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Health-Related Challenges and Programs Among Agriculture Workers: A Narrative Review.

Agriculture is one of the most hazardous occupations, with many workers experiencing occupational accidents and ill health. The misuse of toxic substances, often due to inadequate protective measures, raises concerns about both individual and nature safety. However, the strenuous tasks done by the agricultural workers, especially those related to pesticide exposure and some challenges affect the farmer's health and well-being. This review paper used databases like PubMed and Google Scholar to elaborate this. English language studies are included and other languages are excluded. The health sys

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… In low and middle-income countries like India and Nepal in Asia, there has been a gradual decline in the yearly consumption of food calories, ranging from 0.8% to 2.2% annually [ 8 ]. In terms of farm outputs, India ranks second globally. …

Back pain as an initial feature of advanced gastric cancer mimicking multiple myeloma: A case report and literature review.

BackgroundBack pain is a rare initial presentation of gastric cancer. Isolated back pain with red flags in middle-aged patients might indicate multiple myeloma. However, it is rarely present in advanced gastric adenocarcinoma; hence, data are limited to case reports only. For a timely diagnosis of the underlying malignancy, endoscopy should be considered if the initial workup for this backache is unrevealing.Case presentationWe present a 34-year-old previously healthy gentleman with severe unremitting backache. He was ultimately diagnosed with gastric adenocarcinoma stage IV and received palli

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… Presentation and Outcomes of Gastric Cancer at a University Teaching Hospital in Nepal. Asian Pac J Cancer Prev. 2015;;16((13):):5385–8. doi: 10.7314/apjcp.2015.16.13.5385. 3. Brigle K, Rogers B. Pathobiology and Diagnosis of Multiple Myeloma. …

Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways.

BACKGROUND: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL). METHODS: A prospective cohort study was conducted from 2017 to 2022 at the Facult

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… Perceived Maternal Role Competence among the Mothers Attending Immunization Clinics of Dharan, Nepal. Int J Community Based Nurs Midwifery. 2016;4:100–6. [ PMC Free Article ] 35. Galaugher T. …

Бремя множественной миеломы в азиатских странах 1990 в адрес 2021 и прогнозирование тенденций 2050:: анализ, основанный на Глобальном исследовании бремени болезней 2021.

Множественная миелома (ММ) создает растущую угрозу для здоровья населения во всем мире, причем региональные различия в бремени болезней становятся все более заметными. Являясь самым густонаселенным континентом, Азия переживает быстрые демографические и социально-экономические изменения и играет решающую роль в формировании эволюционной траектории глобального бремени ММ. Цель этого исследования заключается в оценке бремени болезней, связанных с множественной миеломой в азиатских странах. 1990 в адрес 2021Данные этого исследования были получены на основе исследования глобального бремени болезней

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… South Asia encompasses India, Pakistan, Bangladesh, Sri Lanka, Nepal, Bhutan, the Maldives, and Afghanistan. … 6.44–9.33] | 15.3 [11.39–21.06] | 31.83 [23.83–43.57] | 6.04 [5.42– 6.66] India | 738.21 [428.55–939.88] | 14.78 [8.71–18.84] | 2994.44 [2361.3–3978.64] | 24.22 [19.08–32.16] | 1.46 [1.27– 1.65] Viet Nam | 12.73 [8.8–16.76] | 3.11 [2.15–4.09] | 67.37 [45.89–93.2] | 6.52 [4.42–8.85] | 2.59 [2.54– 2.64] Nepal …

Infections and Their Outcomes in Cancer Patients With and Without Neutropenia: A Single-Center Experience.

Background Patients with cancer are at a high risk of developing infections due to immunosuppression resulting from cancer treatment. Infections may occur both during neutropenic and non-neutropenic episodes and negatively impact outcomes both in terms of hospital stay and mortality. In this study, we aimed to determine the infection types, microbiological picture of infections, their outcomes, and associated factors in cancer patients during neutropenic and non-neutropenic episodes. Methods This is a retrospective cross-sectional study conducted at the Department of Medical Oncology, Geetanja

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… Lebanon: a view of the past decade Int J Infect Dis Kanafani ZA Dakdouki GK El-Chammas KI Eid S Araj GF Kanj SS 450 453 11 2007 17337226 10.1016/j.ijid.2006.12.008 15 Bacterial profile and antibiotic resistance among cancer patients with urinary tract infection in a national tertiary cancer hospital of Nepal …

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk-outcome associations. METHODS: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and

Information and communications technology use to prevent and respond to sexual and gender-based violence in low- and middle-income countries: An evidence and gap map.

BACKGROUND: The use of information and communications technologies (ICT) in low- and middle-income countries (LMIC) has increased significan … onse outcomes. Countries represented among the eligible individual studies include Cambodia, Kenya, Nepal Democratic Republic of Congo (DRC), and Lebanon. Of the 10 eligible studies (individual and reviews), most focused on intimate partner violence against women (IPV). Intervention areas among the eligible studies include safety planning using decision …

Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive disease, often punctuated by recurrent flare-ups or ex … anged from 62 to 76 years. Trials were single- or two-centre trials conducted in Iran, New Zealand, Nepal, Turkey, the UK, Tunisia and the USA between 2004 and 2018. We judged studies to be at low or unclear risk of bias for most of the domains. Three studies were at high risk for blinding and other biases.  Intravenous magnesium sulfate versus placebo …

Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats.

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating, treatment-limiting, side-effect of several classes of chemotherapy drugs. While negatively impacting oncology patients' quality of life, chemotherapy-induced large-fiber (LF) neuropathy is amongst the least well understood components of CIPN, and one for which there is currently no established therapy. Preliminary clinical observations have led to the suggestion that Duloxetine, which is used for the treatment of pain associated with small-fiber CIPN (SF-CIPN), may be effective against LF-CIPN. In the present experiments we d

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… Nepal MR, Taheri H, Li Y, Talebi Z, Uddin ME, Jin Y, DiGiacomo DF, Gibson AA, Lustberg MB, Hu S, Sparreboom A. Targeting OCT2 with Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neurotoxicity. Cancer Res Commun 2022; 2(11): 1334–1343. DOI: 10.1158/2767-9764.crc-22-0172. 36. …

Всеобъемлющая оценка взаимодействия капсикум генотипа-окружающей среды с использованием моделей Biplot AMMI и GПЭ в различных поэтапных средах трансплантации.

Генотип х взаимодействие с окружающей средой (ГЭИ) создает серьезную проблему для выявления стабильных, высокоурожайных капсикум генотипов при неоднородных агроклиматических условиях. В настоящем исследовании дается оценка 96 Генотипы различных капсикум (Capsicum annuum L.) four поэтапная трансплантация среды в течение 2022 и 2023 в северо-западных Гималаях для разборки ГЭИ в целях получения фруктовой урожайности и ее составных характеристик. Совокупный анализ разницы показал, что она весьма значительна (p) ≤ 0.01) воздействие генотипа, окружающей среды и ГЭИ на все признаки, что свидетельству

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… Joshi BK Yield stability of Tartary buckwheat genotypes in Nepal Fagopyrum 2004 21 1 5 Joshi, B. K. Yield stability of Tartary buckwheat genotypes in Nepal. Fagopyrum 21 , 1–5 (2004). 33. Barchenger, D. W. et al. …

Health Impacts of High BMI in China: Terrible Present and Future.

Temporal trends and future expectations of health effects due to high body mass index (BMI) remain uncertain in China. The trends of high-BMI-related death in China were evaluated and predicted until 2040 using data and methods from the Global Burden of Disease study. The absolute numbers and age-standardized rates of death and disability-adjusted life years (DALYs) were also calculated by age, gender, and cause. From 1990 to 2019, the high-BMI-related death percent, number and rate were all significantly increased in China, and death rate may exceed that globally in the next 10 years. High BM

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… Mortality and risk factors of disease in Nepal: Trend and projections from 1990 to 2040. PLoS ONE. 2020;15:e0243055. doi: 10.1371/journal.pone.0243055. 17. Wang W.X., Hu K.L., Liu H., Zhang X.Y., Li H.M., Zhou F., Liu Y., Lei F., Qin J., Zhao Y., et al. …

Poster Presentation

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… PP-33 Novel intervention of low-dose menthol application for neuropathic pain: 308 case studies from a nepal hospital Dr Ruth Powys, Ms Sunita Bhandari, Ms Purna Maya Thapa Green Pastures Hospital Background: Topical cold-induced analgesia with low-dose menthol for neuropathic pain (NP) is being … Significant burdens of NP for spinal cord injury (SCI) and leprosy-affected patients (LAP) were previously highlighted in studies in Nepal: 51% (69/136) LAP had NP with moderate-severe impact on sleep (64%), mood (81%) and daily function (87%). …

Anti-carcinogenic and Anti-bacterial Properties of Selected Spices: Implications in Oral Health.

"Let food be thy medicine and medicine be thy food", as said by the father of medicine, Hippocrates in 431 B.C. Nature has provided us with a variety of treatment modalities in the form of food. For the first 5,000 years of civilization, humans relied on herbs and foods for medicine. Only in the past 60 years have we forgotten our medicinal "roots" in favor of patented medicines. While pharmaceutical ingredients have their value, we should not overlook the well-documented, non-toxic and inexpensive healing properties of food. As an individual we consume food several times a day without a compl

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… Because of pharmaceutical effect of curcumin, it is now used as a supplement in several countries including the United States, India, Japan, Korea, Thailand, China, Turkey, South Africa, Nepal, and Pakistan [ 17 ]. …

Early-stage IgM kappa proliferative glomerulonephritis with monoclonal immunoglobulin deposition presenting with atypical renal insufficiency: a case report and literature review.

INTRODUCTION: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a rare subtype of monoclonal gammopathy of renal significance (MGRS). While the IgG subtype has been well characterized, the IgM-κ variant is extremely rare, with a low detection rate of circulating monoclonal proteins and limited real-world data on its clinical course under conservative management. This case report describes a biopsy-proven IgM-κ PGNMID in an elderly patient with negative hematological screening, to expand the current understanding of this rare entity. PATIENT CONCERNS AND DIAG

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… Edited by: Vittoria Mattioni Marchetti , University of Pavia, Italy Reviewed by: Anil Dev Pant , Tribhuvan University Teaching Hospital, Nepal Matthew Abramson , Mount Sinai Hospital, United States Data availability statement The original contributions presented in the study are included in the article …

Vitamin B12 supplementation for growth, development, and cognition in children.

RATIONALE: Vitamin B12 deficiency is an important public health problem in children, and has been associated with anaemia and impaired growt … ed 16 trials (4083 children; 2 days to 11 years) in 10 countries, including India, Japan, Thailand, Nepal, United Kingdom, Italy, Spain, the United States, El Salvador, and Guatemala. Follow-up periods for outcomes in most studies ranged from five weeks to 31 months, with one study extending follow-up to nine years. Duration of vitamin B12 supplementati …

Immunomodulatory Потенциал Bibenzil-diгидрофенантрен дериватив изолируется от Calanthe cardioglossa.

Бибензы и дигидрофенантрены демонстрируют многообещающие иммуномудуляторные эффекты в различных заболеваниях человека. В этом исследовании мы изолировали one новая производная дигидрофентена (1), two новые производные бибензил-дигидрофенантрена (2, 3) вместе с 12 известные соединения (4-15) из метанола, выходящего из Calanthe cardioglosa. Эти соединения были выявлены с помощью физико-химических анализов и спектроскопических методов. :: three Новые соединения обладают энантиомерными формами, и их конфигурации были определены путем сопоставления экспериментального электронного дикроза (ЭОД) спек

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… significant role in the commercial cut flower industry, and many of its species have documented uses as remedies for various diseases. 1 The genus Calanthe has a rich history of use in traditional medicine across China (Traditional Chinese Medicine, TCM), Thailand, India (Ayurveda), Indonesia, and Nepal …

The effects of spiritual wellbeing on life satisfaction in hematologic cancer patients aged 65 and older in Turkey: mediating role of hope.

BackgroundThe mediating role of hope in the effects of spiritual wellbeing on life satisfaction in elderly haematologic cancer patients in Turkey was investigated in the present study.MethodsThe study was conducted in a descriptive, cross-sectional and correlational design. The study was conducted with 150 patients aged 65 and older who were diagnosed with haematologic cancer and who were referred to a university hospital haematology clinic and outpatient clinic. Research data were collected with Descriptive Information Form, Dispositional Hope Scale (DHS), Spiritual Well-being Scale (FACIT-Sp

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… Life satisfaction among elderly patients in Nepal: associations with nutritional and mental well‐being. Health Qual Life Outcomes 2018; 16: 1–10. 47. Chehregosha M, Bastaminia A, Vahidian F et al . …

Анализ тенденций и межнациональный анализ неравноправия в отношении иммунизированных подстрекательских заболеваний у детей и подростков в возрасте от 10 до 24 лет в период с 1990 по 2021 год.

IMID - это хронические подстрекательские заболевания, вызываемые дисрегулированием иммунной системы и затрагивающие многочисленные системы и органы. Дети и подростки в возрасте от 10 до 24 лет относятся к группам повышенного риска, и глобальное бремя является значительным. МЕТОДЫ: Используя самые последние данные о глобальном бремени заболеваний (ГБЗ) 2021 года, мы использовали регрессионный анализ " Компонт " , корреляционный анализ социально-демографического индекса (ИОД) и межнациональный анализ справедливости для разъяснения диспропорциональных различий в бремени ИМНИ среди детей

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… The countries with the lowest asthma incidence rates were Pakistan (173.68, 95% UI: 119.73 to 242.18), Bhutan (157.55, 95% UI: 107.44 to 225.09), and Nepal (136.90, 95% UI: 95.85 to 191.12). …

Crowdfunding for complementary and alternative medicine: What are cancer patients seeking?

BackgroundComplementary and alternative medicine (CAM) is increasingly being integrated into conventional medical care for cancer, used to counter the side effects of conventional cancer treatment, and offered as an alternative to conventional cancer care. Our aim is to gain a broader understanding of trends in CAM interventions for cancer and crowdfunding campaigns for these interventions.MethodsGoFundMe campaigns fundraising for CAM were retrieved through a database of crowdfunding campaign data. Search terms were drawn from two National Institutes of Health lists of CAM cancer interventions

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… Campaign categories irrelevant to those funding for medical purposes were removed, including: animals, business, California fire, Canada 150, competitions, creative, education, Hurricane Maria, memorials, Nepal, newlyweds, sports, volunteer, and wishes. …

Serum free light chain level at diagnosis in myeloma cast nephropathy-a multicentre study.

Myeloma cast nephropathy (MCN) is a common cause of severe renal impairment in multiple myeloma (MM). The level of free light chain (FLC) that causes MCN varies substantially and there is uncertainty about the threshold level that should be used to inform clinical practice. In a multicentre cohort study of 103 patients with a diagnosis of MM and biopsy-confirmed MCN made between 2002-2014, we report prospectively measured levels of serum FLC at diagnosis obtained using a single nephelometric assay (Freelite®) and we explore the relationship between serum FLC level at diagnosis with renal outco

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… Nepal Med. Assoc. 2012 52 192 195 23591252 34. Mehta S Use of continuous venovenous hemofiltration for acute renal failure due to multiple myeloma cast nephropathy Hematology 2012 17 229 231 10.1179/1607845412Y.0000000003 22889516 35. …