Результаты поиска

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

Совпадение в полном тексте источника
… Clindamycin, a well-established antibiotic derived from lincomycin, traditionally inhibits bacterial protein synthesis through binding to the 50S ribosomal subunit [ 167 ]. … Interestingly, clindamycin derivatives target β-adrenergic receptors in HCC cells, while metronidazole sulfonamide derivatives inhibit EGFR and HER2 kinases in adenocarcinoma and melanoma cell lines [ 168 , 169 ]. …

Bisphosphonate-Related Osteonecrosis of the Jaw and Oral Microbiome: Clinical Risk Factors, Pathophysiology and Treatment Options.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) represents a serious health condition, impacting the lives of many patients worldwide. The condition challenges clinical care due to its complex etiology and limited therapeutic options. A thorough understanding of the pathophysiological and patient-related factors that promote disease development is essential. Recently, the oral microbiome has been implicated as a potential driver and modulating factor of BRONJ by several studies. Modern genomic sequencing methods have provided a wealth of data on the microbial composition of BRONJ lesio

Совпадение в полном тексте источника
… It is important to note that, in this study, patients who were diagnosed with stage 2 or stage 3 BRONJ were given a 7-day preoperative treatment of oral decontamination using chlorhexidine rinses and antibiotics such as amoxicillin with clavulanic acid, clindamycin, or moxifloxacin, depending on their … For patients allergic to penicillin, or in cases of antibiotic resistance, alternatives such as fluoroquinolones, metronidazole, clindamycin, doxycycline, and erythromycin can be used [ 74 ]. …

Oral health, dental treatment, and medication related osteonecrosis of the jaw in multiple myeloma - a longitudinal cohort study.

OBJECTIVE: The objective of the present study was to investigate oral health status, oral health related quality of life, and identify risk factors associated with invasive dental treatment and medication related osteonecrosis of the jaw in patients with multiple myeloma. MATERIAL AND METHODS: Patients newly diagnosed with multiple myeloma (n = 144) referred between January 2015 and September 2022 were retrospectively included. The patients underwent a thorough clinical and radiological oral examination and odontogenic infections were treated before the start of bisphosphonate treatment. The

Совпадение в полном тексте источника
… New onset apical periodontitis discovered during annual check-ups or due to emergency visits was treated with root canal treatment by specialist in endodontics under antibiotic prophylaxis with Amoxicillin 2 g one-hour prior treatment or Clindamycin 300 mg in case of penicillin allergy. … These patients received antibiotic treatment with Phenoxymethylpenicillin 1.6 g × 3 for 7 days or Clindamycin 150 mg × 3 for 7 days, and healing control within 3 weeks. Fig. 1 Scheme of the study design The annual follow-ups continued until September 2022 or until the death of the patient. …

How does the clinical and tomographic appearance of MRONJ influences its treatment prognosis?

OBJECTIVES: To identify clinical and tomographic prognostic factors for conservative and surgical treatment of medication-related osteonecrosis of the jaws (MRONJ). METHODS: A retrospective search identified patients treated with antiresorptive drugs (ARDs), diagnosed with Stage 1, 2 or 3 MRONJ, and having CBCT scans previous to conservative or surgical treatment. Following data collection, imaging assessment of the following parameters on each MRONJ site was performed: involvement of teeth and/or implants, presence of osteosclerosis, osteolysis, sequestrum formation, periosteal reaction, and

Совпадение в полном тексте источника
… Additionally, amoxicillin 875 mg/clavulanic acid 125 mg or clindamycin 300 mg three times per day were prescribed in the first 2 weeks. … Once the outpatient surgery was scheduled, they were prescribed amoxicillin 875 mg/clavulanic acid 125 mg or clindamycin 300 mg three times per day 2 days before surgery. …

The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction-An Animal Experimental Study.

The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM I

Совпадение в полном тексте источника
… An antibiotic prophylaxis of 10 mg/kg clindamycin (WDT, Garbsen, Germany) was administered intravenously pre-operative. … The post-operative treatment consists of 4 mg/kg Carprofen (Zoetis Inc., Florham Park, NJ) once per day and 10 mg/kg clindamycin (WDT, Garbsen, Germany) twice per day orally for ten days. …

Medication-Related Osteonecrosis of the Jaw: A Systematic Review of Case Reports and Case Series.

Medication-related osteonecrosis of the jaw (MRONJ) is a rare condition, typically seen in patients receiving antiresorptive or antiangiogenic drugs. This study aims to synthesize reports and case series of MRONJ regarding sociodemographic and clinical characteristics and to evaluate the effectiveness of the treatments applied. Following PRISMA guidelines, a search for case reports and case series was carried out in the PubMed-Medline database until March 2024. A total of 88 articles were included in this review, in a total of 151 cases. The key findings reveal that females were the most affec

Совпадение в полном тексте источника
… For stage 2, treatment recommendations include antibiotics (amoxicillin/clavulanate or clindamycin), chlorhexidine rinses, and analgesics. Limited debridement is one of the recommendations, but extensive surgery should be avoided. … Clindamycin was administered, alone and at an unknown dose, in 3% of cases ( n = 4) and at a dose of 300 mg, alone, in 2% of cases ( n = 3) ( Figure 10 ). …

Acute Pneumonia

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature.

Infection with Toxoplasma gondii is a rare but often fatal complication in hematopoietic stem cell transplantation (HSCT) recipients. Most cases have been reported in allogeneic (allo-) HSCT recipients, with only narrative reports following autologous HSCT (ASCT). We report the case of a 58-year-old Caucasian male presenting with toxoplasma encephalitis following tandem ASCT for myeloma and successfully treated with diagnosis by polymerase chain reaction analysis of cerebrospinal fluid. He was treated with sulfadiazine and pyrimethamine (with leucovorin) followed by pyrimethamine and atovaquon

Совпадение в полном тексте источника
… He developed crystal nephropathy with renal failure while on sulfadiazine and was changed to clindamycin and pyrimethamine for 8 weeks. Response to treatment was favorable at 1-month follow-up, as assessed by clinical and radiological means. …

Review of Myeloma Therapies and Their Potential for Oral and Maxillofacial Side Effects.

Myeloma is a common haematological malignancy in which adverse skeletal related events are frequently seen. Over recent years, treatment for myeloma has evolved leading to improved survival. Antiresorptive therapy is an important adjunct therapy to reduce the risk of bone fractures and to improve the quality of life for myeloma patients; however, this has the potential for unwanted side effects in the oral cavity and maxillofacial region. Osteonecrosis of the jaw related to antiresorptive medications and other myeloma therapies is not uncommon. This review serves to highlight the risk of osteo

Совпадение в полном тексте источника
… Different types of antibiotics have been recommended including penicillin, metronidazole, clindamycin, doxycycline, erythromycin, and spiramycin [ 3 , 55 ]. … Other studies have demonstrated a high prevalence of Actinomyces spp. in the necrotic bone of MRONJ patients and support the use of a prolonged antimicrobial regimen of either systemic Augmentin or Clindamycin for four weeks prior to surgical debridement as the mainstay of treatment [ 57 ]. …

Prospective study evaluating the incidence of bacteraemia and bacteruria in afebrile and febrile neutropaenic dogs undergoing chemotherapy.

The purpose of this prospective study was to determine the incidence and character of bacteraemia and bacteruria in afebrile and febrile neutropaenic dogs undergoing cytotoxic chemotherapy. Fifty-five neutropaenic dogs presenting to the University of Wisconsin Veterinary Medical Teaching Hospital were enrolled for a total of 57 neutropaenic episodes. The overall incidence of bacteraemia was 12.3% (n = 7/57). Three afebrile dogs and four febrile dogs were bacteraemic; this difference was not significant (P = 0.6968). The overall incidence of bacteruria was 7.5% (n = 4/53). Two afebrile dogs and

Совпадение в полном тексте источника
… The S. pseudintermedius infection (febrile group) was resistant to all antibiotics tested (chloramphenicol, ciprofloxacin, clindamycin, erythromycin, gentamicin, minocycline, tetracycline, penicillin and TMS) except amikacin and oxacillin. … The Staphylococcus pseudintermedius was multi‐drug–resistant including resistance to chloramphenicol, ciprofloxacin, clindamycin, erythromycin, gentamicin, minocycline, tetracycline, penicillin and TMS, with susceptibility for oxacillin (and beta‐lactam agents) and amikacin. …

Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT-A Prospective Comparative Study.

OBJECTIVES: The purpose of this study was to investigate the imaging characteristics of medication-related osteonecrosis of the jaw (MRONJ) using [18F]fluoride positron emission tomography/computed tomography (PET/CT) and [18F]fluorodeoxyglucose (FDG) PET/magnetic resonance imaging (MRI) for preoperative assessment and to correlate them with microarchitectural and histomorphometric data with respect to clinical findings. METHODS: Twelve patients (five female; mean age 75 ± 7.6 yr) with symptomatic MRONJ underwent both scans on the same day, and imaging findings were used to plan surgical inte

Совпадение в полном тексте источника
… . | Prostate cancer | Zoledronate; iv | 79 months | Clindamycin; Moxifloxacin | 32 (25o; 7iv) | cured | 30 months | cured 2 | female; 76 yr. | Breast cancer | Zoledronate; iv | 22 months | Cefuroxime; Moxifloxacin | 32 (25o; 7iv) | cured | 29 months | cured at origin; new necrosis at the upper jaw 3 … | female; 68 yr. | Breast cancer | Denosumab; sc | 48 months | Sultamicillin; Ampicillin/Sulbactam; Metronidazole; Cefuroxime | 29 (22o; 7iv) | cured | 40 months | cured 4 | male; 65 yr. | Kidney cancer | Denosumab; sc | 6 months | Sultamicillin; Ampicillin/Sulbactam; Clindamycin | 32 (25o; 7iv) | cured …

Дело о фульминантном некротизирующем фасиите верхней конечности в иммунокомпрометированном пациенте.

Некротизирующий фаскиит (NF) — редкий, чрезвычайно агрессивный и угрожающий конечностям и жизни инфекция мягких тканей, требующая хирургического вмешательства. Диагноз часто задерживается неспециализированными ранними исследованиями, и иммунокомпромиссные пациенты подвергаются особому риску в связи с хладнокровными, атипичными представлениями. Мы представляем случай 70-летнего мужчины с отдаленной историей множественных миелом, обработанных трансплантацией стволовых клеток, который разработал большой NF правой верхней конечности в течение 24 часов после небольшой тупой травмы. Несмотря на появ

Совпадение в полном тексте источника
… The consult found no evidence of recurrent necrotizing fasciitis and recommended continued intravenous cefepime, clindamycin, and vancomycin. At 4-month follow-up, the patient reported that he was overall doing well and continuing wound care. His clinical timeline is shown in Figure 7 . …

An Approach for the Prevention, Diagnosis, and Treatment of Jaw Osteonecrosis: Report of a Case Associated with Zoledronic Acid.

BACKGROUND Osteonecrosis of the jaw is a condition manifesting as necrotic bone for 8 weeks or more, with no history of radiotherapy. It is linked to the use of antiresorptive drugs, such as bisphosphonates and denosumab. We discuss in this case report the importance of infection control during clinical procedures in patients taking antiresorptives. CASE REPORT Our case report describes a 52-year-old woman who had received zoledronic acid injections for 7 years, who presented with osteonecrosis of the jaw in the region of teeth 24, 25, and 26, with no local trauma. The report proceeds to descr

Совпадение в полном тексте источника
… After the extraction, 300 mg clindamycin was prescribed for 10 days. The patient has stopped taking zoledronic acid and is stable. She has been followed for 6 months without any recurrence of the disease. …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

Совпадение в полном тексте источника
… Methicillin, rifampin, ciprofloxacin Incidence < 30 cases reported Acyclovir, amoxicillin, ampicillin, atazanivir, carbenicillin, cefazolin, cefaclor, cefamandole, cefotaxime, cefotetan, cefoperazone, cefoxitin, ceftriaxone, cephalothin, cephalexin, cephradine, cephaloridine, cephapirin, chloramphenicol, clindamycin … Methicillin, rifampin, ciprofloxacin Incidence < 30 cases reported Acyclovir, amoxicillin, ampicillin, atazanivir, carbenicillin, cefazolin, cefaclor, cefamandole, cefotaxime, cefotetan, cefoperazone, cefoxitin, ceftriaxone, cephalothin, cephalexin, cephradine, cephaloridine, cephapirin, chloramphenicol, clindamycin …

Совместное обнаружение вируса кори и сезонного коронавируса у иммунокомпромиссированного пациента с пневмонией.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Рекомендована вакцинация от кори для лиц, получающих трансплантацию стволовых клеток (ГХЦТ) ≥24 месяцев после трансплантации в отсутствие трансплантации и иммунодепрессивной терапии. Управление живыми вакцинами во время иммунодепрессии может привести к иатрогенным повреждениям. РЕЗЮМЕ: Мы описываем 76-year-old пациент со сценой 3 Множественная миэлома, которая прошла аутологический HSCT и получила многотрадиционную терапию, включая химерик антигенный рецептор Т-клеток и недавнюю терапию даратумумаба. Примерно 1 Через месяц после прививки от кори, свинки и краснухи у неё

Совпадение в полном тексте источника
… The patient was also switched to meropenem and clindamycin due to concern of superimposed bacterial pneumonia secondary to viral pneumonia. Two days later (day 6), the patient was transferred to the ICU due to increased oxygen requirements. …

Manifestations of systemic disease in the retina and fundus of cats and dogs.

The fundus is unique in that it is the only part of the body that allows for a noninvasive and uninterrupted view of vasculature and nervous tissue. Utilization of this can be a powerful tool in uncovering salient incidental findings which point to underlying systemic diseases, and for monitoring response to therapy. Retinal venules and arterioles allow the clinician to assess changes in vascular color, diameter, outline, and tortuosity. The retina and optic nerve may exhibit changes associated with increased or decreased thickness, inflammatory infiltrates, hemorrhages, and detachments. While

Совпадение в полном тексте источника
… Babesiosis may be challenging to treat, often requiring combinations of anti-protozoal medications such as imidocarb, and anti-protozoal antibiotics such as clindamycin or azithromycin ( 130 ). … Four-weeks of treatment with clindamycin and trimethoprim-sulfonamide are usually needed, though complete clearance of the parasite is unlikely ( 145 ). …

Observational study of the bisphosphonate-related osteonecrosis of jaws.

INTRODUCTION: The bisphosphonate-related osteonecrosis of the jaw was first referred to in 2003. Bisphosphonates action is focused on the osteoclasts. The drastic inhibition of the osteoclastic function is harmful for the jaws which are the only bones of the human skeleton in relative contact with the external environment. The adverse effects of the bisphosphonate-related therapy include the pathology for which they are prescribed, the atypical fractures in pathological bone. METHOD: The aim of this research was to analyze the risk factors and the treatment methods in case of osteonecrosis of

Совпадение в полном тексте источника
… Most commonly, patients admitted to the study received amoxicillin with clavulanic acid (Augmentin®), 30% received Cefuroxime, 20% clindamycin and only 10% ciprofloxacin. …

Different antibiotic treatments for group A streptococcal pharyngitis.

BACKGROUND: Antibiotics provide only modest benefit in treating sore throat, although their effectiveness increases in people with positive … hree compared penicillin with carbacephem; one compared penicillin with sulphonamides; one compared clindamycin with ampicillin; and one compared azithromycin with amoxicillin in children. All participants had confirmed acute GABHS tonsillopharyngitis, and ages ranged from one month to 80 years. Nine trials included only, or predominantly, children. Most tria …

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

Совпадение в полном тексте источника
… For mild or low-grade rash, observation or topical antibiotics (e.g., clindamycin, dapsone, or erythromycin) and/or low potency topical corticosteroids (e.g., hydrocortisone 2.5%) may be used. … Topical antibiotics (mupirocin, clindamycin) and topical corticosteroids may be used to treat acute bacterial infection and chronic paronychia, respectively ( Hu et al., 2007 , Pinto et al., 2011 ). …