Результаты поиска

Beyond CAR T-Cell Therapy: Continued Monitoring and Management of Complications.

Chimeric antigen receptor (CAR) T-cell therapy has recently emerged as a groundbreaking treatment for CD19-expressing hematologic malignancies and received rapid approval by the U.S. Food & Drug Administration. Tisagenlecleucel and axicabtagene ciloleucel are now widely available at CAR T-cell therapy centers around the United States. Many patients have achieved complete response or remission despite failing multiple previous lines of therapy, but some patients endure the severe risks of cytokine release syndrome, neurotoxicity, and other immunologic effects. As more patients receive this ther

Совпадение в полном тексте источника
… Patients should be prescribed ciprofloxacin at 500 mg po every 8 hours with amoxicillin-clavulanate at 500 mg po every 8 hours (or clindamycin at 600 mg po every 8 hours with penicillin allergy). …

Bisphophonates related osteonecrosis of the jaw.

OBJECTIVE: With sporadic reporting of BPs related osteonecrosis of jaw and in absence of definitive guidelines regarding the management of such patients, the dentists and the oral and maxillofacial surgeons need to be updated about this issue. The objective of this article was to produce an updated bibliographic review of BPs related ONJ. This paper reviews the literature regarding the same for better understanding of the problem and its management. BACKGROUND: Bisphosphonates (BPs) are potent inhibitors of bone resorption and are widely used in the treatment of osteoporosis and other disease

Совпадение в полном тексте источника
… Table 1 Staging and treatment strategies The use of oral antimicrobial rinses in combination with oral systemic antibiotic therapy; penicillin, metronidazole, quinolones, clindamycin, doxycycline, and erythromycin is indicated for stages I and II of BRONJ.[ 5 , 55 ] Treatment goals The major goals …

An Observational Analysis of a Large Cohort of Pneumocystis jirovecii Pneumonia.

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is increasingly seen in patients who are non-HIV immunocompromised hosts, yet modern risk factors and outcomes are poorly recognized and defined. METHODS: A retrospective review was conducted of adult patients who met criteria for proven or probable PCP from 2017 to 2024 across a large academic multicenter health system. The primary outcome was mortality among cohorts, defined by etiology of immunosuppression through univariate and age-adjusted logistic regression. Secondary analyses included trends in annual diagnoses and testing patterns.

Совпадение в полном тексте источника
… . (%) Final treatment regimen a | Atovaquone | 114 (16.3) Trimethoprim/sulfamethoxazole | 538 (76.7) Clindamycin/primaquine | 33 (4.7) Pentamidine | 5 (0.7) None b | 11 (1.6) Treated with steroids | 497 (70.9) Empiric treatment | 124 (17.7) Degree of hypoxemia | None | 87 (12.4) Nasal cannula | 295 …

Расследование результатов и лечение длинных коронавирусных заболеваний 2019 года у пациентов с множественным склерозом, обработанных ритуксимаб: тематическое исследование.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, затрагивающее центральную нервную систему, характеризующееся разрушением миелинской ножки нервов. Пациенты MS, которые лечились ритуксимабом, иммунодепрессивным препаратом, страдают от снижения уровня иммуноглобулина, что повышает их риск различных инфекций, включая коронавирусную болезнь 2019 года (COVID-19). Во время пандемии COVID-19 у многих из этих пациентов появились долгосрочные симптомы после инфицирования. Эти хронические симптомы привели к значительным осложнениям, а в некоторых случаях к росту смертности. В ходе этог

Совпадение в полном тексте источника
… Prior to admission, she had received treatment with cefixime, azithromycin, clindamycin, levofloxacin, and ceftriaxone, which yielded no improvement. The patient reported no comorbidities other than MS and denied tobacco, alcohol, or illicit drug use. …

Sclerotic bone: a sign of bone reaction in patients with medication related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction associated with antiresorptive drugs such as bisphosphonates and denosumab. When dealing with advanced and/or multiple MRONJ lesions undergoing surgical therapy, the extent of surgery is often a topic of discussion. The aim of this study was to identify the differences in bone density in and around the MRONJ lesion before and after surgical treatment to evaluate the needed surgical extend of the modelling osteotomy. In this retrospective study 26 patients with MRONJ lesions that were surgically treated in our dep

Совпадение в полном тексте источника
… In addition pre and postoperative antibiotic therapy (3 g Ampcillin/Sulbactam or 600 mg Clindamycin in case of penicillin allergy three times per day) was applied in all patients. …

Association between Hyperglycemia and Medication-Related Osteonecrosis of the Jaw (MRONJ).

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a type of jawbone necrosis caused by the use of drugs for some types of cancer and osteoporosis. The current study aimed to evaluate the associations between hyperglycemia and the development of medication-related osteonecrosis of the jaw. METHODS: Our research group investigated data collected between 1 January 2019 and 31 December 2020. A total of 260 patients were selected from the Inpatient Care Unit, Department of Oromaxillofacial Surgery and Stomatology, Semmelweis University. Fasting glucose data were used and included

Совпадение в полном тексте источника
… Antibiotics such as penicillin, clindamycin, and metronidazole are commonly used. The duration of antibiotic therapy is typically 7–14 days. Pain management: Pain management is an important aspect of MRONJ therapy. …

Risk factors for medication-related osteonecrosis of the jaw and salivary IL-6 IN cancer patients.

INTRODUCTION: Medication-related osteonecrosis of the jaws is a severe complication of the use of antiresorptive and antiangiogenic therapy, with limited treatment options and great impact on patient's quality pf life. OBJECTIVE: The aim of this study was to assess the risk factors associated with medication-related osteonecrosis of the jaws in oncologic patients undergoing bisphosphonate treatment. In addition, salivary levels of interleukin-6, IL-6, were measured to investigate their association with severity and risk of medication-related osteonecrosis of the jaws. METHODS: Case-control s

Совпадение в полном тексте источника
… Hospital 1 performed a minimally traumatic surgical protocol, primary closure of the surgical area, pre- and postoperative antibiotic therapy with amoxicillin 500 mg or clindamycin 600 mg for patients allergic to penicillin and periodic followup with these patients. …

Respiratory and Thoracic Medicine

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Clindamycin penetrates bone and tissues well and has an excellent anaerobic spectrum. Administering the liquid form of this drug is generally well tolerated if given cold. … Class Drug Dosage Antibiotics Amoxicillin 10-22 mg/kg, PO, every 12 hours Amoxicillin-clavulanate 13.75 mg/kg, PO, every 12 hours Azithromycin 15 mg/kg, PO, every 24 hours Cefadroxil 22 mg/kg, PO, every 12 hours Cephalexin 22 mg/kg, PO, every 8 hours Chloramphenicol 10-15 mg/kg, PO, every 12 hours Clindamycin …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Among the 25 patients with PTs performed for the 3 MLS subclasses, 2 (8%) had cross-reactivity by PT (1 positive to pristinamycin and erythromycin and 1 to clindamycin and pristinamycin). … PT were significantly more often positive in pristinamycin (19/41, 46.3%) than in macrolide (2/20, 10%) or clindamycin-suspected (3/10, 30%) DCADR (p = 0.015). …

Successful Management of Neutropenic Sepsis Is Key to Better Survival of Patients With Blood Cancer in Sri Lanka: Real-World Data From the Resource-Limited Setting.

PurposeSepsis is the main cause of nonrelapse mortality, and there are no published data on applicability of supportive care protocols from high-income countries such as Sri Lanka. The aim of the study was to investigate management and mortality of neutropenic episodes among Hemato-Oncology patients.Materials and methodsRetrospective analysis of clinical characteristics, management, morbidity, and mortality of neutropenic Hemato-Oncology patients presented to the Lanka Hospital Blood Cancer Centre from January 1, 2019 to December 31, 2019 was performed.ResultsA total of 169 neutropenic episode

Совпадение в полном тексте источника
… ciprofloxacin, amikacin, pip + taz Urine | Klebsiella pneumoniae | Gentamycin, cefotaxime, ciprofloxacin Sputum | Acinetobacter species | Colistin Sputum | Candida albicans | Fluconazole Sputum | Candida albicans | Fluconazole Sputum | Candida species | Fluconazole Other (ICD) | Staphylococcus | Tetracycline, clindamycin …

Review of Hematology-Oncology Emergencies for Internal Medicine Residents.

The prevalence of cancer continues to grow globally every year. With therapeutic advances over the recent decades, the prevalence of individuals living with cancer continues to increase. Internal medicine residents can see patients admitted to the hospital for cancer-related emergencies. Early identification and appropriate management of these emergencies have been shown to improve mortality and morbidity. In this article, we aim to review the recent updates in the management of commonly encountered oncologic emergencies in the practice of internal medicine residents. This review will cover sp

Совпадение в полном тексте источника
… Clindamycin may be used in patients allergic to penicillin. Further evaluation is advised if the fever recurs or persists after 48 hours [ 42 , 43 ]. Table 2 MASCC score Multinational Association of Supportive Care in Cancer (MASCC) risk index factors and their individual weights. …

Evaluation of advanced platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam.

OBJECTIVES: Mechanisms of wound healing are often impaired in patients with osteonecrosis of the jaw (ONJ). According to the guidelines for the treatment of this disease, early surgical intervention is indicated. However, surgery often faces complications such as wound healing disorders. The application of platelet-rich fibrin (PRF) after necrosectomy between bone and mucosa may constitute a promising approach to improve surgical results. An aspect that was not investigated until now is that PRF acts as a "bio-carrier" for antibiotics previously applied intravenously. MATERIALS AND METHODS: W

Совпадение в полном тексте источника
… Polak et al., for example prepared PRF with the addition of metronidazole, penicillin, or clindamycin to the blood sample before centrifugation. The antimicrobial effect was tested on two bacterial strains. This antibiotic-loaded PRF showed a locally antimicrobial effect [ 20 ]. …

P941 – P1197

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… MIC results for β-lactams, aminoglycosides, clindamycin, fluoroquinolones, and tetracycline demonstrated resistance, whereas, results for vancomycin were susceptible. With respect to vancomycin, the MIC 90 was 2.0 µg/ml while linezoloid showed the most activity at 0.5 µg/ml. …

Indian Society of Periodontology Good Clinical Practice Recommendations for dental pain management and use of analgesics.

Pain is one of the most frequent reasons for seeking dental care and significantly influences patient comfort, treatment acceptance, and clinical outcomes. Effective management of dental pain requires accurate diagnosis, timely intervention, and the rational use of analgesics supported by evidence-based clinical decision-making. Recognizing the need for structured guidance for everyday dental practice, the Indian Society of Periodontology has developed Good Clinical Practice Recommendations on Pain Management and the Use of Analgesics in Dental Clinics. These recommendations were formulated by

Обнаружить важную роль гута микробиота и диета в многоразовом склерозе.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы (CNS), характеризующееся нейродегенерацией, повреждением аксона, обезвоживанием и воспалением. В последнее время кишечный дисбиоз связан с MS и другими аутоиммунными условиями. А именно, кишечная микробиота играет жизненно важную роль в регулировании иммунной функции, оказывая влияние на развитие иммунных клеток, производство цитокина и целостность кишечника. В то время как сбалансированная микробиота способствует иммунной терпимости, дисбиоз нарушает иммунное регулирование, наносит ущерб проницаемо

Совпадение в полном тексте источника
… For example, the administration of clindamycin has been linked with the longest-lasting effects on the gut microbiota [ 26 , 27 ]. Gut dysbiosis caused by early antibiotic exposure in neonates is a potential risk factor for inflammatory bowel disease later in life [ 28 , 29 , 30 ]. …

Epidemiology and source of infection in cancer patients with febrile neutropenia: an experience from a developing country.

BackgroundFebrile neutropenia (FN) is a life-threatening complication that predisposes cancer patients to serious infections. This study aims to describe the epidemiology and source of infection in cancer patients with FN in a tertiary care hospital.MethodsA hospital-based retrospective study was conducted in a large tertiary care hospital from January 2020 to December 2021. Data on cancer patients with FN were collected from the hospital information system.Results150 cancer patients with FN were identified during the study period. Most patients were males (98; 65.3%), and the mean age of part

Совпадение в полном тексте источника
… | 0 | – | – | – | 0 | 0 | 0 S. oralis | 2 | – | – | – | – | – | – | – | 0 | 0 | – | – | 2 (100) | 1 (100) TMP/SMX | Gentamicin | Streptomycin | Amikacin | Benzylpenicillin | Oxacillin | Erythromycin | Quinupristin/Dalfopristin | Vancomycin | Tetracycline | Tigecycline | Nitrofurantoin | Linezolid | Clindamycin …

Role of Actinomyces spp. and related organisms in the development of medication-related osteonecrosis of the jaw (MRONJ): Clinical evidence based on a case series.

Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common consequence of antiresorptive treatment, which often leads to the development of necrotic exposed bone surfaces with inflammatory processes affecting the jawbone. Although the development of MRONJ is often associated with the inflammatory response or infections caused by the colonizing members of the oral microbiota, the exact pathogenesis of MRONJ is still not fully understood. In the present paper, we aimed to provide additional, microbiological culture-supported evidence, supporting the "infection hypothesis" that

Совпадение в полном тексте источника
… Finally, therapeutic success of MRONJ (depending on the stage of the disease) largely depends on the use of appropriate, long-term antibiotic therapy (which most commonly entails the administration of penicillin-derivatives, like amoxicillin and ampicillin; alternatively, macrolides or clindamycin may …

Распространяется жизнь, угрожая вирусом Нокардии отитидискавиарум у молодой женщины с недавно диагностированным системным волшебством эритематос, отчетом по делу и анализом литературы.

По сообщениям, инфекция, вызванная нокардией, наблюдается главным образом у иммунокомпромиссированных пациентов. Обычно он представляет собой легочную или распространенную болезнь с предрасположенностью к мозгу. Инфекции - это редкая этиология внутричерепной сосудистой аневризмы. В этой связи мы сообщаем о случае распространения Nocardia otitidiscaviarum (N. otitidiscaviarum) у молодой женщины, у которой недавно был диагностирован системный волчан (SLE), осложняемый развитием инфекционной внутричерепной аневризмы. Насколько нам известно, это четвертый случай внутричерепной аневризмы, связанной

Совпадение в полном тексте источника
… 69/M | Rheumatoid arthritis | Lung | also showed the presence of fluid encap-sulated by an irregularly thickened pleural membrane | TMP-SMX + Levofloxacin +Gentamicin | + | Recovered | [40] Fabre et al . , 2005 | 70/M | Rheumatoid arthritis, Infliximab | Skin | CT head and Lung Normal | Ofloxacin + Clindamycin …

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].

Совпадение в полном тексте источника
… Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria. Malaria J. 2008;7:225. doi: 10.1186/1475-2875-7-225. 19. …

Кислотная терапия и риск излечения в случае воспламенительной болезни лопатки: сравнительное исследование в целях информирования о личностном лечении в мире.

Предыстория/цели: Известно, что ингибиторы протонных насосов (ИПЦ) изменяют состав кишечника микробиота; однако их связь с курсами заболеваний и результатами у пациентов с воспалительным кишечным заболеванием (ИБД) остается неопределенной. Наши цели заключались в оценке связи между использованием ИЦП и эскалацией лечения, диффицией Клостридиодов и использованием медицинских услуг в ИБД. Методы: Мы провели ретроспективное когортное исследование на платформе TriNetX. Пациенты IBD с ИЦП или histamine-2 Совпадали антагонисты рецептора (H2RA) one- чтобы...one с помощью баллов склонности. Итогом это

Совпадение в полном тексте источника
… 2008 (15.7) | 2020 (15.7) | 0.003 Aspirin, n (%) | 8287 (17.6) | 1953 (14.9) | 0.074 | 1862 (14.5) | 1936 (15.1) | 0.016 Hydrocortisone, n (%) | 5012 (10.7) | 2008 (15.3) | 0.139 | 1852 (14.4) | 1859 (14.5) | 0.002 Budesonide, n (%) | 4016 (8.6) | 998 (7.6) | 0.034 | 1010 (7.9) | 975 (7.6) | 0.010 Clindamycin …