) monitoring. This systematic review evaluates the independent prognostic value and clinical utility of quantitative MS-based pro

From Time-Limited Therapy to Treatment-Free Observation: The Evolving Role of MRD in CLL Management.

The integration of measurable residual disease (MRD) into the management of chronic lymphocytic leukemia (CLL) has emerged as a major advance in risk stratification and trial design, particularly in the context of time-limited, targeted regimens. High-sensitivity MRD assessment, enabled by multicolor flow cytometry, allele-specific oligonucleotide PCR, and next-generation sequencing (NGS), provides a robust, quantifiable measure for depth of remission and long-term outcomes. Landmark trials-including CLL14, MURANO, CAPTIVATE, and GLOW-have consistently demonstrated that achieving undetectable

Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ).

PURPOSE: To assess and classify the strategies employed in various dental specialities for the prevention and management of medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: A comprehensive literature review was conducted, acquiring studies sourced from Google Scholar and PubMed. The emphasis was on studies published in recent years, focusing on successful MRONJ prevention techniques across various dental specialties. RESULTS: Four types of prevention were identified. Primary prevention strategies include optimizing oral hygiene, managing dental caries, and extracti