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Otitis media: the chinchilla model.

Streptococcus pneumoniae infection and disease have been modeled in several animal species including infant and adult mice, infant and adult … oid metabolites, and ME epithelial cell adhesion and mucous glycoprotein production. Both clinical (tympanic membrane appearance) and histopathology (ME, Eustachian tube, inner ear) endpoints can be quantified. Immunologic and inflammatory studies have been facilitated by the production of affinity-purified antichinchilla immunoglobulin G (IgG), IgM, and secretory …

Pooled analysis of two clinical trials comparing the clinical outcomes of topical ciprofloxacin/dexamethasone otic suspension and polymyxin B/neomycin/hydrocortisone otic suspension for the treatment of acute otitis externa in adults and children.

OBJECTIVE: This study aimed to compare the clinical outcome of patients receiving topical ciprofloxacin 0.3%/dexamethasone 0.1% (CD) otic su … OE were considered for inclusion in the studies. Patients with AOE >4 weeks' duration, a perforated tympanic membrane, chronic suppurative otitis media, or use of either antibiotics or steroids within the previous 7 days were excluded from the studies. Patients were randomly assigned to receive CD or PNH for 7 days. CD was administered as 3 drops in children and 4 …

Когда уши болеют больше: отомастоидитные двусторонние краниальные Neurophies в иммунокомпрометированном пациенте.

Отомастоидит — это инфекция и воспаление как отитной среды (мидлушное ухо), так и мастоидной воздушной клетки. Если инфекция проходит мимо среднего уха, чтобы повлиять на прилежащие структуры, то могут быть задействованы мастоидные воздушные элементы. Фунгальный мастоидит очень редкий и почти исключительно наблюдается у иммунокомпромиссированных пациентов. Мы представляем необычный случай типа 2 диабетик с грибковым отомастоидитом, проявляющимся как боль в левом ухе, а также нейропатия левого черепного нерва VII и правого черепного нерва III. Хотя паралич лицевого нерва часто объясняется идиоп

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… Complications include tympanic membrane perforation, abscess formation, labyrinthitis, sinus thrombosis, cranial nerve (CN) VI or CN VII palsies, and skull base osteomyelitis [ 4 , 7 ]. … On admission, examination of his left ear revealed thick debris with granulation tissue at the inferior tympanic membrane. Neurological examination demonstrated intermittent binocular diplopia on horizontal and vertical extremes with spared pupillary function. …

Diode laser myringotomy for chronic otitis media with effusion in adults.

OBJECTIVE: To analyze the closure time of diode laser-assisted myringotomies, the incidence of complications, and the hearing results in comparison with the "cold" procedure in adults with otitis media with effusion (OME). STUDY DESIGN: Prospective case-control study. SETTING: Tertiary referral center, university hospital. PATIENTS: Twenty-eight adult patients (39 ears), 13 men and 15 women, age 13 to 76 years (mean, 51.9). Inclusion criteria included 3 months (or more) history of OME resistant to medical therapy. Twenty-two control patients (34 ears) underwent cold myringotomies with knife

MPO-ANCA-Associated Hypertrophic Pachymeningitis Mimicking IgG4-Related Disease: A Case Report and Literature Review.

Hypertrophic pachymeningitis (HP) is a rare and chronic clinical disease characterized by thickening of the dura mater, leading to persistent headache, cranial neuropathy, seizures, and other neurological symptoms. Immune-mediated causes, particularly antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and IgG4-related disease (IgG4-RD), are among the most common etiologies. We report a case of a 54-year-old female with recurrent headache, blepharoptosis, hearing loss, and markedly elevated inflammatory markers. Blood tests, and serum levels of IgG4 were within normal ranges. Cont

Tinnitus program at Brasília University Medical School.

Over the last 6 months, all patients seen at the otologic clinic of Brasília University Medical School answered a questionnaire designed to identify and describe the symptom of tinnitus. A total of 500 patients reported and described this symptom. They underwent physical examination, laboratory tests and audiological evaluation. In their order of frequency, presbycusis, chronic otitis media, otosclerosis, acoustic trauma, Menière's disease, ototoxicity, and vestibular schwannoma were found. Tinnitus was rated as minor in 81%, moderate in 18%, and severely disabling in 1%. Those who requested t

Intratympanic gentamicin treatment for Meniere's disease.

OBJECTIVES: The purpose of this study was to evaluate the safety and efficacy of a modified intratympanic gentamicin technique in patients with intractable unilateral or bilateral Meniere's disease. METHODS: A retrospective review of 25 consecutive patients who underwent gentamicin treatment for Meniere's disease was conducted between 1992 and 1996. Two separate delivery systems were used during this study, with the last 13 subjects undergoing placement of the new system (flanged polyethylene tubing). RESULTS: Follow-up averaged 23 months. Absence of vertigo spells was reported in 88%, and s

Hyperbaric oxygen therapy for acute coronary syndrome.

BACKGROUND: Acute coronary syndrome (ACS), includes acute myocardial infarction and unstable angina, is common and may prove fatal. Hyperbar … ogical oxygen toxicity and only a single patient was reported to have significant barotrauma to the tympanic membrane. One trial suggested a significant incidence of claustrophobia in single occupancy chambers of 15% (RR of claustrophobia with HBOT 31.6, 95% CI 1.92 to 521). AUTHORS' CONCLUSIONS: For people with ACS, there is some evidence from small trials to sug …

[Lymphoma of the parotid salivary gland].

INTRODUCTION: Lymphomas appear mostly in lymph nodes and parenchymal organs such as liver and spleen, while other localizations are less fre … as hyperaemic and sporadically livid. ORL status excerpt: subtotal reniform perforation of the left tympanic membrane enclosing all parts except the attic, with slight transparent secretion. Enlarged lymph nodes were not palpable. On August 10, 1995, under general endotracheal anaesthesia, a pre-operative aspiration of tumor was performed in three positions. The ob …

Provider and patient drivers of ototopical antibiotic prescription variability.

OBJECTIVE: To determine if providers prescribe more affordable topical antibacterial therapy for patients who are economically disadvantaged or come from economically disadvantaged communities. STUDY DESIGN: Prescription drug database review. SETTING: Large academic hospital network. SUBJECTS AND METHODS: Ototopical prescription records of 2416 adults and children presenting with acute and chronic otologic infections from 2009 to 2013 were reviewed. Prescription, patient, provider, and institution variables including diagnosis, prescription type, demographics, health insurance status, healt

Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss in children.

OBJECTIVES/HYPOTHESIS: To evaluate clinical characteristics and possible associated factors of idiopathic sudden sensorineural hearing loss (ISSNHL) in children using univariate and multivariate analyses. STUDY DESIGN: A retrospective case series with comparisons. METHODS: From January 2007 to December 2013, medical records of 37 pediatric ISSNHL patients were reviewed to assess hearing recovery rate and examine factors associated with prognosis (gender; side of hearing loss; opposite side hearing loss; treatment onset; presence of vertigo, tinnitus, and ear fullness; initial hearing thresho

На пути к изоляции восприятия и физиологических факторов, способствующих тепловой чувствительности при множественном склерозе: осмысления из новой экспериментальной модели.

ЦЕЛЬ: Определение того, смягчают ли снижение теплового ощущения всего кузова при локальном охлаждении кожи, вызванное теплотворным эффектом, визуальное обесценение у людей с множественным склерозом (MS), оптическим невритом и симптомами, чувствительными к воздействию тепла, независимо от повышения температуры ядра.МЕТОДЫ: Thirteen Участники7 :: повторное выделение эмиссий MS (MS) пациентами с односторонним (левым) оптическим невритом и симптомами, чувствительными к воздействию тепла; 6 Проведено визуальное испытание на эффективность каждого глаза на исходном уровне и при пассивном нагревании (

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… T tym was measured using a Mon-a-therm general-purpose thermistor probe 400TM (Covidien, Mansfield, MA, USA) self-inserted into the aural canal until resting near the tympanic membrane and then insulated with cotton wool and ear defenders. …

Efficacy and Safety of Ciprofloxacin Plus Fluocinolone Acetonide Among Patients With Acute Otitis Externa: A Randomized Clinical Trial.

IMPORTANCE: Ciprofloxacin, 0.3%, plus fluocinolone acetonide, 0.025%, otic solution seems to be efficacious and safe in treating acute otiti … n with otorrhea, moderate or severe otalgia, and edema, as well as a Brighton grading of II or III (tympanic membrane obscure but without systemic illness). Statistical analysis was performed from November 14, 2018, to February 14, 2019. INTERVENTIONS: Participants were randomly assigned to receive ciprofloxacin plus fluocinolone, ciprofloxacin, or fluocinolone tw …

Systemic corticosteroids for acute otitis media in children.

BACKGROUND: Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotic … l or specific symptoms was presented as improvement in clinical symptoms and resolution of inflamed tympanic membranes without the need for additional antibiotic treatment: at Day 5 (94% of children in the treatment group (N = 89) versus 89% in the placebo group (N = 90); risk ratio (RR) 1.06, 95% confidence interval (CI) 0.97 to 1.16) and Day 14 (91% versus 87%; R …

Evaluation of a magnetic resonance-compatible dentoalveolar tactile stimulus device.

BACKGROUND: Few methods exist to study central nervous system processes following dentoalveolar tactile stimulation using functional magneti … jority of the intracranial contents 1 and to specialized structures (tongue, nasal mucosa, auricle, tympanic membrane, cornea and part of the conjunctiva) 2. Somatic sensory information transmitted by the trigeminal nerve is crucial for normal orofacial function; however, the mechanisms of many chronic pain conditions affecting areas innervated by this sensory syst …

Topical antiseptics for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Topical antiseptics, one of the possible treatments for CSOM, inhibit the micro-organisms that may be responsible for the infection. Antiseptics can be used alone or in addition to other treatments for CSOM, such as antibiotics or ear cleaning (aural toileting). A…

Executive Summary of Clinical Practice Guideline on Tympanostomy Tubes in Children (Update).

OBJECTIVE: This executive summary of the guideline update provides evidence-based recommendations for patient selection and surgical indicat … sion is no longer present, significant hearing loss is detected, or structural abnormalities of the tympanic membrane or middle ear are suspected. (6) Clinicians should not perform tympanostomy tube insertion in children with recurrent acute otitis media (AOM) who do not have middle ear effusion (MEE) in either ear at the time of assessment for tube candidacy. (7) …

APOE4 ослабляет липофагическую липофагию и поощряет демиэлизацию спиральных ганглионов в мышином кохлее.

АпоЭ-4 Ген представляет собой прочно установившийся генетический фактор риска для нейродегенеративных заболеваний, таких, как болезнь Альцгеймера и множественный склероз, которые характеризуются аксонной демиелинацией в центральной нервной системе. В недавних исследованиях были замешаны АпоЕ-4 в связи с возрастной потерей слуха (ARHL), что предполагает потенциальную роль изоформы APOE4 в дегенерации периферической нервной системы. Однако роль APOE4 в ARHL по-прежнему не ясна. В этом исследовании мы изучили потенциальную роль APOE4 в аксонной демиелиции спиральных ганглионов (SGN). АпоЭ-4/ __4

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… To investigate the phagocytosis of myelin debris by RCMs, lysophosphatidylcholine (LPC), a rapidly demyelinating drug, was injected through the mouse tympanic membrane [ 27 ]. … Briefly, APOE3 and APOE4 10-month-old mice were anesthetised and tympanic membranes were exposed using forceps; 1 μL of 1% LPC (MCE, USA) with Evans Blue as an indicator was injected into the cochleae of the left ears of each mouse to serve as the experimental group, while an equal volume of PBS was …

Topical versus systemic antibiotics for chronic suppurative otitis media.

BACKGROUND: Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection (involving more than one micro-organism) of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and hearing loss. Antibiotics are the most common treatment for CSOM, which act to kill or inhibit the growth of micro-organisms that may be responsible for the infection. Antibiotics can be administered both topically an…