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Optimal Treatment of Retinal Vein Occlusion: An Updated Canadian Review and Recommendations.

Retinal vein occlusion (RVO) represents a heterogeneous group of disorders that remains the second most common retinal vascular disease and can be associated with vision loss. RVO confers a substantial burden of illness that affects patients, caregivers, medical systems, and physicians. Complications of RVO - including cystoid macular edema, macular ischemia, and neovascularization sequelae - may result in severe visual morbidity and blindness. Canadian expert consensus recommendations on the optimal treatment of patients with RVO were published in 2015. Since that time, advances in diagnosis

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… arteries (venous thrombosis at area of AV crossing) External compression or disease of retinal venous wall i.e vasculitis Changes in lamina cribrosa (CRVO) Hyperopia/short axial length Central serous chorioretinopathy Hyperhomocysteinemia Antiphospholipid syndrome Anticardiolipin antibody Prothrombin … Associations of retinal artery occlusion and retinal vein occlusion to mortality, stroke, and myocardial infarction: a systematic review . Eye . 2016 ; 30 ( 8 ): 1031 – 1038 . doi: 10.1038/eye.2016.111 27256303 PMC4985669 63. Bucciarelli P , Passamonti SM , Gianniello F , Artoni A , Martinelli I . …

Annual review of section on ocular disease: diseases of the optic nerve, tracts, and visual cortex.

The ophthalmic literature dealing with diseases of the optic nerve, tracts, and visual cortex was reviewed for the period November 1977 to December 1978. Fifty-nine papers of interest to optometrists have been abstracted. Main areas of interest include: role of axoplasmic transport in production of disc edema and cotton-wool spots; ocular effects of local and systemic vascular disturbances; congenital abnormalities of the eye alone and in association with other bodily malformation; field testing, including an ingenious ophthalmoscopic method which can lead to detection of very small scotomas;

Ocular Signs and Ocular Comorbidities in Monoclonal Gammopathy: Analysis of 80 Subjects.

PURPOSE: To examine the ocular signs of monoclonal gammopathy and to evaluate ocular comorbidities in subjects with monoclonal gammopathy. Patients and Methods. We analyzed patients from two large referral hematology centers in Budapest, diagnosed and/or treated with monoclonal gammopathy between 1997 and 2020. As a control group, randomly selected individuals of the same age group, without hematological disease, have been included. There were 160 eyes of 80 patients (38.75% males; age 67.61 ± 10.48 (range: 38-85) years) with monoclonal gammopathy and 86 eyes of 43 control subjects (32.56% mal

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… As ocular signs of gammopathy, corneal deposits, conjunctival deposits, acute/chronic uveitis [ 18 , 19 ], maculopathy, foveolar drusen [ 20 – 22 ], Doyne retinal dystrophy [ 23 ], central retinal artery or vein occlusion [ 24 ], myositis, and proptosis [ 25 ] have been described. … This is well displayed in ophthalmic findings in our patients, as we found 1 subject with previous central retinal artery occlusion and 1 with branch retinal vein occlusion. Both entities warrant regular ophthalmic checkups and ophthalmic treatment. …

Синдром Сусака: история инвалидности из-за позднего признания.

Синдром Сусака является редкой провокационной микроангиопатией, характеризующейся триадой ретинопатии, энцефалопатии и потери слуха. Синдром вызывает повторяющиеся микроинфаркты в этих органах, которые, в свою очередь, проявляются в неоднократных атаках, связанных с потерей визуального поля, потерей слуха и слуха, а также различными синдромами мозга. Это часто приводит к значительному накоплению инвалидности с течением времени, особенно в случае задержек или неудач в диагностике. Повреждения мозга, связанные с этим заболеванием, могут быть похожи на повреждения, вызванные множественным склероз

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… The clue to the microangiopathic underpinning of the enigmatic presentation had come from ophthalmoscopic observations of multiple non-embolic branch retinal artery occlusions (BRAOs) as well as brain biopsy findings of sclerosis of small pial and cortical arteries. … Todd Hardy | Susac's syndrome | Multiple sclerosis Clinical Headache | Common | Uncommon Encephalopathy | Common at outset | Uncommon at outset Visual loss | Branch retinal artery occlusions | Optic neuritis Hearing loss and tinnitus | Common | Uncommon Focal neurological signs | Common | Common MRI …

Retinal Vein Occlusion-Background Knowledge and Foreground Knowledge Prospects-A Review.

Thrombosis of retinal veins is one of the most common retinal vascular diseases that may lead to vascular blindness. The latest epidemiological data leave no illusions that the burden on the healthcare system, as impacted by patients with this diagnosis, will increase worldwide. This obliges scientists to search for new therapeutic and diagnostic options. In the 21st century, there has been tremendous progress in retinal imaging techniques, which has facilitated a better understanding of the mechanisms related to the development of retinal vein occlusion (RVO) and its complications, and conseq

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… Among the very rare changes observed in the course of RVO are occlusion of the cilio-retinal artery and whitening of the retina around the veins, considered severe acute macular neuroretinopathy (PAMM) [ 56 , 57 ]. Table 3 Clinical features characteristic for acute and late stages of RVO [ 55 ]. … However, they share common risk factors, such as diabetic retinopathy or retinal artery occlusion [ 104 , 105 , 106 ]. …

17th Конгресс ЕВНОС: Милан, Италия, 4–6 Июнь, 2026 года

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Prospective study of retinal diffusion-weighted imaging in central retinal artery occlusion Charlotte Pietrock 1 , Milena Miszczuk 2 , Eberhard Siebert 2 , Leon Alexander Danyel 1 1 Department of Neurology with Experimental Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie …

PB2683: MODERN DIAGNOSTIC CAPABILITIES OF THE OPHTHALMOLOGICAL STATUS OF PATIENTS WITH ONCO-HEMATOLOGICAL DISEASES.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… The analysis of ocular blood flow according to CDM data showed a decrease in all velocity characteristics mainly in the central retinal artery (CRA) and posterior short ciliary arteries (PSCA) (p < 0.01). According to the electrophysiological study, subnormal o-ERG was recorded in 71.4% of cases. …

[The efficacy of topotecan versus topotecan combined with melphalan in the treatment of vitreous seeds in retinoblastoma].

Objective: To comparatively evaluate the efficacy and safety of intravitreal topotecan (IVT) versus intravitreal melphalan (IVM) combined with IVT in the treatment of vitreous seeds in retinoblastoma (RB). Methods: Retrospective cohort study. This study collected clinical data from 34 patients with unilateral vitreous seeds in RB who were diagnosed and treated at the Department of Ophthalmology of Eye & ENT Hospital of Fudan University from December 2015 to May 2025. All patients developed refractory or recurrent vitreous seeds after receiving intravenous chemotherapy or intra-arterial chemoth

Prevention of coronary heart disease. Part I. Primary prevention.

The first concern in primary prevention is the physician's belief that primary prevention is important for all adults and that intervention can significantly affect risk. Given the coronary plaque burden over many years and the importance of the development of healthy lifestyles early in adulthood to decrease coronary plaque burden, there are excellent reasons to begin prevention even with young adults. At the very least, a patient seen for any reason should provide a smoking history, have knowledge of the presence of early CHD in first-degree relatives and measurements of blood pressure, heig

Surgery for nonarteritic anterior ischemic optic neuropathy.

BACKGROUND: Nonarteritic ischemic optic neuropathy (NAION) is characterized by sudden and painless loss of vision in the eye, accompanied by … eceived surgery experienced both intraoperative and postoperative adverse events, including central retinal artery occlusion during surgery and light perception vision at six months (one participant); and immediate loss of light perception following surgery and loss of vision that persisted to the 12-month visit (two participants). In the careful follow-up group …

[Post-traumatic systemic fat embolism syndrome. Retrospective autopsy study].

INTRODUCTION: The obstruction of blood vessels or heart chambers with fat globules, reached by circulation, is fat embolism [1, 2]. Clinical manifestation of the presence of fat emboli in vital organs is Fat Embolism Syndrome (FES). This syndrome is characterized by neurologic, respiratory and cutaneous signs and different symptoms [5-8], grouped in major and minor signs by Gurd and Wilson. PURPOSE: The purpose of this paper is to analyze and compare the autopsy findings and clinical data in cases where FES is emphasized as the single or concurrent cause of death after performed autopsy. MAT

Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives.

Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maintenance of homeostasis. VEGF ligands and their receptors orchestrate endothelial cell proliferation, migration, and survival, playing a pivotal role in dynamic vascular remodeling. Dysregulated VEGF signaling drives diverse pathological conditions, including tumor angiogenesis, cardiovascular diseases, and ocular disorders. Excessive VEGF activity promotes tu

Histologic and morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroidal neovascular membranes.

OBJECTIVE: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized countries. Different risk factors have been associated with AMD. We performed a histopathologic and morphometric study to compare eyes with different stages of AMD to age-matched eyes. This study aimed to investigate the correlation among morphometric characteristics of choroidal vessels, the retinal pigment epithelium, and Bruch's membrane, to study the association between these characteristics and the presence and type of AMD, and to identify morphologic risk factors for exudati

Ocular Manifestations in Hematological Disorders.

Background Ophthalmic manifestations are a common feature in hematological malignancies and may be divided into two groups: those attributable to the disease's infiltration of the eye, and the ocular consequences due to blood abnormalities. This study aims to determine the prevalence of ocular manifestations and their association with the different hematological disease subgroups. Materials and methods We conducted a retrospective and observational study enrolling 137 consecutive patients on active treatment or follow-up for hematological malignancies from January 2016 to January 2020 at the C

Aspirin use and bleeding events during thrombocytopenia after autologous stem-cell transplantation for multiple myeloma.

BACKGROUND: In patients with cardiovascular (CV) comorbidities that necessitate antiplatelet therapy (APT), its optimal management during chemotherapy-induced thrombocytopenia remains elusive, as the risk of bleeding has to be balanced against the risk of CV events. The purpose of this study was to assess the risk for bleeding with APT during thrombocytopenia in patients with multiple myeloma undergoing high-dose chemotherapy and subsequent autologous stem-cell transplantation (ASCT) with and without acetylsalicylic acid (ASA) as comedication. METHODS: We assessed patients who underwent ASCT

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… AF, atrial fibrillation; ASA, acetylsalicylic acid; ASCT, autologous stem-cell transplantation; CAD, coronary artery disease; CNS, central nervous system; CRAO, central retinal artery occlusion; DVT, deep vein thrombosis; GCS, glucocorticosteroids; GI, gastrointestinal; HF, heart failure; OSA, obstructive …

Galectins in the Pathogenesis of Common Retinal Disease.

Diseases of the retina are major causes of visual impairment and blindness in developed countries and, due to an ageing population, their prevalence is continually rising. The lack of effective therapies and the limitations of those currently in use highlight the importance of continued research into the pathogenesis of these diseases. Vascular endothelial growth factor (VEGF) plays a major role in driving vascular dysfunction in retinal disease and has therefore become a key therapeutic target. Recent evidence also points to a potentially similarly important role of galectins, a family of β-g

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… Focusing on the retina, the central retinal artery and the choriocapillaris are the main vessel systems that supply blood to the inner retina and the RPE and the outer retina, respectively ( Figure 3B ; Joyal, et al., 2018 ). … Branching out from the central retinal artery, three capillary layers then supply blood to the inner retina: the superficial, intermediate and deep retinal vasculature ( Gariano and Gardner, 2005 ). …

Окулярная токсичность целевой терапии и иммунотерапии гематологов.

Целенаправленная терапия и иммунная терапия изменили методы борьбы с гематологическими заболеваниями. Однако эти агенты могут также иметь непреднамеренные окулярные неблагоприятные последствия. Эти токсичные вещества часто недооцениваются, но могут существенно повлиять на качество жизни пациентов и на процесс принятия терапевтических решений. Всеобъемлющее понимание этих последствий имеет важное значение для междисциплинарного управления. В этом обзоре обобщаются имеющиеся в настоящее время данные об окулярной токсичности, связанной с современными целенаправленными и иммунными терапиями, испол

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… Ibrutinib has been anecdotally associated with cataracts and retinal artery occlusion; however, a clinical trial involving over 500 patients found no increased incidence of cataracts compared to the general population. … Cases of irreversible damage were isolated (e.g. a missed immune-mediated optic neuritis or a severe retinal artery occlusion). This suggests that with vigilant care, patients can avoid serious outcomes. …

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders.

The field of gene therapy is striving more than ever to define a path to the clinic and the market. Twenty gene therapy products have already been approved and over two thousand human gene therapy clinical trials have been reported worldwide. These advances raise great hope to treat devastating rare and inherited diseases as well as incurable illnesses. Understanding of the precise pathomechanisms of diseases as well as the development of efficient and specific gene targeting and delivery tools are revolutionizing the global market. Currently, human cancers and monogenic disorders are indicati

Ангиография оптической согласованности — полезное средство для отличия первичного феномена Рейно от системного склероза и/или очень ранней болезни системного склероза.

Цель этого межсекторального исследования заключалась в сопоставлении результатов оптической ангиографии, полученной пациентами, с первичным явлением Рейно (PRP; n = 22), очень раннее заболевание системного склероза (VEDOS; n = 19), и системный склероз (SSc; 25 пациентов с ограниченным количеством SSc (lcSSc) и 13 - пациентов с диффузным резиновым SSc (dcSSc)). Целые, парафовиальные и перифовенные поверхностные капиллярные сплексы (ПХФ) плотность судна (ДГ), глубокие капиллярные сплетения VD и целые, внутренние и перипапольные VD были значительно выше в группе ПРП (p) < 0.001). В группе IcSSc п