Результаты поиска

Current and upcoming radionuclide therapies in the direction of precision oncology: A narrative review.

As new molecular tracers are identified to target specific receptors, tissue, and tumor types, opportunities arise for the development of both diagnostic tracers and their therapeutic counterparts, termed "theranostics." While diagnostic tracers utilize positron emitters or gamma-emitting radionuclides, their theranostic counterparts are typically bound to beta and alpha emitters, which can deliver specific and localized radiation to targets with minimal collateral damage to uninvolved surrounding structures. This is an exciting time in molecular imaging and therapy and a step towards personal

Совпадение в полном тексте источника
… Future directions Combining TARE with either targeted or immunotherapy drugs and in combination with CT-guided high-dose-rate interstitial brachytherapy for efficient tumor destruction has been conceived and applied [85] , [86] . … Combining transarterial radioembolization (TARE) and CT-guided high-dose-rate interstitial brachytherapy (CT-HDRBT): a retrospective analysis of advanced primary and secondary liver tumor treatment Cancers (Basel) 14 1 2021 10.3390/cancers14010072 PMC8750400 35008236 87 Postema E.J. Boerman O.C. …

The contribution of spirituality and religiousness to the quality of life of cancer patients treated with radiotherapy in Ghana: a cross-sectional study.

Cancer is one of the leading causes of morbidity and mortality globally. A significant proportion of all patients with cancer require radiotherapy as part of their treatment. Cancer can be very terrifying for patients undergoing radiotherapy, especially when it undermines their ability to hope or cope. In Ghana, where religious and spiritual beliefs play a significant role in many individuals' lives, understanding how these factors affect patients' well-being during cancer treatment is crucial. This study examined the contribution of spirituality and religiousness to the quality of life (QoL)

Совпадение в полном тексте источника
… Patients undergoing brachytherapy and those receiving external beam radiotherapy for benign conditions or hematological malignancies such as plasmacytoma and multiple myeloma were not included in the study. …

Proceedings to the 2020 Online Conference of the Particle Therapy Cooperative Group (PTCOG2020Online): 13-14 September 2020Organized by the Particle Therapy Cooperative Group (PTCOG), this special online meeting featured abstracts and programs that enabled the communication and cross fertilization for which PTCOG meetings are known.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Customized Marketing Strategies for Cancer Immunocyte Therapy Based on its Distinctive Attributes.

Cancer constitutes a persistent global health challenge, and immunocyte therapy has emerged as one approach in oncological care. This narrative review aimed to systematically analyze, synthesize, and critically interpret the therapeutic characteristics, advantages, market landscape, and current access barriers of cancer immunocyte therapy, based on thematic clustering and cross‑study integration of clinical evidence, market data, and industry reports. Immunocyte therapy exhibits distinctive features including personalization, long‑term immune memory, and observed efficacy in refractory maligna

Совпадение в полном тексте источника
… Salvage resection plus cesium-131 brachytherapy durably controls post-SRS recurrent brain metastases . J Neurooncol . 2022 ; 159 ( 3 ): 609 – 618 . doi: 10.1007/s11060-022-04101-9 35896906 PMC9328626 32. Pe’er J . Ruthenium-106 brachytherapy . …

IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy.

Interferon regulatory factor 4 (IRF4), a critical member of the IRF transcription factor family, harbors an elusive biological role in cervical cancer. Through immunohistochemical staining and immunoblotting, CCK-8 viability assays, EdU incorporation tests, clonogenic survival experiments, flow cytometric detection, transmission electron microscopy, immunofluorescence staining and heterotopic transplantation model, we discover that IRF4 expression was markedly decreased in cervical cancer tissues and cell lines compared to normal controls. Overexpression of IRF4 suppressed proliferation, migra

Совпадение в полном тексте источника
… S., Challapalli S., MariappanSenthiappan A., et al., “Clinical and Dosimetric Correlation in Terms of Treatment Response, Bladder and Rectal Toxicities in Cervical Cancer Patients Treated With Cobalt 60 High Dose Rate Brachytherapy,” PeerJ 12 (2024): e17759, 10.7717/peerj.17759. 34. Kong F. …

Gram-Negative Taxa and Antimicrobial Susceptibility after Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.

Fecal microbiota transplantation (FMT) has promising applications in reducing multidrug-resistant organism (MDRO) colonization and antibiotic resistance (AR) gene abundance. However, data on clinical microbiology results after FMT are limited. We examined the changes in antimicrobial susceptibility profiles in patients with Gram-negative infections in the year before and the year after treatment with FMT for recurrent Clostridioides difficile infection (RCDI). We also examined whether a history of FMT changed health care provider behavior with respect to culture ordering and antibiotic prescri

Совпадение в полном тексте источника
… repair | 3 | Unknown | Colonoscopy/1 | Fecal DON 2014-1 | Continued diarrhea | | Until present-day | | | | | | | | | | | | 230 | 65 | M | Caucasian | T3N2 rectal cancer, atrial fibrillation, prostate cancer, CAD, genital herpes simplex, urinary retention complicated by recurrent UTIs | Brachytherapy …

Cancer survivors not participating in observational patient-reported outcome studies have a lower survival compared to participants: the population-based PROFILES registry.

PurposeThe 'Patient Reported Outcomes Following Initial treatment and Long-term Evaluation of Survivorship' (PROFILES) registry collects patient-reported outcomes (PROs) from short- and long-term cancer survivors in the Netherlands, in a population-based setting. The aim of this analysis is to assess the generalizability of observational PRO research among cancer survivors by comparing socio-demographic and clinical characteristics, and survival of participants and non-participants in cancer survivors invited for questionnaire research through the PROFILES registry.MethodsBetween 2008 and 2015

Совпадение в полном тексте источника
… Primary treatments received were classified into surgery, systemic therapy (chemotherapy, targeted therapy, immune therapy), radiation therapy (including brachytherapy), hormone therapy, no treatment/active surveillance or unknown. …

Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.

Image-guided percutaneous ablation methods have been further developed during the recent two decades and have transformed the minimally invasive and precision features of treatment options targeting primary and metastatic tumors. They work by percutaneously introducing applicators to precisely destroy a tumor and offer much lower risks than conventional methods. There are usually shorter recovery periods, less bleeding, and more preservation of organ parenchyma, expanding the treatment options of patients with cancer who may not be eligible for resection. Image-guided ablation techniques are c

Совпадение в полном тексте источника
… Prostate Tumors The recent increase in screening measures has led to the detection of prostate cancers at earlier stages, calling into question the current standard treatments of radical prostatectomy, high dose prostate brachytherapy, and external beam radiation therapy that target the whole-gland … Other ablation techniques for prostate tumors include cryoablation, vascular-targeted photodynamic therapy (VP), RFA, MWA, and brachytherapy, but further comparative studies are needed. Figure 15 Irreversible electroporation of left prostate adenocarcinoma. …

Timeline of Translational Formulation Technologies for Cancer Therapy: Successes, Failures, and Lessons Learned Therefrom.

Over the past few decades, the field of cancer therapy has seen a significant change in the way in which formulations are designed and developed, resulting in more efficient products that allow us to ultimately achieve improved drug bioavailability, efficacy, and safety. However, although many formulations have entered the market, many others have fallen by the wayside leaving the scientific community with several lessons to learn. The successes (and failures) achieved with formulations that have been approved in Europe and/or by the FDA for the three major types of cancer therapy (peptide-bas

Совпадение в полном тексте источника
… The second is brachytherapy, in which a radioactive source is inserted into the body to deliver the dose to a small, well-defined anatomy [ 11 ]. … Radical prostatectomy, external beam radiotherapy, or external beam radiotherapy with brachytherapy boost and disease progression and mortality in patients with gleason score 9-10 prostate cancer. JAMA J. Am. Med. Assoc. 2018;319:896–905. doi: 10.1001/jama.2018.0587. 12. …

Classic Kaposi Sarcoma: Current Treatment Strategies and Emerging Therapeutic Approaches.

Classic Kaposi sarcoma (CKS) is a rare vascular neoplasm driven by infection with Kaposi sarcoma-associated herpesvirus (KSHV) and characterized by a heterogeneous geographic distribution. While the etiology of other Kaposi's sarcoma (KS) variants is well established, the underlying mechanisms of CKS appear multifactorial, with several risk factors, among which advanced age and male sex are most significant. Due to the rarity of CKS and its often indolent clinical course, clinical trials are sparse, and current knowledge of therapeutic approaches remains limited. Most available clinical trials

Совпадение в полном тексте источника
… Brachytherapy represents an alternative RT modality, demonstrating high response rates in small lesions, especially in elderly patients or in cases where cosmetic outcomes are a concern [ 31 ]. …

Patient reported change in pain outcome among stage IV cancer patients with bone metastases following palliative radiotherapy: A prospective study from Ethiopia.

BackgroundCancer is reported to be on the rise in low-income countries where most patients present in either locally advanced or metastatic stage of the disease. The standard treatment for cancer patients with metastatic bone disease includes radiotherapy, systemic agents and surgical intervention. Most cancer patients in Ethiopia present in advanced stage of the disease. Among these patients with advanced cancer are those with painful metastasis to the bone. Most commonly these patients are offered palliative single fraction 8 gy or fractionated 20 gy of radiotherapy to painful bone metastase

Совпадение в полном тексте источника
… There are five clinical oncologists, one functional cobalt teletherapy machine and one high dose brachytherapy for 110 million Ethiopian populations. …

The EORTC QLQ-C30 Summary Score as Prognostic Factor for Survival of Patients with Cancer in the "Real-World": Results from the Population-Based PROFILES Registry.

BACKGROUND: Health-related quality of life (HRQoL) has been shown to be a prognostic factor for cancer survival in randomized clinical trials and observational "real-world" cohort studies; however, it remains unclear which HRQoL domains are the best prognosticators. The primary aims of this population-based, observational study were to (a) investigate the association between the novel European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (QLQ-C30) summary score and all-cause mortality, adjusting for the more traditional sociodemographic and clinical pr

Совпадение в полном тексте источника
… Primary treatments received (first 6 months after diagnosis) were classified into surgery, systemic therapy (chemotherapy, targeted therapy, immunotherapy), radiation therapy (including brachytherapy), hormonal therapy, no treatment or active surveillance, or unknown. …

Innovations in chemotherapy and radiation therapy: Implications and opportunities for the Asia-Pacific Rim.

New cases of invasive cancer in the United States occur among nearly 1.5 million people annually. In 2007, more than 1,500 people died per day with this diagnosis. Cancer is responsible for nearly one in every four deaths reported in the country. Enormous amounts of money and research have been, and are being spent, in an attempt to improve these numbers. While prevention and early detection remain the key to long-term success, treatment in the neo-adjuvant, adjuvant and metastatic settings still centre around two main treatment modalities - radiation therapy and chemotherapy. This article wil

Совпадение в полном тексте источника
… The availability of teletherapy and brachytherapy services were clearly based on the economic status of the countries examined. In many countries, patients were treated with CT or fluoroscopy-based systems. Treatment planning is also quite basic and often was performed without computers. …

Prevalence and clinicopathological characteristics of de novo metastatic cancer at a major radiotherapy centre in West Africa: a cross-sectional study.

BackgroundCancer is a major public health challenge in West Africa, with a significant proportion of cancer-related deaths attributed to distant metastasis. De novo metastatic cancer (DnMC), where metastasis is detected at diagnosis, presents considerable therapeutic challenges, particularly in limited-resource settings where novel treatments are often unavailable and/or unaffordable.AimTo determine the prevalence, incidence and clinicopathological characteristics of patients diagnosed with DnMC at a major radiotherapy center in West Africa.MethodsThis was a single-institution-based quantitati

Совпадение в полном тексте источника
… None of the patients 7was treated with brachytherapy. Figure 9. Treatment modalities utilised in managing patients with de novo metastasis. EBRT: external beam radiotherapy, RAI: radioactive iodine therapy. …

Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review.

The actinium-225 (225Ac) radioisotope exhibits highly attractive nuclear properties for application in radionuclide therapy. However, the 225Ac radionuclide presents multiple daughter nuclides in its decay chain, which can escape the targeted site, circulate in plasma, and cause toxicity in areas such as kidneys and renal tissues. Several ameliorative strategies have been devised to circumvent this issue, including nano-delivery. Alpha-emitting radionuclides and nanotechnology applications in nuclear medicine have culminated in major advancements that offer promising therapeutic possibilities

Совпадение в полном тексте источника
… Salvanou et al. (2020) recently reported on a study to evaluate gold nanoparticles radiolabeled with 225 Ac as an injectable radiopharmaceutical form of brachytherapy for local cancer radiation treatment [ 52 ]. …

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods.

In accordance with the World Health Organization data, cancer remains at the forefront of fatal diseases. An upward trend in cancer incidence and mortality has been observed globally, emphasizing that efforts in developing detection and treatment methods should continue. The diagnostic path typically begins with learning the medical history of a patient; this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle biopsy. Prompt initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and hospita

Совпадение в полном тексте источника
… Typically, radiation is systematically administered via external beam radiotherapy; however, it can also be provided by brachytherapy – an invasive procedure delivering a source of radiation close to the cancerous lesion[ 28 ]. … Reddy CA Stephenson AJ Klein EA Song DY Tosoian JJ Hegde JV Yoo SM Fiano R D'Amico AV Nickols NG Aronson WJ Sadeghi A Greco S Deville C McNutt T DeWeese TL Reiter RE Said JW Steinberg ML Horwitz EM Kupelian PA King CR Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy …

Interventional Radiology in the Management of Metastases and Bone Tumors.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc.). Primary malignant bone tumors are extremely rare compared with secondary bone

Совпадение в полном тексте источника
… recurrent or metastatic bone and soft tissue tumor: initial experience | 9 Bianchi G. et al. [ 122 ] | World J Surg | 2016 | ECT | Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial | 29 Jiao D. et al. [ 123 ] | Oncotarget | 2016 | RFA | Radiofrequency ablation versus 125I-seed brachytherapy …

Wisely frugal: ensuring sustainable funding for novel cancer therapeutics through a budget impact analysis in resource-limited settings.

IntroductionCancer care in Sri Lanka is predominantly provided through its state health system which is free at the point of delivery. We performed a budget impact analysis of novel cancer drugs with a view to enabling better prioritising of their procurement.MethodsMedian survival gain was obtained for each indication of a novel cancer drug by a review of the literature. The direct cost of drug procurement was obtained from the Ministry of Health of Sri Lanka and the cost per life year gained was computed for each indication. Two thresholds - per capita gross domestic product (GDP) per life y

Совпадение в полном тексте источника
… Radical external beam radiotherapy in combination with brachytherapy for cervical cancer in Sri Lanka: Is treatment delayed treatment denied? JCO Global Oncol. 2020;6:1574–1581. doi: 10.1200/GO.20.00196. 15. Rupasinghe T, Silva DC, Balawardena J, et al. …

Translational Bioinformatics Applied to the Study of Complex Diseases.

Translational Bioinformatics (TBI) is defined as the union of translational medicine and bioinformatics. It emerges as a major advance in science and technology by covering everything, from the most basic database discoveries, to the development of algorithms for molecular and cellular analysis, as well as their clinical applications. This technology makes it possible to access the knowledge of scientific evidence and apply it to clinical practice. This manuscript aims to highlight the role of TBI in the study of complex diseases, as well as its application to the understanding and treatment o

Совпадение в полном тексте источника
… . | Uterine Cervical Cancer | Drug: Hydrochloride anlotinib, Drug: cis Platinum/carboplatin, Radiation: External beam radiotherapy and brachytherapy | China | NCT04772001 Lethal Prostate Cancer Biology–Urine Metabolomics | A prospective, observational and investigational study that aims to find new markers …

Advances and Challenges in Cervical Cancer: From Molecular Mechanisms and Global Epidemiology to Innovative Therapies and Prevention Strategies.

BackgroundIn the global scenario of public health, cervical cancer poses a major threat with high mortality rates, especially in women. New incidence cases and prevalence vary across different regions, as recently shown by GLOBOCAN data. The development of cervical cancer is primarily due to persistent infection by high-risk genotypes of human papillomavirus (HPV), which is a multifaceted process that is influenced by genetic, environmental, and lifestyle factors.PurposeThe goal of this study is to thoroughly investigate cervical cancer, including its etiology, molecular mechanisms, progressio

Совпадение в полном тексте источника
… Radiotherapy Radiotherapy exposes the body to high-energy X-rays; it is a central component of the therapy for cervical cancer. 127 The three forms of radiation therapy that are currently used to manage cervical cancer are external beam radiation therapy (EBRT), intensity-modulated radiotherapy (IMRT), and brachytherapy … Similar to IMRT, brachytherapy also protects the nearby tissue structures by either giving a massive dose of radiation to the tumor or inserting a radioactive implant at the tumor location. 128 However, there are several side effects commonly related to radiotherapy, and these include diarrhea, abdominal …