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Management of Medication-Related Osteonecrosis of the Jaws With Hyperbaric Oxygen Therapy: A Case Report.

Medication-related osteonecrosis of the jaw (MRONJ) refers to the condition where the maxillary or mandibular bone becomes exposed and necrotic as a result of bisphosphonate therapy. The number of patients on bisphosphonates is increasing and so are the MRONJ cases. Since the initial data were published in the early 2000s, research into MRONJ has expanded significantly to enhance the understanding of this emerging condition. Various treatment options are available, but none have been established as the definitive "gold standard" for managing this disease. Hyperbaric oxygen therapy (HOT) is one

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… Amoxicillin is the drug of choice, but clindamycin or doxycycline could offer the extra benefit of bone penetration. …

Use of Platelet Rich Fibrin (PRF)-Based Autologous Membranes for Tooth Extraction in Patients under Bisphosphonate Therapy: A Case Report.

Tooth extraction in patients treated with bisphosphonates (BPs) for osteoporosis or cancer exposes the patient to the risk of osteonecrosis of the jaw. An autologous membrane using platelet-rich fibrin (PRF) is an innovative technique to promote wound healing, which allows obtaining a hermetic closure of the post-extractive surgical site without the need of mucoperiosteal flaps or periosteal releasing incisions. Here, we report the case of a 70-year-old woman, in therapy with alendronate for 12 years, requiring the upper right premolar extraction because of a crown fracture. After the tooth ex

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… Several protocols have been proposed, in particular using broad-spectrum antibiotics such as amoxicillin (1 g, 3 times/day) with or without clavulanic acid, also in combination with metronidazole (500 mg, 2 times/day), in case of allergy to penicillin, erythromycin (600 mg, 3 times/day), clindamycin …

Community-acquired pneumonia

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… with a quinolone) for patients with severe CAP Empiric therapy for CA-MRSA should be confined to patients with severe pneumonia and evidence of necrotizing infection, particularly after a viral infection Consider using an antitoxin-producing agent with an antibiotic, either vancomycin combined with clindamycin … For that reason, it may be necessary to add clindamycin to vancomycin or to use linezolid, with rifampin (rifampicin) in severe illness, since both of these latter agents can inhibit toxin production. 27 Patients with HCAP are a heterogeneous group, with some at risk for MDR Gram-negatives and MRSA, …

The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw.

BACKGROUND: Non-surgical treatment has generally been recommended for stage II medication-related osteonecrosis of the jaw (MRONJ) in preference to surgery. However, non-surgical treatment is not empirically effective. The aim of this study was to evaluate whether surgical or non-surgical treatment leads to better outcomes for stage II MRONJ. MATERIAL AND METHODS: In this retrospective study, surgery was performed in a total of 28 patients while 24 patients underwent non-surgical treatment. The outcomes of both treatment approaches after 6 months were evaluated and statistically compared. In

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… When swelling and pain were exacerbated, we administered effective antibiotics (amoxicillin, ceftriaxone, clindamycin, and/or cefcapene pivoxil) and analgesics (loxoprofen, acetaminophen, and/or tramadol hydrochloride) accompanied by incisional drainage. …

Conservative treatment of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients.

The use of intravenous bisphosphonates (pamidronate or zoledronic acid) is the cornerstone for the management of multiple myeloma-(MM-) related bone disease. However, osteonecrosis of the jaw (ONJ) is a rare, but sometimes difficult to manage, adverse effect of bisphosphonates therapy. A retrospective review of all MM patients who were treated with bisphosphonates in our department, from 2003 to 2013, and developed ONJ was performed. According to inclusion criteria, 38 patients were studied. All these patients were treated as conservatively as possible according to the American Association of

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… According to literature, the use of clindamycin in patients with BRONJ is not indicated after 2005 [ 12 ]. When bone spindles were present, only minor debridement procedures were attempted, in order to reduce trauma of the adjacent soft tissues. …

Nitrogen containing bisphosphonates associated osteonecrosis of the jaws: A review for past 10 year literature.

Nitrogen containing bisphosphonate (N-BP) therapy is used extensively to treat osteoporosis and osteolytic bone lesions. Recently, a special form of osteonecrosis limited to the maxillofacial skeleton has been discovered especially within those patients who are receiving either long-term N-BP therapy alone and/or associated with invasive dental procedure. Bisphosphonates accumulate almost exclusively in maxillofacial skeleton owing to high bone turn over remodeling to maintain the mechanical competence. The pathogenesis and why it commonly appears in maxillofacial skeleton and the fixed treatm

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… If patient was allergic to above group then choice of drug is Quinolones, Metronidazole, Clindamycin, Doxycycline and Erythromycin. If microbial cultures show positive evidence of Actinomyces species then antibiotic regimen should be adjusted accordingly. …

Intestinal/Multivisceral Transplantation

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… Table 30.3 Drugs commonly used in transplant recipients incriminated in the occurrence of severe neutropenia and agranulocytosis Drug category Frequently used drugs in transplant recipients incriminated in neutropenia Antimicrobials Aciclovir, cephalosporins, ciprofloxacin, clindamycin, dapsone, fluconazole … tacrolimus, thymoglobulin Table 30.3 Drugs commonly used in transplant recipients incriminated in the occurrence of severe neutropenia and agranulocytosis Drug category | Frequently used drugs in transplant recipients incriminated in neutropenia Antimicrobials | Aciclovir, cephalosporins, ciprofloxacin, clindamycin …

Атипичные презентации Acolovir-Resistant Herpes Simplex Virus в иммунокомпромиссированных пациентах: Серия дел.

Инфекции, связанные с вирусом герпеса (HSV), у иммунокомпромиссированных пациентов могут иметь атипичные представления - от грануломатных до линейных эрозийных повреждений - и превращаться в рефракторную и стандартную терапию. Мы сообщаем three :: случаи некротизации категорической инфекции HSV у иммунокомпромиссированных пациентов с гематологическими малигнациями или предшествующими химиотерапиями, все из которых имеют нетипичные и рефракторные проявления заболевания. One дело касалось 53-year-old :: пациентка с реанимацией/рефрактом острой миэлоидной лейкемией (АМЛ), разработавшая некротизир

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… Table 1 Clinical course, diagnostic findings, and therapeutic escalations HSV: Herpes simplex virus; EEG: Electroencephalogram; PCR: Polymerase chain reaction; EBV: Epstein–Barr virus Hospital Day | Event | Therapy 0 | Admission: fever + buttock plaque; CT/MRI shows abscess/myositis | Clindamycin → cefepime …

Topical, light-based, and complementary interventions for acne: an overview of systematic reviews.

BACKGROUND: Acne is a chronic inflammatory and immune-mediated disease of the pilosebaceous unit (the skin structure consisting of a hair fo … weeks; very low-certainty evidence). Benzoyl peroxide versus topical antibiotics: When compared to clindamycin, benzoyl peroxide may have little to no effect on the following outcomes (long-term treatment): total lesion counts (MD -3.50, 95% CI -7.54 to 0.54; 1 trial, 641 participants, 12 weeks; very low-certainty evidence), inflammatory lesion counts (MD -1 …

Antibiotics for trachoma.

BACKGROUND: Trachoma is the world's leading infectious cause of blindness. In 1996, WHO launched the Alliance for the Global Elimination of … tococcus pneumoniae, Staphylococcus aureus, and Escherichia coli to azithromycin, tetracycline, and clindamycin in communities treated with azithromycin, with approximately 5-fold risk ratios at 12 months. The evidence did not support increased resistance to penicillin or trimethoprim-sulfamethoxazole. None of the studies measured resistance to C trachomatis. …

Interventions for rosacea.

BACKGROUND: Rosacea is a common chronic skin condition affecting the face, characterised by flushing, redness, pimples, pustules and dilated … nfirmed these data. There was no rebound or worsening of erythema after treatment cessation.Topical clindamycin phosphate combined with tretinoin was not considered to be effective compared to placebo (moderate quality evidence).Topical ciclosporin ophthalmic emulsion demonstrated effectiveness and improved quality of life for people with ocular rosacea (low …

Cryoglobulinemia Associated With Multiple Myeloma in a Dog Presenting With Epistaxis and Skin Lesions.

A 10-year-old female neutered Labrador Retriever presented with epistaxis, discoloration and crusting of the nose and a necrotic lesion on the lip. Bloodwork revealed pancytopenia, azotemia, hypoalbuminemia and hyperglobulinemia. Aggregates of amorphous basophilic material were seen in a room-temperature blood smear which were not present in the sample after warming to 37°C, and grossly a cryoprecipitate was noted in the patient's serum at 4°C. This was interpreted as cryoglobulin. Computed tomography showed multiple heterogeneous lesions in the spleen. Cytology of the splenic lesions revealed

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… No response to symptomatic treatment with antibiotic (clindamycin, Zodon 10 mg/kg PO BID) and non‐steroidal anti‐inflammatory (firocoxib, Previcox 3.8 mg/kg PO SID) medications was noted, with worsening of the epistaxis, which became bilateral. …

The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection.

Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during surgical treatment of MRONJ and evaluated by histology and microbiology for the presence of Actinomyces spp. Microbiological, demographic and clinicpathological data were analyzed for risk of Actinomyces-associated MRONJ. Between 2005 and 2014, 111 patients suffering from histologic

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… According to this standard treatment algorithm, all patients received systemic antibiotic treatment with amoxicillin (2 × 1 g/24 hours)/clavulanic acid (2 × 500 mg/24 hours) or clindamycin (3 × 300 mg/24 hours) for approximately 4 weeks between admittance and surgery 16 , 17 . …

Two Cases of Hidradenitis Suppurativa Treated with Adalimumab at the Department of Dermatology and Venereology, Clinical Hospital Mostar.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presentin … rument for dynamically measuring clinical severity of HS (10). The treatment of HS includes topical clindamycin, triamcinolone acetonide, clobetasol, topical resorcinol, oral antibiotics, hormonal therapy, oral retinoids, and biologic therapies (11). Biologic therapies are increasingly used in patients who fail to sufficiently respond to antibiotic and hormon …

Эмпирический антибиотиковый режим для больных раком фебриловой нейтропении: опыт работы в онкологическом центре.

ВВЕДЕНИЕ: Нейтропения является одним из основных препятствий на пути лечения больных раком. Обычно это происходит у пациентов, получающих химиотерапию, связанную со значительной заболеваемостью и смертностью. 5-30% у пациентов с твердыми опухолями 80% из тех, кто проходит химиотерапию гематологов. ЦЕЛИ: Цель этого исследования заключалась в оценке клинических результатов различных антибиотических режимов. Второй момент заключался в том, чтобы оценить микробиологическую целесообразность охвата антибиотиками нашего эмпирического режима карбапенема спаривания для нейтральной лихорадки у пациентов

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… For low-risk patients, outpatient oral antibiotics are recommended, the recommended regimen includes a fluoroquinolone (ciprofloxacin/levofloxacin) plus amoxicillin/clavulanate, clindamycin can be substituted for those who are penicillin-allergic ( 4 ). …

Determinants of outcome in cancer patients with medication-related osteonecrosis of the jaw: A 19-year retrospective study.

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… Patients diagnosed with MRONJ were generally treated using a conservative approach with close monitoring, prescription of chlorhexidine gluconate 0.12 % oral rinse, antibiotic (amoxicillin, amoxicillin with clavulanic acid, clindamycin and/or metronidazole) therapy in the presence of symptoms or soft …

Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw.

PURPOSE: The treatment of advanced stages of medication-related osteonecrosis of the jaw (MRONJ) remains challenging. In order to improve decision making concerning the therapy, we examined the change of patients' quality of life (QoL) after surgical treatment of MRONJ stage III. METHOD: The primary outcome variable was patients' QoL. It was preoperative (T0), 6 weeks postoperative (T1) and 6 months postoperative (T2) assessed by the European Organisation for Research and Treatment of Cancer QoL-H&N35 (EORTC QoL-H&N35) and the Oral Health Impact Factor-G14 (OHIP-G14) questionnaire in a prospe

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… In that case clindamycin was administered. Food intake was ensured by a nasogastric feeding tube for 10 days. Antimicrobial mouth rinse with chlorhexidine (0.12%) was used 3 times a day. After patients were discharged from hospital; they had an examination at 14 days and 6 weeks after surgery. …

Nocardia Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review.

BACKGROUND: Nocardia is a gram-positive bacterium capable of causing both local and systemic infections, typically in immunocompromised patients. The most common clinical presentation is pulmonary infection. Muscle abscess due to Nocardia infection without disseminated nocardiosis is rare. CASE REPORT: In this report, we describe the case of a 67-year-old male kidney transplant recipient who developed a swelling of the right biceps muscle. CT imaging showed an intramuscular abscess, which was subsequently surgically drained. The drained fluid grew Nocardia pseudobrasiliensis, which was resist

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… plexitis | No | TMP-SMX, MEM and AMK, changed to CIP and LZD | Stereotactic decompression | Resolution of symptoms [ 21 ] (2003) | 71 | M | Metastatic solid organ tumour on chemotherapy | Pulmonary | No | NS | NS | NS [ 22 ] (1999) | 33 | M | HIV/AIDS | Pulmonary | Yes—cutaneous and septic arthritis | Clindamycin …

Platelet rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw: personal experience and review of the literature.

Bisphosphonates (BPs) are a class of synthetic drugs commonly used to treat bone metastasis and various bone diseases that cause osseous fragility (such as osteoporosis). Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a common complication in patients who received BPs, especially intravenously. Recently, osteonecrosis of the jaw (ONJ) caused by chemotherapeutic not belonging to BPs drug class has been reported. For this reason, it has been proposed recently to rename BRONJ in antiresorptive agents related osteonecrosis of the jaw (ARONJ), to include a wider spectrum of drugs that m

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… Among systemic antimicrobials, penicillin-based ones are commonly and widely used (phenoxymethylpenicillin, amoxicillin, co-amoxiclav, or clindamycin with or without metronidazole) [ 4 , 25 , 27 , 28 ]. …

Клинические характеристики, диагноз, лечение и прогноз заболевания сывороткой ритуксимаба: ретроспективный анализ 39 Количество зарегистрированных случаев.

Заболевание сывороткой, вызванное ритуксимабом (РИСС), представляет собой необычайно запоздалую гиперчувствительность, характеризующуюся неполной клиническими характеристиками и управлением. Мы намеревались обобщить опубликованные доклады/серии с целью определения клинических моделей, терапевтических стратегий и результатов. МЕТОДЫ: PubMed, EMBASE, Web of Science, WanFang Data и China National Knowledge Infrastructure (CNKI) были найдены отчеты о болезни сыворотки, выпущенные до ноября 31, 2025, используя ключевые слова и свободные текстовые термины (например, "Rituximab", "Serum Bealth", "Ser

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… Immediate and delayed hypersensitivity reactions to antibiotics: aminoglycosides, clindamycin, linezolid, and metronidazole. Clin Rev Allergy Immunol. (2022) 62:463–75. doi: 10.1007/s12016-021-08878-x. PMID: 7. Khalaf R, Choi U, Prosty C, Ben-Shoshan M. …